The efficiency of a cosmetic product depends not only on the active ingredients, but also on the carrier system devoted to improve its bioavailability. This article aims to encapsulate two couples of UV molecular absorbers, with a blocking action on both UV-A and UV-B domains, into efficient lipid nanoparticles. The effect of encapsulation on the specific properties such as sun protection factor and photostability behaviour has been demonstrated. The lipid nanoparticles with size range 30-350 nm and a polydispersity index between 0.217 and 0.244 are obtained using a modified high shear homogenisation method. The nanoparticles had spherical shapes with a single crystallisation form of lipid matrices characteristic for the least ordered crystal structure (α-form). The in vitro determination of photoprotection has led to high SPF ratings, with values of about 20, which assure a good photoprotection and filtering about 95% of UV radiation. The photoprotection effect after irradiation stage was observed to be increased more than twice compared to initial samples as a result of isomerisation phenomena. All the results have shown that good photoprotection effect and improved photostability could be obtained using such sunscreen couples, thus demonstrating that UV absorbers-solid lipid nanoparticles are promising carriers for cosmetic formulations.

The aim of this study was to evaluate the potential role of naringenin (NAR) in developing polyphenol-rich sunscreens by encapsulation into nanostructured lipid carriers (NLCs) based on vegetable oils. The functionality of NLCs loaded with NAR (NAR–NLC), NAR together with an UVA filter (NAR–UVA–NLC), and with an UVA filter (UVA–NLC) was evaluated by studying their photostability, UV protection factors, antioxidant activity and cytotoxic effect on L929 mouse fibroblasts. The photostability study revealed that NLCs loaded with NAR and/or the UVA filter were photostable under UV exposure. NAR–UVA–NLCs formulated into hydrogels exhibited the best photoprotection with an SPF of 8.4 and a UVAPF of 13.8, as compared with the same formulation without NAR which showed an SPF of 6 and a UVAPF of 10.5. The photoprotective values obtained for NAR–UVA–NLCs underline an efficient sunscreen performance, 87.5% of UVB radiation and 81.1% of UVA radiation being filtered. The antioxidant activity against short- and long-life radicals was also improved by co-loading NAR and a UVA filter into lipid nanocarriers. At low concentrations (25 and 50 μg mL⁻¹) the nanocarriers showed no cytotoxicity and the presence of NAR inside the nanocarriers increased the cell viability. The in vitro drug release studies showed that the NLC system provides an increased release and permeation of NAR. All results indicated that NAR has the potential to be used in developing safer and efficient polyphenol-rich sunscreens, by improving the anti-UV and antioxidant performance of the vegetable nanocarriers.

The use of bio-based reagents for silver nanoparticle (AgNP) production has gained much attention among researchers as it has paved the way for environmentally friendly approaches at low cost for synthesizing nanomaterials while maintaining their properties. In this study, Stellaria media aqueous extract was used for silver nanoparticle phyto-synthesis, and the resulting treatment was applied to textile fabrics to test its antimicrobial properties against bacteria and fungi strains. The chromatic effect was also established by determining the L*a*b* parameters. For optimizing the synthesis, different ratios of extract to silver precursor were tested using UV-Vis spectroscopy to observe the SPR-specific band. Moreover, the AgNP dispersions were tested for their antioxidant properties using chemiluminescence and TEAC methods, and the phenolic content was evaluated by the Folin-Ciocâlteu method. For the optimal ratio, values of average size, 50.11 ± 3.25 nm, zeta potential, −27.10 ± 2.16 mV, and polydispersity index, 0.209, were obtained via the DLS technique and zeta potential measurements. AgNPs were further characterized by EDX and XRD techniques to confirm their formation and by microscopic techniques to evaluate their morphology. TEM measurements revealed cvasi-spherical particles with sizes in the range of 10–30 nm, while SEM images confirmed their uniform distribution on the textile fiber surface.

Although many phytochemicals have been used in traditional medicine, there is a great need to refresh the health benefits and adjust the shortcomings of herbal medicine. In this research, two herbal principles (Diosgenin and Glycyrrhiza glabra extract) coopted in the Nanostructured Lipid Carriers have been developed for improving the most desirable properties of herbal medicine—antioxidant and anti-inflammatory actions. The contribution of phytochemicals, vegetable oils and of lipid matrices has been highlighted by comparative study of size, stability, entrapment efficiency, morphological characteristics, and thermal behavior. According to the in vitro MTS and RTCA results, the dual herbal-NLCs were no cytotoxic toward endothelial cells at concentrations between 25 and 100 µg/mL. A rapid release of Glycyrrhiza glabra and a motivated delay of Diosgenin was detected by the in vitro release experiments. Dual herbal-NLCs showed an elevated ability to annihilate long-life cationic radicals (ABTS^•+) and short-life oxygenated radicals (an inhibition of 63.4% ABTS^•+, while the ability to capture radical oxygen species reached 96%). The production of pro-inflammatory cytokines was significantly inhibited by the newly herbals-NLC (up to 97.9% inhibition of TNF-α and 62.5% for IL-6). The study may open a new pharmacotherapy horizon; it provides a comprehensive basis for the use of herbal-NLC in the treatment of inflammatory diseases.

The main purpose of the present research was to test the ability of nanostructured lipid carriers (NLCs) to efficiently host a hydrophilic polyphenol active with health-promoting activities (caffeic acid (CA)). The caffeic acid-loaded lipid nanocarriers (CA-NLCs) were obtained by high-pressure homogenization technique using a surfactant mixture of Tween 20 and L-α-phosphatidylcholine in association with a lipid mixture of linseed oil, hexadecyl palmitate, and glycerol monostearate. In the first stage, the proportion between surfactant mixture and lipid phase has been varied to obtain appropriate stable nanocarriers. The optimized NLCs have been further loaded with different amounts of caffeic acid and were analyzed in terms of physical stability, size characteristics, and encapsulation efficiency. The antioxidant activity of CA-loaded NLCs and their release behavior have been tested by specific in vitro methods, e.g., ABTS (2,2-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid)) assay and release experiments, by Franz cell diffusion. The ABTS assay highlighted a high antioxidant potential of the caffeic acid in association with linseed oil. The capacity to capture ABTS cationic radicals was superior for the NLC entrapping an initial amount of 1.5 CA, the level of antioxidant capacity being 91.3. The in vitro release experiments showed a different release behavior, depending on the initial amount of caffeic acid used. NLC loaded with a higher concentration of CA manifests a gradual slow release, e.g., 45 CA after 24h of in vitro experiments, while the NLC loaded with smaller concentration of CA assured a higher release in time, around 65.