Parkinson’s disease (PD) is a chronic and progressive neurological disease that mostly shakes and compromises the motor system of the human brain. Patients with PD can face resting tremors, loss of balance, bradykinesia, and rigidity problems. Complex patterns of PD, i.e., with relevance to other neurological diseases and minor changes in brain structure, make the diagnosis of this disease a challenge and cause inaccuracy of about 25% in the diagnostics. The research community utilizes different machine learning techniques for diagnosis using handcrafted features. This paper proposes a computer-aided diagnostic system using a convolutional neural network (CNN) to diagnose PD. CNN is one of the most suitable models to extract and learn the essential features of a problem. The dataset is obtained from Parkinson’s Progression Markers Initiative (PPMI), which provides different datasets (benchmarks), such as T2-weighted MRI for PD and other healthy controls (HC). The mid slices are collected from each MRI. Further, these slices are registered for alignment. Since the PD can be found in substantia nigra (i.e., the midbrain), the midbrain region of the registered T2-weighted MRI slice is selected using the freehand region of interest technique with a 33 × 33 sized window. Several experiments have been carried out to ensure the validity of the CNN. The standard measures, such as accuracy, sensitivity, specificity, and area under the curve, are used to evaluate the proposed system. The evaluation results show that CNN provides better accuracy than machine learning techniques, such as naive Bayes, decision tree, support vector machine, and artificial neural network.

A personalized recommender system is broadly accepted as a helpful tool to handle the information overload issue while recommending a related piece of information. This work proposes a hybrid personalized recommender system based on affinity propagation (AP), namely, APHPRS. Affinity propagation is a semisupervised machine learning algorithm used to cluster items based on similarities among them. In our approach, we first calculate the cluster quality and density and then combine their outputs to generate a new ranking score among clusters for the personalized recommendation. In the first phase, user preferences are collected and normalized as items rating matrix. This generated matrix is then clustered offline using affinity propagation and kept in a database for future recommendations. In the second phase, online recommendations are generated by applying the offline model. Negative Euclidian similarity and the quality of clusters are used together to select the best clusters for recommendations. The proposed APHPRS system alleviates problems such as sparsity and cold‐start problems. The use of affinity propagation and the hybrid recommendation technique used in the proposed approach helps in improving results against sparsity. Experiments reveal that the proposed APHPRS performs better than most of the existing recommender systems.

The field of digital twins (DT) is a rapidly expanding area in healthcare. Although DTs have long been established in engineering and military contexts, their adoption in medicine remains in its infancy. However, in cancer care, DTs have extraordinary potential to revolutionise early disease detection, treatment response prediction, prognostication, decision-making and personalised patient management. In this review, we focus on oncology DTs with emphasis on [a] current applications, [b] identifying key deployment challenges and bottlenecks to clinical adoption, [c] describing available development tools, and [d] discussing ethical considerations. We also chart the growing influence of DTs as a transformative force in personalised cancer care.