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Dr. Monica Nardi
Università Magna Graecia di Catanzaro

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Journal article
Published: 23 November 2020 in Molecules
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Oleuropein, a glycosylated secoiridoid present in olive leaves, is known to be an important antioxidant phenolic compound. We studied the antioxidant effect of low doses of oleuropein aglycone (3,4-DHPEA-EA) and oleuropein aglycone peracetylated (3,4-DHPEA-EA(P)) in murine C2C12 myocytes treated with hydrogen peroxide (H2O2). Both compounds were used at a concentration of 10 μM and were able to inhibit cell death induced by the H2O2 treatment, with 3,4-DHPEA-EA(P) being more. Under our experimental conditions, H2O2 efficiently induced the phosphorylated-active form of JNK and of its downstream target c-Jun. We demonstrated, by Western blot analysis, that 3,4-DHPEA-EA(P) was efficient in inhibiting the phospho-active form of JNK. This data suggests that the growth arrest and cell death of C2C12 proceeds via the JNK/c-Jun pathway. Moreover, we demonstrated that 3,4-DHPEA-EA(P) affects the myogenesis of C2C12 cells; because MyoD mRNA levels and the differentiation process are restored with 3,4-DHPEA-EA(P) after treatment. Overall, the results indicate that 3,4-DHPEA-EA(P) prevents ROS-mediated degenerative process by functioning as an efficient antioxidant.

ACS Style

Monica Nardi; Sara Baldelli; Maria Rosa Ciriolo; Paola Costanzo; Antonio Procopio; Carmela Colica. Oleuropein Aglycone Peracetylated (3,4-DHPEA-EA(P)) Attenuates H2O2-Mediated Cytotoxicity in C2C12 Myocytes via Inactivation of p-JNK/p-c-Jun Signaling Pathway. Molecules 2020, 25, 5472 .

AMA Style

Monica Nardi, Sara Baldelli, Maria Rosa Ciriolo, Paola Costanzo, Antonio Procopio, Carmela Colica. Oleuropein Aglycone Peracetylated (3,4-DHPEA-EA(P)) Attenuates H2O2-Mediated Cytotoxicity in C2C12 Myocytes via Inactivation of p-JNK/p-c-Jun Signaling Pathway. Molecules. 2020; 25 (22):5472.

Chicago/Turabian Style

Monica Nardi; Sara Baldelli; Maria Rosa Ciriolo; Paola Costanzo; Antonio Procopio; Carmela Colica. 2020. "Oleuropein Aglycone Peracetylated (3,4-DHPEA-EA(P)) Attenuates H2O2-Mediated Cytotoxicity in C2C12 Myocytes via Inactivation of p-JNK/p-c-Jun Signaling Pathway." Molecules 25, no. 22: 5472.

Journal article
Published: 28 July 2020 in Catalysts
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The use of toxic solvents, high energy consumption, the production of waste and the application of traditional processes that do not follow the principles of green chemistry are problems for the pharmaceutical industry. The organic synthesis of chemical structures that represent the starting point for obtaining active pharmacological compounds, such as benzimidazole derivatives, has become a focal point in chemistry. Benzimidazole derivatives have found very strong applications in medicine. Their synthesis is often based on methods that are not convenient and not very respectful of the environment. A simple montmorillonite K10 (MK10) catalyzed method for the synthesis of benzimidazole derivatives has been developed. The use of MK10 for heterogeneous catalysis provides various advantages: the reaction yields are decidedly high, the work-up procedures of the reaction are easy and suitable, there is an increase in selectivity and the possibility of recycling the catalyst without waste formation is demonstrated. The reactions were carried out in solvent-free conditions and in a short reaction time using inexpensive and environmentally friendly heterogeneous catalysis. It has been shown that the reaction process is applicable in the industrial field.

ACS Style

Sonia Bonacci; Giuseppe Iriti; Stefano Mancuso; Paolo Novelli; Rosina Paonessa; Sofia Tallarico; Monica Nardi. Montmorillonite K10: An Efficient Organo-Heterogeneous Catalyst for Synthesis of Benzimidazole Derivatives. Catalysts 2020, 10, 845 .

AMA Style

Sonia Bonacci, Giuseppe Iriti, Stefano Mancuso, Paolo Novelli, Rosina Paonessa, Sofia Tallarico, Monica Nardi. Montmorillonite K10: An Efficient Organo-Heterogeneous Catalyst for Synthesis of Benzimidazole Derivatives. Catalysts. 2020; 10 (8):845.

Chicago/Turabian Style

Sonia Bonacci; Giuseppe Iriti; Stefano Mancuso; Paolo Novelli; Rosina Paonessa; Sofia Tallarico; Monica Nardi. 2020. "Montmorillonite K10: An Efficient Organo-Heterogeneous Catalyst for Synthesis of Benzimidazole Derivatives." Catalysts 10, no. 8: 845.

Preprint
Published: 16 July 2020
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Oleuropein, glycosylated secoiridoid present in olive leaves is known to be an important antioxidant phenolic compound. We studied the antioxidant effect of low doses of oleuropein aglycone (3,4-DHPEA-EA) and oleuropein aglycone peracetylated (3,4-DHPEA-EA(P)) in murine C2C12 myocytes treated with hydrogen peroxide (H2O2). Both compounds were used at a concentration of 10 μM and were able to inhibit cell death induced by the H2O2 treatment, with 3,4-DHPEA-EA(P) being more. Under our experimental conditions, H2O2 efficiently induced the phosphorylated-active form of JNK and of its downstream target c-Jun. We demonstrated, by Western blot analysis, that 3,4-DHPEA-EA(P) was efficient in inhibiting the phospho-active form of JNK. This data suggests that the growth arrest and cell death of C2C12 proceeds via the JNK/c-Jun pathway. Moreover, we demonstrated that 3,4-DHPEA-EA(P) affects the myogenesis of C2C12 cells; because MyoD mRNA levels and the differentiation process are restored with 3,4-DHPEA-EA(P) after treatment. Overall, the results indicate that 3,4-DHPEA-EA(P) prevents ROS-mediated degenerative process in a genomic and epigenomic manner by functioning as an efficient antioxidant.

ACS Style

Monica Nardi; Sara Baldelli; Maria Rosa Ciriolo; Paola Costanzo; Antonio Procopio; Carmela Colica. Oleuropein Aglycone Peracetylated (3,4-DHPEA-EA(P)) Attenuates H2O2-mediated Cytotoxicity in C2C12 Myocytes Via Inactivation of p-JNK/p-c-Jun Signaling Pathway. 2020, 1 .

AMA Style

Monica Nardi, Sara Baldelli, Maria Rosa Ciriolo, Paola Costanzo, Antonio Procopio, Carmela Colica. Oleuropein Aglycone Peracetylated (3,4-DHPEA-EA(P)) Attenuates H2O2-mediated Cytotoxicity in C2C12 Myocytes Via Inactivation of p-JNK/p-c-Jun Signaling Pathway. . 2020; ():1.

Chicago/Turabian Style

Monica Nardi; Sara Baldelli; Maria Rosa Ciriolo; Paola Costanzo; Antonio Procopio; Carmela Colica. 2020. "Oleuropein Aglycone Peracetylated (3,4-DHPEA-EA(P)) Attenuates H2O2-mediated Cytotoxicity in C2C12 Myocytes Via Inactivation of p-JNK/p-c-Jun Signaling Pathway." , no. : 1.

Preprint
Published: 12 July 2020
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Oleuropein, glycosylated secoiridoid present in olive leaves is known to be an important antioxidant phenolic compound. We studied the antioxidant effect of low doses of oleuropein aglycone (3,4-DHPEA-EA) and oleuropein aglycone peracetylated (3,4-DHPEA-EA(P)) in murine C2C12 myocytes treated with hydrogen peroxide (H2O2). Both compounds were used at a concentration of 10 μM and were able to inhibit cell death induced by the H2O2 treatment, with 3,4-DHPEA-EA(P) being more. Under our experimental conditions, H2O2 efficiently induced the phosphorylated-active form of JNK and of its downstream target c-Jun. We demonstrated, by Western blot analysis, that 3,4-DHPEA-EA(P) was efficient in inhibiting the phospho-active form of JNK. This data suggests that the growth arrest and cell death of C2C12 proceeds via the JNK/c-Jun pathway. Moreover, we demonstrated that 3,4-DHPEA-EA(P) affects the myogenesis of C2C12 cells; because MyoD mRNA levels and the differentiation process are restored with 3,4-DHPEA-EA(P) after treatment. Overall, the results indicate that 3,4-DHPEA-EA(P) prevents ROS-mediated degenerative process in a genomic and epigenomic manner by functioning as an efficient antioxidant.

ACS Style

Monica Nardi; Sara Baldelli; Maria Rosa Ciriolo; Paola Costanzo; Antonio Procopio; Carmela Colica. Oleuropein Aglycone Peracetylated (3,4-DHPEA-EA(P)) Attenuates H2O2-Mediated Cytotoxicity in C2C12 Myocytes via Inactivation of p-JNK/p-c-Jun Signaling Pathway. 2020, 1 .

AMA Style

Monica Nardi, Sara Baldelli, Maria Rosa Ciriolo, Paola Costanzo, Antonio Procopio, Carmela Colica. Oleuropein Aglycone Peracetylated (3,4-DHPEA-EA(P)) Attenuates H2O2-Mediated Cytotoxicity in C2C12 Myocytes via Inactivation of p-JNK/p-c-Jun Signaling Pathway. . 2020; ():1.

Chicago/Turabian Style

Monica Nardi; Sara Baldelli; Maria Rosa Ciriolo; Paola Costanzo; Antonio Procopio; Carmela Colica. 2020. "Oleuropein Aglycone Peracetylated (3,4-DHPEA-EA(P)) Attenuates H2O2-Mediated Cytotoxicity in C2C12 Myocytes via Inactivation of p-JNK/p-c-Jun Signaling Pathway." , no. : 1.

Preprint
Published: 06 July 2020
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The use of alternative synthetic methods, in the face of traditional processes that do not conform to the principles of Green Chemistry, represent a problem in the pharmaceutical industry. The procedures for the synthesis of benzimidazole derivatives have become a focus in synthetic organic chemistry, as they are building blocks of strong interest for the synthesis of compounds with pharmacological activity. Various benzimidazole derivatives have found very strong application in medicine and their synthesis is reported in the literature. A simple and environmental Montmorillonite K10 (MK10) catalyzed method for the synthesis of benzimidazole derivatives has been developed. The use of MK10 as heterogeneous catalysis provides various advantages in terms of yields, in the work up procedure of the reaction, selectivity and the possible recycle of catalyst without waste formation. The reactions were carried out in solvent free condition and in short reaction time using an inexpensive and environmentally friendly heterogeneous catalysis and it has been shown that the reaction process is applicable in the industrial field.

ACS Style

Sonia Bonacci; Giuseppe Iriti; Stefano Mancuso; Paolo Novelli; Rosina Paonessa; Sofia Tallarico; Monica Nardi. Montmorillonite K10: An Efficient Organo- Heterogeneous Catalyst for Synthesis of Benzimidazole Derivatives. 2020, 1 .

AMA Style

Sonia Bonacci, Giuseppe Iriti, Stefano Mancuso, Paolo Novelli, Rosina Paonessa, Sofia Tallarico, Monica Nardi. Montmorillonite K10: An Efficient Organo- Heterogeneous Catalyst for Synthesis of Benzimidazole Derivatives. . 2020; ():1.

Chicago/Turabian Style

Sonia Bonacci; Giuseppe Iriti; Stefano Mancuso; Paolo Novelli; Rosina Paonessa; Sofia Tallarico; Monica Nardi. 2020. "Montmorillonite K10: An Efficient Organo- Heterogeneous Catalyst for Synthesis of Benzimidazole Derivatives." , no. : 1.

Journal article
Published: 11 June 2020 in Antioxidants
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In this new century, sustainable development challenges chemical sciences to develop new and clean technological processes. The agri-food industry produces significant quantities of waste, raising significant economic and environmental concerns. Food waste valorization using environmentally friendly procedures is of increasing importance. This study describes the use of several Natural Deep Eutectic Solvents (NADESs) for the microwave-assisted extraction (MAE) of valuable bioactive phenolic compounds from olive oil processing wastes. The extracted samples were characterized by liquid chromatography electrospray ionization quadrupole time-of-flight mass spectrometry (LC-ESI-QTOF/MS) analysis and the quantification of the phenolic compounds was performed by HPLC analysis. The obtained data were compared with those obtained using water as the solvent in the same extraction conditions. The extraction process is nontoxic, simple and selective and meets most of the criteria to be considered as a sustainable process, with the solvents arising directly from nature.

ACS Style

Sonia Bonacci; Maria Luisa Di Gioia; Paola Costanzo; Loredana Maiuolo; Sofia Tallarico; Monica Nardi. Natural Deep Eutectic Solvent as Extraction Media for the Main Phenolic Compounds from Olive Oil Processing Wastes. Antioxidants 2020, 9, 513 .

AMA Style

Sonia Bonacci, Maria Luisa Di Gioia, Paola Costanzo, Loredana Maiuolo, Sofia Tallarico, Monica Nardi. Natural Deep Eutectic Solvent as Extraction Media for the Main Phenolic Compounds from Olive Oil Processing Wastes. Antioxidants. 2020; 9 (6):513.

Chicago/Turabian Style

Sonia Bonacci; Maria Luisa Di Gioia; Paola Costanzo; Loredana Maiuolo; Sofia Tallarico; Monica Nardi. 2020. "Natural Deep Eutectic Solvent as Extraction Media for the Main Phenolic Compounds from Olive Oil Processing Wastes." Antioxidants 9, no. 6: 513.

Journal article
Published: 28 November 2019 in Molecules
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The procedures for the extraction and separation of lipids and nutraceutics from microalgae using classic solvents have been frequently used over the years. However, these production methods usually require expensive and toxic solvents. Based on our studies involving the use of eco-sustainable methodologies and alternative solvents, we selected ethanol (EtOH) and cyclopentyl methyl ether (CPME) for extracting bio-oil and lipids from algae. Different percentages of EtOH in CPME favor the production of an oil rich in saturated fatty acids (SFA), useful to biofuel production or rich in bioactive compounds. The proposed method for obtaining an extract rich in saturated or unsaturated fatty acids from dry algal biomass is disclosed as eco-friendly and allows a good extraction yield. The method is compared both in extracted oil percentage yield and in extracted fatty acids selectivity to extraction by supercritical carbon dioxide (SC-CO2).

ACS Style

Ilaria Santoro; Monica Nardi; Cinzia Benincasa; Paola Costanzo; Girolamo Giordano; Antonio Procopio; Giovanni Sindona. Sustainable and Selective Extraction of Lipids and Bioactive Compounds from Microalgae. Molecules 2019, 24, 4347 .

AMA Style

Ilaria Santoro, Monica Nardi, Cinzia Benincasa, Paola Costanzo, Girolamo Giordano, Antonio Procopio, Giovanni Sindona. Sustainable and Selective Extraction of Lipids and Bioactive Compounds from Microalgae. Molecules. 2019; 24 (23):4347.

Chicago/Turabian Style

Ilaria Santoro; Monica Nardi; Cinzia Benincasa; Paola Costanzo; Girolamo Giordano; Antonio Procopio; Giovanni Sindona. 2019. "Sustainable and Selective Extraction of Lipids and Bioactive Compounds from Microalgae." Molecules 24, no. 23: 4347.

Journal article
Published: 25 September 2019 in Molecules
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Olive tree (Olea europaea L.) leaf, a waste by-product of the olive oil industry, is an inexpensive and abundant source of biophenols of great interest for various industrial applications in the food supplement, cosmetic, and pharmaceutical industries. In this work, the aqueous extraction of high-added value compounds from olive leaves by using microfiltered (MF), ultrapure (U), and osmosis-treated (O) water was investigated. The extraction of target compounds, including oleuropein (Olp), hydroxytyrosol (HyTyr), tyrosol (Tyr), verbascoside (Ver), lutein (Lut), and rutin (Rut), was significantly affected by the characteristics of the water used. Indeed, according to the results of liquid chromatography tandem mass spectrometry, the extracting power of microfiltered water towards rutin resulted very poor, while a moderate extraction was observed for oleuropein, verbascoside, and lutein. On the other hand, high concentrations of hydroxytyrosol were detected in the aqueous extracts produced with microfiltered water. The extraction power of ultrapure and osmosis-treated water proved to be very similar for the bio-active compounds oleuropein, verbascoside, lutein, and rutin. The results clearly provide evidence of the possibility of devising new eco-friendly strategies based on the use of green solvents which can be applied to recover bioactive compounds from olive leaves.

ACS Style

Cinzia Benincasa; Ilaria Santoro; Monica Nardi; Alfredo Cassano; Giovanni Sindona. Eco-Friendly Extraction and Characterisation of Nutraceuticals from Olive Leaves. Molecules 2019, 24, 3481 .

AMA Style

Cinzia Benincasa, Ilaria Santoro, Monica Nardi, Alfredo Cassano, Giovanni Sindona. Eco-Friendly Extraction and Characterisation of Nutraceuticals from Olive Leaves. Molecules. 2019; 24 (19):3481.

Chicago/Turabian Style

Cinzia Benincasa; Ilaria Santoro; Monica Nardi; Alfredo Cassano; Giovanni Sindona. 2019. "Eco-Friendly Extraction and Characterisation of Nutraceuticals from Olive Leaves." Molecules 24, no. 19: 3481.

Journal article
Published: 10 August 2019 in Molecules
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Nucleobase-containing isoxazolidines spiro-bonded to an indane core have been synthesized in very good yields by regio- and diastereoselective 1,3-dipolar cycloaddition starting from indanyl nitrones and N-vinylnucleobases by using environmentally benign microwave technology. The contemporary presence of various structural groups that are individually active scaffolds of different typology of drugs, has directed us to speculate that these compounds may act as inhibitors of MDM2–p53 interaction. Therefore, both computational calculations and antiproliferative screening against A549 human lung adenocarcinoma cells and human SH-SY5Y neuroblastoma cells were carried out to support this hypothesis.

ACS Style

Loredana Maiuolo; Vincenzo Algieri; Beatrice Russo; Matteo Antonio Tallarida; Monica Nardi; Maria Luisa Di Gioia; Zahra Merchant; Pedro Merino; Ignacio Delso; Antonio De Nino. Synthesis, Biological and In Silico Evaluation of Pure Nucleobase-Containing Spiro (Indane-Isoxazolidine) Derivatives as Potential Inhibitors of MDM2–p53 Interaction. Molecules 2019, 24, 2909 .

AMA Style

Loredana Maiuolo, Vincenzo Algieri, Beatrice Russo, Matteo Antonio Tallarida, Monica Nardi, Maria Luisa Di Gioia, Zahra Merchant, Pedro Merino, Ignacio Delso, Antonio De Nino. Synthesis, Biological and In Silico Evaluation of Pure Nucleobase-Containing Spiro (Indane-Isoxazolidine) Derivatives as Potential Inhibitors of MDM2–p53 Interaction. Molecules. 2019; 24 (16):2909.

Chicago/Turabian Style

Loredana Maiuolo; Vincenzo Algieri; Beatrice Russo; Matteo Antonio Tallarida; Monica Nardi; Maria Luisa Di Gioia; Zahra Merchant; Pedro Merino; Ignacio Delso; Antonio De Nino. 2019. "Synthesis, Biological and In Silico Evaluation of Pure Nucleobase-Containing Spiro (Indane-Isoxazolidine) Derivatives as Potential Inhibitors of MDM2–p53 Interaction." Molecules 24, no. 16: 2909.

Journal article
Published: 08 August 2019 in Molecules
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The exploitation and use of alternative synthetic methods, in the face of classical procedures that do not conform to the ethics of green chemistry, represent an ever-present problem in the pharmaceutical industry. The procedures for the synthesis of benzimidazoles have become a focus in synthetic organic chemistry, as they are building blocks of strong interest for the development of compounds with pharmacological activity. Various benzimidazole derivatives exhibit important activities such as antimicrobial, antiviral, anti-inflammatory, and analgesic activities, and some of the already synthesized compounds have found very strong applications in medicine praxis. Here we report a selective and sustainable method for the synthesis of 1,2-disubstituted or 2-substituted benzimidazoles, starting from o-phenylenediamine in the presence of different aldehydes. The use of deep eutectic solvent (DES), both as reaction medium and reagent without any external solvent, provides advantages in terms of yields as well as in the work up procedure of the reaction.

ACS Style

Maria Luisa Di Gioia; Roberta Cassano; Paola Costanzo; Natividad Herrera Cano; Loredana Maiuolo; Monica Nardi; Fiore Pasquale Nicoletta; Manuela Oliverio; Antonio Procopio. Green Synthesis of Privileged Benzimidazole Scaffolds Using Active Deep Eutectic Solvent. Molecules 2019, 24, 2885 .

AMA Style

Maria Luisa Di Gioia, Roberta Cassano, Paola Costanzo, Natividad Herrera Cano, Loredana Maiuolo, Monica Nardi, Fiore Pasquale Nicoletta, Manuela Oliverio, Antonio Procopio. Green Synthesis of Privileged Benzimidazole Scaffolds Using Active Deep Eutectic Solvent. Molecules. 2019; 24 (16):2885.

Chicago/Turabian Style

Maria Luisa Di Gioia; Roberta Cassano; Paola Costanzo; Natividad Herrera Cano; Loredana Maiuolo; Monica Nardi; Fiore Pasquale Nicoletta; Manuela Oliverio; Antonio Procopio. 2019. "Green Synthesis of Privileged Benzimidazole Scaffolds Using Active Deep Eutectic Solvent." Molecules 24, no. 16: 2885.

Journal article
Published: 16 July 2019 in Cancers
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Olive oil contains different biologically active polyphenols, among which oleacein, the most abundant secoiridoid, has recently emerged for its beneficial properties in various disease contexts. By using in vitro models of human multiple myeloma (MM), we here investigated the anti-tumor potential of oleacein and the underlying bio-molecular sequelae. Within a low micromolar range, oleacein reduced the viability of MM primary samples and cell lines even in the presence of bone marrow stromal cells (BMSCs), while sparing healthy peripheral blood mononuclear cells. We also demonstrated that oleacein inhibited MM cell clonogenicity, prompted cell cycle blockade and triggered apoptosis. We evaluated the epigenetic impact of oleacein on MM cells, and observed dose-dependent accumulation of both acetylated histones and α-tubulin, along with down-regulation of several class I/II histone deacetylases (HDACs) both at the mRNA and protein level, providing evidence of the HDAC inhibitory activity of this compound; conversely, no effect on global DNA methylation was found. Mechanistically, HDACs inhibition by oleacein was associated with down-regulation of Sp1, the major transactivator of HDACs promoter, via Caspase 8 activation. Of potential translational significance, oleacein synergistically enhanced the in vitro anti-MM activity of the proteasome inhibitor carfilzomib. Altogether, these results indicate that oleacein is endowed with HDAC inhibitory properties, which associate with significant anti-MM activity both as single agent or in combination with carfilzomib. These findings may pave the way to novel potential anti-MM epi-therapeutic approaches based on natural agents.

ACS Style

Giada Juli; Manuela Oliverio; Dina Bellizzi; Maria Eugenia Gallo Cantafio; Katia Grillone; Giuseppe Passarino; Carmela Colica; Monica Nardi; Marco Rossi; Antonio Procopio; Pierosandro Tagliaferri; Pierfrancesco Tassone; Nicola Amodio. Anti-tumor Activity and Epigenetic Impact of the Polyphenol Oleacein in Multiple Myeloma. Cancers 2019, 11, 990 .

AMA Style

Giada Juli, Manuela Oliverio, Dina Bellizzi, Maria Eugenia Gallo Cantafio, Katia Grillone, Giuseppe Passarino, Carmela Colica, Monica Nardi, Marco Rossi, Antonio Procopio, Pierosandro Tagliaferri, Pierfrancesco Tassone, Nicola Amodio. Anti-tumor Activity and Epigenetic Impact of the Polyphenol Oleacein in Multiple Myeloma. Cancers. 2019; 11 (7):990.

Chicago/Turabian Style

Giada Juli; Manuela Oliverio; Dina Bellizzi; Maria Eugenia Gallo Cantafio; Katia Grillone; Giuseppe Passarino; Carmela Colica; Monica Nardi; Marco Rossi; Antonio Procopio; Pierosandro Tagliaferri; Pierfrancesco Tassone; Nicola Amodio. 2019. "Anti-tumor Activity and Epigenetic Impact of the Polyphenol Oleacein in Multiple Myeloma." Cancers 11, no. 7: 990.

Journal article
Published: 26 March 2019 in Catalysts
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A simple and eco-friendly montmorillonite K10 (MK10)-catalyzed method for the synthesis of cyclopentenone derivatives from biomass-produced furfural has been developed. The versatility of this protocol is that the reactions were performed under solvent-free conditions and in a short reaction time under heterogeneous catalysis. Montmorillonite K10 is mostly explored as a heterogeneous catalyst since it is inexpensive and environmentally friendly.

ACS Style

Sonia Bonacci; Monica Nardi; Paola Costanzo; Antonio De Nino; Maria Luisa Di Gioia; Manuela Oliverio; Antonio Procopio. Montmorillonite K10-Catalyzed Solvent-Free Conversion of Furfural into Cyclopentenones. Catalysts 2019, 9, 301 .

AMA Style

Sonia Bonacci, Monica Nardi, Paola Costanzo, Antonio De Nino, Maria Luisa Di Gioia, Manuela Oliverio, Antonio Procopio. Montmorillonite K10-Catalyzed Solvent-Free Conversion of Furfural into Cyclopentenones. Catalysts. 2019; 9 (3):301.

Chicago/Turabian Style

Sonia Bonacci; Monica Nardi; Paola Costanzo; Antonio De Nino; Maria Luisa Di Gioia; Manuela Oliverio; Antonio Procopio. 2019. "Montmorillonite K10-Catalyzed Solvent-Free Conversion of Furfural into Cyclopentenones." Catalysts 9, no. 3: 301.

Journal article
Published: 01 February 2019 in Tetrahedron Letters
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ACS Style

Loredana Maiuolo; Beatrice Russo; Vincenzo Algieri; Monica Nardi; Maria Luisa Di Gioia; Matteo Antonio Tallarida; Antonio De Nino. Regioselective synthesis of 1,5-disubstituted 1,2,3-triazoles by 1,3-dipolar cycloaddition: Role of Er(OTf)3, ionic liquid and water. Tetrahedron Letters 2019, 60, 672 -674.

AMA Style

Loredana Maiuolo, Beatrice Russo, Vincenzo Algieri, Monica Nardi, Maria Luisa Di Gioia, Matteo Antonio Tallarida, Antonio De Nino. Regioselective synthesis of 1,5-disubstituted 1,2,3-triazoles by 1,3-dipolar cycloaddition: Role of Er(OTf)3, ionic liquid and water. Tetrahedron Letters. 2019; 60 (9):672-674.

Chicago/Turabian Style

Loredana Maiuolo; Beatrice Russo; Vincenzo Algieri; Monica Nardi; Maria Luisa Di Gioia; Matteo Antonio Tallarida; Antonio De Nino. 2019. "Regioselective synthesis of 1,5-disubstituted 1,2,3-triazoles by 1,3-dipolar cycloaddition: Role of Er(OTf)3, ionic liquid and water." Tetrahedron Letters 60, no. 9: 672-674.

Journal article
Published: 17 January 2019 in ChemEngineering
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The orange press liquor is a by-product of the orange juice production containing bioactive compounds recognized for their beneficial implications in human health. The recovery of these compounds offers new opportunities for the formulation of products of interest in food, pharmaceutical and cosmetic industry. The clarification of orange press liquor by microfiltration (MF) and/or ultrafiltration (UF) processes is a valid approach to remove macromolecules, colloidal particles, and suspended solids from sugars and bioactive compounds. In this work the clarification of orange press liquor was studied by using three flat-sheet polymeric membranes: a MF membrane with a pore size of 0.2 μm and two UF membranes with nominal molecular weight cut-off (MWCO) of 150 and 200 kDa, respectively. The membrane performance, in terms of permeate flux and membrane rejection towards hesperidin and sugars, was studied according to a multivariate analyses approach. In particular, characteristics influencing the performance of the investigated membranes, such as molecular weight cut-off (MWCO), contact angle, membrane thickness, pore size distribution, as well as operating conditions, including temperature, and operating time, were analysed through the partial least square regression (PLSR). The multivariate method revealed crucial information on variables which are relevant to maximize the permeate flux and to minimize the rejection of hesperidin and sugars in the clarification of orange press liquor.

ACS Style

René Ruby-Figueroa; Monica Nardi; Giovanni Sindona; Carmela Conidi; Alfredo Cassano. A Multivariate Statistical Analyses of Membrane Performance in the Clarification of Citrus Press Liquor. ChemEngineering 2019, 3, 10 .

AMA Style

René Ruby-Figueroa, Monica Nardi, Giovanni Sindona, Carmela Conidi, Alfredo Cassano. A Multivariate Statistical Analyses of Membrane Performance in the Clarification of Citrus Press Liquor. ChemEngineering. 2019; 3 (1):10.

Chicago/Turabian Style

René Ruby-Figueroa; Monica Nardi; Giovanni Sindona; Carmela Conidi; Alfredo Cassano. 2019. "A Multivariate Statistical Analyses of Membrane Performance in the Clarification of Citrus Press Liquor." ChemEngineering 3, no. 1: 10.

Journal article
Published: 01 October 2018 in Food & Function
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Acetylated oleuropein, a safe, biologically active semi-synthetic stable derivative of oleuropein, is proposed as an easy alternative to make oleuropein more bioavailable and suitable to be added to fatty foods.

ACS Style

Sonia Bonacci; Rosina Paonessa; Paola Costanzo; Raffaele Salerno; Jessica Maiuolo; Monica Nardi; Antonio Procopio; Oliverio Manuela. Peracetylation as a strategy to improve oleuropein stability and its affinity to fatty foods. Food & Function 2018, 9, 5759 -5767.

AMA Style

Sonia Bonacci, Rosina Paonessa, Paola Costanzo, Raffaele Salerno, Jessica Maiuolo, Monica Nardi, Antonio Procopio, Oliverio Manuela. Peracetylation as a strategy to improve oleuropein stability and its affinity to fatty foods. Food & Function. 2018; 9 (11):5759-5767.

Chicago/Turabian Style

Sonia Bonacci; Rosina Paonessa; Paola Costanzo; Raffaele Salerno; Jessica Maiuolo; Monica Nardi; Antonio Procopio; Oliverio Manuela. 2018. "Peracetylation as a strategy to improve oleuropein stability and its affinity to fatty foods." Food & Function 9, no. 11: 5759-5767.

Journal article
Published: 29 August 2018
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An efficient, eco-compatible, and very cheap method for the construction of triazoles via eliminative azide–olefin cycloaddition (EAOC) reaction has been developed by a catalytic system, IL/FeCl3, offering a highly regioselective approach to structurally diverse 1,5-disubstituted 1,2,3-triazoles in up to 95% yield. This strategy features the reuse of a catalytic system through simple operations. Mechanistic studies indicated that an asynchronous concerted dipolar cycloaddition–elimination process might be involved.

ACS Style

Antonio De Nino; Pedro Merino; Vincenzo Algieri; Monica Nardi; Maria Luisa Di Gioia; Beatrice Russo; Matteo Antonio Tallarida; Loredana Maiuolo. Synthesis of 1,5-Functionalized 1,2,3-Triazoles Using Ionic Liquid/Iron(III) Chloride as an Efficient and Reusable Homogeneous Catalyst. 2018, 8, 1 .

AMA Style

Antonio De Nino, Pedro Merino, Vincenzo Algieri, Monica Nardi, Maria Luisa Di Gioia, Beatrice Russo, Matteo Antonio Tallarida, Loredana Maiuolo. Synthesis of 1,5-Functionalized 1,2,3-Triazoles Using Ionic Liquid/Iron(III) Chloride as an Efficient and Reusable Homogeneous Catalyst. . 2018; 8 (9):1.

Chicago/Turabian Style

Antonio De Nino; Pedro Merino; Vincenzo Algieri; Monica Nardi; Maria Luisa Di Gioia; Beatrice Russo; Matteo Antonio Tallarida; Loredana Maiuolo. 2018. "Synthesis of 1,5-Functionalized 1,2,3-Triazoles Using Ionic Liquid/Iron(III) Chloride as an Efficient and Reusable Homogeneous Catalyst." 8, no. 9: 1.

Preprint
Published: 31 July 2018
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An efficient, eco-compatible and very cheap method for the construction of triazoles via eliminative azide–olefin cycloaddition (EAOC) reaction has been developed by a catalytic system IL/FeCl3, offering an highly regioselective approach to structurally diverse 1,5-disubstituted 1,2,3-triazoles in up to 95% yield. This strategy features the reuse of catalytic system through simple operations. Mechanistic studies indicated that an asynchronous concerted dipolar cycloaddition-elimination process might be involved.

ACS Style

Antonio De Nino; Pedro Merino; Vincenzo Algieri; Monica Nardi; Maria Luisa Di Gioia; Beatrice Russo; Antonio Tallarida Matteo; Loredana Maiuolo. Synthesis of 1,5-Functionalized 1,2,3-Triazoles Using Ionic Liquid/Iron(III) Chloride as Efficient and Reusable Homogeneous Catalyst. 2018, 1 .

AMA Style

Antonio De Nino, Pedro Merino, Vincenzo Algieri, Monica Nardi, Maria Luisa Di Gioia, Beatrice Russo, Antonio Tallarida Matteo, Loredana Maiuolo. Synthesis of 1,5-Functionalized 1,2,3-Triazoles Using Ionic Liquid/Iron(III) Chloride as Efficient and Reusable Homogeneous Catalyst. . 2018; ():1.

Chicago/Turabian Style

Antonio De Nino; Pedro Merino; Vincenzo Algieri; Monica Nardi; Maria Luisa Di Gioia; Beatrice Russo; Antonio Tallarida Matteo; Loredana Maiuolo. 2018. "Synthesis of 1,5-Functionalized 1,2,3-Triazoles Using Ionic Liquid/Iron(III) Chloride as Efficient and Reusable Homogeneous Catalyst." , no. : 1.

Journal article
Published: 28 July 2018 in Molecules
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The development of novel synthetic routes to produce bioactive compounds starting from renewable sources has become an important research area in organic and medicinal chemistry. Here, we present a low-cost procedure for the tunable and selective conversion of biomass-produced furfural to cyclopentenone derivatives using a mixture of choline chloride and urea as a biorenewable deep eutectic solvent (DES). The proposed medium is a nontoxic, biodegradable, and could be reused up to four times without any unfavorable effect on the reaction yield. The process is tunable, clean, cheap, simple and scalable and meets most of the criteria; therefore, it can be considered as an environmental sustainable process in a natural reaction medium.

ACS Style

Maria Luisa Di Gioia; Monica Nardi; Paola Costanzo; Antonio De Nino; Loredana Maiuolo; Manuela Oliverio; Antonio Procopio. Biorenewable Deep Eutectic Solvent for Selective and Scalable Conversion of Furfural into Cyclopentenone Derivatives. Molecules 2018, 23, 1891 .

AMA Style

Maria Luisa Di Gioia, Monica Nardi, Paola Costanzo, Antonio De Nino, Loredana Maiuolo, Manuela Oliverio, Antonio Procopio. Biorenewable Deep Eutectic Solvent for Selective and Scalable Conversion of Furfural into Cyclopentenone Derivatives. Molecules. 2018; 23 (8):1891.

Chicago/Turabian Style

Maria Luisa Di Gioia; Monica Nardi; Paola Costanzo; Antonio De Nino; Loredana Maiuolo; Manuela Oliverio; Antonio Procopio. 2018. "Biorenewable Deep Eutectic Solvent for Selective and Scalable Conversion of Furfural into Cyclopentenone Derivatives." Molecules 23, no. 8: 1891.

Review
Published: 06 March 2018 in Sustainability
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Green catalysts must be non-toxic, easy to manage, able to be recovered and reused, active under alternative reaction conditions and cheap. Erbium salts meet all the previously listed characteristics and today they are emerging as a valuable catalytic solution to a number of organic transformations needing a Lewis acid catalyst in wet conditions or under alternative heating sources. This review aims to summarize the application of erbium salts in green organic transformations, with particular emphasis on their versatility under both homogeneous and heterogeneous conditions. The erbium salts’ role in bifunctional catalysis is also presented.

ACS Style

Manuela Oliverio; Monica Nardi; Paola Costanzo; Maria Luisa Di Gioia; Antonio Procopio. Erbium Salts as Non-Toxic Catalysts Compatible with Alternative Reaction Media. Sustainability 2018, 10, 721 .

AMA Style

Manuela Oliverio, Monica Nardi, Paola Costanzo, Maria Luisa Di Gioia, Antonio Procopio. Erbium Salts as Non-Toxic Catalysts Compatible with Alternative Reaction Media. Sustainability. 2018; 10 (3):721.

Chicago/Turabian Style

Manuela Oliverio; Monica Nardi; Paola Costanzo; Maria Luisa Di Gioia; Antonio Procopio. 2018. "Erbium Salts as Non-Toxic Catalysts Compatible with Alternative Reaction Media." Sustainability 10, no. 3: 721.

Journals
Published: 20 December 2017 in MedChemComm
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Isatinyl and indanyl nitrones (INs) were synthesized and evaluated for their antiproliferative activity and antioxidant properties.

ACS Style

Loredana Maiuolo; Giordana Feriotto; Vincenzo Algieri; Monica Nardi; Beatrice Russo; Maria Luisa Di Gioia; Emilia Furia; Matteo Antonio Tallarida; Carlo Mischiati; Antonio De Nino. Antiproliferative activity of novel isatinyl/indanyl nitrones (INs) as potential spin trapping agents of free radical intermediates† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7md00537g. MedChemComm 2017, 9, 299 -304.

AMA Style

Loredana Maiuolo, Giordana Feriotto, Vincenzo Algieri, Monica Nardi, Beatrice Russo, Maria Luisa Di Gioia, Emilia Furia, Matteo Antonio Tallarida, Carlo Mischiati, Antonio De Nino. Antiproliferative activity of novel isatinyl/indanyl nitrones (INs) as potential spin trapping agents of free radical intermediates† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7md00537g. MedChemComm. 2017; 9 (2):299-304.

Chicago/Turabian Style

Loredana Maiuolo; Giordana Feriotto; Vincenzo Algieri; Monica Nardi; Beatrice Russo; Maria Luisa Di Gioia; Emilia Furia; Matteo Antonio Tallarida; Carlo Mischiati; Antonio De Nino. 2017. "Antiproliferative activity of novel isatinyl/indanyl nitrones (INs) as potential spin trapping agents of free radical intermediates† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7md00537g." MedChemComm 9, no. 2: 299-304.