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Dr. Manuela Oliverio
Dipartimento di Scienze della Salute, Università Magna Græcia, Viale Europa, Germaneto, Catanzaro, Italy

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0 Catalysis
0 Green Chemistry
0 Organic Synthesis
0 Synthetic Organic Chemistry
0 bioactive compounds

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Catalysis
Green Chemistry
bioactive compounds
Synthetic Organic Chemistry
Organic Synthesis

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Journal article
Published: 02 January 2021 in Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
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Chemocatalytic conversion of cellulose into lactic acid is a valuable alternative to simple sugar fermentation. Nevertheless, the procedures still need optimization to be translated to the industrial scale. Such translation would benefit by on-line monitoring of reaction parameters by fast, inexpensive, direct spectroscopic techniques. In this work, we propose the application of FT-NIR spectroscopy as a suitable analytical tool for monitoring the chemocatalytic conversion of cellulose into lactic acid. Comparison between different FT-NIR spectra at different reaction temperatures and times was exploited to qualitatively indicate the feasibility of the reaction. Besides, an FT-NIR prediction model was proposed for rapidly estimating the molar distribution of cellulose catalytic degradation components in the reaction mixtures. The calibration model was based on reference samples analysed by HPLC. The model was validated by an external validation set. Relevant statistical values of Ratio Performance to Deviations (RPD) referred to both calibration and external validation were obtained, thus demonstrating the potential of such analytical technique in process monitoring.

ACS Style

Sofia Tallarico; Sonia Bonacci; Stefano Mancuso; Paola Costanzo; Manuela Oliverio; Antonio Procopio. Quali-quantitative monitoring of chemocatalytic cellulose conversion into lactic acid by FT-NIR spectroscopy. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 2021, 250, 119367 .

AMA Style

Sofia Tallarico, Sonia Bonacci, Stefano Mancuso, Paola Costanzo, Manuela Oliverio, Antonio Procopio. Quali-quantitative monitoring of chemocatalytic cellulose conversion into lactic acid by FT-NIR spectroscopy. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 2021; 250 ():119367.

Chicago/Turabian Style

Sofia Tallarico; Sonia Bonacci; Stefano Mancuso; Paola Costanzo; Manuela Oliverio; Antonio Procopio. 2021. "Quali-quantitative monitoring of chemocatalytic cellulose conversion into lactic acid by FT-NIR spectroscopy." Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 250, no. : 119367.

Journal article
Published: 18 December 2020 in Pathogens
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The worldwide increased difficulty to counteract gastrointestinal nematode (GIN) infection in sheep, due to progressing anthelmintic resistance, has led to the evaluation of other alternative helminth control options, mainly from plants. The anthelmintic efficacy of an aqueous Punica granatum macerate was evaluated in sheep naturally infected by GIN in southern Italy. The macerate was chemically characterized by chromatographic analysis coupled with high-resolution mass spectrometry (LC/HRMS) and an aliquot was concentrated to obtain a dry extract. A part was characterized, the remaining washed with methanol to obtain an insoluble residue and methanol phase. In the methanol fraction, the quantitatively predominant gallic acid was purified to obtain the pure molecule. The three fractions thus obtained were used for in vitro studies (i.e., egg hatch test) to verify anthelmintic efficacy. For this purpose, fecal samples were collected from sheep naturally infected by GINs. Fractions were diluted in H2O/DMSO 0.5% at 1.00, 0.5, 0.25, 0.125, 0.05, and 0.005 mg/mL concentrations. Thiabendazole (0.25 and 0.5 mg/mL) and deionized water were used as positive and negative controls, respectively. Egg hatch test results indicated that all fractions caused a significant (p < 0.05) egg hatch inhibition within 48 h of exposure highlighting a high (>82%) efficacy in vitro at all tested doses. Maximal egg hatching inhibition effect was exhibited by the methanol fraction (99.3% and 89.3% at 1 and 0.005 mg/mL concentrations), followed by the insoluble residue and gallic acid (94.7% and 85.3% and 94.0% and 82.7% at 1 and 0.005 mg/mL, respectively). The current study validated the anthelmintic potential of traditional P. granatum macerate against GIN infection in sheep, thus highlighting the role of gallic acid as principal component and justifying a need to undertake further in vivo studies on these ethno-veterinary remedies.

ACS Style

Fabio Castagna; Domenico Britti; Manuela Oliverio; Antonio Bosco; Sonia Bonacci; Giuseppe Iriti; Monica Ragusa; Vincenzo Musolino; Laura Rinaldi; Ernesto Palma; Vincenzo Musella. In Vitro Anthelminthic Efficacy of Aqueous Pomegranate (Punica granatum L.) Extracts against Gastrointestinal Nematodes of Sheep. Pathogens 2020, 9, 1063 .

AMA Style

Fabio Castagna, Domenico Britti, Manuela Oliverio, Antonio Bosco, Sonia Bonacci, Giuseppe Iriti, Monica Ragusa, Vincenzo Musolino, Laura Rinaldi, Ernesto Palma, Vincenzo Musella. In Vitro Anthelminthic Efficacy of Aqueous Pomegranate (Punica granatum L.) Extracts against Gastrointestinal Nematodes of Sheep. Pathogens. 2020; 9 (12):1063.

Chicago/Turabian Style

Fabio Castagna; Domenico Britti; Manuela Oliverio; Antonio Bosco; Sonia Bonacci; Giuseppe Iriti; Monica Ragusa; Vincenzo Musolino; Laura Rinaldi; Ernesto Palma; Vincenzo Musella. 2020. "In Vitro Anthelminthic Efficacy of Aqueous Pomegranate (Punica granatum L.) Extracts against Gastrointestinal Nematodes of Sheep." Pathogens 9, no. 12: 1063.

Review article
Published: 10 December 2020 in Natural Product Reports
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Semi-synthesis is an effective strategy to obtain both natural and synthetic analogues of the olive secoiridoids, starting from easy accessible natural compounds.

ACS Style

Manuela Oliverio; Monica Nardi; Maria Luisa Di Gioia; Paola Costanzo; Sonia Bonacci; Stefano Mancuso; Antonio Procopio. Semi-synthesis as a tool for broadening the health applications of bioactive olive secoiridoids: a critical review. Natural Product Reports 2020, 38, 444 -469.

AMA Style

Manuela Oliverio, Monica Nardi, Maria Luisa Di Gioia, Paola Costanzo, Sonia Bonacci, Stefano Mancuso, Antonio Procopio. Semi-synthesis as a tool for broadening the health applications of bioactive olive secoiridoids: a critical review. Natural Product Reports. 2020; 38 (3):444-469.

Chicago/Turabian Style

Manuela Oliverio; Monica Nardi; Maria Luisa Di Gioia; Paola Costanzo; Sonia Bonacci; Stefano Mancuso; Antonio Procopio. 2020. "Semi-synthesis as a tool for broadening the health applications of bioactive olive secoiridoids: a critical review." Natural Product Reports 38, no. 3: 444-469.

Minireview
Published: 23 March 2020 in European Journal of Organic Chemistry
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Similarity and competition between multicomponent reactions with similar mechanisms and leading to similar scaffolds can be a useful tool for medicinal chemistry. In this review, we have summarized the studies disclosing the mechanism of such competition between the Biginelli and Hantzsch reactions. We focused our attention in particular on those studies exploiting similarity and competition as an opportunity to switch from one reaction to another, by simply changing the reaction conditions, thus opening the possibility to obtain, using the same experimental setup, molecular libraries of both 3,4‐dihydropyrimidin‐2‐(1H)‐ones (DHPM) and 1,4‐dihydropyridines (1,4‐DHP) scaffolds. The aim of this review is to encourage further exploitation of such synthetic strategy as a tool for enhancing the chemical space in medicinal chemistry.

ACS Style

Paola Costanzo; Monica Nardi; Manuela Oliverio. Similarity and Competition between Biginelli and Hantzsch Reactions: an Opportunity for Modern Medicinal Chemistry. European Journal of Organic Chemistry 2020, 2020, 3954 -3964.

AMA Style

Paola Costanzo, Monica Nardi, Manuela Oliverio. Similarity and Competition between Biginelli and Hantzsch Reactions: an Opportunity for Modern Medicinal Chemistry. European Journal of Organic Chemistry. 2020; 2020 (26):3954-3964.

Chicago/Turabian Style

Paola Costanzo; Monica Nardi; Manuela Oliverio. 2020. "Similarity and Competition between Biginelli and Hantzsch Reactions: an Opportunity for Modern Medicinal Chemistry." European Journal of Organic Chemistry 2020, no. 26: 3954-3964.

Journal article
Published: 11 December 2019 in Scientific Reports
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Cellulose is the main component of lignocellulosic biomass. Its direct chemocatalytic conversion into lactic acid (LA), a powerful biobased chemical platform, represents an important, and more easily scalable alternative to the fermentative way. In this paper, we present the selective hydrothermal conversion of cellulose and simple sugars into LA, under mild reaction conditions in presence of ErCl3 grafted on the mesoporous silica (MCM-41) surface. High yields and selectivity were obtained for the conversion of sugars under microwave (MW) irradiation at a relatively low temperature (200 °C) and short reaction times (10 min) under microwave (MW) irradiation. Ultrasounds (US) pre-treatment was investigated to reduce the cellulose crystallinity, before the MW-assisted conversion, providing LA with a yield of 64% within 90 min at 220 °C below the subcritical water conditions with increased operational safety. We finally discuss the scalability of the process and the recyclability of the catalyst.

ACS Style

Sofia Tallarico; Paola Costanzo; Sonia Bonacci; Anastasia Macario; Maria Luisa Di Gioia; Monica Nardi; Antonio Procopio; Manuela Oliverio. Combined Ultrasound/Microwave Chemocatalytic Method for Selective Conversion of Cellulose into Lactic Acid. Scientific Reports 2019, 9, 1 -8.

AMA Style

Sofia Tallarico, Paola Costanzo, Sonia Bonacci, Anastasia Macario, Maria Luisa Di Gioia, Monica Nardi, Antonio Procopio, Manuela Oliverio. Combined Ultrasound/Microwave Chemocatalytic Method for Selective Conversion of Cellulose into Lactic Acid. Scientific Reports. 2019; 9 (1):1-8.

Chicago/Turabian Style

Sofia Tallarico; Paola Costanzo; Sonia Bonacci; Anastasia Macario; Maria Luisa Di Gioia; Monica Nardi; Antonio Procopio; Manuela Oliverio. 2019. "Combined Ultrasound/Microwave Chemocatalytic Method for Selective Conversion of Cellulose into Lactic Acid." Scientific Reports 9, no. 1: 1-8.

Journal article
Published: 08 August 2019 in Molecules
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The exploitation and use of alternative synthetic methods, in the face of classical procedures that do not conform to the ethics of green chemistry, represent an ever-present problem in the pharmaceutical industry. The procedures for the synthesis of benzimidazoles have become a focus in synthetic organic chemistry, as they are building blocks of strong interest for the development of compounds with pharmacological activity. Various benzimidazole derivatives exhibit important activities such as antimicrobial, antiviral, anti-inflammatory, and analgesic activities, and some of the already synthesized compounds have found very strong applications in medicine praxis. Here we report a selective and sustainable method for the synthesis of 1,2-disubstituted or 2-substituted benzimidazoles, starting from o-phenylenediamine in the presence of different aldehydes. The use of deep eutectic solvent (DES), both as reaction medium and reagent without any external solvent, provides advantages in terms of yields as well as in the work up procedure of the reaction.

ACS Style

Maria Luisa Di Gioia; Roberta Cassano; Paola Costanzo; Natividad Herrera Cano; Loredana Maiuolo; Monica Nardi; Fiore Pasquale Nicoletta; Manuela Oliverio; Antonio Procopio. Green Synthesis of Privileged Benzimidazole Scaffolds Using Active Deep Eutectic Solvent. Molecules 2019, 24, 2885 .

AMA Style

Maria Luisa Di Gioia, Roberta Cassano, Paola Costanzo, Natividad Herrera Cano, Loredana Maiuolo, Monica Nardi, Fiore Pasquale Nicoletta, Manuela Oliverio, Antonio Procopio. Green Synthesis of Privileged Benzimidazole Scaffolds Using Active Deep Eutectic Solvent. Molecules. 2019; 24 (16):2885.

Chicago/Turabian Style

Maria Luisa Di Gioia; Roberta Cassano; Paola Costanzo; Natividad Herrera Cano; Loredana Maiuolo; Monica Nardi; Fiore Pasquale Nicoletta; Manuela Oliverio; Antonio Procopio. 2019. "Green Synthesis of Privileged Benzimidazole Scaffolds Using Active Deep Eutectic Solvent." Molecules 24, no. 16: 2885.

Preprint
Published: 22 July 2019
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The exploitation and use of alternative synthetic methods, in the face of classical procedures that do not conform to the ethics of Green Chemistry, represent an ever present problem in pharmaceutical industry. The procedures for the synthesis of benzimidazoles have become a focus in synthetic organic chemistry, as they are building blocks of strong interest for the development of compounds with pharmacological activity. Various benzimidazole derivatives exhibit important activities such as antimicrobial, antiviral, anti-inflammatory and analgesic and some of the already synthesized compounds have found very strong application in medicine praxis. Here we report a selective and sustainable method for the synthesis of 1,2-disubstituted or 2-substituted benzimidazoles, starting from o-phenylenediamine in the presence of different aldehydes. The use of deep eutectic solvent (DES) both as reaction medium and reagent without any external solvent provides advantages in terms of yields as well as in the work up procedure of the reaction.

ACS Style

Maria Luisa Di Gioia; Roberta Cassano; Paola Costanzo; Natividad Herrera Cano; Loredana Maiuolo; Monica Nardi; Fiore Pasquale Nicoletta; Manuela Oliverio; Antonio Procopio. Green Synthesis of Privileged Benzimidazole Scaffolds using Active Deep Eutectic Solvent. 2019, 1 .

AMA Style

Maria Luisa Di Gioia, Roberta Cassano, Paola Costanzo, Natividad Herrera Cano, Loredana Maiuolo, Monica Nardi, Fiore Pasquale Nicoletta, Manuela Oliverio, Antonio Procopio. Green Synthesis of Privileged Benzimidazole Scaffolds using Active Deep Eutectic Solvent. . 2019; ():1.

Chicago/Turabian Style

Maria Luisa Di Gioia; Roberta Cassano; Paola Costanzo; Natividad Herrera Cano; Loredana Maiuolo; Monica Nardi; Fiore Pasquale Nicoletta; Manuela Oliverio; Antonio Procopio. 2019. "Green Synthesis of Privileged Benzimidazole Scaffolds using Active Deep Eutectic Solvent." , no. : 1.

Journal article
Published: 16 July 2019 in Cancers
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Olive oil contains different biologically active polyphenols, among which oleacein, the most abundant secoiridoid, has recently emerged for its beneficial properties in various disease contexts. By using in vitro models of human multiple myeloma (MM), we here investigated the anti-tumor potential of oleacein and the underlying bio-molecular sequelae. Within a low micromolar range, oleacein reduced the viability of MM primary samples and cell lines even in the presence of bone marrow stromal cells (BMSCs), while sparing healthy peripheral blood mononuclear cells. We also demonstrated that oleacein inhibited MM cell clonogenicity, prompted cell cycle blockade and triggered apoptosis. We evaluated the epigenetic impact of oleacein on MM cells, and observed dose-dependent accumulation of both acetylated histones and α-tubulin, along with down-regulation of several class I/II histone deacetylases (HDACs) both at the mRNA and protein level, providing evidence of the HDAC inhibitory activity of this compound; conversely, no effect on global DNA methylation was found. Mechanistically, HDACs inhibition by oleacein was associated with down-regulation of Sp1, the major transactivator of HDACs promoter, via Caspase 8 activation. Of potential translational significance, oleacein synergistically enhanced the in vitro anti-MM activity of the proteasome inhibitor carfilzomib. Altogether, these results indicate that oleacein is endowed with HDAC inhibitory properties, which associate with significant anti-MM activity both as single agent or in combination with carfilzomib. These findings may pave the way to novel potential anti-MM epi-therapeutic approaches based on natural agents.

ACS Style

Giada Juli; Manuela Oliverio; Dina Bellizzi; Maria Eugenia Gallo Cantafio; Katia Grillone; Giuseppe Passarino; Carmela Colica; Monica Nardi; Marco Rossi; Antonio Procopio; Pierosandro Tagliaferri; Pierfrancesco Tassone; Nicola Amodio. Anti-tumor Activity and Epigenetic Impact of the Polyphenol Oleacein in Multiple Myeloma. Cancers 2019, 11, 990 .

AMA Style

Giada Juli, Manuela Oliverio, Dina Bellizzi, Maria Eugenia Gallo Cantafio, Katia Grillone, Giuseppe Passarino, Carmela Colica, Monica Nardi, Marco Rossi, Antonio Procopio, Pierosandro Tagliaferri, Pierfrancesco Tassone, Nicola Amodio. Anti-tumor Activity and Epigenetic Impact of the Polyphenol Oleacein in Multiple Myeloma. Cancers. 2019; 11 (7):990.

Chicago/Turabian Style

Giada Juli; Manuela Oliverio; Dina Bellizzi; Maria Eugenia Gallo Cantafio; Katia Grillone; Giuseppe Passarino; Carmela Colica; Monica Nardi; Marco Rossi; Antonio Procopio; Pierosandro Tagliaferri; Pierfrancesco Tassone; Nicola Amodio. 2019. "Anti-tumor Activity and Epigenetic Impact of the Polyphenol Oleacein in Multiple Myeloma." Cancers 11, no. 7: 990.

Journal article
Published: 26 March 2019 in Catalysts
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A simple and eco-friendly montmorillonite K10 (MK10)-catalyzed method for the synthesis of cyclopentenone derivatives from biomass-produced furfural has been developed. The versatility of this protocol is that the reactions were performed under solvent-free conditions and in a short reaction time under heterogeneous catalysis. Montmorillonite K10 is mostly explored as a heterogeneous catalyst since it is inexpensive and environmentally friendly.

ACS Style

Sonia Bonacci; Monica Nardi; Paola Costanzo; Antonio De Nino; Maria Luisa Di Gioia; Manuela Oliverio; Antonio Procopio. Montmorillonite K10-Catalyzed Solvent-Free Conversion of Furfural into Cyclopentenones. Catalysts 2019, 9, 301 .

AMA Style

Sonia Bonacci, Monica Nardi, Paola Costanzo, Antonio De Nino, Maria Luisa Di Gioia, Manuela Oliverio, Antonio Procopio. Montmorillonite K10-Catalyzed Solvent-Free Conversion of Furfural into Cyclopentenones. Catalysts. 2019; 9 (3):301.

Chicago/Turabian Style

Sonia Bonacci; Monica Nardi; Paola Costanzo; Antonio De Nino; Maria Luisa Di Gioia; Manuela Oliverio; Antonio Procopio. 2019. "Montmorillonite K10-Catalyzed Solvent-Free Conversion of Furfural into Cyclopentenones." Catalysts 9, no. 3: 301.

Journals
Published: 05 December 2018 in MedChemComm
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In this work we synthesized and tested a series of unsaturated disulfides. Two compounds showed a promising anticancer activity in vitro on A549 lung cancer cells compared to the natural analogue.

ACS Style

Fabrizio Olivito; Nicola Amodio; Maria Luisa Di Gioia; Monica Nardi; Manuela Oliverio; Giada Juli; Pierfrancesco Tassone; Antonio Procopio. Synthesis and preliminary evaluation of the anti-cancer activity on A549 lung cancer cells of a series of unsaturated disulfides. MedChemComm 2018, 10, 116 -119.

AMA Style

Fabrizio Olivito, Nicola Amodio, Maria Luisa Di Gioia, Monica Nardi, Manuela Oliverio, Giada Juli, Pierfrancesco Tassone, Antonio Procopio. Synthesis and preliminary evaluation of the anti-cancer activity on A549 lung cancer cells of a series of unsaturated disulfides. MedChemComm. 2018; 10 (1):116-119.

Chicago/Turabian Style

Fabrizio Olivito; Nicola Amodio; Maria Luisa Di Gioia; Monica Nardi; Manuela Oliverio; Giada Juli; Pierfrancesco Tassone; Antonio Procopio. 2018. "Synthesis and preliminary evaluation of the anti-cancer activity on A549 lung cancer cells of a series of unsaturated disulfides." MedChemComm 10, no. 1: 116-119.

Journal article
Published: 04 December 2018 in Bioorganic Chemistry
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Phenolic compounds present in extra virgin olive oil have recently attracted considerable attention due to their pharmacological activities. Among them oleacein (3,4-DHPEA-EDA), structurally related to oleochantal (4-HPEA-EDA), is one of the most studied. 3,4-DHPEA-EDA has been synthesized through decarboxylation of demethyloleuropein catalyzed by Er(OTf)3. Demethyloleuropein is extracted from black olives drupes in very limited amounts and only in particular periods of the year. The availability of demethyloleuropein could be increased by a selective hydrolysis of the methyl ester moiety of oleuropein, a secoiridoid present in large amount in olive leaves. In this work we describe a new enzymatic method for carrying out a selective hydrolysis of oleuropein via the screening of a panel of hydrolases (lipases, esterases and proteases). Among all the enzymes tested the best results was obtained using α-chymotrypsyn from bovine pancreas as biocatalyst, thus revealing a classic example of catalytic enzyme promiscuity.

ACS Style

Luca Cariati; Manuela Oliverio; Francesco Mutti; Sonia Bonacci; Tanja Knaus; Paola Costanzo; Antonio Procopio. Hydrolases-mediated transformation of oleuropein into demethyloleuropein. Bioorganic Chemistry 2018, 84, 384 -388.

AMA Style

Luca Cariati, Manuela Oliverio, Francesco Mutti, Sonia Bonacci, Tanja Knaus, Paola Costanzo, Antonio Procopio. Hydrolases-mediated transformation of oleuropein into demethyloleuropein. Bioorganic Chemistry. 2018; 84 ():384-388.

Chicago/Turabian Style

Luca Cariati; Manuela Oliverio; Francesco Mutti; Sonia Bonacci; Tanja Knaus; Paola Costanzo; Antonio Procopio. 2018. "Hydrolases-mediated transformation of oleuropein into demethyloleuropein." Bioorganic Chemistry 84, no. : 384-388.

Journal article
Published: 01 October 2018 in Food & Function
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Acetylated oleuropein, a safe, biologically active semi-synthetic stable derivative of oleuropein, is proposed as an easy alternative to make oleuropein more bioavailable and suitable to be added to fatty foods.

ACS Style

Sonia Bonacci; Rosina Paonessa; Paola Costanzo; Raffaele Salerno; Jessica Maiuolo; Monica Nardi; Antonio Procopio; Oliverio Manuela. Peracetylation as a strategy to improve oleuropein stability and its affinity to fatty foods. Food & Function 2018, 9, 5759 -5767.

AMA Style

Sonia Bonacci, Rosina Paonessa, Paola Costanzo, Raffaele Salerno, Jessica Maiuolo, Monica Nardi, Antonio Procopio, Oliverio Manuela. Peracetylation as a strategy to improve oleuropein stability and its affinity to fatty foods. Food & Function. 2018; 9 (11):5759-5767.

Chicago/Turabian Style

Sonia Bonacci; Rosina Paonessa; Paola Costanzo; Raffaele Salerno; Jessica Maiuolo; Monica Nardi; Antonio Procopio; Oliverio Manuela. 2018. "Peracetylation as a strategy to improve oleuropein stability and its affinity to fatty foods." Food & Function 9, no. 11: 5759-5767.

Journals
Published: 27 September 2018 in Organic & Biomolecular Chemistry
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A green, mild and safe synthetic procedure to obtain organic thioacetates in almost quantitative yield via aqueous nucleophilic displacement.

ACS Style

Fabrizio Olivito; Paola Costanzo; Maria Luisa Di Gioia; Monica Nardi; Oliverio M.; Antonio Procopio. Efficient synthesis of organic thioacetates in water. Organic & Biomolecular Chemistry 2018, 16, 7753 -7759.

AMA Style

Fabrizio Olivito, Paola Costanzo, Maria Luisa Di Gioia, Monica Nardi, Oliverio M., Antonio Procopio. Efficient synthesis of organic thioacetates in water. Organic & Biomolecular Chemistry. 2018; 16 (41):7753-7759.

Chicago/Turabian Style

Fabrizio Olivito; Paola Costanzo; Maria Luisa Di Gioia; Monica Nardi; Oliverio M.; Antonio Procopio. 2018. "Efficient synthesis of organic thioacetates in water." Organic & Biomolecular Chemistry 16, no. 41: 7753-7759.

Journal article
Published: 13 August 2018 in Journal of Cleaner Production
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The first example of the use of ammonia, the waste material of the bulk glycerol carbonate (GC) production, for the formation of another valuable organic molecule, a 1,4-dihydropyridine (1,4-DHP), by an in line two reactor system was presented. Two Q-tube reactors, one for the urea glycerolysis and the other for the Hantzsch reaction, were used, connected through a PTFE tube. Urea glycerolysis using La2O3 as heterogeneous catalyst, under N2 pressure or in vacuum conditions, was optimized. A catalyst free and organic solvent free condition was selected to realize a Hantzsch reaction in an ecofriendly way. Glycerol carbonate and a 1,4-dihydropyridine were synthesized in two subsequent reactions, converting wastes into added value products. The best result was that glycerol carbonate was obtained at 36% with 77% of selectivity, and at the same time the Hantzsch product was synthesized with a 75% of yield.

ACS Style

Paola Costanzo; Carla Calandruccio; Maria Luisa Di Gioia; Monica Nardi; Manuela Oliverio; Antonio Procopio. First multicomponent reaction exploiting glycerol carbonate synthesis. Journal of Cleaner Production 2018, 202, 504 -509.

AMA Style

Paola Costanzo, Carla Calandruccio, Maria Luisa Di Gioia, Monica Nardi, Manuela Oliverio, Antonio Procopio. First multicomponent reaction exploiting glycerol carbonate synthesis. Journal of Cleaner Production. 2018; 202 ():504-509.

Chicago/Turabian Style

Paola Costanzo; Carla Calandruccio; Maria Luisa Di Gioia; Monica Nardi; Manuela Oliverio; Antonio Procopio. 2018. "First multicomponent reaction exploiting glycerol carbonate synthesis." Journal of Cleaner Production 202, no. : 504-509.

Journal article
Published: 28 July 2018 in Molecules
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The development of novel synthetic routes to produce bioactive compounds starting from renewable sources has become an important research area in organic and medicinal chemistry. Here, we present a low-cost procedure for the tunable and selective conversion of biomass-produced furfural to cyclopentenone derivatives using a mixture of choline chloride and urea as a biorenewable deep eutectic solvent (DES). The proposed medium is a nontoxic, biodegradable, and could be reused up to four times without any unfavorable effect on the reaction yield. The process is tunable, clean, cheap, simple and scalable and meets most of the criteria; therefore, it can be considered as an environmental sustainable process in a natural reaction medium.

ACS Style

Maria Luisa Di Gioia; Monica Nardi; Paola Costanzo; Antonio De Nino; Loredana Maiuolo; Manuela Oliverio; Antonio Procopio. Biorenewable Deep Eutectic Solvent for Selective and Scalable Conversion of Furfural into Cyclopentenone Derivatives. Molecules 2018, 23, 1891 .

AMA Style

Maria Luisa Di Gioia, Monica Nardi, Paola Costanzo, Antonio De Nino, Loredana Maiuolo, Manuela Oliverio, Antonio Procopio. Biorenewable Deep Eutectic Solvent for Selective and Scalable Conversion of Furfural into Cyclopentenone Derivatives. Molecules. 2018; 23 (8):1891.

Chicago/Turabian Style

Maria Luisa Di Gioia; Monica Nardi; Paola Costanzo; Antonio De Nino; Loredana Maiuolo; Manuela Oliverio; Antonio Procopio. 2018. "Biorenewable Deep Eutectic Solvent for Selective and Scalable Conversion of Furfural into Cyclopentenone Derivatives." Molecules 23, no. 8: 1891.

Data article
Published: 31 May 2018 in Data in Brief
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Bergamot Polyphenol Fraction (BPF®) is a natural mixture of Citrus flavonoids extracted from processed bergamot fruits. It has been shown to counteract cardiovascular risk factors and to prevent liver steatosis in rats and patients. Hepatic effects of BPF correlate with its ability to stimulate liver autophagy. Six aglyconic flavonoids have been identified in the proautophagic fraction of the hydrolysis product of BPF (A-BPF): naringenin, hesperetin, eridictyol, diosmetin, apigenin and luteolin. We report here the output parameters of high resolution mass spectrometry analysis of these flavonoids and chemical structures of their parent compounds. The second set of data shows the proautophagic activity of BPF flavonoids in a hepatic cell line HepG2 analyzed by a flow cytometry approach. The method is based on the red to green fluorescence intensity ratio analysis of DsRed -LC3- GFP, which is stably expressed in HepG2 cells. Proportional analysis of ATG indexes allowed us to address a relative contribution of individual compounds to the proautophagic activity of the A-BPF mixture and evaluate if the effect was additive. Qualitative analysis of ATG indexes compared the effects of flavonoids at equal concentrations in the presence and absence of palmitic acid and chloroquine. The Excel files reporting the analysis of flow cytometry data are available in the public repository.

ACS Style

Elzbieta Janda; Raffaele Salerno; Concetta Martino; Antonella LaScala; Daniele La Russa; Manuela Oliverio. Qualitative and quantitative analysis of the proautophagic activity of Citrus flavonoids from Bergamot Polyphenol Fraction. Data in Brief 2018, 19, 1327 -1334.

AMA Style

Elzbieta Janda, Raffaele Salerno, Concetta Martino, Antonella LaScala, Daniele La Russa, Manuela Oliverio. Qualitative and quantitative analysis of the proautophagic activity of Citrus flavonoids from Bergamot Polyphenol Fraction. Data in Brief. 2018; 19 ():1327-1334.

Chicago/Turabian Style

Elzbieta Janda; Raffaele Salerno; Concetta Martino; Antonella LaScala; Daniele La Russa; Manuela Oliverio. 2018. "Qualitative and quantitative analysis of the proautophagic activity of Citrus flavonoids from Bergamot Polyphenol Fraction." Data in Brief 19, no. : 1327-1334.

Journal article
Published: 26 April 2018 in The Journal of Nutritional Biochemistry
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Autophagy dysfunction has been implicated in the pathogenesis of nonalcoholic fatty liver disease (NAFLD). Natural compounds present in bergamot polyphenol fraction (BPF) prevent NAFLD and induce autophagy in rat livers. Here, we employed HepG2 cells expressing DsRed–LC3–GFP, a highly sensitive model system to screen for proautophagic compounds present in BPF. BPF induced autophagy in a time- and dose-dependent fashion and the effect was amplified in cells loaded with palmitic acid. Autophagy was mediated by the hydrophobic fraction of acid-hydrolyzed BPF (A-BPF), containing six flavanone and flavone aglycones as identified by liquid chromatography–high-resolution mass spectrometry. Among them, naringenin, hesperitin, eriodictyol and diosmetin were weak inducers of autophagy. Apigenin showed the strongest and dose-dependent proautophagic activity at early time points (6 h). Luteolin induced a biphasic autophagic response, strong at low doses and inhibitory at higher doses. Both flavones were toxic in HepG2 cells and in differentiated human liver progenitors HepaRG upon longer treatments (24 h). In contrast, BPF and A-BPF did not show any toxicity, but induced a persistent increase in autophagic flux. A mixture of six synthetic aglycones mimicking A-BPF was sufficient to induce a similar autophagic response, but it was mildly cytotoxic. Thus, while six main BPF flavonoids fully account for its proautophagic activity, their combined effect is not sufficient to abrogate cytotoxicity of individual compounds. This suggests that a natural polyphenol phytocomplex, such as BPF, is a safer and more effective strategy for the treatment of NAFLD than the use of pure flavonoids.

ACS Style

Antonella Lascala; Concetta Martino; Maddalena Parafati; Raffaele Salerno; Manuela Oliverio; Daniela Pellegrino; Vincenzo Mollace; Elzbieta Janda. Analysis of proautophagic activities of Citrus flavonoids in liver cells reveals the superiority of a natural polyphenol mixture over pure flavones. The Journal of Nutritional Biochemistry 2018, 58, 119 -130.

AMA Style

Antonella Lascala, Concetta Martino, Maddalena Parafati, Raffaele Salerno, Manuela Oliverio, Daniela Pellegrino, Vincenzo Mollace, Elzbieta Janda. Analysis of proautophagic activities of Citrus flavonoids in liver cells reveals the superiority of a natural polyphenol mixture over pure flavones. The Journal of Nutritional Biochemistry. 2018; 58 ():119-130.

Chicago/Turabian Style

Antonella Lascala; Concetta Martino; Maddalena Parafati; Raffaele Salerno; Manuela Oliverio; Daniela Pellegrino; Vincenzo Mollace; Elzbieta Janda. 2018. "Analysis of proautophagic activities of Citrus flavonoids in liver cells reveals the superiority of a natural polyphenol mixture over pure flavones." The Journal of Nutritional Biochemistry 58, no. : 119-130.

Journal article
Published: 05 April 2018 in Electronic Journal of General Medicine
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Introduction: Increasing microbial resistance to antibiotics is one of the main contributors for replacing the appropriate compounds to treat microbial infections. Staphylococcus is one of the most important genera of the bacteria as some strains present on the skin as normal flora and...

ACS Style

Masih Ghalandari; Mohsen Naghmachi; Manuela Oliverio; Monica Nardi; Hamid Reza Ghafarian Shirazi; Owrang Eilami. Antimicrobial effect of Hydroxytyrosol, Hydroxytyrosol Acetate and Hydroxytyrosol Oleate on Staphylococcus Aureus and Staphylococcus Epidermidis. Electronic Journal of General Medicine 2018, 15, 1 .

AMA Style

Masih Ghalandari, Mohsen Naghmachi, Manuela Oliverio, Monica Nardi, Hamid Reza Ghafarian Shirazi, Owrang Eilami. Antimicrobial effect of Hydroxytyrosol, Hydroxytyrosol Acetate and Hydroxytyrosol Oleate on Staphylococcus Aureus and Staphylococcus Epidermidis. Electronic Journal of General Medicine. 2018; 15 (4):1.

Chicago/Turabian Style

Masih Ghalandari; Mohsen Naghmachi; Manuela Oliverio; Monica Nardi; Hamid Reza Ghafarian Shirazi; Owrang Eilami. 2018. "Antimicrobial effect of Hydroxytyrosol, Hydroxytyrosol Acetate and Hydroxytyrosol Oleate on Staphylococcus Aureus and Staphylococcus Epidermidis." Electronic Journal of General Medicine 15, no. 4: 1.

Review
Published: 06 March 2018 in Sustainability
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Green catalysts must be non-toxic, easy to manage, able to be recovered and reused, active under alternative reaction conditions and cheap. Erbium salts meet all the previously listed characteristics and today they are emerging as a valuable catalytic solution to a number of organic transformations needing a Lewis acid catalyst in wet conditions or under alternative heating sources. This review aims to summarize the application of erbium salts in green organic transformations, with particular emphasis on their versatility under both homogeneous and heterogeneous conditions. The erbium salts’ role in bifunctional catalysis is also presented.

ACS Style

Manuela Oliverio; Monica Nardi; Paola Costanzo; Maria Luisa Di Gioia; Antonio Procopio. Erbium Salts as Non-Toxic Catalysts Compatible with Alternative Reaction Media. Sustainability 2018, 10, 721 .

AMA Style

Manuela Oliverio, Monica Nardi, Paola Costanzo, Maria Luisa Di Gioia, Antonio Procopio. Erbium Salts as Non-Toxic Catalysts Compatible with Alternative Reaction Media. Sustainability. 2018; 10 (3):721.

Chicago/Turabian Style

Manuela Oliverio; Monica Nardi; Paola Costanzo; Maria Luisa Di Gioia; Antonio Procopio. 2018. "Erbium Salts as Non-Toxic Catalysts Compatible with Alternative Reaction Media." Sustainability 10, no. 3: 721.

Research paper
Published: 01 January 2018 in Journal of Enzyme Inhibition and Medicinal Chemistry
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Acetylcholinesterase inhibitors were introduced for the symptomatic treatment of Alzheimer’s disease (AD). Among the currently approved inhibitors, donepezil (DNP) is one of the most preferred choices in AD therapy. The X-ray crystal structures of Torpedo californica AChE in complex with two novel rigid DNP-like analogs, compounds 1 and 2, have been determined. Kinetic studies indicated that compounds 1 and 2 show a mixed-type inhibition against TcAChE, with Ki values of 11.12 ± 2.88 and 29.86 ± 1.12 nM, respectively. The DNP rigidification results in a likely entropy-enthalpy compensation with solvation effects contributing primarily to AChE binding affinity. Molecular docking evidenced the molecular basis for the binding of compounds 1 and 2 to the active site of β-secretase-1. Overall, these simplified DNP derivatives may represent new structural templates for the design of lead compounds for a more effective therapeutic strategy against AD by foreseeing a dual AChE and BACE-1 inhibitory activity.

ACS Style

Rosanna Caliandro; Alessandro Pesaresi; Luca Cariati; Antonio Procopio; Manuela Oliverio; Doriano Lamba. Kinetic and structural studies on the interactions of Torpedo californica acetylcholinesterase with two donepezil-like rigid analogues. Journal of Enzyme Inhibition and Medicinal Chemistry 2018, 33, 794 -803.

AMA Style

Rosanna Caliandro, Alessandro Pesaresi, Luca Cariati, Antonio Procopio, Manuela Oliverio, Doriano Lamba. Kinetic and structural studies on the interactions of Torpedo californica acetylcholinesterase with two donepezil-like rigid analogues. Journal of Enzyme Inhibition and Medicinal Chemistry. 2018; 33 (1):794-803.

Chicago/Turabian Style

Rosanna Caliandro; Alessandro Pesaresi; Luca Cariati; Antonio Procopio; Manuela Oliverio; Doriano Lamba. 2018. "Kinetic and structural studies on the interactions of Torpedo californica acetylcholinesterase with two donepezil-like rigid analogues." Journal of Enzyme Inhibition and Medicinal Chemistry 33, no. 1: 794-803.