In this study, the microstructure and related corrosion behavior of AM60 alloys with/without Ca and Y addition upon gravity casting (GC) and high-pressure die-casting (HPDC) are investigated by means of SEM/EDS characterization, immersion/salt spray test, hydrogen releasing, as well as electrochemistry examination. When utilizing GC, AM60 alloy with Ca and Y addition (named AZXW6000 alloy) has better corrosion resistance compared with AM60 alloy. Thanks to grain refinement and second phase networks introduced in HPDC, the anti-corrosion properties of the AM alloy seem much better than those of the GC counterpart. The corrosion mechanism of both GCed and HPDCed AM60-based alloys is also investigated in detail. The inspiration from present work can provide more thinking for developing high corrosion-resistant Mg alloys using different casting methods.