Hounsfield units (HU) are a measure of radiodensity, related to the density of a tissue and the composition of kidney stones. Hounsfield density is what is related to the composition of kidney stones. In the standard acquisition method, these measures are arbitrary and dependent on the operator. This study describes the implementation of a technique based on the HU and Hounsfield density to predict the stone compositions of patients with nephrolithiasis. By conventional percutaneous nephrolithotomy, thirty kidney stone samples corresponding to the cortex, middle, and nucleus were obtained. The HU were obtained by CT scanning with a systematic grid. Hounsfield density was calculated as the HU value divided by the stone’s greatest diameter (HU/mm). With that method and after analyzing the samples by IR-spectroscopy, anhydrous uric acid and ammonium magnesium phosphate were identified as the compounds of kidney stones. Additionally, anhydrous uric acid, magnesium ammonium phosphate, and calcium oxalate monohydrate were identified via Hounsfield density calculation. The study identified HU ranges for stone compounds using a systematic technique that avoids bias in its analysis. In addition, this work could contribute to the timely diagnosis and development of personalized therapies for patients with this pathology.

Background and objective: Nephrolithiasis (NL) is a public health problem in the population of Southeast Mexico because of its high prevalence and recurrence. The evolution of this pathology can result in renal damage and may even cause chronic kidney disease (CKD), leading to a reduced glomerular filtration rate (GFR), decreased kidney function, and kidney loss in advanced stages. However, few studies support this evidence in the population. The present study aimed to determine risk factors associated with CKD in adult patients in an endemic population of Mexico. Materials and methods: A case-control study was carried out with patients diagnosed with NL. Additionally, the clinical information of patients (age, weight, height, blood pressure, comorbidities, and time of progress of NL), characteristics of the stones (number, location, and Hounsfield units), and biochemical parameters were collected. Results: The recurrence of NL was associated with CKD (OR 1.91; 95% CI 1.37–2.27; p = 0.003). In addition, male sex (p = 0.016), surgical history (p = 0.011), bilateral kidney stones (p < 0.001), and urinary tract infections (p = 0.004) were other factors associated with CKD. Interestingly, thirty-two patients younger than 50 years old with >2 surgical events presented a significant decrease in GFR (p < 0.001). Conclusions: The recurrence of NL and the number of surgical events were risk factors associated with CKD in patients with NL treated in our population.

Adenosine triphosphate (ATP) is an energy and signaling molecule. It is synthesized endogenously and can be taken as an oral supplement. This review aimed to identify the effects of oral ATP supplementation on anaerobic exercise in healthy resistance-trained adults. A systematic review and meta-analysis were performed based on the Preferred Reporting Items of Systematic Reviews and Meta-Analysis (PRISMA) criteria. The inclusion criteria were articles published from 2000 to 2022, with anaerobic variables (maximal strength, maximum repetitions, and maximum anaerobic power) measurable in healthy adults with experience in resistance training, only randomized placebo-controlled clinical trials (RCTs), and with the acute (a single dose 30 min to 24 h before the tests) and/or chronic (>1 day) oral supplementation of ATP. A total of five RCTs with 121 adult men were included. The oral ATP supplementation achieved significantly greater gains in maximal strength compared with the placebo (PL) (MD = 8.13 kg, 95%CI [3.36–12.90], p < 0.001). Still, no differences were observed in the maximum number of repetitions or the maximum anaerobic power. Furthermore, 400 mg of ATP showed improvement in anaerobic exercise regardless of the duration of the supplementation protocol. In conclusion, supplementation with 400 mg of ATP doses can improve maximal muscle strength in resistance-trained men.

Introducción: La determinación de la composición corporal forma parte de la valoración morfofuncional del atleta; existiendo diferentes instrumentos para evaluarla. Objetivo: Comparar las mediciones de la composición corporal entre un InBody 120 y un Skulpt Chisel en una muestra de atletas de combate adolescentes. Metodología: Estudio cuantitativo con enfoque analítico, en el que se incluyó 24 varones (14,2±1,9años, 1,6±0,1m, 62,3±16,1kg, IMC 24,2±4,7kg/m2). Los sujetos fueron medidos con ambos instrumentos obteniendo los valores del porcentaje de grasa corporal (%GC), masa grasa (MG), porcentaje de masa muscular (%MM), masa muscular (MM) y calidad muscular (CM); siguiendo las instrucciones de los fabricantes. Se utilizó la prueba de t de student para muestras relacionadas, el coeficiente de correlación de Pearson, el coeficiente de correlación concordancia de Lin y los gráficos de Bland-Altman. Se consideró significativo una p<0,05. Resultados: No hubo diferencia significativa entre los valores medios del %GC (p=0,161) y MG (p=0,141) en la población total, pero si en la MG de los taekwondogas (p=0,042). El %GC y MG correlacionaron de manera positiva significativa entre ambos equipos de medición (r=0,898 y 0,959, de manera respectiva, p<0,01), similar para %MM y CM (r=0,771, p+/-5% y >+/-3kg, de manera respectiva). Conclusiones: Se concluye que las mediciones realizadas por ambos instrumentos presentaron correlaciones elevadas, pero no son concordantes ni intercambiables.