Biomedical named entity recognition (Bio-NER) is a fundamental task in handling biomedical text terms, such as RNA, protein, cell type, cell line, and DNA. Bio-NER is one of the most elementary and core tasks in biomedical knowledge discovery from texts. The system described here is developed by using the BioNLP/NLPBA 2004 shared task. Experiments are conducted on a training and evaluation set provided by the task organizers. Our results show that, compared with a baseline having a 70.09% F1 score, the RNN Jordan- and Elman-type algorithms have F1 scores of approximately 60.53% and 58.80%, respectively. When we use CRF as a machine learning algorithm, CCA, GloVe, and Word2Vec have F1 scores of 72.73%, 72.74%, and 72.82%, respectively. By using the word embedding constructed through the unsupervised learning, the time and cost required to construct the learning data can be saved.

Reducing the time to diagnose COVID-19 helps to manage insufficient isolation-bed resources and adequately accommodate critically ill patients. There is currently no alternative method to real-time reverse transcriptase polymerase chain reaction (RT-PCR), which requires 40 cycles to diagnose COVID-19. We propose a deep learning (DL) model to improve the speed of COVID-19 RT-PCR diagnosis. We developed and tested a DL model using the long short-term memory method with a dataset of fluorescence values measured in each cycle of 5810 RT-PCR tests. Among the DL models developed here, the diagnostic performance of the 21st model showed an area under the receiver operating characteristic (AUROC), sensitivity, and specificity of 84.55%, 93.33%, and 75.72%, respectively. The diagnostic performance of the 24th model showed an AUROC, sensitivity, and specificity of 91.27%, 90.00%, and 92.54%, respectively.

Screening test using CA-125 is the most common test for detecting ovarian cancer. However, the level of CA-125 is diverse by variable condition other than ovarian cancer. It has led to misdiagnosis of ovarian cancer. In this paper, we explore the 16 serum biomarker for finding alternative biomarker combination to reduce misdiagnosis. For experiment, we use the serum samples that contain 101 cancer and 92 healthy samples. We perform two major tasks: Marker selection and Classification. For optimal marker selection, we use genetic algorithm, random forest, T-test and logistic regression. For classification, we compare linear discriminative analysis, K-nearest neighbor and logistic regression. The final results show that the logistic regression gives high performance for both tasks, and HE4-ELISA, PDGF-AA, Prolactin, TTR is the best biomarker combination for detecting ovarian cancer. We find the combination which contains TTR and Prolactin gives high performance for cancer detection. Early detection of ovarian cancer can reduce high mortality rates. Finding a combination of multiple biomarkers for diagnostic tests with high sensitivity and specificity is very important.

Recently, with the development of Speech to Text, which converts voice to text, and machine translation, technologies for simultaneously translating the captions of video into other languages have been developed. Using this, YouTube, a video-sharing site, provides captions in many languages. Currently, the automatic caption system extracts voice data when uploading a video and provides a subtitle file converted into text. This method creates subtitles suitable for the running time. However, when extracting subtitles from video using Speech to Text, it is impossible to accurately translate the sentence because all sentences are generated without periods. Since the generated subtitles are separated by time units rather than sentence units, and are translated, it is very difficult to understand the translation result as a whole. In this paper, we propose a method to divide text into sentences and generate period marks to improve the accuracy of automatic translation of English subtitles. For this study, we use the 27,826 sentence subtitles provided by Stanford University’s courses as data. Since this lecture video provides complete sentence caption data, it can be used as training data by transforming the subtitles into general YouTube-like caption data. We build a model with the training data using the LSTM-RNN (Long-Short Term Memory – Recurrent Neural Networks) and predict the position of the period mark, resulting in prediction accuracy of 70.84%. Our research will provide people with more accurate translations of subtitles. In addition, we expect that language barriers in online education will be more easily broken by achieving more accurate translations of numerous video lectures in English.

Intracerebral hemorrhage is a severe problem where more than one-third of patients die within a month. In diagnosing intracranial hemorrhage, neuroimaging examinations are essential. As a result, the interpretation of neuroimaging becomes a crucial process in medical procedures. However, human-based image interpretation has inherent limitations, as it can only handle a restricted range of tasks. To address this, a study on medical image captioning has been conducted, but it primarily focused on single medical images. However, actual medical images often consist of continuous sequences, such as CT scans, making it challenging to directly apply existing studies. Therefore, this paper proposes a CT image captioning model that utilizes a 3D-CNN model and distilGPT-2. In this study, four combinations of 3D-CNN models and language models were compared and analyzed for their performance. Additionally, the impact of applying penalties to the loss function and adjusting penalty values during the training process was examined. The proposed CT image captioning model demonstrated a maximum BLEU score of 0.35 on the in-house dataset, and it was observed that the text generated by the model became more similar to human interpretations in medical image reports with the application of loss function penalties.