Skin cancer, a common type of cancer, is generally divided into basal cell carcinoma (BCC), squamous cell carcinoma (SCC) and malignant melanoma (MM). The incidence of skin cancer has continued to increase worldwide in recent years. Early detection can greatly reduce its morbidity and mortality. Hyperspectral microscopic imaging (HMI) technology can be used as a powerful tool for skin cancer diagnosis by reflecting the changes in the physical structure and microenvironment of the sample through the differences in the HMI data cube. Based on spectral data, this work studied the staging identification of SCC and the influence of the selected region of interest (ROI) on the staging results. In the SCC staging identification process, the optimal result corresponded to the standard normal variate transformation (SNV) for spectra preprocessing, the partial least squares (PLS) for dimensionality reduction, the hold-out method for dataset partition and the random forest (RF) model for staging identification, with the highest staging accuracy of 0.952 ± 0.014, and a kappa value of 0.928 ± 0.022. By comparing the staging results based on spectral characteristics from the nuclear compartments and peripheral regions, the spectral data of the nuclear compartments were found to contribute more to the accurate staging of SCC.

We report on an improved ytterbium-doped yttrium aluminum garnet thin-disk multi-pass amplifier for kilowatt-level ultrafast lasers, showcasing excellent beam quality. At a repetition rate of 800 kHz, the 6.8 ps, 276 W seed laser is amplified up to an average power of 1075 W, corresponding to a pulse energy of 1.34 mJ. The 36-pass amplifier is designed as a compact mirror array in which the beam alternately propagates between the mirrors and the disk by a quasi-collimated state. We adopted a quasi-collimated propagation to confine stray and diffracted light by the slight curvature of the disk, which enables us to achieve an outstanding extraction efficiency of up to 57% with excellent beam quality in stable laser operation at high power. The beam quality at 1075 W was measured to be M² < 1.51. Furthermore, stability testing was demonstrated with a root-mean-square power fluctuation of less than 1.67% for 10 min.

A photovoltaic panels is a device used for converting solar and other energy into electrical energy. In laser wireless power transmission, there is a problem that the conversion efficiency of the photovoltaic panel is not as high as that of a single photovoltaic cell, and the output power is not as large as expected. This is not conducive to the popularization and use of wireless power transmission via laser. It is important to find out why the output power of the photovoltaic panel irradiated by lasers is not high. According to the laser intensity distribution equation, it is deduced that the laser in a very small area has an equivalent uniformity intensity distribution through the comparative calculation of the light intensity of two adjacent points. Then, the input non-uniform laser can be broken down into many equivalent uniform small lasers with different light intensity values. Based on this theory, the photovoltaic array model under laser was established, and it was simulated by MATLAB/Simulink. The simulation results reveal that the greater the difference between the light intensity values of these small spots, that is to say, the more non-uniform the laser, the lower the output power of the photovoltaic module illuminated by it. A multi-wavelength experimental platform was built, and comparative experiments of laser wireless power transmission were carried out using three kinds of lasers: 808, 532, and 1030 nm. The experimental result was in good agreement with the simulation result. The above results show that the deduced theory and the model based on it are correct.

Significant progress has been made in high-power ultrafast laser technology since the development of diode-pumped solid-state laser systems. Three main types of diode-pumped laser systems, InnoSlab, fiber, and thin disk lasers, offer highly efficient cooling geometries that are essential for high-power ultrafast amplifiers. These systems employ amplifier chain configurations customized to their individual geometries, scaling the low-power seed lasers to high power via multi-pass, multi-stage, and regenerative amplification techniques. The partially end-pumped InnoSlab amplifier is distinguished by its slab-shaped gain medium and a highly compact design. This design offers a large surface-to-volume ratio, moderate gain per pass, and reduced nonlinear effects, facilitating the amplification of low-power ultrafast seed laser pulses to kilowatt-level output power at high repetition rates in the multi-MHz range. This review highlights the characteristics of InnoSlab technology and its amplifier configurations, discussing recent advancements in new cavity designs aimed at enhancing gain and beam quality. Additionally, it covers the mechanisms of generating high peak power few-cycle pulses, including non-linear post-pulse compression. The review also explores the potential applications of InnoSlab systems for generating extreme ultraviolet (XUV) and terahertz (THz) frequencies.

We have theoretically investigated the polarization-dependent ultrashort pulse amplification in erbium-doped fluoride fibers. The numerical model is based on the coupled generalized nonlinear Schrödinger equations and the rate equations. It is found that the Raman effect can be weakened by converting the seed polarization from linear to circular. Compared with the linearly polarized seed pulses, amplification of the circularly polarized seed pulses can generate Raman solitons with a larger pulse energy of the same central wavelength, although more pump power is needed. Furthermore, the amplification dynamics when no pulse splitting occurs have also been investigated. We demonstrate that amplification of the circularly polarized seed pulses allows the main pulse to accumulate more energy while maintaining a single-pulse profile. It is predicted that sub-two-cycle laser pulses at 2.8 μm with megawatt peak power and hundreds of nanojoules pulse energy can be directly generated from the erbium-doped fluoride fiber amplifiers. The investigations conducted in this paper can provide guidelines for the design of Raman-soliton-based tunable fiber laser systems and high-power few-cycle fiber laser systems.