Chronic diseases are becoming more widespread. Treatment and monitoring of these diseases require going to hospitals frequently, which increases the burdens of hospitals and patients. Presently, advancements in wearable sensors and communication protocol contribute to enriching the healthcare system in a way that will reshape healthcare services shortly. Remote patient monitoring (RPM) is the foremost of these advancements. RPM systems are based on the collection of patient vital signs extracted using invasive and noninvasive techniques, then sending them in real-time to physicians. These data may help physicians in taking the right decision at the right time. The main objective of this paper is to outline research directions on remote patient monitoring, explain the role of AI in building RPM systems, make an overview of the state of the art of RPM, its advantages, its challenges, and its probable future directions. For studying the literature, five databases have been chosen (i.e., science direct, IEEE-Explore, Springer, PubMed, and science.gov). We followed the (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) PRISMA, which is a standard methodology for systematic reviews and meta-analyses. A total of 56 articles are reviewed based on the combination of a set of selected search terms including RPM, data mining, clinical decision support system, electronic health record, cloud computing, internet of things, and wireless body area network. The result of this study approved the effectiveness of RPM in improving healthcare delivery, increase diagnosis speed, and reduce costs. To this end, we also present the chronic disease monitoring system as a case study to provide enhanced solutions for RPMs.

The increasing use of Internet of Things (IoT) applications in various aspects of our lives has created a huge amount of data. IoT applications often require the presence of many technologies such as cloud computing and fog computing, which have led to serious challenges to security. As a result of the use of these technologies, cyberattacks are also on the rise because current security methods are ineffective. Several artificial intelligence (AI)-based security solutions have been presented in recent years, including intrusion detection systems (IDS). Feature selection (FS) approaches are required for the development of intelligent analytic tools that need data pretreatment and machine-learning algorithm-performance enhancement. By reducing the number of selected features, FS aims to improve classification accuracy. This article presents a new FS method through boosting the performance of Gorilla Troops Optimizer (GTO) based on the algorithm for bird swarms (BSA). This BSA is used to boost performance exploitation of GTO in the newly developed GTO-BSA because it has a strong ability to find feasible regions with optimal solutions. As a result, the quality of the final output will increase, improving convergence. GTO-BSA’s performance was evaluated using a variety of performance measures on four IoT-IDS datasets: NSL-KDD, CICIDS-2017, UNSW-NB15 and BoT-IoT. The results were compared to those of the original GTO, BSA, and several state-of-the-art techniques in the literature. According to the findings of the experiments, GTO-BSA had a better convergence rate and higher-quality solutions.

Coronavirus (COVID-19) is a new virus of viral pneumonia. It can outbreak in the world through person-to-person transmission. Although several medical companies provide cooperative monitoring healthcare systems, these solutions lack offering of the end-to-end management of the disease. The main objective of the proposed framework is to bridge the current gap between current technologies and healthcare systems. The wireless body area network, cloud computing, fog computing, and clinical decision support system are integrated to provide a comprehensive and complete model for disease detection and monitoring. By monitoring a person with COVID-19 in real time, physicians can guide patients with the right decisions. The proposed framework has three main layers (i.e., a patient layer, cloud layer, and hospital layer). In the patient layer, the patient is tracked through a set of wearable sensors and a mobile app. In the cloud layer, a fog network architecture is proposed to solve the issues of storage and data transmission. In the hospital layer, we propose a convolutional neural network-based deep learning model for COVID-19 detection based on patient’s X-ray scan images and transfer learning. The proposed model achieved promising results compared to the state-of-the art (i.e., accuracy of 97.95% and specificity of 98.85%). Our framework is a useful application, through which we expect significant effects on COVID-19 proliferation and considerable lowering in healthcare expenses.

Carpal tunnel syndrome (CTS) is a prevalent medical condition resulting from compression of the median nerve in the hand, often caused by overuse or age-related factors. In this study, a total of 160 patients participated, including 80 individuals with CTS presenting varying levels of severity across different age groups. Numerous studies have explored the use of machine learning (ML) and deep learning (DL) techniques for CTS diagnosis. However, further research is required to fully leverage the potential of artificial intelligence (AI) technology in CTS diagnosis, addressing the challenges and limitations highlighted in the existing literature. In our work, we propose a novel approach for CTS diagnosis, prediction, and monitoring disease progression. The proposed framework consists of three main layers. Firstly, we employ three distinct DL models for CTS diagnosis. Through our experiments, the proposed approach demonstrates superior performance across multiple evaluation metrics, with an accuracy of 0.969%, precision of 0.982%, and recall of 0.963%. The second layer focuses on predicting the cross-sectional area (CSA) at 1, 3, and 6 months using ML models, aiming to forecast disease progression during therapy. The best-performing model achieves an accuracy of 0.9522, an R2 score of 0.667, a mean absolute error (MAE) of 0.0132, and a median squared error (MdSE) of 0.0639. The highest predictive performance is observed after 6 months. The third layer concentrates on assessing significant changes in the patients’ health status through statistical tests, including significance tests, the Kruskal-Wallis test, and a two-way ANOVA test. These tests aim to determine the effect of injections on CTS treatment. The results reveal a highly significant reduction in symptoms, as evidenced by scores from the Symptom Severity Scale and Functional Status Scale, as well as a decrease in CSA after 1, 3, and 6 months following the injection. SHAP is then utilized to provide an understandable explanation of the final prediction. Overall, our study presents a comprehensive approach for CTS diagnosis, prediction, and monitoring, showcasing promising results in terms of accuracy, precision, and recall for CTS diagnosis, as well as effective prediction of disease progression and evaluation of treatment effectiveness through statistical analysis.

Carpal tunnel syndrome (CTS) is a clinical disease that occurs due to compression of the median nerve in the carpal tunnel. The determination of the severity of carpal tunnel syndrome is essential to provide appropriate therapeutic interventions. Machine learning (ML)-based modeling can be used to classify diseases, make decisions, and create new therapeutic interventions. It is also used in medical research to implement predictive models. However, despite the growth in medical research based on ML and Deep Learning (DL), CTS research is still relatively scarce. While a few studies have developed models to predict diagnosis of CTS, no ML model has been presented to classify the severity of CTS based on comprehensive clinical data. Therefore, this study developed new classification models for determining CTS severity using ML algorithms. This study included 80 patients with other diseases that have an overlap in symptoms with CTS, such as cervical radiculopathysasas, de quervian tendinopathy, and peripheral neuropathy, and 80 CTS patients who underwent ultrasonography (US)-guided median nerve hydrodissection. CTS severity was classified into mild, moderate, and severe grades. In our study, we aggregated the data from CTS patients and patients with other diseases that have an overlap in symptoms with CTS, such as cervical radiculopathysasas, de quervian tendinopathy, and peripheral neuropathy. The dataset was randomly split into training and test data, at 70% and 30%, respectively. The proposed model achieved promising results of 0.955%, 0.963%, and 0.919% in terms of classification accuracy, precision, and recall, respectively. In addition, we developed a machine learning model that predicts the probability of a patient improving after the hydro-dissection injection process based on the aggregated data after three different months (one, three, and six). The proposed model achieved accuracy after six months of 0.912%, after three months of 0.901%, and after one month 0.877%. The overall performance for predicting the prognosis after six months outperforms the prediction after one and three months. We utilized statistics tests (significance test, Spearman’s correlation test, and two-way ANOVA test) to determine the effect of injection process in CTS treatment. Our data-driven decision support tools can be used to help determine which patients to operate on in order to avoid the associated risks and expenses of surgery.