Background. Postoperative nausea and vomiting (PONV) is one of common complications in patients undergoing laparoscopic cholecystectomy (LC). Aim of this study was to compare the efficacy of subhypnotic (1 mg/kg/h) infusion of propofol with dexamethasone on PONV in patients undergoing LC.Methods. A total of 120 patients were included in this randomized, double-blind, placebo-controlled study. Patients were randomly assigned to 3 groups; patients of group dexamethasone (group D) were administrated 8 mg dexamethasone before induction of anesthesia, patients of group propofol (group P) were infused to subhypnotic (1 mg/kg/h) propofol during operation and patients of group control (group C) were applied infusion of 10% intralipid. The incidence of PONV and needs for rescue analgesic and antiemetic were recorded in the first 24 h postoperatively.Results. In the 0–24 h, the incidence of PONV was significantly lower in the group D and group P compared with the group C (37.5%, 40%, and 72.5%, resp.). There was no significant difference in the incidence of PONV and use of antiemetics and analgesic between group D and group P.Conclusion. We concluded that infusion of propofol 1 mg/kg/h is as effective as dexamethasone for the prevention of PONV during the first 24 hours after anesthesia in patients undergoing LC.

Objective: Coronavirus 2019 disease presents in a spectrum that can range from mild viral infection to pneu- monia. Common symptoms of coronavirus disease 2019 pneumonia include cough, sputum, and shortness of breath. High-frequency chest wall oscillation is a pulmonary rehabilitation method used for the recovery of pulmonary functions and removal of secretions in the lungs. The aim of the study was to evaluate the efficacy of high-frequency chest wall oscillation on patients with coronavirus disease 2019 pneumonia. Materials and Methods: In this study, 100 patients, between 18 and 70 years old, with a positive polymerase chain reaction result for coronavirus disease 2019, were included. Standard medical treatment was applied to all patients. In group rehabilitation, high-frequency chest wall oscillation treatment was applied twice a day for 20 minutes for 5 days. No additional intervention was made to the control group. Pulmonary function tests and oxygenation were evaluated on the first and fifth days. Patients’ high-flow oxygen, non-invasive mechani- cal ventilation, and invasive mechanical ventilation needs were evaluated and recorded. Results: Compared with the control group, the forced expiratory volume in 1 second, forced vital capacity, and peak expiratory flow rates were statistically higher in the rehabilitation group on the fifth day (P < .05). On evaluating the oxygenation of patients, the fifth day to first-day oxygen saturation difference was signifi- cantly higher in rehabilitation group than in control group (P < .05). Furthermore, the number of patients who needed non-invasive mechanical ventilation was lower in the rehabilitation group (P < .05). Conclusion: This study demonstrated that pulmonary rehabilitation applied with the high-frequency chest wall oscillation device in patients with coronavirus disease 2019 in the early period contributed to the improvement of oxygenation by providing significant improvement as observed in the pulmonary function tests of the patients. Cite this article as: Çelik M, Murat Yayık A, Kerget B, et al. High-frequency chest wall oscillation in patients with COVID-19: A pilot feasibility study. Eurasian J Med 2022;54(2):150-156.

Amaç: Sepsiste akciğer komplikasyonları önemli bir yer tutar (ARDS, diffüz pnömoni gibi). Akut respiratuar distres sendromu (ARDS) akciğerde alveollere aşırı nötrofil migrasyonu ile karakterizedir. Propofol ve midazolam yoğun bakımlarda hasta sedasyonu için çok yaygın olarak kullanılan ilaçlardır. Escherichia Coli endotoksini ile oluşturulan sepsis modelinde propofol ve midazolam anestezisi altında akciğerlere nötrofil göçünü ve hemodinamik parametreleri değerlendirmeyi amaçladık. Gereç ve Yöntem: 40 adet rat (Spraque-Dawley cinsi) rastgele dört gruba- ayrıldı. 1- Grup E (Endotoksemi grubu) 2- Grup K (Kontrol grubu) 3- Grup PE (Propofol-Endotoksemi grubu) 4- Grup ME (Midazolam-Endotoksemi grubu). Tüm deneklere intraperitoneal 30 mg/kg tiyopental sodyum verildi. Denekler trakestomi yoluyla ventile edildiler. Devamlı kan basıncının ölçülmesi ve kan örneklerinin alınabilmesi için femoral arter kanüle edildi. Grup E’deki deneklere E.Coli’den elde edilmiş lipopolisakkarit derivesi intravenöz olarak 15 mg/kg uygulandı. Grup K’daki deneklere %0,9 NaCL 1 mL/kg intravenöz uygulandıktan sonra 1 mL/kg/saat infüzyona devam edildi. Grup PE’deki deneklere E. Coli endotoksininden 15 mg/kg intravenöz uygulandıktan sonra 10 mg/kg Propofol intravenöz olarak uygulandı Daha sonra 10 mg/kg/saat propofol infuzyonuna devam edildi. Grup ME’deki deneklere de E.Coli endotoksininden 15 mg/kg intravenöz uygulandıktan sonra 0,1 mg/kg Midazolam enjekte edildi. 0,1 mg/kg/saat midazolam infüzyonu uygulandı. Denekler 5. saat sonunda intravenöz potasyum klorid verilerek sakrifıye edildi. Akciğerleri çıkarıldı. %10 formalin içinde 3-5 gün fıkse edildi ve parafın bloklarına gömüldü. Akciğer kesitleri, nötrofıl yoğunluğuna göre 0-3 arasında histopatolojik olarak skorlandı. Bulgular: Grup E deki deneklerin akciğer dokularında yoğun nötrofil göçü mevcuttu (grade 2, 3). Grup ME deki denek akciğerlerinde orta derecede nötrofil göçü mevcutken (grade 1, 2) Grup PE de sadece %30 denekte hafif nötrofil göçüne rastlandı (grade 1). Sonuç: Endotoksinle indüklenen sepsis modelinde propofol infüzyonunun midazolamla karşılaştırıldığında akciğerlere daha az nötrofil göçü ile ilişkili olduğu ve literatürün de ışığında serbest radikal aracılı lipit peroksidasyonunu ve hastaların sistemik inflamasyonu hafifletebileceği sonucuna vardık.