Prof. Mohamed Hegazy
National Research Center, Dokki, Cairo, Egypt
+1
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Academic Career Length
25Years (2002-Present)
(Calculated once Scilit publication data is synced: current year − year of first publication + 1)
Representative Publications
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Journal Article
SKShaden Khalifa
Shaden Khalifa
Nizar EliasMFMohamed A. Farag
Mohamed A. Farag
LCLei Chen
Lei ChenASAamer Saeed
Aamer Saeed
Hesham El-Seedi +10
Cancer remains one of the most lethal diseases worldwide. There is an urgent need for new drugs with novel modes of action and thus considerable research has been conducted for new anticancer drugs from natural sources, especially plants, microbes and marine organisms. Marine populations represent reservoirs of novel bioactive metabolites with diverse groups of chemical structures. This review highlights the impact of marine organisms, with particular emphasis on marine plants, algae, bacteria, actinomycetes, fungi, sponges and soft corals. Anti-cancer effects of marine natural products in in vitro and in vivo studies were first introduced; their activity in the prevention of tumor formation and the related compound-induced apoptosis and cytotoxicities were tackled. The possible molecular mechanisms behind the biological effects are also presented. The review highlights the diversity of marine organisms, novel chemical structures, and chemical property space. Finally, therapeutic strategies and the present use of marine-derived components, its future direction and limitations are discussed.
1 September 2019 in Cancer Letters
Journal Article
JBJoelle C. Boulos
Joelle C. BoulosMRMuhammad Rahama
Muhammad Rahama
Mohamed Hegazy
Thomas EfferthJournal Article
SKShaden Khalifa
Shaden Khalifa
Mohamed Hamdi ElashalNYNermeen Yosri
Nermeen Yosri
Ming DuSMSyed Ghulam Musharraf
Syed Ghulam MusharrafHesham El-Seedi +9
Bee pollen is a combination of plant pollen and honeybee secretions and nectar. The Bible and ancient Egyptian texts are documented proof of its use in public health. It is considered a gold mine of nutrition due to its active components that have significant health and medicinal properties. Bee pollen contains bioactive compounds including proteins, amino acids, lipids, carbohydrates, minerals, vitamins, and polyphenols. The vital components of bee pollen enhance different bodily functions and offer protection against many diseases. It is generally marketed as a functional food with affordable and inexpensive prices with promising future industrial potentials. This review highlights the dietary properties of bee pollen and its influence on human health, and its applications in the food industry.
1 January 2015 in Journal of Advanced Research
Journal Article
Mohamed HegazyTMTarik Mohamed
Tarik Mohamed
Abdelsamed ElshamyAMAbou-El-Hamd H. Mohamed
Abou-El-Hamd H. Mohamed
UMUsama A. Mahalel
Usama A. Mahalel
FHFayza M. Hammouda
Fayza M. Hammouda +6
Natural products are structurally and biologically interesting metabolites, but they have been isolated in minute amounts. The syntheses of such natural products help in obtaining them in bulk amounts. The recognition of microbial biotransformation as important manufacturing tool has increased in chemical and pharmaceutical industries. In recent years, microbial transformation is increasing significantly from limited interest into highly active area in green chemistry including preparation of pharmaceutical products. This is the first review published on the usage of microbial biocatalysts for some natural product classes and natural product drugs.
1 November 2020 in Computers in Biology and Medicine
Journal Article
Mahmoud A. A. IbrahimAAAlaa H.M. Abdelrahman
Alaa H.M. Abdelrahman
THTaha A. Hussien
Taha A. Hussien
EBEsraa A.A. Badr
Esraa A.A. Badr
TMTarik A. Mohamed
Tarik A. Mohamed
Mohamed Hegazy +3
1 February 2007 in Journal of Sulfur Chemistry
Journal Article
Ashraf A. AlyEAEssam K. Ahmed
Essam K. Ahmed
KEKhaled M. El-Mokadem
Khaled M. El-Mokadem
Mohamed HegazyThe literature on synthesis and applications of aroyl substituted thioureas is updated to 2006. Emphasis is placed on the relationship of structural features of the thioureas to their applications, which are in such diverse areas as the trace analysis of metals, materials science and agriculture. The review contains 93 references.
About Me
Professor Mohamed-Elamir F. Hegazy, National Research Centre, Egypt, is working in the field of natural product chemistry, biochemistry, and the microbial transformation of natural metabolites. He is a highly motivated and goal-oriented scientist with broad experience in the chemical identification and biological characterization of natural compounds from medicinal plants and marine organisms using high-performance techniques (1D and 2D NMR analyses). He works in the area of natural product chemistry, and his research focuses on the challenging as well as medically important area of biologically active natural metabolites. His current H-index value of 20 is based on over 115 peer-reviewed articles. Regarding his record in the field of natural product chemistry, he is currently a guest editor for the Special Issue in Marine Drugs (MDPI) (Middle-Eastern Marine Natural Products) and a reviewer on the reviewing board of Plants (MDPI). He received his PhD in Chemical Biology from Hiroshima University, Japan, and his Ph.D. in Natural Product Chemistry from Minia university, Egypt. He has obtained several very competitive post-doctoral fellowships as JSPS (Japan Society for the Promotion of Science) and AVH (Alexander von Humboldt), which enabled him to gain and develop his research interests.