Ljubisa Nikolic

Prof. Dr. Ljubisa Nikolic

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Academic Career Length

24Years (2003-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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20 January 2022 in Antibiotics
Verified
Journal Article
Open access
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MUMaja Urošević
Maja Urošević
LNLjubisa Nikolic
Ljubisa Nikolic
IGIvana Lj Gajić
Ivana Lj Gajić
VNVesna Nikolić
Vesna Nikolić
ADAna Dinić
Ana Dinić
VMVojkan Miljković
Vojkan Miljković
Curcumin (1,7-bis-(4-hydroxy-3-methoxyphenyl)-hepta-1,6-diene-3,5-dione) is a natural lipophilic polyphenol that exhibits significant pharmacological effects in vitro and in vivo through various mechanisms of action. Numerous studies have identified and characterised the pharmacokinetic, pharmacodynamic, and clinical properties of curcumin. Curcumin has an anti-inflammatory, antioxidative, antinociceptive, antiparasitic, antimalarial effect, and it is used as a wound-healing agent. However, poor curcumin absorption in the small intestine, fast metabolism, and fast systemic elimination cause poor bioavailability of curcumin in human beings. In order to overcome these problems, a number of curcumin formulations have been developed. The aim of this paper is to provide an overview of recent research in biological and pharmaceutical aspects of curcumin, methods of sample preparation for its isolation (Soxhlet extraction, ultrasound extraction, pressurised fluid extraction, microwave extraction, enzyme-assisted aided extraction), analytical methods (FTIR, NIR, FT-Raman, UV-VIS, NMR, XRD, DSC, TLC, HPLC, HPTLC, LC-MS, UPLC/Q-TOF-MS) for identification and quantification of curcumin in different matrices, and different techniques for developing formulations. The optimal sample preparation and use of an appropriate analytical method will significantly improve the evaluation of formulations and the biological activity of curcumin.
16 July 2009 in Sensors
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Journal Article
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Ljiljana StanojevićLjiljana Stanojević
Ljiljana Stanojević
MSMihajlo Stanković
Mihajlo Stanković
VNVesna Nikolić
Vesna Nikolić
LNLjubisa Nikolic
Ljubisa Nikolic
DIDušica Petar Ilić
Dušica Petar Ilić
VTVesna Tumbas
Vesna Tumbas
The antioxidant activity ofwater, ethanol and methanol Hieracium pilosella L.extracts is reported. The antioxidative activity was tested by spectrophotometrically measuring their ability to scavenge a stable DPPH· free radical and a reactive hydroxyl radical trapped by DMPO during the Fenton reaction, using the ESR spectroscopy. Total phenolic content and total flavonoid content were evaluated according to the Folin-Ciocalteu procedure, and a colorimetric method, respectively. A HPLC method was used for identification of some phenolic compounds (chlorogenic acid, apigenin-7-O-glucoside and umbelliferone). The antioxidant activity of the investigated extracts slightly differs depending on the solvent used. The concentration of 0.30 mg/mL of water, ethanol and methanol extract is less effective in scavenging hydroxyl radicals (56.35, 58.73 and 54.35%, respectively) in comparison with the DPPH· radical scavenging activity (around 95% for all extracts). The high contents of total phenolic compounds (239.59–244.16 mg GAE/g of dry extract) and total flavonoids (79.13–82.18 mg RE/g of dry extract) indicated that these compounds contribute to the antioxidative activity.
1 March 2015 in Industrial Crops and Products
Verified
Journal Article
Closed access
Aleksandra Cvetanović KljakićAleksandra Cvetanović Kljakić
Aleksandra Cvetanović Kljakić
JŠJaroslava Švarc-Gajić
Jaroslava Švarc-Gajić
PMPavle Mašković
Pavle Mašković
SSSaša Savić
Saša Savić
LNLjubisa Nikolic
Ljubisa Nikolic
20 May 2010 in Sensors
Verified
Journal Article
Open access
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LNLjubisa Nikolic
Ljubisa Nikolic
IRIvan Ristic
Ivan Ristic
BABorivoj Adnadjevic
Borivoj Adnadjevic
VNVesna Nikolić
Vesna Nikolić
JJJelena Jovanovic
Jelena Jovanovic
MSMihajlo Stankovic
Mihajlo Stankovic
Poly(D,L-lactide) synthesis using tin(II) 2-ethylhexanoate initiated ring-opening polymerization (ROP) takes over 30 hours in bulk at 120 °C. The use of microwave makes the same bulk polymerization process with the same initiator much faster and energy saving, with a reaction time of about 30 minutes at 100 °C. Here, the poly(lactide) synthesis was done in a microwave reactor, using frequency of 2.45 GHz and maximal power of 150 W. The reaction temperature was controlled via infra-red system for in-bulk-measuring, and was maintained at 100 °C. Different molar ratios of monomer and initiator, [M]/[I], of 1,000, 5,000 and 10,000 were used. The achieved average molar masses for the obtained polymers (determined by gel permeation chromatography) were in the interval from 26,700 to 112,500 g/mol. The polydispersion index was from 2.436 to 3.425. For applicative purposes, the obtained material was purified during the procedure of microsphere preparation. Microspheres were obtained by spraying a fine fog of polymer (D,L-lactide) solution in tetrahydrofuran into the water solution of poly(vinyl alcohol) with intensive stirring.
28 April 2015 in Frontiers in Plant Science
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Ivan SavicIvan Savic
Ivan Savic
VNVesna Nikolić
Vesna Nikolić
Ivan SavicIvan Savic
Ivan Savic
LNLjubisa Nikolic
Ljubisa Nikolic
SISvetlana R. Ibric
Svetlana R. Ibric
DGDragoljub G Gajic
Dragoljub G Gajic
The process of amygdalin extraction from plum seeds was optimized using central composite design (CCD) and multilayer perceptron (MLP). The effect of time, ethanol concentration, solid-to-liquid ratio and temperature on the amygdalin content in the extracts was estimated using both mathematical models. The MLP 4-3-1 with exponential function in hidden layer and linear function in output layer was used for describing the extraction process. MLP model was more superior compared with CCD model due to better prediction ability. According to MLP model, the suggested optimal conditions are: time of 120 min, 100% (v/v) ethanol, solid-to liquid ratio of 1:25 (m/v) and temperature of 34.4 °C. The predicted value of amygdalin content in the dried extract (25.42 g per 100 g) at these conditions was experimentally confirmed (25.30 g per 100 g of dried extract). Amygdalin (>90%) was isolated from the complex extraction mixture and structurally characterized by FT-IR, UV and MS methods.
25 October 2022 in Polymers
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MKMilena Kostić
Milena Kostić
MIMarko Igić
Marko Igić
NGNikola Rade Gligorijević
Nikola Rade Gligorijević
VNVesna Nikolić
Vesna Nikolić
NSNenad Stošić Milivoje Nenad Stošić
Nenad Stošić Milivoje Nenad Stošić
LNLjubisa Nikolic
Ljubisa Nikolic
The manuscript aimed to review the types of acrylate polymers used in dentistry, as well as their chemical, physical, mechanical, and biological properties. Regarding their consistency and purpose, dental acrylate polymers are divided into hard (brittle), which includes acrylates for the production of plate denture bases, obturator prostheses, epitheses and maxillofacial prostheses, their repairs and lining, and soft (flexible), which are used for lining denture bases in special indications. Concerning the composition and method of polymerization initiation, polymers for the production of denture bases are divided into four types: heat-, cold-, light-, and microwave-polymerized. CAD/CAM acrylate dentures are made from factory blocks of dental acrylates and show optimal mechanical and physical properties, undoubtedly better monomer polymerization and thus biocompatibility, and stability of the shape and colour of the base and dentures. Regardless of the number of advantages that these polymers have to offer, they also exhibit certain disadvantages. Technological development enables the enhancement of all acrylate properties to respond better to the demands of the profession. Special attention should be paid to improving the biological characteristics of acrylate polymers, due to reported adverse reactions of patients and dental staff to potentially toxic substances released during their preparation and use.