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Prof. Antonio Procopio
Dipartimento di Scienze della Salute, Università Magna Græcia Catanzaro, Italy

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0 Catalysis
0 Green Chemistry
0 Organic Synthesis
0 natural compounds
0 Sustainable chemical processes

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Review article
Published: 10 December 2020 in Natural Product Reports
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Semi-synthesis is an effective strategy to obtain both natural and synthetic analogues of the olive secoiridoids, starting from easy accessible natural compounds.

ACS Style

Manuela Oliverio; Monica Nardi; Maria Luisa Di Gioia; Paola Costanzo; Sonia Bonacci; Stefano Mancuso; Antonio Procopio. Semi-synthesis as a tool for broadening the health applications of bioactive olive secoiridoids: a critical review. Natural Product Reports 2020, 38, 444 -469.

AMA Style

Manuela Oliverio, Monica Nardi, Maria Luisa Di Gioia, Paola Costanzo, Sonia Bonacci, Stefano Mancuso, Antonio Procopio. Semi-synthesis as a tool for broadening the health applications of bioactive olive secoiridoids: a critical review. Natural Product Reports. 2020; 38 (3):444-469.

Chicago/Turabian Style

Manuela Oliverio; Monica Nardi; Maria Luisa Di Gioia; Paola Costanzo; Sonia Bonacci; Stefano Mancuso; Antonio Procopio. 2020. "Semi-synthesis as a tool for broadening the health applications of bioactive olive secoiridoids: a critical review." Natural Product Reports 38, no. 3: 444-469.

Journal article
Published: 23 November 2020 in Molecules
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Oleuropein, a glycosylated secoiridoid present in olive leaves, is known to be an important antioxidant phenolic compound. We studied the antioxidant effect of low doses of oleuropein aglycone (3,4-DHPEA-EA) and oleuropein aglycone peracetylated (3,4-DHPEA-EA(P)) in murine C2C12 myocytes treated with hydrogen peroxide (H2O2). Both compounds were used at a concentration of 10 μM and were able to inhibit cell death induced by the H2O2 treatment, with 3,4-DHPEA-EA(P) being more. Under our experimental conditions, H2O2 efficiently induced the phosphorylated-active form of JNK and of its downstream target c-Jun. We demonstrated, by Western blot analysis, that 3,4-DHPEA-EA(P) was efficient in inhibiting the phospho-active form of JNK. This data suggests that the growth arrest and cell death of C2C12 proceeds via the JNK/c-Jun pathway. Moreover, we demonstrated that 3,4-DHPEA-EA(P) affects the myogenesis of C2C12 cells; because MyoD mRNA levels and the differentiation process are restored with 3,4-DHPEA-EA(P) after treatment. Overall, the results indicate that 3,4-DHPEA-EA(P) prevents ROS-mediated degenerative process by functioning as an efficient antioxidant.

ACS Style

Monica Nardi; Sara Baldelli; Maria Rosa Ciriolo; Paola Costanzo; Antonio Procopio; Carmela Colica. Oleuropein Aglycone Peracetylated (3,4-DHPEA-EA(P)) Attenuates H2O2-Mediated Cytotoxicity in C2C12 Myocytes via Inactivation of p-JNK/p-c-Jun Signaling Pathway. Molecules 2020, 25, 5472 .

AMA Style

Monica Nardi, Sara Baldelli, Maria Rosa Ciriolo, Paola Costanzo, Antonio Procopio, Carmela Colica. Oleuropein Aglycone Peracetylated (3,4-DHPEA-EA(P)) Attenuates H2O2-Mediated Cytotoxicity in C2C12 Myocytes via Inactivation of p-JNK/p-c-Jun Signaling Pathway. Molecules. 2020; 25 (22):5472.

Chicago/Turabian Style

Monica Nardi; Sara Baldelli; Maria Rosa Ciriolo; Paola Costanzo; Antonio Procopio; Carmela Colica. 2020. "Oleuropein Aglycone Peracetylated (3,4-DHPEA-EA(P)) Attenuates H2O2-Mediated Cytotoxicity in C2C12 Myocytes via Inactivation of p-JNK/p-c-Jun Signaling Pathway." Molecules 25, no. 22: 5472.

Preprint
Published: 16 July 2020
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Oleuropein, glycosylated secoiridoid present in olive leaves is known to be an important antioxidant phenolic compound. We studied the antioxidant effect of low doses of oleuropein aglycone (3,4-DHPEA-EA) and oleuropein aglycone peracetylated (3,4-DHPEA-EA(P)) in murine C2C12 myocytes treated with hydrogen peroxide (H2O2). Both compounds were used at a concentration of 10 μM and were able to inhibit cell death induced by the H2O2 treatment, with 3,4-DHPEA-EA(P) being more. Under our experimental conditions, H2O2 efficiently induced the phosphorylated-active form of JNK and of its downstream target c-Jun. We demonstrated, by Western blot analysis, that 3,4-DHPEA-EA(P) was efficient in inhibiting the phospho-active form of JNK. This data suggests that the growth arrest and cell death of C2C12 proceeds via the JNK/c-Jun pathway. Moreover, we demonstrated that 3,4-DHPEA-EA(P) affects the myogenesis of C2C12 cells; because MyoD mRNA levels and the differentiation process are restored with 3,4-DHPEA-EA(P) after treatment. Overall, the results indicate that 3,4-DHPEA-EA(P) prevents ROS-mediated degenerative process in a genomic and epigenomic manner by functioning as an efficient antioxidant.

ACS Style

Monica Nardi; Sara Baldelli; Maria Rosa Ciriolo; Paola Costanzo; Antonio Procopio; Carmela Colica. Oleuropein Aglycone Peracetylated (3,4-DHPEA-EA(P)) Attenuates H2O2-mediated Cytotoxicity in C2C12 Myocytes Via Inactivation of p-JNK/p-c-Jun Signaling Pathway. 2020, 1 .

AMA Style

Monica Nardi, Sara Baldelli, Maria Rosa Ciriolo, Paola Costanzo, Antonio Procopio, Carmela Colica. Oleuropein Aglycone Peracetylated (3,4-DHPEA-EA(P)) Attenuates H2O2-mediated Cytotoxicity in C2C12 Myocytes Via Inactivation of p-JNK/p-c-Jun Signaling Pathway. . 2020; ():1.

Chicago/Turabian Style

Monica Nardi; Sara Baldelli; Maria Rosa Ciriolo; Paola Costanzo; Antonio Procopio; Carmela Colica. 2020. "Oleuropein Aglycone Peracetylated (3,4-DHPEA-EA(P)) Attenuates H2O2-mediated Cytotoxicity in C2C12 Myocytes Via Inactivation of p-JNK/p-c-Jun Signaling Pathway." , no. : 1.

Preprint
Published: 12 July 2020
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Oleuropein, glycosylated secoiridoid present in olive leaves is known to be an important antioxidant phenolic compound. We studied the antioxidant effect of low doses of oleuropein aglycone (3,4-DHPEA-EA) and oleuropein aglycone peracetylated (3,4-DHPEA-EA(P)) in murine C2C12 myocytes treated with hydrogen peroxide (H2O2). Both compounds were used at a concentration of 10 μM and were able to inhibit cell death induced by the H2O2 treatment, with 3,4-DHPEA-EA(P) being more. Under our experimental conditions, H2O2 efficiently induced the phosphorylated-active form of JNK and of its downstream target c-Jun. We demonstrated, by Western blot analysis, that 3,4-DHPEA-EA(P) was efficient in inhibiting the phospho-active form of JNK. This data suggests that the growth arrest and cell death of C2C12 proceeds via the JNK/c-Jun pathway. Moreover, we demonstrated that 3,4-DHPEA-EA(P) affects the myogenesis of C2C12 cells; because MyoD mRNA levels and the differentiation process are restored with 3,4-DHPEA-EA(P) after treatment. Overall, the results indicate that 3,4-DHPEA-EA(P) prevents ROS-mediated degenerative process in a genomic and epigenomic manner by functioning as an efficient antioxidant.

ACS Style

Monica Nardi; Sara Baldelli; Maria Rosa Ciriolo; Paola Costanzo; Antonio Procopio; Carmela Colica. Oleuropein Aglycone Peracetylated (3,4-DHPEA-EA(P)) Attenuates H2O2-Mediated Cytotoxicity in C2C12 Myocytes via Inactivation of p-JNK/p-c-Jun Signaling Pathway. 2020, 1 .

AMA Style

Monica Nardi, Sara Baldelli, Maria Rosa Ciriolo, Paola Costanzo, Antonio Procopio, Carmela Colica. Oleuropein Aglycone Peracetylated (3,4-DHPEA-EA(P)) Attenuates H2O2-Mediated Cytotoxicity in C2C12 Myocytes via Inactivation of p-JNK/p-c-Jun Signaling Pathway. . 2020; ():1.

Chicago/Turabian Style

Monica Nardi; Sara Baldelli; Maria Rosa Ciriolo; Paola Costanzo; Antonio Procopio; Carmela Colica. 2020. "Oleuropein Aglycone Peracetylated (3,4-DHPEA-EA(P)) Attenuates H2O2-Mediated Cytotoxicity in C2C12 Myocytes via Inactivation of p-JNK/p-c-Jun Signaling Pathway." , no. : 1.

Paper
Published: 13 March 2020 in Food & Function
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The present findings demonstrate that oleacein, the main secoiridoid of extravirgin olive oil, acts against neuroblastoma cells, by reducing cell adhesion and migration, inducing apoptotic death and modulating STAT3-dependent pathway.

ACS Style

Santa Cirmi; Marilena Celano; Giovanni Enrico Lombardo; Valentina Maggisano; Antonio Procopio; Diego Russo; Michele Navarra. Oleacein inhibits STAT3, activates the apoptotic machinery, and exerts anti-metastatic effects in the SH-SY5Y human neuroblastoma cells. Food & Function 2020, 11, 3271 -3279.

AMA Style

Santa Cirmi, Marilena Celano, Giovanni Enrico Lombardo, Valentina Maggisano, Antonio Procopio, Diego Russo, Michele Navarra. Oleacein inhibits STAT3, activates the apoptotic machinery, and exerts anti-metastatic effects in the SH-SY5Y human neuroblastoma cells. Food & Function. 2020; 11 (4):3271-3279.

Chicago/Turabian Style

Santa Cirmi; Marilena Celano; Giovanni Enrico Lombardo; Valentina Maggisano; Antonio Procopio; Diego Russo; Michele Navarra. 2020. "Oleacein inhibits STAT3, activates the apoptotic machinery, and exerts anti-metastatic effects in the SH-SY5Y human neuroblastoma cells." Food & Function 11, no. 4: 3271-3279.

Journal article
Published: 28 November 2019 in Molecules
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The procedures for the extraction and separation of lipids and nutraceutics from microalgae using classic solvents have been frequently used over the years. However, these production methods usually require expensive and toxic solvents. Based on our studies involving the use of eco-sustainable methodologies and alternative solvents, we selected ethanol (EtOH) and cyclopentyl methyl ether (CPME) for extracting bio-oil and lipids from algae. Different percentages of EtOH in CPME favor the production of an oil rich in saturated fatty acids (SFA), useful to biofuel production or rich in bioactive compounds. The proposed method for obtaining an extract rich in saturated or unsaturated fatty acids from dry algal biomass is disclosed as eco-friendly and allows a good extraction yield. The method is compared both in extracted oil percentage yield and in extracted fatty acids selectivity to extraction by supercritical carbon dioxide (SC-CO2).

ACS Style

Ilaria Santoro; Monica Nardi; Cinzia Benincasa; Paola Costanzo; Girolamo Giordano; Antonio Procopio; Giovanni Sindona. Sustainable and Selective Extraction of Lipids and Bioactive Compounds from Microalgae. Molecules 2019, 24, 4347 .

AMA Style

Ilaria Santoro, Monica Nardi, Cinzia Benincasa, Paola Costanzo, Girolamo Giordano, Antonio Procopio, Giovanni Sindona. Sustainable and Selective Extraction of Lipids and Bioactive Compounds from Microalgae. Molecules. 2019; 24 (23):4347.

Chicago/Turabian Style

Ilaria Santoro; Monica Nardi; Cinzia Benincasa; Paola Costanzo; Girolamo Giordano; Antonio Procopio; Giovanni Sindona. 2019. "Sustainable and Selective Extraction of Lipids and Bioactive Compounds from Microalgae." Molecules 24, no. 23: 4347.

Journal article
Published: 08 August 2019 in Molecules
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The exploitation and use of alternative synthetic methods, in the face of classical procedures that do not conform to the ethics of green chemistry, represent an ever-present problem in the pharmaceutical industry. The procedures for the synthesis of benzimidazoles have become a focus in synthetic organic chemistry, as they are building blocks of strong interest for the development of compounds with pharmacological activity. Various benzimidazole derivatives exhibit important activities such as antimicrobial, antiviral, anti-inflammatory, and analgesic activities, and some of the already synthesized compounds have found very strong applications in medicine praxis. Here we report a selective and sustainable method for the synthesis of 1,2-disubstituted or 2-substituted benzimidazoles, starting from o-phenylenediamine in the presence of different aldehydes. The use of deep eutectic solvent (DES), both as reaction medium and reagent without any external solvent, provides advantages in terms of yields as well as in the work up procedure of the reaction.

ACS Style

Maria Luisa Di Gioia; Roberta Cassano; Paola Costanzo; Natividad Herrera Cano; Loredana Maiuolo; Monica Nardi; Fiore Pasquale Nicoletta; Manuela Oliverio; Antonio Procopio. Green Synthesis of Privileged Benzimidazole Scaffolds Using Active Deep Eutectic Solvent. Molecules 2019, 24, 2885 .

AMA Style

Maria Luisa Di Gioia, Roberta Cassano, Paola Costanzo, Natividad Herrera Cano, Loredana Maiuolo, Monica Nardi, Fiore Pasquale Nicoletta, Manuela Oliverio, Antonio Procopio. Green Synthesis of Privileged Benzimidazole Scaffolds Using Active Deep Eutectic Solvent. Molecules. 2019; 24 (16):2885.

Chicago/Turabian Style

Maria Luisa Di Gioia; Roberta Cassano; Paola Costanzo; Natividad Herrera Cano; Loredana Maiuolo; Monica Nardi; Fiore Pasquale Nicoletta; Manuela Oliverio; Antonio Procopio. 2019. "Green Synthesis of Privileged Benzimidazole Scaffolds Using Active Deep Eutectic Solvent." Molecules 24, no. 16: 2885.

Journal article
Published: 07 August 2019 in Nutrients
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Oleacein is one of the most abundant polyphenolic compounds of olive oil, which has been shown to play a protective role against several metabolic abnormalities, including dyslipidemia, insulin resistance, and glucose intolerance. Herein, we investigated the effects of oleacein on certain markers of adipogenesis and insulin-resistance in vitro, in 3T3-L1 adipocytes, and in vivo in high-fat diet (HFD)-fed mice. During the differentiation process of 3T3-L1 preadipocytes into adipocytes, oleacein strongly inhibited lipid accumulation, and decreased protein levels of peroxisome proliferator-activated receptor gamma (PPARγ) and fatty acid synthase (FAS), while increasing Adiponectin levels. In vivo, treatment with oleacein of C57BL/6JOlaHsd mice fed with HFD for 5 and 13 weeks prevented the increase in adipocyte size and reduced the inflammatory infiltration of macrophages and lymphocytes in adipose tissue. These effects were accompanied by changes in the expression of adipose tissue-specific regulatory elements such as PPARγ, FAS, sterol regulatory element-binding transcription factor-1 (SREBP-1), and Adiponectin, while the expression of insulin-sensitive muscle/fat glucose transporter Glut-4 was restored in HFD-fed mice treated with oleacein. Collectively, our findings indicate that protection against HFD-induced adiposity by oleacein in mice is mediated by the modulation of regulators of adipogenesis. Protection against HFD-induced obesity is effective in improving peripheral insulin sensitivity.

ACS Style

Saverio Massimo Lepore; Valentina Maggisano; Stefania Bulotta; Chiara Mignogna; Biagio Arcidiacono; Antonio Procopio; Antonio Brunetti; Diego Russo; Marilena Celano. Oleacein Prevents High Fat Diet-Induced A Diposity and Ameliorates Some Biochemical Parameters of Insulin Sensitivity in Mice. Nutrients 2019, 11, 1829 .

AMA Style

Saverio Massimo Lepore, Valentina Maggisano, Stefania Bulotta, Chiara Mignogna, Biagio Arcidiacono, Antonio Procopio, Antonio Brunetti, Diego Russo, Marilena Celano. Oleacein Prevents High Fat Diet-Induced A Diposity and Ameliorates Some Biochemical Parameters of Insulin Sensitivity in Mice. Nutrients. 2019; 11 (8):1829.

Chicago/Turabian Style

Saverio Massimo Lepore; Valentina Maggisano; Stefania Bulotta; Chiara Mignogna; Biagio Arcidiacono; Antonio Procopio; Antonio Brunetti; Diego Russo; Marilena Celano. 2019. "Oleacein Prevents High Fat Diet-Induced A Diposity and Ameliorates Some Biochemical Parameters of Insulin Sensitivity in Mice." Nutrients 11, no. 8: 1829.

Journal article
Published: 16 July 2019 in Cancers
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Olive oil contains different biologically active polyphenols, among which oleacein, the most abundant secoiridoid, has recently emerged for its beneficial properties in various disease contexts. By using in vitro models of human multiple myeloma (MM), we here investigated the anti-tumor potential of oleacein and the underlying bio-molecular sequelae. Within a low micromolar range, oleacein reduced the viability of MM primary samples and cell lines even in the presence of bone marrow stromal cells (BMSCs), while sparing healthy peripheral blood mononuclear cells. We also demonstrated that oleacein inhibited MM cell clonogenicity, prompted cell cycle blockade and triggered apoptosis. We evaluated the epigenetic impact of oleacein on MM cells, and observed dose-dependent accumulation of both acetylated histones and α-tubulin, along with down-regulation of several class I/II histone deacetylases (HDACs) both at the mRNA and protein level, providing evidence of the HDAC inhibitory activity of this compound; conversely, no effect on global DNA methylation was found. Mechanistically, HDACs inhibition by oleacein was associated with down-regulation of Sp1, the major transactivator of HDACs promoter, via Caspase 8 activation. Of potential translational significance, oleacein synergistically enhanced the in vitro anti-MM activity of the proteasome inhibitor carfilzomib. Altogether, these results indicate that oleacein is endowed with HDAC inhibitory properties, which associate with significant anti-MM activity both as single agent or in combination with carfilzomib. These findings may pave the way to novel potential anti-MM epi-therapeutic approaches based on natural agents.

ACS Style

Giada Juli; Manuela Oliverio; Dina Bellizzi; Maria Eugenia Gallo Cantafio; Katia Grillone; Giuseppe Passarino; Carmela Colica; Monica Nardi; Marco Rossi; Antonio Procopio; Pierosandro Tagliaferri; Pierfrancesco Tassone; Nicola Amodio. Anti-tumor Activity and Epigenetic Impact of the Polyphenol Oleacein in Multiple Myeloma. Cancers 2019, 11, 990 .

AMA Style

Giada Juli, Manuela Oliverio, Dina Bellizzi, Maria Eugenia Gallo Cantafio, Katia Grillone, Giuseppe Passarino, Carmela Colica, Monica Nardi, Marco Rossi, Antonio Procopio, Pierosandro Tagliaferri, Pierfrancesco Tassone, Nicola Amodio. Anti-tumor Activity and Epigenetic Impact of the Polyphenol Oleacein in Multiple Myeloma. Cancers. 2019; 11 (7):990.

Chicago/Turabian Style

Giada Juli; Manuela Oliverio; Dina Bellizzi; Maria Eugenia Gallo Cantafio; Katia Grillone; Giuseppe Passarino; Carmela Colica; Monica Nardi; Marco Rossi; Antonio Procopio; Pierosandro Tagliaferri; Pierfrancesco Tassone; Nicola Amodio. 2019. "Anti-tumor Activity and Epigenetic Impact of the Polyphenol Oleacein in Multiple Myeloma." Cancers 11, no. 7: 990.

Articles
Published: 04 June 2019 in Food Additives & Contaminants: Part A
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Tuna is one of the most frequently consumed fish and, as a predator, can biomagnify pollutants. Metal and other elements pollution is an important worldwide concern. Based on these considerations, the aim of this work was to investigate the occurrence of As, Cd, Cr, Ni, Hg and Pb in tuna coming from different FAO areas to evaluate human exposure. The analysis was performed on muscle tissues through a quadrupole inductively coupled mass spectrometry. One hundred thirty-one samples were analysed. One red tuna from the Adriatic Sea and 11 yellow tunas exceeded Pb maximum levels (MLs) with a concentration ranging 0.31–0.86 mg kg−1; three red tunas from different Mediterranean sub-areas exceeded Hg MLs, with a concentration range 1.19 to 1.80 mg kg−1. All the Hazard Indexes (HIs) were lower than one, indicating that only a negligible health hazard could derive from the ingestion of tuna, for both average and high consumers. The risk of carcinogenicity from Cr is still under debate at the concentrations detectable in food.

ACS Style

Luca Maria Chiesa; Federica Ceriani; Antonio Procopio; Sonia Bonacci; Renato Malandra; Sara Panseri; Francesco Arioli. Exposure to metals and arsenic from yellow and red tuna consumption. Food Additives & Contaminants: Part A 2019, 36, 1228 -1235.

AMA Style

Luca Maria Chiesa, Federica Ceriani, Antonio Procopio, Sonia Bonacci, Renato Malandra, Sara Panseri, Francesco Arioli. Exposure to metals and arsenic from yellow and red tuna consumption. Food Additives & Contaminants: Part A. 2019; 36 (8):1228-1235.

Chicago/Turabian Style

Luca Maria Chiesa; Federica Ceriani; Antonio Procopio; Sonia Bonacci; Renato Malandra; Sara Panseri; Francesco Arioli. 2019. "Exposure to metals and arsenic from yellow and red tuna consumption." Food Additives & Contaminants: Part A 36, no. 8: 1228-1235.

Journal article
Published: 26 March 2019 in Catalysts
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A simple and eco-friendly montmorillonite K10 (MK10)-catalyzed method for the synthesis of cyclopentenone derivatives from biomass-produced furfural has been developed. The versatility of this protocol is that the reactions were performed under solvent-free conditions and in a short reaction time under heterogeneous catalysis. Montmorillonite K10 is mostly explored as a heterogeneous catalyst since it is inexpensive and environmentally friendly.

ACS Style

Sonia Bonacci; Monica Nardi; Paola Costanzo; Antonio De Nino; Maria Luisa Di Gioia; Manuela Oliverio; Antonio Procopio. Montmorillonite K10-Catalyzed Solvent-Free Conversion of Furfural into Cyclopentenones. Catalysts 2019, 9, 301 .

AMA Style

Sonia Bonacci, Monica Nardi, Paola Costanzo, Antonio De Nino, Maria Luisa Di Gioia, Manuela Oliverio, Antonio Procopio. Montmorillonite K10-Catalyzed Solvent-Free Conversion of Furfural into Cyclopentenones. Catalysts. 2019; 9 (3):301.

Chicago/Turabian Style

Sonia Bonacci; Monica Nardi; Paola Costanzo; Antonio De Nino; Maria Luisa Di Gioia; Manuela Oliverio; Antonio Procopio. 2019. "Montmorillonite K10-Catalyzed Solvent-Free Conversion of Furfural into Cyclopentenones." Catalysts 9, no. 3: 301.

Journal article
Published: 07 December 2018 in Chemosphere
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Mercury (Hg) is a widespread, highly toxic persistent pollutant with adverse health effects on humans. So far, concentrations below the method detection limit have always been reported by studies on the concentration of mercury in bottled water when determined using instrumental analytical methods. These are often very expensive and are unaffordable for many laboratories. In this work, a less expensive method based on cold vapour atomic fluorescence spectrometry has been employed to determine total mercury (HgT) concentrations in bottled natural mineral waters. In all, 255 waters representing 164 different typologies were analysed. They came from 136 springs located in 18 Italian regions. In all samples, HgT concentrations were found in the range of sub-nanogram to a few nanograms per litre, well below the National and European regulatory limit (1 μg L−1). Differences in HgT concentrations were related not only to the environmental characteristics of the springs but also to the extent and impact of human activities. Higher concentrations were found in waters coming from regions with former mining and/or natural thermal and volcanic activity. These data allowed us to estimate the mercury intake by population (adults, children and toddlers) from drinkable mineral waters consumption. The mean mercury daily intake was found to be remarkably lower, not only than the provisional tolerable value (1 μg L−1 according to European and Italian legislation) but also than the estimated provisional tolerable weekly intake (PTWI) value (4 μg kg−1 body weight) recommended by the Joint FAO/WHO Expert Committee on Food Additives (JECFA).

ACS Style

Massimiliano Vardè; Alessandro Servidio; Giovanni Vespasiano; Luisa Pasti; Alberto Cavazzini; Mario Di Traglia; Annalisa Rosselli; Franco Cofone; Carmine Apollaro; Warren Cairns; Elisa Scalabrin; Rosanna De Rosa; Antonio Procopio. Ultra-trace determination of total mercury in Italian bottled waters. Chemosphere 2018, 219, 896 -913.

AMA Style

Massimiliano Vardè, Alessandro Servidio, Giovanni Vespasiano, Luisa Pasti, Alberto Cavazzini, Mario Di Traglia, Annalisa Rosselli, Franco Cofone, Carmine Apollaro, Warren Cairns, Elisa Scalabrin, Rosanna De Rosa, Antonio Procopio. Ultra-trace determination of total mercury in Italian bottled waters. Chemosphere. 2018; 219 ():896-913.

Chicago/Turabian Style

Massimiliano Vardè; Alessandro Servidio; Giovanni Vespasiano; Luisa Pasti; Alberto Cavazzini; Mario Di Traglia; Annalisa Rosselli; Franco Cofone; Carmine Apollaro; Warren Cairns; Elisa Scalabrin; Rosanna De Rosa; Antonio Procopio. 2018. "Ultra-trace determination of total mercury in Italian bottled waters." Chemosphere 219, no. : 896-913.

Journals
Published: 05 December 2018 in MedChemComm
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In this work we synthesized and tested a series of unsaturated disulfides. Two compounds showed a promising anticancer activity in vitro on A549 lung cancer cells compared to the natural analogue.

ACS Style

Fabrizio Olivito; Nicola Amodio; Maria Luisa Di Gioia; Monica Nardi; Manuela Oliverio; Giada Juli; Pierfrancesco Tassone; Antonio Procopio. Synthesis and preliminary evaluation of the anti-cancer activity on A549 lung cancer cells of a series of unsaturated disulfides. MedChemComm 2018, 10, 116 -119.

AMA Style

Fabrizio Olivito, Nicola Amodio, Maria Luisa Di Gioia, Monica Nardi, Manuela Oliverio, Giada Juli, Pierfrancesco Tassone, Antonio Procopio. Synthesis and preliminary evaluation of the anti-cancer activity on A549 lung cancer cells of a series of unsaturated disulfides. MedChemComm. 2018; 10 (1):116-119.

Chicago/Turabian Style

Fabrizio Olivito; Nicola Amodio; Maria Luisa Di Gioia; Monica Nardi; Manuela Oliverio; Giada Juli; Pierfrancesco Tassone; Antonio Procopio. 2018. "Synthesis and preliminary evaluation of the anti-cancer activity on A549 lung cancer cells of a series of unsaturated disulfides." MedChemComm 10, no. 1: 116-119.

Journal article
Published: 01 October 2018 in Food & Function
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Acetylated oleuropein, a safe, biologically active semi-synthetic stable derivative of oleuropein, is proposed as an easy alternative to make oleuropein more bioavailable and suitable to be added to fatty foods.

ACS Style

Sonia Bonacci; Rosina Paonessa; Paola Costanzo; Raffaele Salerno; Jessica Maiuolo; Monica Nardi; Antonio Procopio; Oliverio Manuela. Peracetylation as a strategy to improve oleuropein stability and its affinity to fatty foods. Food & Function 2018, 9, 5759 -5767.

AMA Style

Sonia Bonacci, Rosina Paonessa, Paola Costanzo, Raffaele Salerno, Jessica Maiuolo, Monica Nardi, Antonio Procopio, Oliverio Manuela. Peracetylation as a strategy to improve oleuropein stability and its affinity to fatty foods. Food & Function. 2018; 9 (11):5759-5767.

Chicago/Turabian Style

Sonia Bonacci; Rosina Paonessa; Paola Costanzo; Raffaele Salerno; Jessica Maiuolo; Monica Nardi; Antonio Procopio; Oliverio Manuela. 2018. "Peracetylation as a strategy to improve oleuropein stability and its affinity to fatty foods." Food & Function 9, no. 11: 5759-5767.

Journals
Published: 27 September 2018 in Organic & Biomolecular Chemistry
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A green, mild and safe synthetic procedure to obtain organic thioacetates in almost quantitative yield via aqueous nucleophilic displacement.

ACS Style

Fabrizio Olivito; Paola Costanzo; Maria Luisa Di Gioia; Monica Nardi; Oliverio M.; Antonio Procopio. Efficient synthesis of organic thioacetates in water. Organic & Biomolecular Chemistry 2018, 16, 7753 -7759.

AMA Style

Fabrizio Olivito, Paola Costanzo, Maria Luisa Di Gioia, Monica Nardi, Oliverio M., Antonio Procopio. Efficient synthesis of organic thioacetates in water. Organic & Biomolecular Chemistry. 2018; 16 (41):7753-7759.

Chicago/Turabian Style

Fabrizio Olivito; Paola Costanzo; Maria Luisa Di Gioia; Monica Nardi; Oliverio M.; Antonio Procopio. 2018. "Efficient synthesis of organic thioacetates in water." Organic & Biomolecular Chemistry 16, no. 41: 7753-7759.

Journal article
Published: 28 July 2018 in Molecules
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The development of novel synthetic routes to produce bioactive compounds starting from renewable sources has become an important research area in organic and medicinal chemistry. Here, we present a low-cost procedure for the tunable and selective conversion of biomass-produced furfural to cyclopentenone derivatives using a mixture of choline chloride and urea as a biorenewable deep eutectic solvent (DES). The proposed medium is a nontoxic, biodegradable, and could be reused up to four times without any unfavorable effect on the reaction yield. The process is tunable, clean, cheap, simple and scalable and meets most of the criteria; therefore, it can be considered as an environmental sustainable process in a natural reaction medium.

ACS Style

Maria Luisa Di Gioia; Monica Nardi; Paola Costanzo; Antonio De Nino; Loredana Maiuolo; Manuela Oliverio; Antonio Procopio. Biorenewable Deep Eutectic Solvent for Selective and Scalable Conversion of Furfural into Cyclopentenone Derivatives. Molecules 2018, 23, 1891 .

AMA Style

Maria Luisa Di Gioia, Monica Nardi, Paola Costanzo, Antonio De Nino, Loredana Maiuolo, Manuela Oliverio, Antonio Procopio. Biorenewable Deep Eutectic Solvent for Selective and Scalable Conversion of Furfural into Cyclopentenone Derivatives. Molecules. 2018; 23 (8):1891.

Chicago/Turabian Style

Maria Luisa Di Gioia; Monica Nardi; Paola Costanzo; Antonio De Nino; Loredana Maiuolo; Manuela Oliverio; Antonio Procopio. 2018. "Biorenewable Deep Eutectic Solvent for Selective and Scalable Conversion of Furfural into Cyclopentenone Derivatives." Molecules 23, no. 8: 1891.

Journal article
Published: 01 April 2018 in Food Chemistry
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A simple and very environmental friendly microwave assisted method to produce oleacein in good yield starting from the easily available oleuropein is here presented. The methodology is proposed to produce the appropriate amount of hydroxytyrosol derivatives to enrich a commercial oil for an oil which provides beneficial effects on the human health.

ACS Style

Paola Costanzo; Sonia Bonacci; Luca Cariati; Monica Nardi; Manuela Oliverio; Antonio Procopio. Simple and efficient sustainable semi-synthesis of oleacein [2-(3,4-hydroxyphenyl) ethyl (3S,4E)-4-formyl-3-(2-oxoethyl)hex-4-enoate] as potential additive for edible oils. Food Chemistry 2018, 245, 410 -414.

AMA Style

Paola Costanzo, Sonia Bonacci, Luca Cariati, Monica Nardi, Manuela Oliverio, Antonio Procopio. Simple and efficient sustainable semi-synthesis of oleacein [2-(3,4-hydroxyphenyl) ethyl (3S,4E)-4-formyl-3-(2-oxoethyl)hex-4-enoate] as potential additive for edible oils. Food Chemistry. 2018; 245 ():410-414.

Chicago/Turabian Style

Paola Costanzo; Sonia Bonacci; Luca Cariati; Monica Nardi; Manuela Oliverio; Antonio Procopio. 2018. "Simple and efficient sustainable semi-synthesis of oleacein [2-(3,4-hydroxyphenyl) ethyl (3S,4E)-4-formyl-3-(2-oxoethyl)hex-4-enoate] as potential additive for edible oils." Food Chemistry 245, no. : 410-414.

Review
Published: 06 March 2018 in Sustainability
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Green catalysts must be non-toxic, easy to manage, able to be recovered and reused, active under alternative reaction conditions and cheap. Erbium salts meet all the previously listed characteristics and today they are emerging as a valuable catalytic solution to a number of organic transformations needing a Lewis acid catalyst in wet conditions or under alternative heating sources. This review aims to summarize the application of erbium salts in green organic transformations, with particular emphasis on their versatility under both homogeneous and heterogeneous conditions. The erbium salts’ role in bifunctional catalysis is also presented.

ACS Style

Manuela Oliverio; Monica Nardi; Paola Costanzo; Maria Luisa Di Gioia; Antonio Procopio. Erbium Salts as Non-Toxic Catalysts Compatible with Alternative Reaction Media. Sustainability 2018, 10, 721 .

AMA Style

Manuela Oliverio, Monica Nardi, Paola Costanzo, Maria Luisa Di Gioia, Antonio Procopio. Erbium Salts as Non-Toxic Catalysts Compatible with Alternative Reaction Media. Sustainability. 2018; 10 (3):721.

Chicago/Turabian Style

Manuela Oliverio; Monica Nardi; Paola Costanzo; Maria Luisa Di Gioia; Antonio Procopio. 2018. "Erbium Salts as Non-Toxic Catalysts Compatible with Alternative Reaction Media." Sustainability 10, no. 3: 721.

Research paper
Published: 01 January 2018 in Journal of Enzyme Inhibition and Medicinal Chemistry
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Acetylcholinesterase inhibitors were introduced for the symptomatic treatment of Alzheimer’s disease (AD). Among the currently approved inhibitors, donepezil (DNP) is one of the most preferred choices in AD therapy. The X-ray crystal structures of Torpedo californica AChE in complex with two novel rigid DNP-like analogs, compounds 1 and 2, have been determined. Kinetic studies indicated that compounds 1 and 2 show a mixed-type inhibition against TcAChE, with Ki values of 11.12 ± 2.88 and 29.86 ± 1.12 nM, respectively. The DNP rigidification results in a likely entropy-enthalpy compensation with solvation effects contributing primarily to AChE binding affinity. Molecular docking evidenced the molecular basis for the binding of compounds 1 and 2 to the active site of β-secretase-1. Overall, these simplified DNP derivatives may represent new structural templates for the design of lead compounds for a more effective therapeutic strategy against AD by foreseeing a dual AChE and BACE-1 inhibitory activity.

ACS Style

Rosanna Caliandro; Alessandro Pesaresi; Luca Cariati; Antonio Procopio; Manuela Oliverio; Doriano Lamba. Kinetic and structural studies on the interactions of Torpedo californica acetylcholinesterase with two donepezil-like rigid analogues. Journal of Enzyme Inhibition and Medicinal Chemistry 2018, 33, 794 -803.

AMA Style

Rosanna Caliandro, Alessandro Pesaresi, Luca Cariati, Antonio Procopio, Manuela Oliverio, Doriano Lamba. Kinetic and structural studies on the interactions of Torpedo californica acetylcholinesterase with two donepezil-like rigid analogues. Journal of Enzyme Inhibition and Medicinal Chemistry. 2018; 33 (1):794-803.

Chicago/Turabian Style

Rosanna Caliandro; Alessandro Pesaresi; Luca Cariati; Antonio Procopio; Manuela Oliverio; Doriano Lamba. 2018. "Kinetic and structural studies on the interactions of Torpedo californica acetylcholinesterase with two donepezil-like rigid analogues." Journal of Enzyme Inhibition and Medicinal Chemistry 33, no. 1: 794-803.

Journals
Published: 15 November 2017 in Food & Function
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A set of oleuropein aglycone derivatives were synthesized by transacetalization under mild and environmental friendly conditions. The antioxidant activities of the obtained compounds exhibited a dependence on their level of lipophilicity thus demonstrating their potential application as a preservative in fatty foods.

ACS Style

M. Nardi; S. Bonacci; L. Cariati; P. Costanzo; M. Oliverio; G. Sindona; A. Procopio. Synthesis and antioxidant evaluation of lipophilic oleuropein aglycone derivatives. Food & Function 2017, 8, 4684 -4692.

AMA Style

M. Nardi, S. Bonacci, L. Cariati, P. Costanzo, M. Oliverio, G. Sindona, A. Procopio. Synthesis and antioxidant evaluation of lipophilic oleuropein aglycone derivatives. Food & Function. 2017; 8 (12):4684-4692.

Chicago/Turabian Style

M. Nardi; S. Bonacci; L. Cariati; P. Costanzo; M. Oliverio; G. Sindona; A. Procopio. 2017. "Synthesis and antioxidant evaluation of lipophilic oleuropein aglycone derivatives." Food & Function 8, no. 12: 4684-4692.