Rheumatoid arthritis (RA), an autoimmune disease, is characterized by chronic joint inflammation and pain. We previously found that the deletion of T-cell death-associated gene 8 (TDAG8) significantly reduces disease severity and pain in RA mice. Whether it is by modulating gut microbiota remains unclear. In this study, 64 intestinal samples of feces, cecal content, and cecal mucus from the complete Freund’s adjuvant-induced arthritis mouse models were compared. The α- and β-diversity indices of the microbiome were significantly lower in RA mice. Cecal mucus showed a higher ratio of Firmicutes to Bacteroidetes in RA than healthy mice, suggesting the ratio could serve as an RA indicator. Four core genera, Eubacterium_Ventriosum, Alloprevotella, Rikenella, and Treponema, were reduced in content in both feces and mucus RA samples, and could serve microbial markers representing RA progression. TDAG8 deficiency decreased the abundance of proinflammation-related Eubacterium_Xylanophilum, Clostridia, Ruminococcus, Paraprevotella, and Rikenellaceae, which reduced local mucosal inflammation to relieve RA disease severity and pain. The pharmacological block of the TDAG8 function by a salicylanilide derivative partly restored the RA microbiome to a healthy composition. These findings provide a further understanding of specific bacteria interactions with host gut mucus in the RA model. The modulation by TDAG8 on particular bacteria can facilitate microbiota-based therapy.

Rhodosporidium toruloides strain VN1 is of special interest because of its capability for high astaxanthin production. Here, we report the draft genome sequence of R. toruloides VN1, which comprises 20.01 Mb in 424 contigs with an overall G + C content of 61.8%. This whole-genome shotgun project has been deposited at DDBJ/EMBL/GenBank under the accession number SJTE00000000.

Modern personal protective armor has been generally based on the Kevlar fabrics, with the main goal to offer defense against bullets. In addition to the high cost and poor processability, Kevlar has the disadvantage of limited stab-proofing capability. On the other hand, a large number of crimes involving deadly injures represent knife attacks. Our goal in this work was to investigate composites based on traditional commercially available fabrics of linen and silk, using different adhesives-polymers for forming laminates. The silk composites also contained different amounts of in-woven polyester. Three different water-based adhesives of polyurethane, urea formaldehyde and polyvinyl alcohol were considered. It was found, that besides the strength of the fabrics themselves, the adhesives polymers played a crucial role in the obtained performance of the laminates. The laminates were characterized in their mechanical properties, as well as with scanning electron microscopy and FTIR spectroscopy.

As Vietnam navigates challenges to its animal, human, and environmental health (One Health) during rapid economic transitions, understanding local perceptions of sustainable food systems, particularly aquatic foods, is vital. This study employs a transdisciplinary, autoethnographic approach to exploring the cultural significance of aquatic food perceptions within Vietnamese communities. Data were primarily sourced through an autoethnographic triangulation method, involving detailed field diaries, vignettes, and interactive workshop data collected from local stakeholders. Our distinctive approach, involving researchers from environmental science, computer science, linguistics, political ecology, aquaculture, nutrition, human physiology, marketing, and accounting and accountability, as both participants and observers, illuminates the lived experiences that shape food perceptions within Vietnam’s specific food agro-ecosystems. By embedding aquatic food perceptions within the One Health framework, we identify key intersections between human, animal, and environmental health. Through cross-disciplinary narrative analysis, our study uncovers the social, political, economic, cultural, and linguistic dimensions surrounding aquatic food perceptions at local, regional, and national levels in Vietnam. Our study highlights the unique contribution of qualitative methods to addressing questions that hard data cannot answer in understanding perceptions of aquatic foods. The study emphasizes the need for an integrated, culturally informed, and transdisciplinary approach to addressing the complex factors influencing One Health outcomes in Vietnam. This research contributes to the broader discourse on sustainable food practices and One Health initiatives, proposing culturally informed interventions aimed at enhancing ecological resilience and public health.