The dynamic nature and unsustainable exploitation of groundwater aquifers pose a range of management challenges. The accurate basin-wide hydrological assessment is very critical for the quantification of abstraction rates, spatial patterns of groundwater usage, recharge and discharge processes, and identification of critical areas having groundwater mining. This study provides the appraisal of remote sensing technology in comparison with traditionally prevailing tools and methodologies and introduces the practical use of remote sensing technology to bridge the data gaps. It demonstrates the example of Gravity Recovery and Climate Experiment (GRACE) satellite inferred Total Water Storage (TWS) information to quantify the behavior of the Upper Indus Plain Aquifer. The spatio-temporal changes in aquifer usage are investigated particularly for irrigation and anthropogenic purposes in general. The GRACE satellite is effective in capturing the water balance components. The basin-wide monthly scale groundwater storage monitoring is a big opportunity for groundwater managers and policymakers. The remote sensing integrated algorithms are useful tools to provide timely and valuable information on aquifer behavior. Such tools are potentially helpful to support the implementation of groundwater management strategies, especially in the developing world where data scarcity is a major challenge. Groundwater resources have not grown to meet the growing demands of the population, consequently, overexploitation of groundwater resources has occurred in these decades, leading to groundwater decline. However, future developments in the field of space technology are envisioned to overcome the currently faced spatio-temporal challenges.