Long-term survival data in relation to sub-sites, human papillomavirus (HPV), and p16^INK4a (p16) for patients with oropharyngeal squamous cell carcinoma (OPSCC) is still sparse. Furthermore, reports have indicated atypical and late recurrences for patients with HPV and p16 positive OPSCC. Therefore, we assessed long-term survival and recurrence in relation to oropharyngeal subsite and HPV/p16 status. A total of 529 patients with OPSCC, diagnosed in the period 2000–2010, with known HPVDNA and p16-status, were included. HPV/p16 status and sub-sites were correlated to disease-free and overall survival (DFS and OS respectively). The overexpression of p16 (p16⁺) is associated with significantly better long-term OS and DFS in tonsillar and base of tongue carcinomas (TSCC/BOTSCC), but not in patients with other OPSCC. Patients with HPVDNA⁺/p16⁺ TSCC/BOTSCC presented better OS and DFS compared to those with HPVDNA⁻/p16⁻ tumors, while those with HPVDNA⁻/p16⁺ cancer had an intermediate survival. Late recurrences were rare, and significantly more frequent in patients with p16⁻ tumors, while the prognosis after relapse was poor independent of HPVDNA^+/−/p16^+/− status. In conclusion, patients with p16⁺ OPSCC do not have more late recurrences than p16⁻, and a clear prognostic value of p16⁺ was only observed in TSCC/BOTSCC. Finally, the combination of HPVDNA and p16 provided superior prognostic information compared to p16 alone in TSCC/BOTSCC.

Background: Sentinel lymph node biopsy (SLNB) is used to improve the staging of and guide treatment in patients with early‐stage T1–T2 N0 oral squamous cell carcinoma (OSCC). The role of sentinel nodes (SNs) and the use of SN‐technique in advanced OSCC (T3–T4 and/or N+) remain to be evaluated. This study investigates the nodal drainage and the rate of positive SNs (SNs+) in all stages of OSCC.Materials and Methods: In total, 85 patients with T1–T4 OSCC diagnosed 2019–2021 were included. We used a prolonged interval between peritumoral injection of radionuclide and SPECT–CT to include all SNs.Results: Patients with advanced OSCC presented a higher proportion of contralateral lymphatic drainage and a higher rate of SN+ compared to patients with early‐stage disease. T3–T4 and N+ tumors presented a tendency for a higher rate of contralateral lymphatic drainage compared to T1–T2 and N0 tumors (p = 0.1). The prevalence of positive nodes (SNs+) was higher among patients with advanced disease, T3–T4 versus T1–T2 (p = 0.0398).Conclusion: SN‐assisted ND enables identification and removal of all SNs + and has the potential for more accurate staging and could possibly give prognostic advantages regarding regional recurrence for all OSCC patients, especially among those with advanced disease. The precise localization of the SNs + also suggests that a more individualized ND approach might be possible in the future even for patients with advanced OSCC.

Ranula is a rare benign cystic lesion in the floor of the mouth, which can herniate through the mylohyoid muscle and become a plunging ranula. Treatment for ranulas is currently surgical excision o... 背景：舌下囊肿是一种口腔底部的罕见良性囊性病变, 可穿过髓样肌突起, 并形成一个下陷囊肿。目前, 对舌下囊肿的治疗是舌下腺的手术切除。使用OK-432进行硬化疗法是一种公认​​的淋巴畸形治疗方法, 但用于舌下囊肿尚未得到全面评估。目的：在一项随机双盲试验中, 评估OK-432对舌下囊肿的硬化治疗。材料和方法：将20例下陷或口内舌下囊肿患者随机分为两组, 分别用OK-432或生理盐水进行双盲注...