Carpal tunnel syndrome (CTS) is a prevalent medical condition resulting from compression of the median nerve in the hand, often caused by overuse or age-related factors. In this study, a total of 160 patients participated, including 80 individuals with CTS presenting varying levels of severity across different age groups. Numerous studies have explored the use of machine learning (ML) and deep learning (DL) techniques for CTS diagnosis. However, further research is required to fully leverage the potential of artificial intelligence (AI) technology in CTS diagnosis, addressing the challenges and limitations highlighted in the existing literature. In our work, we propose a novel approach for CTS diagnosis, prediction, and monitoring disease progression. The proposed framework consists of three main layers. Firstly, we employ three distinct DL models for CTS diagnosis. Through our experiments, the proposed approach demonstrates superior performance across multiple evaluation metrics, with an accuracy of 0.969%, precision of 0.982%, and recall of 0.963%. The second layer focuses on predicting the cross-sectional area (CSA) at 1, 3, and 6 months using ML models, aiming to forecast disease progression during therapy. The best-performing model achieves an accuracy of 0.9522, an R2 score of 0.667, a mean absolute error (MAE) of 0.0132, and a median squared error (MdSE) of 0.0639. The highest predictive performance is observed after 6 months. The third layer concentrates on assessing significant changes in the patients’ health status through statistical tests, including significance tests, the Kruskal-Wallis test, and a two-way ANOVA test. These tests aim to determine the effect of injections on CTS treatment. The results reveal a highly significant reduction in symptoms, as evidenced by scores from the Symptom Severity Scale and Functional Status Scale, as well as a decrease in CSA after 1, 3, and 6 months following the injection. SHAP is then utilized to provide an understandable explanation of the final prediction. Overall, our study presents a comprehensive approach for CTS diagnosis, prediction, and monitoring, showcasing promising results in terms of accuracy, precision, and recall for CTS diagnosis, as well as effective prediction of disease progression and evaluation of treatment effectiveness through statistical analysis.

The American Sign Language Recognition Dataset is a pivotal resource for research in visual-gestural languages for American Sign Language and Sign-Language MNIST Dataset. The dataset contains over 64,000 images meticulously labeled with the corresponding ASL gesture or letter to recognize and classify ASL signs. Recent computer vision and deep learning advances have enabled various ASL recognition techniques. However, further improvements in accuracy and robustness are still needed. This study comprehensively evaluates different ASL recognition methods and introduces a novel architecture called Sign Nevestro Densenet Attention (SNDA). All methods are evaluated on the ASL Recognition Dataset to ensure a representative evaluation. SNDA employs the Nadam optimizer for faster convergence during training. Accurate ASL classification has practical implications for improving communication accessibility. SNDA achieves state-of-the-art performance with 99.76% accuracy, perfect sensitivity, and high specificity and precision. These results validate the effectiveness of SNDA for ASL gesture recognition and highlight its potential to promote inclusivity for deaf and hard-of-hearing communities. The fused attention mechanism demonstrates how deep learning models can be enhanced for specific application domains.

Carpal tunnel syndrome (CTS) is a clinical disease that occurs due to compression of the median nerve in the carpal tunnel. The determination of the severity of carpal tunnel syndrome is essential to provide appropriate therapeutic interventions. Machine learning (ML)-based modeling can be used to classify diseases, make decisions, and create new therapeutic interventions. It is also used in medical research to implement predictive models. However, despite the growth in medical research based on ML and Deep Learning (DL), CTS research is still relatively scarce. While a few studies have developed models to predict diagnosis of CTS, no ML model has been presented to classify the severity of CTS based on comprehensive clinical data. Therefore, this study developed new classification models for determining CTS severity using ML algorithms. This study included 80 patients with other diseases that have an overlap in symptoms with CTS, such as cervical radiculopathysasas, de quervian tendinopathy, and peripheral neuropathy, and 80 CTS patients who underwent ultrasonography (US)-guided median nerve hydrodissection. CTS severity was classified into mild, moderate, and severe grades. In our study, we aggregated the data from CTS patients and patients with other diseases that have an overlap in symptoms with CTS, such as cervical radiculopathysasas, de quervian tendinopathy, and peripheral neuropathy. The dataset was randomly split into training and test data, at 70% and 30%, respectively. The proposed model achieved promising results of 0.955%, 0.963%, and 0.919% in terms of classification accuracy, precision, and recall, respectively. In addition, we developed a machine learning model that predicts the probability of a patient improving after the hydro-dissection injection process based on the aggregated data after three different months (one, three, and six). The proposed model achieved accuracy after six months of 0.912%, after three months of 0.901%, and after one month 0.877%. The overall performance for predicting the prognosis after six months outperforms the prediction after one and three months. We utilized statistics tests (significance test, Spearman’s correlation test, and two-way ANOVA test) to determine the effect of injection process in CTS treatment. Our data-driven decision support tools can be used to help determine which patients to operate on in order to avoid the associated risks and expenses of surgery.

Safety-critical Industrial Internet of Things (IIoT) sensor networks deployed in disaster scenarios require intelligent routing mechanisms that prioritize mission-critical packets without relying on centralized coordination. Federated learning on resource-constrained edge nodes presents three primary challenges: the absence of an interpretable supervisory signal, the inability to act conservatively based on per-inference confidence, and vulnerability to partial node availability. The proposed FedCARE framework addresses these issues by employing a Mamdani Fuzzy Inference System to generate traceable criticality labels from multi-modal sensor telemetry, a dropout-aware aggregation protocol that normalizes over only reachable nodes, and a confidence-gated resolver that defers to symbolic fuzzy classification when model confidence is insufficient, otherwise applying an auditable maximization rule to prevent under-prioritization of safety-critical data. Evaluation on 50-, 100-, and 200-node Watts–Strogatz topologies under fault rates up to 50%, using the Edge-IIoTset and WUSTL-IIoT-2021 benchmarks, demonstrates 99.00% critical recall and up to $1.8\times$ higher overall-packet delivery compared to RPL-RP under severe fault conditions. Routing improvements are primarily attributed to fuzzy criticality labeling and multi-path replication. These findings indicate that fuzzy-supervised federated inference offers a practical and interpretable solution for safety-critical IIoT routing, with an observed energy overhead of 7.8% per delivered packet.