The rising incidence of obesity has coincided with rising levels of poor reproductive outcomes. The molecular basis for the association of infertility in obese males is now being explained through various mechanisms. Insulin resistance, hyperglycemia, and changes in serum and gonadal concentrations of adipokines, like leptin, adiponectin, resistin, and ghrelin have been implicated as causes of male infertility in obese males. The effects of obesity and hypogonadism form a vicious cycle whereby dysregulation of the hypothalamic–pituitary–testicular axis—due to the effect of the release of multiple mediators, thus decreasing GnRH release from the hypothalamus—causes decreases in LH and FSH levels. This leads to lower levels of testosterone, which further increases adiposity because of increased lipogenesis. Cytokines such as TNF-α and interleukins, sirtuins, and other inflammatory mediators like reactive oxygen species are known to affect fertility in obese male adults. There is evidence that parental obesity can be transferred through subsequent generations to offspring through epigenetic marks. Thus, negative expressions like obesity and infertility have been linked to epigenetic marks being altered in previous generations. The interesting aspect is that these epigenetic expressions can be reverted by removing the triggering factors. These positive modifications are also transmitted to subsequent generations.

With provisional restorations, properties such as flexural strength play a key role in maintaining the abutment teeth in position over the interim period until the final restorations are placed. This study aimed to evaluate and compare the flexural strength of four commonly used provisional resin materials. Ten identical 25 × 2 × 2 mm specimens were made from four different groups of provisional resin material, namely 1: SR Ivocron (Ivoclar Vivadent) cold-polymerized poly-methyl methacrylate (PMMA), 2: S Ivocron (Ivoclar Vivadent) heat-polymerized PMMA, 3: Protemp (3M Germany-ESPE) auto-polymerized bis-acryl composite, and 4: Revotek LC (GC Corp, Tokyo) light-polymerized urethane dimethacrylate resin. The mean values of the flexural strength of each group were calculated and the data were analyzed using one-way ANOVA and Tukey post hoc tests. The mean values (MPa) were as follows: for cold-polymerized PMMA, it was 125.90 MPa; for heat-polymerized PMMA, it was 140.00 MPa, with auto-polymerized bis-acryl composite 133.00 MPa; and for light-polymerized urethane dimethacrylate resin, it was 80.84 MPa. Thus, the highest flexural strength was recorded with heat-polymerized PMMA and the lowest flexural strength with light-polymerized urethane dimethacrylate resin, which was significantly low. The study did not detect a significant difference in the flexural strengths of cold PMMA, hot PMMA, and auto bis-acryl composite.

Objectives This study is aimed to evaluate the cleaning efficacy of five different irrigation systems as SonicMax, RinsEndo, EndoVac, passive ultrasonic irrigation (PUI), and manual needle irrigation (MNI) to histologically evaluate the presence of organic structures and the penetration of irrigation solution. Materials and Methods Forty-two single-rooted, extracted human mandibular premolars were used in the study. Each tooth was decoronated at the cementoenamel junction and the root canals were instrumented using ProTaper rotary instruments in a crown-down manner. The specimens were randomly divided into five experimental groups (n = 7) Group (1) SonicMax, group (2) RinsEndo,group (3) EndoVac, group (4) PUI, group (5) MNI, and the control groups (n = 7). Each system used 2.5% sodium hypochlorite (NaOCl), 17% ethylenediamine tetraacetic acid (EDTA), and 2.5% NaOCl, respectively, in the experimental groups. The control group did not receive any final irrigation.The measurements were analyzed by employing two-way analysis of variance multivariate results to show significant differences between the length of the dentin tubules in the apical, middle, and coronal of the six groups. The post-hoc test was used when groups were compared by pairs. Results The results of this study indicate that among the five groups, the RinsEndo and EndoVac were found to be most effective in the cleaning of root canals. The RinsEndo shows highly significant results in the cleaning efficiency of the coronal and middle parts compared with the other groups. The cleaning efficiency in the apical area was the same for RinsEndo and EndoVac. Conclusion The result of our study indicates that RinsEndo and EndoVac may be more effective in clinical practice.

Background: Biological and technical hardware complications in implant-retained prostheses are well documented in the literature. The most frequently reported failures are on the immediate or delayed factors after implant placement. Even when the implant has successfully osseointegrated, there is a chance that the prosthesis can fail if the treatment planning and occlusal aspects are not well studied. Management of failed cases is rarely reported. In this case report, the authors present a failed implant prosthesis and how it was managed well with a more permanent solution. Case presentation: A 55-year-old, male retired bank manager, reported with the chief complaint of frequent fracture of the maxillary acrylic hybrid implant prosthesis that was delivered 6 months ago. He wanted a replacement for the fractured upper maxillary acrylic hybrid prosthesis. On clinical evaluation, the upper maxillary implant prosthesis was opposing the natural tooth, an anterior bridge, and two posterior implants in the lower right and left of the first and second molar region. The patient was happy with the lower restorations. Conclusion: The design of the final restoration based on biological, mechanical, technological, and patient factors should be ideally planned during the initial treatment planning stage itself. In case a prosthesis fails the underlying cause should be analyzed and retreatment planning is to be done. Bangladesh Journal of Medical Science Vol. 23 No. 01 January’24 Page : 266-271

Pediatric esthetic dentistry is a sensitive technique, as children can be less cooperative; hence, minimal appointments are preferred. The most conservative treatment modality for anterior esthetic rehabilitation is using direct composite veneer restorations. In many instances, esthetic improvements using composite resin are the only possible option until the growth phase of the pediatric patient is complete. In this article, we present three different case scenarios in young teenagers with different treatment needs requiring esthetic restorations. The first case report is a patient with amelogenesis imperfecta, the second is with generalized spacing, and the third is with localized microdontia. All three patients were followed up for six months post direct composite veneering and were highly satisfied with their treatment outcomes, which boosted their self-confidence.

Objective. This study explores the impact of infographics on the professional dissemination of medical research. Recognising the burgeoning volume of data in the medical domain, this research aims to bridge the gap by investigating the efficacy of infographics in rendering complex medical concepts understandable to diverse audiences, including policymakers, patients, and the public. Design. The study uses a cross‐sectional survey to assess medical professionals’ familiarity with infographic design and data visualisation principles. Setting. The research targets medical professionals with published articles across various subfields, including Clinical Medicine, Epidemiology, Pharmacology, Healthcare Management, Medical Imaging, and Public Health. Method. Data collection involves an online survey distributed to potential participants through professional networks and research institutions. The survey encompasses Likert‐scale questions and demographic variables. Ethical considerations include obtaining approval from the institutional review board, ensuring participant consent, and maintaining data anonymity and confidentiality. Results. Demographic analysis reveals a diverse participant profile, with 58.7% male and 41.3% female respondents, spanning various age groups, professional experiences, and geographic locations. Assessing familiarity with infographic design and data visualisation principles demonstrates respondents’ proficiency in certain areas while highlighting potential areas for improvement. Conclusion. The study underscores the multifaceted benefits of infographics in research dissemination, as medical professionals perceive. Infographics can effectively convey various kinds of medical research information across diverse platforms and channels.