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PhD candidate at the Chemistry Department, FCT-NOVA University of Lisbon, Portugal
Antiseptics and disinfectants are extensively used for a variety of topical and hard-surface applications. A wide variety of biocides as active chemical agents is found in these products, including alcohols, phenols, iodine, and chlorine. Many of these active agents demonstrate broad-spectrum antimicrobial activity; however, the mode of action of these agents is not well-documented. This review is focused on several examples of ionic systems based on ionic surfactants and ionic liquids as well as nanomaterials and nanoparticles acting as antiseptics and disinfectants for surfaces. It is important to note that many of these biocides may be used singly or in combination in a variety of products, which vary considerably in activity against microorganisms. Antimicrobial activity can be influenced by several factors such as formulation effects, presence of an organic load, synergy, temperature, dilution, and test method. The most promissory compounds based on ionic systems and nanomaterials published in mainly the last decade is chronologically reported in this review.
Francisco Faísca; Luis Filipe; Zeljko Petrovski; Miguel Santos; Sandra Gago; Luís Branco. Ionic Systems and Nanomaterials as Antiseptic and Disinfectant Agents for Surface Applications: A Review. Surfaces 2021, 4, 169 -190.
AMA StyleFrancisco Faísca, Luis Filipe, Zeljko Petrovski, Miguel Santos, Sandra Gago, Luís Branco. Ionic Systems and Nanomaterials as Antiseptic and Disinfectant Agents for Surface Applications: A Review. Surfaces. 2021; 4 (2):169-190.
Chicago/Turabian StyleFrancisco Faísca; Luis Filipe; Zeljko Petrovski; Miguel Santos; Sandra Gago; Luís Branco. 2021. "Ionic Systems and Nanomaterials as Antiseptic and Disinfectant Agents for Surface Applications: A Review." Surfaces 4, no. 2: 169-190.
Mesoporous silica nanoparticles (MSNs) are very promising nanomaterials for treating bacterial infections when combined with pharmaceutical drugs. Herein, we report the preparation of two nanomaterials based on the immobilization of ciprofloxacin in mesoporous silica nanoparticles, either as the counter-ion of the choline derivative cation (MSN-[Ch][Cip]) or via anchoring on the surface of amino-group modified MSNs via an amide bond (MSN-Cip). Both nanomaterials were characterized by TEM, FTIR and solution 1H NMR spectroscopies, elemental analysis, XRD and N2 adsorption at 77 K in order to provide the desired structures. No cytotoxicity from the prepared mesoporous nanoparticles on 3T3 murine fibroblasts was observed. The antimicrobial activity of the nanomaterials was determined against Gram-positive (Staphylococcus aureus and Bacillus subtilis) and Gram-negative (Klebsiella pneumoniae) bacteria and the results were promising against S. aureus. In the case of B. subtilis, both nanomaterials exhibited higher antimicrobial activity than the precursor [Ch][Cip], and in the case of K. pneumoniae they exhibited higher activity than neutral ciprofloxacin.
Blanca De Juan Mora; Luís Filipe; Andreia Forte; Miguel Santos; Celso Alves; Fernando Teodoro; Rui Pedrosa; Manuela Ribeiro Carrott; Luís Branco; Sandra Gago. Boosting Antimicrobial Activity of Ciprofloxacin by Functionalization of Mesoporous Silica Nanoparticles. Pharmaceutics 2021, 13, 218 .
AMA StyleBlanca De Juan Mora, Luís Filipe, Andreia Forte, Miguel Santos, Celso Alves, Fernando Teodoro, Rui Pedrosa, Manuela Ribeiro Carrott, Luís Branco, Sandra Gago. Boosting Antimicrobial Activity of Ciprofloxacin by Functionalization of Mesoporous Silica Nanoparticles. Pharmaceutics. 2021; 13 (2):218.
Chicago/Turabian StyleBlanca De Juan Mora; Luís Filipe; Andreia Forte; Miguel Santos; Celso Alves; Fernando Teodoro; Rui Pedrosa; Manuela Ribeiro Carrott; Luís Branco; Sandra Gago. 2021. "Boosting Antimicrobial Activity of Ciprofloxacin by Functionalization of Mesoporous Silica Nanoparticles." Pharmaceutics 13, no. 2: 218.