Biological pairwise sequence alignment can be used as a method for arranging two biological sequence characters to identify regions of similarity. This operation has elicited considerable interest due to its significant influence on various critical aspects of life (e.g., identifying mutations in coronaviruses). Sequence alignment over large databases cannot yield results within a reasonable time, power, and cost. heuristic methods, such as FASTA, the BLAST family have been demonstrated to perform 40 times faster than DP-based (e.g., Needleman–Wunsch) techniques they cannot guarantee an optimum alignment result An optimized software platform of a widely used DNA sequence alignment algorithm called the Needleman–Wunsch (NW) algorithm based on a lookup table, is described in this study. This global alignment algorithm is the best approach for identifying similar regions between sequences. This study presents a new application of classical machine learning (ML) to global sequence alignment. Customized ML models are used to implement NW global alignment. An accuracy of 99.7% is achieved when using a multilayer perceptron with the ADAM optimizer, and up to 2912 Giga cell updates per second are realized on two real DNA sequences with a length of 4.1 M nucleotides. Our implementation is valid for RNA/DNA sequences. This study aims to parallelize the computation steps involved in the algorithm to accelerate its performance by using ML algorithms. All datasets used in this study are available from https://ieee-dataport.org/documents/dna-sequence-alignment-datasets-based-nw-algorithm.

Dorsal hand vein (DHV) recognition is a burgeoning biometric technology that has recently garnered considerable attention. This article uses image processing and deep learning to present a novel DHV recognition approach. It involves detecting and identifying the unique patterns present in the DHV. The proposed system begins with the preprocessing mechanism that is applied to enhance the quality of the acquired images, including contrast enhancement and noise reduction, by using some filters such as Median and Contrast Limited Adaptive Histogram Equalization (CLAHE). Next, a deep learning model, such as a convolutional neural network (CNN), is employed to automatically abstract discriminative features from the preprocessed vein images. The empirical outcomes prove the influence and reliability of the proposed technique for vein recognition, making it a promising solution for biometric authentication systems. Compared with traditional CNN, the proposed approach shows good accuracy and classification rate results. The suggested model achieved a high recognition rate accuracy, recall, precious, and f-score of 99.7%,97%,96%, and 96%, respectively, and a recognition time of about 1283.45 s. To enrich the model’s capability for feature recognition and reduce recognition time, decrease the intricacy of learning and the connectivity CNN structure, an alternative approach based on Restricted Boltzmann Machines (RBM) was assessed. This strategy exhibits superior accuracy in comparison to other contemporary algorithms. The proposed RBM achieved a high recognition rate accuracy, recall, precious, and f-score of 99.9%,99%,99%, and 99%, respectively, and a recognition time of about 137.235s.

Breast cancer retains its position as the most prevalent form of malignancy among females on a global scale. The careful selection of appropriate treatment for each patient holds paramount importance in effectively managing breast cancer. Neoadjuvant chemotherapy (NACT) plays a pivotal role in the comprehensive treatment of this disease. Administering chemotherapy before surgery, NACT becomes a powerful tool in reducing tumor size, potentially enabling fewer invasive surgical procedures and even rendering initially inoperable tumors amenable to surgery. However, a significant challenge lies in the varying responses exhibited by different patients towards NACT. To address this challenge, researchers have focused on developing prediction models that can identify those who would benefit from NACT and those who would not. Such models have the potential to reduce treatment costs and contribute to a more efficient and accurate management of breast cancer. Therefore, this review has two objectives: first, to identify the most effective radiomic markers correlated with NACT response, and second, to explore whether integrating radiomic markers extracted from radiological images with pathological markers can enhance the predictive accuracy of NACT response. This review will delve into addressing these research questions and also shed light on the emerging research direction of leveraging artificial intelligence techniques for predicting NACT response, thereby shaping the future landscape of breast cancer treatment.

Detection and classification of brain tumors are of formidable importance in neuroscience. Deep learning (DL), specifically convolution neural networks (CNN), has demonstrated breakthroughs in the field of brain image analysis and brain tumors classification. This work proposes a novel CNN based model for brain tumor classification. Our pipeline starts with prepossessing and data augmentation techniques. Then, a CNN classification step is developed and utilizes ResNet50 architecture as its core. Particularly, our design modified the ResNet50 output with a global average pooling (GAP) layer to avoid over-fitting. The proposed model is trained and tested using different optimization algorithms. The final classification is achieved using a sigmoid layer. We tested the proposed structure on T1 weighted contrast-enhanced magnetic resonance images (T1-w MRI) that are collected from three datasets. A total of 3586 images containing two classes (i.e., bengin, and malignant) were used in our experiments. The proposed model reach highest accuracy 99.8%, and optimal error 0.005 using Adam when compared with other six well-known CNN architectures.

In recent years, indescribable suffering from various kidney diseases has been experienced by people all over the world. The situation has been significantly worse because of chronic kidney disease (CKD). Only through an early diagnosis of CKD may kidney disease be hinder in its early stages from progressing. However, it is easier to detect the chronic kidney disease with the aid of machine learning (ML) classifier algorithms sooner than any other existing methods. The present work proposes an approach for potentially predicting CKD infection while considering patient health dataset information into consideration, employing nine distinct ML algorithms; random forest (RF), naïve bayes (NB), support vector machine (SVM), decision tree (DT), logistic regression (LR), extreme gradient boosting (XGB), adaptive boosting (ADB), k-nearest neighbors (KNN), and neural network (NN). Machine learning algorithms had been utilized and conducted in four experiments, then they were compared using five performance measures; F1-score, precision, accuracy, recall and run time are used to evaluate the performance. Results had shown that AdaBoost (ADA) outperformed other techniques with achieved accuracy of 99.17%.