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Dr. Brenda Modak
Universidad de Santiago de Chile
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Academic Career Length
21Years (2006-Present)
(Calculated once Scilit publication data is synced: current year − year of first publication + 1)
Representative Publications
View All Publications1 May 2006 in Phytochemistry
Journal Article
RTRené Torres
René TorresFFFrancesca Faini
Francesca Faini
BMBrenda Modak
Brenda ModakFUFrancisco Urbina
Francisco Urbina
CLCecilia Labbé
Cecilia Labbé
JGJuan Guerrero
Juan Guerrero
1 February 2010 in Veterinary Microbiology
Journal Article
BMBrenda Modak
Brenda ModakASAnamaria Sandino
Anamaria SandinoLALoredana Arata
Loredana Arata
GCGloria Cárdenas-Jirón
Gloria Cárdenas-JirónRTRené Torres
René Torres
Journal Article
H. taltalense (Phil.) Johnst. (Heliotropiaceae) is an endemic species of the northern coast of Chile that produces a resinous exudate that covers its foliar surface and stems. Its chemical composition was analyzed for the first time, and two aromatic geranyl derivatives: filifolinol and filifolinyl senecionate and three flavonoids – naringenin, 3-O-methylgalangin and 7-O-methyleriodictiol – were isolated. The antioxidant activity of the flavonoids and the resinous exudates was carried out by measuring the 1,1-diphenyl-2-picrylhydrazyl (DPPH) bleaching effect in ethanolic solution and in sodium dodecyl sulfate (SDS) micelles. The influence of the reaction medium was analyzed. The initial velocity reactions for the pure compounds and for the extract were higher in SDS media than in ethanolic solution. The velocity of reaction observed was interpreted in terms of the reaction medium environment in the micelle.
Journal Article
MAMaialen Aldabaldetrecu
Maialen AldabaldetrecuMPMick Parra
Mick ParraSSSarita Soto
Sarita SotoPAPablo Arce
Pablo Arce
Mario TelloBMBrenda Modak
Brenda Modak +1
A new copper (I) complex, [Cu(NN1)2](ClO4), was synthesized, where NN1 was a imine ligand 6-((quinolin-2-ylmethylene)amino)-2H-chromen-2-one obtained by a derivatization of natural compound coumarin. The structural characterization in solution was done by NMR techniques, UV-Vis and cyclic voltammetry. The potential antibacterial effect of [Cu(NN1)2](ClO4), was assessed for F. psychrophilum isolated 10094. F. psychrophilum is a Gram-negative bacterium which causes diseases such as bacterial cold-water disease and rainbow trout fry syndrome, causing large economic losses in the freshwater salmonid aquaculture industry. This complex show to have antibacterial activity against F. psychrophilum 10094 at non-cytotoxic concentration in cell line derived from trout (F. psychrophilum 10094 IC50 16.0 ± 0.9; RT-GUT IC50 53.0 ± 3.1 µg/mL).
29 January 2021 in Applied Microbiology and Biotechnology
Journal Article
GRGerardo Retamal-Morales
Gerardo Retamal-Morales
CSChristoph Helmut Rudi Senges
Christoph Helmut Rudi Senges
Manuel StapfAOAngel Olguín
Angel Olguín
BMBrenda Modak
Brenda ModakGLGloria Levicán
Gloria Levicán +3
1 March 2018 in Fish & Shellfish Immunology
Journal Article
BVBeatriz Valenzuela
Beatriz ValenzuelaFRFelipe E. Rodríguez
Felipe E. RodríguezBMBrenda Modak
Brenda Modak
Monica ImaraiAbout Me
Dr. in Chemistry. Department of Environmental Sciences, Faculty of Chemistry and Biology, University of Santiago de Chile. Full Professor.
Research areas: Chemistry of Natural Products and its applications as immunostimulants, antiviral, antibacterial and antioxidant.
Last publications:
• Retamal-Morales.G, Rudi Senges.C, Stapf.M, Olguín.A, Modak.B, Bandow.J, Tischler.D, Schlömann.M, Levicán.G. 2021. Isolation and characterization of arsenic-binding siderophores from Rhodococcus erythropolis S43: role of heterobactin B and other heterobactin variants. Applied Microbiology and Biotechnology,105, 1731–1744. doi.org/10.1007/s00253-021-11123-2. Impact Factor: 3,530.
• Soto-Aguilera, S.; Modak, B.; Aldabaldetrecu, M.; Lozano, C.P.; Guerrero, J.; Lefimil, C.; Parra, M. 2021. In Vitro Effect of Copper (I) Complex [Cu(NN1)2](ClO4) on Vibrio harveyi BB170 Biofilm Formation. Microorganisms 9, 2273. doi.org/10.3390/ microorganisms9112273
• Valenzuela,B.; Benavides A.; Gutierrez D.; Blamey L.; MonsalvesM.T.; Modak B.; Blamey J. 2021. In Press. Journal of Fish Disease. DOI: 10.1111/jfd.13559
• Benavides A , Gutierrez D , Epuyao N, Modak B, Imarai M, Valenzuela B. 2022. Alpinone: A positive regulator molecule of immune antiviral response in Atlantic salmon kidney cells. Developmental & Comparative Immunology,126, 104262, doi.org/10.1016/j.dci.2021.104262.