Prof. Lucie Nováková
Charles University, Faculty of Pharmacy in Hradec Kralove
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Academic Career Length
23Years (2004-Present)
(Calculated once Scilit publication data is synced: current year − year of first publication + 1)
Representative Publications
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Journal Article
MDMartin Doležal
Martin DoležalEJEduard Jirkovský
Eduard Jirkovský
Kateřina MacákováLKLenka Kujovská Krčmová
Lenka Kujovská KrčmováLJLenka Javorská
Lenka JavorskáOOOn Behalf Of The Oemonom
On Behalf Of The Oemonom
+5
Vitamin C (L-ascorbic acid) has been known as an antioxidant for most people. However, its physiological role is much larger and encompasses very different processes ranging from facilitation of iron absorption through involvement in hormones and carnitine synthesis for important roles in epigenetic processes. Contrarily, high doses act as a pro-oxidant than an anti-oxidant. This may also be the reason why plasma levels are meticulously regulated on the level of absorption and excretion in the kidney. Interestingly, most cells contain vitamin C in millimolar concentrations, which is much higher than its plasma concentrations, and compared to other vitamins. The role of vitamin C is well demonstrated by miscellaneous symptoms of its absence—scurvy. The only clinically well-documented indication for vitamin C is scurvy. The effects of vitamin C administration on cancer, cardiovascular diseases, and infections are rather minor or even debatable in the general population. Vitamin C is relatively safe, but caution should be given to the administration of high doses, which can cause overt side effects in some susceptible patients (e.g., oxalate renal stones). Lastly, analytical methods for its determination with advantages and pitfalls are also discussed in this review.
1 December 2009 in Analytica Chimica Acta
Journal Article
Lucie NovákováHVHana Vlčková
Hana Vlčková1 January 2006 in Talanta
Journal Article
1 September 2009 in Analytica Chimica Acta
Journal Article
MSMarcela Seifrtová
Marcela Seifrtová
Lucie NovákováCLCeleste Lino
Celeste Lino
Angelina Lopes Simões PenaPSPetr Solich
Petr Solich1 May 2014 in Analytica Chimica Acta
Journal Article
Lucie NovákováAPAlexandre Grand-Guillaume Perrenoud
Alexandre Grand-Guillaume Perrenoud
IFIsabelle Francois
Isabelle Francois
CWCaroline West
Caroline WestELEric Lesellier
Eric LesellierDGDavy Guillarme
Davy Guillarme
16 May 2022 in Critical Reviews in Clinical Laboratory Sciences
Journal Article
JJJiri Janousek
Jiri JanousekVPVeronika Pilařová
Veronika PilařováKateřina MacákováANAnderson Nomura
Anderson Nomura
JVJéssica Veiga-Matos
Jéssica Veiga-Matos
Premysl Mladenka +6
Vitamin D has a well-known role in the calcium homeostasis associated with the maintenance of healthy bones. It increases the efficiency of the intestinal absorption of dietary calcium, reduces calcium losses in urine, and mobilizes calcium stored in the skeleton. However, vitamin D receptors are present ubiquitously in the human body and indeed, vitamin D has a plethora of non-calcemic functions. In contrast to most vitamins, sufficient vitamin D can be synthesized in human skin. However, its production can be markedly decreased due to factors such as clothing, sunscreens, intentional avoidance of the direct sunlight, or the high latitude of the residence. Indeed, more than one billion people worldwide are vitamin D deficient, and the deficiency is frequently undiagnosed. The chronic deficiency is not only associated with rickets/osteomalacia/osteoporosis but it is also linked to a higher risk of hypertension, type 1 diabetes, multiple sclerosis, or cancer. Supplementation of vitamin D may be hence beneficial, but the intake of vitamin D should be under the supervision of health professionals because overdosing leads to intoxication with severe health consequences. For monitoring vitamin D, several analytical methods are employed, and their advantages and disadvantages are discussed in detail in this review.
About Me
Lucie Nováková is a Full Professor in Analytical Chemistry at the Charles University, Faculty of Pharmacy in Hradec Králové, Department of Analytical Chemistry, the Czech Republic since 2019. She received her Ph.D. from Pharmaceutical Analysis at the same university in 2005 followed by an Associate Professor degree in 2011.
Her research is oriented towards separation techniques, namely ultra-high performance liquid chromatography, supercritical fluid chromatography, and their coupling with mass spectrometry. She is involved in a wide scope of research projects focused on pharmaceutical analysis, doping control, plant analysis, environmental analysis, and bioanalytical methods. An important part of her research also lies in the sample preparation step. She extended her scientific experience during the fellowships at world-recognized universities, such as the University of Geneva and Vrije Universiteit Brussel, beyond others.
She authored two books on HPLC theory and practice and 9 book chapters. She published over 115 peer-reviewed scientific articles and review papers with more than 3650 citations and h index of 33. She is also widely involved in teaching and education activities, such as HPLC and SFC training courses, seminars, and conferences. Currently, she is a principal team manager of the STARSS project and the head of the research program in the EFSA-CDN project.
More details can be found at the scientific profile: http://portal.faf.cuni.cz/Profile/Novakova-Lucie/