Ranitidine is a medication that has been used to alleviate heartburn and other disorders for over 40 years. Following reports of N-nitrosodimethylamine (NDMA) contamination in ranitidine products, there have been many recalls and registration suspensions. Here, we revise the literature information confirming ranitidine association with NDMA. Then, we highlight the documented mechanisms for NDMA release from ranitidine. In addition, the stability issue for this medicine is discussed. After that, we review and discuss the results of the United States Food and Drug Administration and the Australian Therapeutic Goods Administration laboratory testing of ranitidine products and the detected NDMA levels. Finally, the case of NDMA generation in Angiotensin II Receptor Blockers (ARBs) and ranitidine were compared in an attempt to address the circumstances leading to the current contamination.

Essential oils (EOs) have been described as promising eco-friendly secondary products of aromatic plants with several biological activities. The present study aimed to characterize the chemical composition and explore phytotoxic and antimicrobial activities of Teucrium polium and Thymus decussatus EOs extracted using hydrodistillation (HD) and microwave-assisted extraction (MAE) methods. Twenty-seven and twenty-eight compounds were identified from HD and MAE extracted EOs of T. polium, respectively. The oxygenated sesquiterpenes (57.68%) were characterized as the main components of the hydrodistilled EO with a prominence of 6-epi-shyobunol (33.00%), while sesquiterpene hydrocarbons (54.48%) were the main components of the MAE method, with a prominence of delta-cadinene (25.13%). Eighteen and nineteen compounds, were characterized in T. decussatus EOs extracted using HD and MAE methods, respectively, and oxygenated monoterpenes represented the main components of both EOs with carvacrol (94.40% and 75.91%, respectively) as the main compound. The EOs extracted using the MAE method were slightly more phytotoxic than those extracted using the HD method. The T. decussatus EO extracted using the MAE method showed a higher inhibitory effect than T. polium by 16-, 32-, and 24-fold, regarding seed germination, shoot, and root growth of lettuce, respectively. Moreover, EOs extracted by HD method showed a similar pattern with 16-, 28-, and 14-fold effects. Both T. decussatus EOs exhibited potent inhibitory effect against all tested bacteria with an inhibition zone of 34–39 mm and the lowest minimum inhibitory concentration (MIC) of 0.49, 0.98, and 1.95 μg/mL against Aspergillus niger, Escherichia coli, and Staphylococcus aureus, respectively. However, the EOs of T. polium showed weak antibacterial activity and no antifungal effect. Further studies are needed for the characterization of bioactive major compounds, either singular or synergistic, at field scale and to determine their modes of action and safety.

This study used quantitative and qualitative methods to collect data, using questionnaires and interviews, from 792 randomly-selected farmers in two of the governorates in the Nile Delta Region, Egypt. A workshop was organized for 59 extension professionals working in the two governorates, looking at how the adaptive capacity of the agricultural sector towards climate change was being guided by policy-makers. Two focus groups were used: one with senior officials from the regional governorates and the other with central government administrators from the Ministry of Agriculture and Land Reclamation. The study findings suggested that 51.9% of the investigated farmers at the two targeted governorates had no knowledge about the climate change phenomenon. Maximizing the use of manure, changing crop patterns, and crop rotation were the adaptation measures most commonly adopted by aware respondents against climate change. Results of a probit model analysis indicated that farmers’ ability to adapt to climate change was influenced by education level, farm size, diversity of production, and membership of a Water User Association. The study recommended some extension interventions to raise awareness of the anticipated effects of climate change.

Resveratrol (3,4,5-Trihydroxy-trans-stilbene) is a naturally occurring polyphenol that exhibits beneficial pleiotropic health effects. It is one of the most promising natural molecules in the prevention and treatment of chronic diseases and autoimmune disorders. One of the key limitations in the clinical use of resveratrol is its extensive metabolic processing to its glucuronides and sulfates. It has been estimated that around 75% of this polyphenol is excreted via feces and urine. To possibly alleviate the extensive metabolic processing and improve bioavailability, we have added segments of acetylsalicylic acid to resveratrol in an attempt to maintain the functional properties of both. We initially characterized resveratrol-aspirin derivatives as products that can inhibit cytochrome P450 Family 1 Subfamily A Member 1 (CYP1A1) activity, DNA methyltransferase (DNMT) activity, and cyclooxygenase (COX) activity. In this study, we provide a detailed analysis of how resveratrol and its aspirin derivatives can inhibit nuclear factor kappa B (NFκB) activation, cytokine production, the growth rate of cancer cells, and in vivo alleviate intestinal inflammation and tumor growth. We identified resveratrol derivatives C3 and C11 as closely preserving resveratrol bioactivities of growth inhibition of cancer cells, inhibition of NFκB activation, activation of sirtuin, and 5’ adenosine monophosphate-activated protein kinase (AMPK) activity. We speculate that the aspirin derivatives of resveratrol would be more metabolically stable, resulting in increased efficacy for treating immune disorders and as an anti-cancer agent.

The red palm weevil (RPW) (Rhynchophorus ferruginous) is one of the most serious pest insects threatening the sustainability of the date palm sector (Phoenix dactylifera L.). Nevertheless, a gap exists in the body of knowledge regarding patterns in farmers’ adoption of integrated pest management (IPM) for RPW control and how their knowledge of RPW symptomology influences IPM adoption. Data were collected using structured questionnaires from 183 palm growers in Al-Ahsa Governorate, Saudi Arabia. The results indicate that most farmers had insufficient knowledge to visually diagnose RPW symptoms and damage. Farmers moderately adopted preventive measures recommended for protection from RPW infestation. Only 13.11% of the farmers exhibited a high rate of adoption of pest management practices for RPW control and eradication. The findings revealed a strong positive association (0.8, p < 0.01) between the knowledge level regarding symptoms and IPM adoption level, whereby the respondents with more knowledge of RPW symptoms showed a higher level of adoption in all IPM categories. This study contributes to the development of our understanding of the social behaviors and risks associated with RPW. This might enhance the quality of awareness campaigns and extension programs and assist in developing a visual inspection protocol for RPW infestation for farmers.