Nikola Rade Gligorijević

Dr. Nikola Rade Gligorijević

Faculty of Medicine, University of Nis, Serbia, Niš, Serbia
orcid

Research Focus & Metrics

Academic Career Length

12Years (2015-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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25 October 2022 in Polymers
Verified
Journal Article
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MKMilena Kostić
Milena Kostić
MIMarko Igić
Marko Igić
NGNikola Rade Gligorijević
Nikola Rade Gligorijević
VNVesna Nikolić
Vesna Nikolić
NSNenad Stošić Milivoje Nenad Stošić
Nenad Stošić Milivoje Nenad Stošić
LNLjubisa Nikolic
Ljubisa Nikolic
The manuscript aimed to review the types of acrylate polymers used in dentistry, as well as their chemical, physical, mechanical, and biological properties. Regarding their consistency and purpose, dental acrylate polymers are divided into hard (brittle), which includes acrylates for the production of plate denture bases, obturator prostheses, epitheses and maxillofacial prostheses, their repairs and lining, and soft (flexible), which are used for lining denture bases in special indications. Concerning the composition and method of polymerization initiation, polymers for the production of denture bases are divided into four types: heat-, cold-, light-, and microwave-polymerized. CAD/CAM acrylate dentures are made from factory blocks of dental acrylates and show optimal mechanical and physical properties, undoubtedly better monomer polymerization and thus biocompatibility, and stability of the shape and colour of the base and dentures. Regardless of the number of advantages that these polymers have to offer, they also exhibit certain disadvantages. Technological development enables the enhancement of all acrylate properties to respond better to the demands of the profession. Special attention should be paid to improving the biological characteristics of acrylate polymers, due to reported adverse reactions of patients and dental staff to potentially toxic substances released during their preparation and use.

18 July 2022 in Nanomaterials
Verified
Journal Article
Open access
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NGNikola Rade Gligorijević
Nikola Rade Gligorijević
TMTatjana Mihajlov-Krstev
Tatjana Mihajlov-Krstev
MKMilena Kostić
Milena Kostić
LNLjubisa Nikolic
Ljubisa Nikolic
NSNemanja Stankovic
Nemanja Stankovic
Nirit BernsteinNirit Bernstein
Nirit Bernstein
The surface quality of denture base resins allows for easy colonization by microorganisms including Candida albicans and Staphylococcus aureus, which cause major diseases of the oral cavity such as denture stomatitis. The widespread use of silver nanoparticles (AgNPs) in various fields of medicine has led to research of their possible application in dentistry, mostly in the prevention of bacterial adhesion, proliferation, and biofilm formation. The aim of the study was to synthesize cold and heat-curing denture base resins modified with AgNPs and AgCl, and evaluate the potential of the modified resins to reduce the growth of C. albicans and S.aureus. The produced material was characterized by Fourier transform infrared spectroscopy (FTIR). The antimicrobial potential of the modified material was demonstrated by the disc-diffusion method, microdilution method, and a modified microdilution method (i.e., disk-diffusion method in broth with viable counting). Spectroscopy confirmed the incorporation of biocidal materials into the structure of the denture base resins. The AgCl and AgNPs modified resins showed an antimicrobial effect. The significance of the study is in the potential therapeutic effects of the modified materials for prevention and threating staphylococci and candida in elderly patients, who are in most cases denture wearers and have a greater susceptibility to develop opportunistic infections. Modified denture base resins can significantly reduce the presence of infection at the point of contact between the denture and the mucous membrane of the prosthetic restoration. Biological tests of modified denture base resins will follow.

1 December 2017
Verified
Journal Article
Closed access
MKM Kostic
M Kostic
APA Pejcic
A Pejcic
MIM Igic
M Igic
NGNikola Rade Gligorijević
Nikola Rade Gligorijević

9 December 2023 in Medicina
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Journal Article
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MKMilena Kostić
Milena Kostić
NĐNadica S. Đorđević
Nadica S. Đorđević
NGNikola Rade Gligorijević
Nikola Rade Gligorijević
MJMarija Jovanović
Marija Jovanović
Ermin ĐerlekErmin Đerlek
Ermin Đerlek
MIMarko Igić
Marko Igić
Background and Objectives: According to the modified Williams theory, the shape of the maxillary central incisor corresponds to the shape of the maxillary alveolar ridge (dental arch) and the shape of the face. Moreover, the standards of beauty suggest that the center of the face of an individual with a full set of teeth should match the center of the maxillary and mandibular dental arches. The purpose of this study is to conduct a comparative cross-sectional study on the matching of the shape of the face, maxillary central incisor and maxillary dental arch as well as the matching of the midfacial line and dental arches in subjects with complete dentition. Materials and Methods: The study included 90 subjects of both sexes. The matching of the shape of the face and midfacial line, i.e., dental arches and maxillary incisors, was determined by analysing photographs, whereas the shape of the dental arch was determined by analysing plaster models. Results: No significant gender-related differences were found either in the shape of the maxillary central incisor that matched the shape of the maxillary dental arch (p = 0.349) or in the shape of the dental arch that matched the shape of the face (p = 0.697). However, a significant difference was noted in the shape of the teeth that matched the shape of the face (p = 0.043), which was more significantly impaired in men. In addition, the matching of the mid-face and the mid-dental arch was significantly greater in women (p = 0.016). Conclusions: The modified Williams theory was confirmed in most subjects, thus it can be considered a relevant guideline when determining the shape of teeth after their loss. The highest percentage of matching in both sexes was with the shape of the face and dental arch. There was no positive correlation between the middle of the maxillary and mandibular dental arch in most cases.

1 February 2023 in Healthcare
Verified
Journal Article
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MJMarija Goran Jovanović
Marija Goran Jovanović
NZNikola Zivkovic
Nikola Zivkovic
NGNikola Rade Gligorijević
Nikola Rade Gligorijević
MIMarko Igić
Marko Igić
Milica Srbobran PetrovićMilica Srbobran Petrović
Milica Srbobran Petrović
MKMilena Kostić
Milena Kostić
Tooth preparation for a metal-ceramic crown with a subgingival finish line can lead to inflammatory changes in the gingival tissue, often accompanied by cell damage. This study aimed to evaluate the clinical signs of inflammation and the cytomorphological status of the gingival tissue before and after tooth preparation. The research included a homogeneous group of 19 patients with an indication for upper canine preparation. Before and after treatment, the gingival and the gingival bleeding indexes were determined, gingival swabs were taken, and direct smears prepared on slides for cytomorphometric analysis. The values of the measured gingival indexes were statistically significantly higher (p < 0.001) after tooth preparation. They decreased over time, which indicated the reversibility of the resulting changes. Cytological examination showed no statistically significant difference between the values of nuclear area, perimeter, Feret diameter, Feret angle, integrated optical density, MinFeret, and roundness, before and after the treatment. Significantly higher values of circularity, integrated optical density, MinFeret (p < 0.05), as well as roundness (p < 0.001) were found after 72 h, compared to those taken 15 min after tooth crown preparation. This study is a pioneering attempt to show gingival changes during fixed prosthodontic treatment and may shed new light on pathogenetic events in prosthodontic patients.

1 January 2017 in Acta stomatologica Naissi
Verified
Journal Article
Open access
NGNikola Rade Gligorijević
Nikola Rade Gligorijević
MKMilena Kostic
Milena Kostic
ADAna Dinić
Ana Dinić
LNLjubisa Nikolic
Ljubisa Nikolic
VNVesna Nikolić
Vesna Nikolić
Introduction. Porosity and surface adherence of acrylates make them collectors of infectious content from the mouth. This applies particularly to cold-curable acrylates, whose structure is less compact. The aim of this study was to investigate the antimicrobial effects of cold polymerized dental acrylics after impregnation with silver nanoparticles. Material and Methods. Different concentrations (2%, 5% and 10%) of silver nanoparticles were added to the polymer components (powder) of cold polymerizing acrylate, after which disk-shaped samples, 10 mm, in diameter, were made. A disk of silver nanoparticles was used as a control for our study. Antimicrobial activity was investigated using the disc diffusion method on the two most common oral cavity infecting agents - Gram positive bacterium, Staphylococcus aureus ATCC 25923, and fungus Candida albicans ATCC 2091. The results have shown that the control sample as well as the samples of silver impregnated acrylics resins exhibit antibacterial activity. The growth zone inhibition of Staphylococcus aureus in the culture medium is proportional to the concentration of silver nanoparticles in the cold curing acrylic resin. On the other hand, the test samples did not inhibit the growth of Candida albicans in the medium. Conclusion. Silver nanoparticles in cold curing acrylic resin demonstrated antibacterial activity. Expanding their antimicrobial spectrum of activity and their potential clinical application will be the subject of the future research.