In this study, a novel framework is proposed for efficient energy management of residential buildings to reduce the electricity bill, alleviate peak-to-average ratio (PAR), and acquire the desired trade-off between electricity bill and user-discomfort in smart grid. The proposed framework is an integrated framework of artificial neural network (ANN) based forecast engine and our proposed day-ahead grey wolf modified enhanced differential evolution algorithm (DA-GmEDE) based home energy management controller (HEMC). The forecast engine forecasts price-based demand response (DR) signal and energy consumption patterns and HEMC schedules smart home appliances under the forecasted pricing signal and energy consumption pattern for efficient energy management. The proposed DA-GmEDE based strategy is compared with two benchmark strategies: day-ahead genetic algorithm (DA-GA) based strategy, and day-ahead game-theory (DA-game-theoretic) based strategy for performance validation. Moreover, extensive simulations are conducted to test the effectiveness and productiveness of the proposed DA-GmEDE based strategy for efficient energy management. The results and discussion illustrate that the proposed DA-GmEDE strategy outperforms the benchmark strategies by 33.3% in terms of efficient energy management.

Leukemia is the rapid production of abnormal white blood cells that consequently affects the blood and damages the bone marrow. The overproduction of abnormal and immature white blood cells leads to the damage of the immune system due to the reduced production of red blood cells and platelets by the bone marrow of the body. This hematological malignancy is generally diagnosed by manual methods such as complete blood count (CBC), bone marrow aspiration, or microscopic examination of the blood smear. Nevertheless, the manual methods of leukemia diagnosis are economical but are found to be less reliable, time-consuming, and hectic. Technological advancement in the medical field has effectively addressed these issues in the past. The problems in the manual diagnosis of leukemia detection have been overcome by the development of automated methods using the computer-aided diagnostic (CAD) systems for efficient and reliable leukemia diagnosis. Since the last decade, multiple approaches have been proposed for the CAD systems regarding pre-processing, segmentation, feature extraction, feature selection, and for the improvement of the classification accuracy of the CAD system for the leukemia detection. This paper presents a comprehensive review of the CAD systems for the detection of the various types of leukemia. The review presented here entails the details of various CAD systems for the automated diagnosis of various types of leukemia and analyses their methodologies in terms of their efficiency in pre-processing, segmentation, feature extraction and selection, and overall classification accuracy of the CAD system.

Electric energy consumption forecasting enables distribution system operators to perform efficient energy management by flexibly engaging energy consumers under the intelligent demand-response program in smart grids (SG). With this motivation, in this paper, a fast and accurate hybrid electrical energy forecasting (FA-HELF) framework is developed. The proposed framework integrates two modules with support vector machine (SVM) based forecaster. These modules are data pre-processing and feature engineering, and modified enhanced differential evolution (mEDE) based optimizer. First, feature selection algorithms like random forests and relief-F are combined to devise a hybrid feature selection algorithm to alleviate redundancy. Secondly, for feature extraction, a radial basis Kernel-based principal component analysis algorithm is employed to eliminate the dimensionality reduction problem. Finally, to conduct accurate and fast electrical energy consumption forecasting, the mEDE based optimizer is integrated with the SVM based forecaster. The resulting FA-HELF framework is tested on publicly available independent system operator New England (ISO-NE) control area hourly load data. The results demonstrate that the FA-HELF framework is robust and shows significant improvements when compared to other benchmark frameworks in terms of accuracy and convergence speed.

MgO is an attractive choice for carcinogenic cell destruction in photodynamic therapy, as confirmed by manifold analysis. The prime focus of the presented research is to investigate the toxicity caused by morphologically different MgO nanostructures obtained by annealing at various annealing temperatures. Smart (stimuli-responsive) MgO nanomaterials are a very promising class of nanomaterials, and their properties can be controlled by altering their size, morphology, or other relevant characteristics. The samples investigated here were grown by the co-precipitation technique. Toxicity-dependent parameters were assessed in a HeLa cell model after annealing the grown samples at 350 °C, 450 °C, and 550 °C. After the overall characterization, an analysis of toxicity caused by changes in the MgO nanostructure morphology was tested in a HeLa cell model using a neutral red assay and microscopy. The feasibility of using MgO for PDT was assessed. Empirical modelling was applied to corroborate the experimental results obtained from assessing cell viability losses and reactive oxygen species. The results indicate that MgO is an excellent candidate material for medical applications and could be utilized for its potential ability to upgrade conventionally used techniques.

With the emergence of the smart grid (SG), real-time interaction is favorable for both residents and power companies in optimal load scheduling to alleviate electricity cost and peaks in demand. In this paper, a modular framework is introduced for efficient load scheduling. The proposed framework is comprised of four modules: power company module, forecaster module, home energy management controller (HEMC) module, and resident module. The forecaster module receives a demand response (DR), information (real-time pricing scheme (RTPS) and critical peak pricing scheme (CPPS)), and load from the power company module to forecast pricing signals and load. The HEMC module is based on our proposed hybrid gray wolf-modified enhanced differential evolutionary (HGWmEDE) algorithm using the output of the forecaster module to schedule the household load. Each appliance of the resident module receives the schedule from the HEMC module. In a smart home, all the appliances operate according to the schedule to reduce electricity cost and peaks in demand with the affordable waiting time. The simulation results validated that the proposed framework handled the uncertainties in load and supply and provided optimal load scheduling, which facilitates both residents and power companies.

Energy consumption forecasting is of prime importance for the restructured environment of energy management in the electricity market. Accurate energy consumption forecasting is essential for efficient energy management in the smart grid (SG); however, the energy consumption pattern is non-linear with a high level of uncertainty and volatility. Forecasting such complex patterns requires accurate and fast forecasting models. In this paper, a novel hybrid electrical energy consumption forecasting model is proposed based on a deep learning model known as factored conditional restricted Boltzmann machine (FCRBM). The deep learning-based FCRBM model uses a rectified linear unit (ReLU) activation function and a multivariate autoregressive technique for the network training. The proposed model predicts future electrical energy consumption for efficient energy management in the SG. The proposed model is a novel hybrid model comprising four modules: (i) data processing and features selection module, (ii) deep learning-based FCRBM forecasting module, (iii) genetic wind driven optimization (GWDO) algorithm-based optimization module, and (iv) utilization module. The proposed hybrid model, called FS-FCRBM-GWDO, is tested and evaluated on real power grid data of USA in terms of four performance metrics: mean absolute percentage deviation (MAPD), variance, correlation coefficient, and convergence rate. Simulation results validate that the proposed hybrid FS-FCRBM-GWDO model has superior performance than existing models such as accurate fast converging short-term load forecasting (AFC-STLF) model, mutual information-modified enhanced differential evolution algorithm-artificial neural network (MI-mEDE-ANN)-based model, features selection-ANN (FS-ANN)-based model, and Bi-level model, in terms of forecast accuracy and convergence rate.