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Dr. Saravanan Krishnan has been a Senior Research Scientist in the start-up company Dhanvantari Nano Ayushadi Pvt Ltd (NANOLIFE) of Chennai, India since August 2018. He holds a Ph.D. in Biotechnology from Indian Institute of Technology Madras, India. He has completed an M.Sc (Biotechnology) from the School of Biotechnology, BHU Varanasi, India in 2012. His main research and publication interests include green chemistry, nanocatalysis, bio-nanotechnology, and applied microbiology
The infamous COVID-19 outbreak has left a crippling impact on the economy, healthcare infrastructure and lives of the general working class; with all the scientists determined to find suitable and efficient diagnostic techniques and therapies to contain its ramifications. This article presents the complete outline of the diagnostic platforms developed using nanoparticles in the detection of SARS-CoV-2, delineating the direct and indirect use of nanomaterials in COVID-19 diagnosis. Properties of nanostructured materials and their relevance in the development of novel point-of-care diagnostic approaches for COVID-19 are highlighted. More importantly, the advantages of nanotechnologies over conventional reverse transcriptase-polymerase chain reaction technique and few other methods used in the detection of SARS-CoV-2 along with the viewpoint are discussed. Also, the future perspectives highlighting the commercial aspects of the nanotechnology-based diagnostic tools developed to combat the COVID-19 pandemic are presented.
Saravanan Krishnan; Apurva Dusane; Rasmi Morajkar; Akila Venkat; Amit Vernekar. Deciphering the Role of Nanostructured Materials in the Point-of-Care Diagnostics for COVID-19: A Comprehensive Review. Journal of Materials Chemistry B 2021, 1 .
AMA StyleSaravanan Krishnan, Apurva Dusane, Rasmi Morajkar, Akila Venkat, Amit Vernekar. Deciphering the Role of Nanostructured Materials in the Point-of-Care Diagnostics for COVID-19: A Comprehensive Review. Journal of Materials Chemistry B. 2021; ():1.
Chicago/Turabian StyleSaravanan Krishnan; Apurva Dusane; Rasmi Morajkar; Akila Venkat; Amit Vernekar. 2021. "Deciphering the Role of Nanostructured Materials in the Point-of-Care Diagnostics for COVID-19: A Comprehensive Review." Journal of Materials Chemistry B , no. : 1.
Solvents are an inevitable part of industries. They are widely used in manufacturing and processing industries. Despite the numerous controlling measures taken, solvents contaminate our environment to a vast extent. Green and sustainable solvents have been a matter of growing interest within the research community over the past few years due to the increasing environmental concerns. Solvents are categorized as “green” based on their nonvolatility, nonflammability, availability, biodegradability and so on. The use of ionic liquids, super critical carbon dioxide and aqueous solvents for the fabrication of polymer composites is discussed in this review. The progress of utilizing solvent-free approaches for polymer composite preparation and efforts to produce new biobased solvents are also summarized.
Blessy Joseph; Saravanan Krishnan; Sagarika Kavil; Avinash Pai; Jemy James; Nandakumar Kalarikkal; Sabu Thomas. Green Chemistry Approach for Fabrication of Polymer Composites. Sustainable Chemistry 2021, 2, 254 -270.
AMA StyleBlessy Joseph, Saravanan Krishnan, Sagarika Kavil, Avinash Pai, Jemy James, Nandakumar Kalarikkal, Sabu Thomas. Green Chemistry Approach for Fabrication of Polymer Composites. Sustainable Chemistry. 2021; 2 (2):254-270.
Chicago/Turabian StyleBlessy Joseph; Saravanan Krishnan; Sagarika Kavil; Avinash Pai; Jemy James; Nandakumar Kalarikkal; Sabu Thomas. 2021. "Green Chemistry Approach for Fabrication of Polymer Composites." Sustainable Chemistry 2, no. 2: 254-270.
Understanding the biosynthetic mechanism of gold nanoparticle formation is the key to controlling the size, dispersity, and morphology of the nanoparticles. Reduction of gold (III) to gold (0) in cell-free extracts of Candida parapsilosis ATCC 7330 is not only enzymatic, as confirmed by experiments with heat denatured extracts. In addition to proteins, cellular reducing equivalents also contribute to the formation of gold nanoparticles in a concentration-dependent manner. Characterization of the bio-synthesized gold nanoparticles using X-ray photoelectron spectroscopy and elemental analysis revealed that nanoparticles are stabilized by proteins. The importance of protein three-dimensional structure in producing stable gold nanoparticles is also addressed. Making free thiol groups (–SH) unavailable by derivatizing them in protein extracts resulted in monodisperse gold nanoparticles implying that free –SH increase aggregation and emphasize this as a possible strategy to produce monodisperse gold nanoparticles in biological extracts which is otherwise difficult.
Saravanan Krishnan; Deepthy Jayakumar; HarishKumar Madhyastha; Anju Chadha. The Complexity of Microbial Metal Nanoparticle Synthesis: A Study of Candida parapsilosis ATCC 7330 mediated Gold Nanoparticles Formation. BioNanoScience 2021, 11, 336 -344.
AMA StyleSaravanan Krishnan, Deepthy Jayakumar, HarishKumar Madhyastha, Anju Chadha. The Complexity of Microbial Metal Nanoparticle Synthesis: A Study of Candida parapsilosis ATCC 7330 mediated Gold Nanoparticles Formation. BioNanoScience. 2021; 11 (2):336-344.
Chicago/Turabian StyleSaravanan Krishnan; Deepthy Jayakumar; HarishKumar Madhyastha; Anju Chadha. 2021. "The Complexity of Microbial Metal Nanoparticle Synthesis: A Study of Candida parapsilosis ATCC 7330 mediated Gold Nanoparticles Formation." BioNanoScience 11, no. 2: 336-344.
High yielding synthesis of industrially important aryl amines from nitroarenes using yeast supported gold nanoparticles as a sustainable catalyst.
Saravanan Krishnan; Paresh N. Patel; Kalpattu K. Balasubramanian; Anju Chadha. Yeast supported gold nanoparticles: an efficient catalyst for the synthesis of commercially important aryl amines. New Journal of Chemistry 2021, 45, 1915 -1923.
AMA StyleSaravanan Krishnan, Paresh N. Patel, Kalpattu K. Balasubramanian, Anju Chadha. Yeast supported gold nanoparticles: an efficient catalyst for the synthesis of commercially important aryl amines. New Journal of Chemistry. 2021; 45 (4):1915-1923.
Chicago/Turabian StyleSaravanan Krishnan; Paresh N. Patel; Kalpattu K. Balasubramanian; Anju Chadha. 2021. "Yeast supported gold nanoparticles: an efficient catalyst for the synthesis of commercially important aryl amines." New Journal of Chemistry 45, no. 4: 1915-1923.
Developing robust methods to detect the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), a causative agent for the current global health pandemic, is an exciting area of research. Nevertheless, the currently used conventional reverse transcription-polymerase chain reaction (RT-PCR) technique in COVID-19 detection endures with some inevitable limitations. Consequently, the establishment of rapid diagnostic tools and quick isolation of infected patients is highly essential. Furthermore, the requirement of point-of-care testing is the need of the hour. Considering this, we have provided a brief review of the use of very recently reported robust spectral tools for rapid COVID-19 detection. The spectral tools include, colorimetric reverse transcription loop-mediated isothermal amplification (RT-LAMP) and matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS), with the admittance of principal component analysis (PCA) and machine learning (ML) for meeting the high-throughput and fool-proof platforms for the detection of SARS-CoV-2, are reviewed. Recently, these techniques have been readily applied to screen a large number of suspected patients within a short period and they demonstrated higher sensitivity for the detection of COVID-19 patients from unaffected human subjects.
Abhijeet Mohanty; Adarsh P. Fatrekar; Saravanan Krishnan; Amit A. Vernekar. A concise discussion on the potential spectral tools for the rapid COVID-19 detection. Results in Chemistry 2021, 3, 100138 -100138.
AMA StyleAbhijeet Mohanty, Adarsh P. Fatrekar, Saravanan Krishnan, Amit A. Vernekar. A concise discussion on the potential spectral tools for the rapid COVID-19 detection. Results in Chemistry. 2021; 3 ():100138-100138.
Chicago/Turabian StyleAbhijeet Mohanty; Adarsh P. Fatrekar; Saravanan Krishnan; Amit A. Vernekar. 2021. "A concise discussion on the potential spectral tools for the rapid COVID-19 detection." Results in Chemistry 3, no. : 100138-100138.
The use of biopolymers in industrial applications remain elusive due to their hydrophilicity, poor barrier properties, etc. It has been of great interest to the research community to modify the inherent nature of bio-based materials by incorporating nanoscale fillers into the matrix. The resulting bionanocomposites show versatility as future biomaterials, providing a deft alternative to plastics. In general, bionanocomposites are made up of a matrix which is a biopolymer (continuous phase) and the reinforcing agent (dispersed phase), consisting of particles with dimensions in the range of 1–100 nm. The increased research in this field is driven by the biodegradable, biocompatible, and renewable nature of biomaterials. Bionanocomposites find broad applications in food packaging, automobile industries, electronic industries, cosmetics, textile industries, water purification sectors, tissue engineering, etc. A range of approaches have been utilized for the preparation of bionanocomposites including solution casting and 3D printing. However, much more green and sophisticated processing techniques should be developed for industrial applications. Furthermore, precise control over geometry, porosity, internal architecture, etc. is still challenging and need to be overlooked carefully. Graphical Abstract
Blessy Joseph; Saravanan Krishnan; V. K. Sagarika; Abhimanyu Tharayil; Nandakumar Kalarikkal; Sabu Thomas. Bionanocomposites as industrial materials, current and future perspectives: a review. Emergent Materials 2020, 3, 711 -725.
AMA StyleBlessy Joseph, Saravanan Krishnan, V. K. Sagarika, Abhimanyu Tharayil, Nandakumar Kalarikkal, Sabu Thomas. Bionanocomposites as industrial materials, current and future perspectives: a review. Emergent Materials. 2020; 3 (5):711-725.
Chicago/Turabian StyleBlessy Joseph; Saravanan Krishnan; V. K. Sagarika; Abhimanyu Tharayil; Nandakumar Kalarikkal; Sabu Thomas. 2020. "Bionanocomposites as industrial materials, current and future perspectives: a review." Emergent Materials 3, no. 5: 711-725.
Silver nanoparticles (AgNPs) are well recognized for their antimicrobial properties for many years. In the present study, AgNPs synthesized by a green method is investigated for its anti-microbial efficacy, when added in tea leaves. Further, the potential role of AgNPs in controlling the growth of foodborne pathogens was evaluated. Results indicate that AgNPs present in the tea liquor contributes about 50% higher anti-bacterial activity against the foodborne pathogens tested when compared with the untreated tea sample. A significant observation is that the microbial load in the tea reduced due to the presence of AgNPs . Collectively, this study indicates the importance of AgNPs as an anti-microbial agent in controlling the microbial growth associated with food spoilage. In addition, it is likely to enhance the quality and shelf life of tea.
Saravanan Krishnan; Deepak Srisrimal; Abhaya Kumar Srisrimal. Antimicrobial Effectiveness of Silver Nanoparticles enriched Tea Leaves. INTERNATIONAL JOURNAL OF PHARMACEUTICAL QUALITY ASSURANCE 2020, 11, 395 -398.
AMA StyleSaravanan Krishnan, Deepak Srisrimal, Abhaya Kumar Srisrimal. Antimicrobial Effectiveness of Silver Nanoparticles enriched Tea Leaves. INTERNATIONAL JOURNAL OF PHARMACEUTICAL QUALITY ASSURANCE. 2020; 11 (3):395-398.
Chicago/Turabian StyleSaravanan Krishnan; Deepak Srisrimal; Abhaya Kumar Srisrimal. 2020. "Antimicrobial Effectiveness of Silver Nanoparticles enriched Tea Leaves." INTERNATIONAL JOURNAL OF PHARMACEUTICAL QUALITY ASSURANCE 11, no. 3: 395-398.
Nanoparticles of noble metals such as gold, silver, and platinum are useful for important applications in catalysis and biomedical science. Biological methods of nanofabrication include the use of easily available plants, microbes, and enzymes. This chapter presents an overview of microbial methods of preparing gold nanoparticles and the use of these gold nanoparticles in catalytic applications. Mainly, the catalytic performance of biosynthesized gold nanoparticles toward protecting the environment from aromatic toxic pollutants and textile dyes is discussed with relevant examples. The method of preparation of supported gold nanoparticles catalysts using conventional chemical and microbial methods for the hydrogenation/reduction of nitrobenzene to aniline is presented. Toward sustainable catalysis, the application of bio-supported nanoparticles (gold nanoparticles, palladium nanoparticles, and the combination), as heterogeneous catalysts for various chemical reactions like oxidation, reduction, and coupling, to yield value-added fine chemicals and intermediates under environmentally benign conditions is elaborated.
Saravanan Krishnan; Anju Chadha. Microbial Synthesis of Gold Nanoparticles and Their Applications as Catalysts. Handbook of Nanomaterials and Nanocomposites for Energy and Environmental Applications 2020, 1 -28.
AMA StyleSaravanan Krishnan, Anju Chadha. Microbial Synthesis of Gold Nanoparticles and Their Applications as Catalysts. Handbook of Nanomaterials and Nanocomposites for Energy and Environmental Applications. 2020; ():1-28.
Chicago/Turabian StyleSaravanan Krishnan; Anju Chadha. 2020. "Microbial Synthesis of Gold Nanoparticles and Their Applications as Catalysts." Handbook of Nanomaterials and Nanocomposites for Energy and Environmental Applications , no. : 1-28.
The cell free extracts of Candida parapsilosis ATCC 7330 are more efficient than the whole resting cells of the yeast in the synthesis of directly usable gold nanoparticles as revealed by this systematic study. Cell free extracts yielded gold nanoparticles of hydrodynamic diameter (50–200 nm). In this study, the total protein concentration influences the nanofabrication and not only the reductase enzymes as originally thought. Powder X-ray diffraction studies confirm the crystalline nature of the gold nanoparticles. Fourier Transform Infra Red spectroscopy and thermal gravimetric analysis suggests that the biosynthesized gold nanoparticles are capped by peptides/proteins. Dispersion experiments indicate a stable dispersion of gold nanoparticles in pH 12 solutions which is also confirmed by electron microscopic analysis and validated using a surface plasmon resonance assay. The effectiveness of the dispersed nanoparticles for the reduction of 4-nitrophenol using sodium borohydride as a reductant further confirms the formation of functional gold nanoparticles. It is also reported that gold nanoparticles with mean particle diameter of 27 nm are biosynthesized inside the whole cell by transmission electron microscopy analysis. With optimized reaction conditions, maximum gold bioaccumulation with the 24 h culture age of the yeast with cellular uptake of ~1010 gold atoms at the single cell level is achieved but it is not easy to extract the gold nanoparticles from the whole resting cells.
Saravanan Krishnan; Shoba Narayan; Anju Chadha. Whole resting cells vs. cell free extracts of Candida parapsilosis ATCC 7330 for the synthesis of gold nanoparticles. AMB Express 2016, 6, 1 -15.
AMA StyleSaravanan Krishnan, Shoba Narayan, Anju Chadha. Whole resting cells vs. cell free extracts of Candida parapsilosis ATCC 7330 for the synthesis of gold nanoparticles. AMB Express. 2016; 6 (1):1-15.
Chicago/Turabian StyleSaravanan Krishnan; Shoba Narayan; Anju Chadha. 2016. "Whole resting cells vs. cell free extracts of Candida parapsilosis ATCC 7330 for the synthesis of gold nanoparticles." AMB Express 6, no. 1: 1-15.