Polyoxometalates are an emerging class of molecular clusters, with well‐defined structures and chemical compositions that are produced through simple, low‐cost, and highly reproducible methods. In particular, the wheel‐shaped cluster {Mo₁₅₄} is a promising photothermal agent due to its intervalence charge transfer transitions. However, its toxicity hinders its systemic administration, being the development of a localized delivery system still incipient. Herein, an injectable and self‐healing hydrogel of easy preparation and administration is developed, incorporating both {Mo₁₅₄} and doxorubicin for synergistic photothermal and chemotherapy applications. The hydrogel is composed of benzylaldehyde functionalized polyethylene glycol, poly(N‐isopropylacrylamide) functionalized chitosan and {Mo₁₅₄}. The gelation occurs within 60 s at room temperature, and the dual crosslinking by Schiff base and electrostatic interactions generates a dynamic network, which enables self‐healing after injection. Moreover, the hydrogel delivers chemotherapeutic drugs, with a release triggered by dual near infra‐red (NIR) radiation and pH changes. This stimuli‐responsive release system along with the photothermal conversion ability of the hydrogel allows the simultaneous combination of photothermal and chemotherapy. This synergic system efficiently ablates the cancer tumor in vivo with no systemic toxicity. Overall, this work paves the way for the development of novel {Mo₁₅₄}‐based systems, incorporated in self‐healing and injectable hydrogels for dual chemo‐photothermal therapy.

The preparation and characterization of biocomposite materials with improved properties based on poly(lactic acid) (PLA) and bacterial cellulose, and, for comparative purposes, vegetal cellulose fibers, both in their pristine form or after acetylation, is reported. The composite materials were obtained through the simple and green mechanical compounding of a PLA matrix and bacterial cellulose nanofibrils (or vegetable fibers), and were characterized by TGA, DSC, tensile assays, DMA, SEM and water uptake. The bionanocomposites obtained from PLA and acetylated bacterial cellulose were particularly interesting, given the considerable improvement in thermal and mechanical properties, as evidenced by the significant increase in both elastic and Young moduli, and in the tensile strength (increments of about 100, 40 and 25%, respectively) at very low nanofiller loadings (up to 6%). These nanocomposites also showed low hygroscopicity and considerable transparency, features reported here for the first time.