Francesco Siano

Dr. Francesco Siano

Istituto di Scienze dell'Alimentazione - CNR
orcid

Research Focus & Metrics

Academic Career Length

24Years (2003-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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27 December 2018 in Molecules
Verified
Journal Article
Open access
PDF file
FSFrancesco Siano
Francesco Siano
Stefania MocciaStefania Moccia
Stefania Moccia
Gianluca PicarielloGianluca Picariello
Gianluca Picariello
Gian Luigi RussoGian Luigi Russo
Gian Luigi Russo
GSGiuseppe Sorrentino
Giuseppe Sorrentino
Maria Grazia VolpeMaria Grazia Volpe
Maria Grazia Volpe
A series of chemical and biochemical parameters of edible hemp resources (seeds, oil, and flour) from the monoecious EU registered hemp genotype Fedora, was determined, including fatty acid profile, phytosterol composition, total phenolics, antioxidant activity, macro- and micro-elements. The fatty acid ω-3/ω-6 approached the nutritionally optimal 3/1 ratio. β-sitosterol and other phytosterols sterols dominated the unsaponifiable fraction. Hemp seeds, flour, and oil contained 767 ± 41, 744 ± 29, and 21 ± 5 mg GAE kg−1 total polyphenols, respectively. The antioxidant potential of Fedora flour and seeds, evaluated through the DPPH (2,2-Diphenyl-1-picrylhydrazyl) assay, was higher than that of oil. K and Mg were the most abundant macro-elements, particularly in flour, while the concentration of trace elements was Fe > Cu > Ni > Mn. The presence of an array of bioactive compound candidate Fedora products as health-promoting food matrices. The ATR-FTIR spectra of hemp-derived products indicated the proximate composition of macro-nutrients.

1 January 2015 in LWT
Verified
Journal Article
Closed access
MVM.G. Volpe
M.G. Volpe
FSFrancesco Siano
Francesco Siano
Marina PaolucciMarina Paolucci
Marina Paolucci
ASA. Sacco
A. Sacco
ASA. Sorrentino
A. Sorrentino
Ettore VarricchioEttore Varricchio
Ettore Varricchio

1 June 2015 in Journal of the Science of Food and Agriculture
Verified
Journal Article
Closed access
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FSFrancesco Siano
Francesco Siano
MSMaria C Straccia
Maria C Straccia
Marina PaolucciMarina Paolucci
Marina Paolucci
GFGabriella Fasulo
Gabriella Fasulo
FBFloriana Boscaino
Floriana Boscaino
Maria Grazia VolpeMaria Grazia Volpe
Maria Grazia Volpe

27 January 2006 in European Food Research and Technology
Verified
Journal Article
Closed access
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LMLuigi De Masi
Luigi De Masi
PSPietro Siviero
Pietro Siviero
CECastrese Esposito
Castrese Esposito
DCDomenico Castaldo
Domenico Castaldo
FSFrancesco Siano
Francesco Siano
BLBruna Laratta
Bruna Laratta

21 October 2016 in Molecules
Verified
Journal Article
Open access
PDF file
ASAngela Sorice
Angela Sorice
FSFrancesco Siano
Francesco Siano
FCFrancesca Capone
Francesca Capone
EGEliana Guerriero
Eliana Guerriero
Gianluca PicarielloGianluca Picariello
Gianluca Picariello
Maria Grazia VolpeMaria Grazia Volpe
Maria Grazia Volpe
In this study, a hydroalcoholic chestnut shell extract was characterized and tested on six different human cell lines. Gallic, ellagic, and syringic acids were the most abundant non-condensed compounds in the chestnut extract, as determined by high performance liquid chromatography (HPLC). Tannins were mainly represented by condensed monomeric units of epigallocatechin and catechin/epicatechin. After 48 h of treatment, only the human hepatoblastoma HepG2 cells reached an inhibition corresponding to IC50 with an increase of apoptosis and mitochondrial depolarization. The cytokinome evaluation before and after treatment revealed that the vascular endothelial growth factor (VEGF) and the tumor necrosis factor (TNF)-α decreased after the treatment, suggesting a potential anti-angiogenic and anti-inflammatory effect of this extract. Moreover, the metabolome evaluation by 1H-NMR evidenced that the polyphenols extracted from chestnut shell (PECS) treatment affected the levels of some amino acids and other metabolites. Overall, these data highlight the effects of biomolecules on cell proliferation, apoptosis, cell cycle and mitochondrial depolarization, and on cytokinomics and metabolomics profiles.

1 September 2017 in Food Research International
Verified
Journal Article
Closed access
Gianluca PicarielloGianluca Picariello
Gianluca Picariello
LSLeonardo Pablo Sciammaro
Leonardo Pablo Sciammaro
FSFrancesco Siano
Francesco Siano
Maria Grazia VolpeMaria Grazia Volpe
Maria Grazia Volpe
Maria Cecilia PuppoMaria Cecilia Puppo
Maria Cecilia Puppo
GMGianfranco Mamone
Gianfranco Mamone