Efstathia Ioannou

Prof. Dr. Efstathia Ioannou

Department of Pharmacy, National and Kapodistrian University of Athens, Athens, Greece
orcid

Research Focus & Metrics

Academic Career Length

20Years (2007-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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1 August 2019 in Carbohydrate Polymers
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Journal Article
Closed access
Leto-Aikaterini TzivelekaLeto-Aikaterini Tziveleka
Leto-Aikaterini Tziveleka
Efstathia IoannouEfstathia Ioannou
Efstathia Ioannou
Vassilios RoussisVassilios Roussis
Vassilios Roussis

1 January 2015 in Metabolic Engineering
Verified
Journal Article
Closed access
CICodruta Ignea
Codruta Ignea
FTFotini A. Trikka
Fotini A. Trikka
Alexandros NikolaidisAlexandros Nikolaidis
Alexandros Nikolaidis
PGPanagiota Georgantea
Panagiota Georgantea
Efstathia IoannouEfstathia Ioannou
Efstathia Ioannou
SKSotirios Kampranis
Sotirios Kampranis

14 March 2016 in Proceedings of the National Academy of Sciences
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Journal Article
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CICodruta Ignea
Codruta Ignea
AAAnastasia Athanasakoglou
Anastasia Athanasakoglou
Efstathia IoannouEfstathia Ioannou
Efstathia Ioannou
PGPanagiota Georgantea
Panagiota Georgantea
FTFotini A. Trikka
Fotini A. Trikka
SKSotirios Kampranis
Sotirios Kampranis
Significance: Here we report on the development of a modular terpene production platform as a screening tool for the functional characterization of next-generation sequencing information and on the application of this system in the characterization of the biosynthetic pathway leading to the potent antioxidant carnosic acid in Lamiaceae . In addition to revealing an important plant natural product biosynthetic pathway, this work highlights the usefulness of synthetic biology approaches in the elucidation of plant natural product biosynthetic pathways and develops yeast as a tool to exploit the wealth of next-generation sequencing data that are constantly being produced through transcriptomic, genomic, or metagenomic studies. The approach described here will be useful to numerous researchers studying terpene biosynthesis in plants and microorganisms.

8 September 2021 in Antioxidants
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Journal Article
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Leto-Aikaterini TzivelekaLeto-Aikaterini Tziveleka
Leto-Aikaterini Tziveleka
Mohamed Ahmed TammamMohamed Ahmed Tammam
Mohamed Ahmed Tammam
OTOlga Tzakou
Olga Tzakou
Vassilios RoussisVassilios Roussis
Vassilios Roussis
Efstathia IoannouEfstathia Ioannou
Efstathia Ioannou
Reactive oxygen species (ROS) attack biological molecules, such as lipids, proteins, enzymes, DNA, and RNA, causing cellular and tissue damage. Hence, the disturbance of cellular antioxidant homeostasis can lead to oxidative stress and the onset of a plethora of diseases. Macroalgae, growing in stressful conditions under intense exposure to UV radiation, have developed protective mechanisms and have been recognized as an important source of secondary metabolites and macromolecules with antioxidant activity. In parallel, the fact that many algae can be cultivated in coastal areas ensures the provision of sufficient quantities of fine chemicals and biopolymers for commercial utilization, rendering them a viable source of antioxidants. This review focuses on the progress made concerning the discovery of antioxidant compounds derived from marine macroalgae, covering the literature up to December 2020. The present report presents the antioxidant potential and biogenetic origin of 301 macroalgal metabolites, categorized according to their chemical classes, highlighting the mechanisms of antioxidative action when known.

5 February 2014 in Phytochemistry Reviews
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Journal Article
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Efstathia IoannouEfstathia Ioannou
Efstathia Ioannou
Aikaterini KoutsavitiAikaterini Koutsaviti
Aikaterini Koutsaviti
OTOlga Tzakou
Olga Tzakou
Vassilios RoussisVassilios Roussis
Vassilios Roussis

29 May 2017 in Marine Drugs
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Journal Article
Open access
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Leto-Aikaterini TzivelekaLeto-Aikaterini Tziveleka
Leto-Aikaterini Tziveleka
Efstathia IoannouEfstathia Ioannou
Efstathia Ioannou
DTDimitris Tsiourvas
Dimitris Tsiourvas
Panagiotis BerillisPanagiotis Berillis
Panagiotis Berillis
Panagiotis BerillisPanagiotis Berillis
Panagiotis Berillis
Vassilios RoussisVassilios Roussis
Vassilios Roussis
In search of alternative and safer sources of collagen for biomedical applications, the marine demosponges Axinella cannabina and Suberites carnosus, collected from the Aegean and the Ionian Seas, respectively, were comparatively studied for their insoluble collagen, intercellular collagen, and spongin-like collagen content. The isolated collagenous materials were morphologically, physicochemically, and biophysically characterized. Using scanning electron microscopy and transmission electron microscopy the fibrous morphology of the isolated collagens was confirmed, whereas the amino acid analysis, in conjunction with infrared spectroscopy studies, verified the characteristic for the collagen amino acid profile and its secondary structure. Furthermore, the isoelectric point and thermal behavior were determined by titration and differential scanning calorimetry, in combination with circular dichroism spectroscopic studies, respectively.