Two dimensional (2D) graphene and its derivatives modification with nanomaterials for formation of hybrid/nanocomposites undergo stimulus-induced optical and electrical changes which are important for many new switchable device technologies. The feature article deals with a straight forward and versatile technique for the fabrication of semiconductor nanomaterials (CdS and TiO₂) nanomaterials dispersed liquid crystals (NDLC) or graphene dispersed liquid crystal (GDLC) by stretching hydrogen bonds (H-) in the precursor droplets between two substrates to form a liquid bridge. Fewer liquid crystals (LCs) possess a conventional oriented nematic phase with optimal performances. Evolving advantages of thin-film nanocomposite materials and switchable devices have fueled several developments in the field of flexible electronics, high contrast ratio smart display and opto-electronics. These advantages have been complemented with the expansion of novel composite materials such as GDLC and NDLC as sensors to monitor the inflammability, explosive nature and toxicity of chemicals. This discussion also delves into the fabrication of graphene assembly polymer nanocomposites dispersed in LCs, the necessity for bio-polymer incorporation and their bio-sensing and antimicrobial applications. Additionally, discussed the issues and challenges associated with understanding and exploiting the potentials of smart switchable devices fabricated by nanomaterials or polymer/graphene hybrid composite matrix. Following substantial development and optimized over decades, a novel mechanism employed in smart switchable devices via GDLC hybrid nanocomposite matrix has been found to offer numerous benefits including being cost-effective, possessing a large area compatibility and large scalability in addition to seamless heterogeneous integration.

Smart electronic materials ‘nanographene’ stated, its significant authentication has undergone massive improvements and has emerged as a ‘material of the century’ in materialize fields of ‘Chemical Biology’ and ‘Materials Chemistry’. ‘Graphene’ as a wonder material has been proposed to possess a high surface area (∼2600 m² g⁻¹), high portability of charge carriers and excellent mechanical qualities. Moreover, the long-extend π-conjugation of graphene is an essential photocatalytic property enabling wide ranging biosensor activities. Herein, critical review article reflects well known yet a brand-new novel material ‘nanographene’ and its versatile integrations, utilized for substantial enrichment of desired properties. Target cost-effectiveness, plasticity, and environment-friendliness of melt mixing/compounding fabrication strategy employed to utilize in-vivo, in-vitro, and in- situ, pharmaceutical, nano-imaging protocols. Owing to nanographene’s wide range expansion, summarized latest breakthroughs in Materials Science as well as Biomedical utilizations including cancer nanotechnology, drug delivery, tissue manufacturing, scaffold, photo-thermal therapy, antimicrobial activities, made up of exploring the significant opportunities and key challenges in this novel emerging field.