Lavander ( Lavandula sp.) is a precious essential oil plant from the Lamiaceae family. There are 39 lavender species ( Lavandula sp.) most of which have Mediterranean origin and among them three have high commercial value. While the essential oil quality of the lavender species (British lavender) is high the lavandin species (hybrid lavender) have high essential oil yield [2, 52]. In this study, the content of the extracts obtained from Lavandula angustifolia, which were grown in Burdur Örtülü locality, was determined via HPLC and GC analysis and the anti-microbial effect of the essential oil L. angustifolia was investigated. The study was made with the dried flowers of L. angustifolia . Some of the dried flowers were extracted and the essential oil was distilled from the remaining part. Various phenolic compounds in the extract were quantitatively determined by HPLC. Quantitatively cafeic, rosemeric and the 4-hydroxybenzoic acids were the most abundant phenolic acids in the content in decreasing order. In the GC analysis 31 different compounds were determined: Linalool and Linalil Acetate having the highest concentration. Anti-microbial effect was determined against the most frequently encountered microorganisms in the cosmetics: Candida albicans, Staphylococcus aureus, Pseudomonas aeruginosa, Aspergillus brasiliensis. According to the results it is concluded that the essential oil, L. angustifolia , can be used either directly or incorporated into the cosmetics without the necessity for any other extra preservative against the said microrganisms. According to the literature these microorganisms, which are frequently found in creams, cause various diseases. It was observed that the essential oil L. Angustifolia could completely remove the contamination caused by the said micro-organisms as of the 14. day.

N-((2-chloropyridin-3-yl)carbamothioyl)thiophene-2-carboxamide (HL¹), N-((6-methylpyridin-2-yl)carbamothioyl)thiophene-2-carboxamide (HL²), N-(allylcarbamothioyl)thiophene-2-carboxamide (HL³), 2-chloro-N-(methyl(1-phenylethyl)carbamothioyl)benzamide (HL⁴) and 2-chloro-N-(bis((R)-1-phenylethyl)carbamothioyl)benzamide (HL⁵) were synthesized and characterized via FT-IR, ¹H-NMR, ¹³C-NMR and HR-MS techniques and HL³ was characterized via a single crystal X-ray diffraction experiment. The antituberculosis activity of the synthesized thiourea derivatives was tested against the H37RV (ATCC27294), ATCC35822 (INH resistant), ATCC35838 (RIF resistant), ATCC35820 (STM resistant) and ATCC35837 (EMB resistant) standard bacteria strains. The thiourea derivatives were tested on two MDR and one primary drug-sensitive isolates with the microplate nitrate reductase test method. The results indicated that HL² and HL³ had tuberculosis activity on some of the isolates. It was observed that HL⁴ was the most effective among all the thiourea derivatives. The interaction mechanism of the synthesized compounds on 2X23, a tuberculosis protein, was investigated via molecular docking method. The interaction was observed to occur over S and Cl atoms in all the compounds. The compounds containing the methyl group were observed to interact via this group. Graphical Abstract