Obese women were more susceptible to myalgia because of their significantly lower vitamin D concentrations; the present study investigated the efficacy of vitamin D in addition to an aerobic interval training in the management of obese women with myalgia. Forty-five obese women with vitamin D deficiency and myalgia (30 to 40 years old) were assigned randomly into three equal groups. Group A received an aerobic interval training with vitamin D supplementation, Group B received vitamin D supplementation only, and Group C received aerobic interval training only; participants in all groups were on calorie deficient diets. The study outcomes were the Visual Analog Scale (VAS) for Pain Evaluation, serum vitamin D level, and Cooper 12-Minute Walk Test for Functional Capacity Evaluation, while the Short-Form Health Survey (SF) was used for assessment of quality of life. We detected a significant improvement in pain intensity level, serum vitamin D level, and quality of life in all groups with significant difference between Group A and groups B and C. We also detected a significant improvement in functional capacity in groups A and C, with no significant change in Group B. Aerobic interval training with vitamin D supplementation was more effective for the management of obese women with perceived myalgia.

Objective: Transcutaneous electrical neuromuscular stimulation (TENS) is a noninvasive, nonpharmacological, and least expensive technique to improve sensitivity and reduce pain in patients with neuropathy. Evidence reported on the effectiveness of TENS on neuropathy was inconclusive. This study was aimed at providing recent evidence on the effectiveness of TENS for neuropathic pain, using data from randomized controlled trials and nonrandomized studies. Methods: We conducted a comprehensive search across Scopus, CINAHL, Web of Science, Medline, Embase, Cochrane Central Register of Control Trials (CENTRAL), Physiotherapy Evidence Database (Pedro), and Google Scholar from January 1, 1999, to May 5, 2024. Eligible studies included randomized controlled trials and nonrandomized studies on TENS for neuropathic pain, without restrictions based on language or country. Key inclusion criteria were studies on TENS for neuropathic pain, while exclusion criteria included studies on neuropathic pain due to cancer, HIV infection, or stroke. Two independent reviewers selected studies, extracted data, and assessed quality using the GRADE tool. Results: Thirty articles met the eligibility criteria, and 25 were included in the meta‐analysis. Overall, TENS slightly reduced neuropathic pain compared to placebo, but this was not clinically significant (SMD = −0.35; 95% CI: −0.90 to 0.10, p = 0.13). For patients with diabetic neuropathic pain, TENS was similar to placebo and other electrotherapies. However, it was better than placebo and other interventions for reducing neuropathic pain in spinal cord injury patients (SMD = −1.14; 95% CI: −2.22 to −0.06, p = 0.04). Conclusions: TENS generally seems to provide a small reduction in neuropathic pain compared with a placebo, other electrotherapies, or other interventions.

Background: Multiple comorbidities and physiological changes play a role in a range of heart failure conditions and influence the most effective approach to exercise-based rehabilitation. This research aimed to examine and compare the outcomes of continuous training at three different intensities, focusing on left ventricular (LV) remodeling, functional capacity, and quality of life among patients with heart failure with reduced ejection fraction (HFrEF). Methods: In this randomized control trial, a total of 60 male patients (average age: 54.33 ± 2.35 years) with HFrEF were randomly allocated into three groups: 1) High-intensity continuous training group (HICT), 2) Moderate-intensity continuous training group (MICT), and 3) Low-intensity continuous training group (LICT). All the training was performed on a bicycle ergometer 3 times/week for 12 weeks. Echocardiographic parameters (left ventricular ejection fraction, left ventricular end-diastolic dimension, left ventricular end-systolic dimension, N-terminal pro–B-type natriuretic peptide (NT-proBNP), quality of life (Minnesota Living with Heart Failure Questionnaire), and functional capacity (6-minute walking test) were assessed before and the end of the study. Results: The HICT group demonstrated the greatest improvements in all measured variables when compared to the other two groups (P < 0.05). These findings were consistent across all measured outcomes. Conclusion: It was determined that HICT appears to yield the most favorable outcomes in enhancing echocardiographic measures, NT-proBNP levels, quality of life, and functional capacity among HFrEF patients.

Background and purpose Fibromyalgia (FM) is a chronic illness affecting the immune system. Women are more likely than men to be diagnosed with this condition. It causes widespread muscle and bone pain and is most commonly experienced by people between the ages of 20 and 60. Recent studies have shown that people with fibromyalgia may experience heart abnormalities and arrhythmias after exercise. This study explores how different aerobic exercise levels affect pain, cholesterol levels, and overall quality of life (QoL) for women with fibromyalgia. Materials and Methods In a study conducted at Abu-Kabir Central Hospital in Al Sharquia, 60 women diagnosed with fibromyalgia were randomly allocated to a moderate-intensity aerobic exercise (AE) (n=30) or a low-intensity aerobic exercise AE (n=30). The women were between the ages of 30 and 40 and had a body mass index (BMI) between 20 and 26 kg/m2. Before and after the intervention, all patients in both groups were evaluated using a visual analog scale (VAS), Fibromyalgia Impact Questionnaire (FIQ), symptom severity scale (SS-scale), and cholesterol level measurements. Results After the intervention, the group that engaged in moderate-intensity aerobic exercise showed significant improvements in all measured outcomes compared to the group that engaged in low-intensity aerobic exercise. The effect size was high for VAS (MD = -3.73; ES = 0.395 and p = 0.001), cholesterol level (MD = -52.19; ES = 0.681 and p = 0.001), FIQ (MD=-36.26; ES = 0.746 and p = 0.001), and symptom severity scale (MD = -473; ES = 0.273 and p = 0.001). Conclusion Our research has shown that moderate-intensity AE performed at 60% to 70% of maximum heart rate, is more effective in reducing pain, improving overall QoL, and lowering cholesterol levels than low-intensity AE at 45% to 55%.

The authors have efficiently explained the contraindications of the pneumatic compression. The manuscript is well written and the idea is interesting. However, more references are needed to justify their idea.