Cristina Salar-Andreu

Dr. Cristina Salar-Andreu


Research Focus & Metrics

Academic Career Length

6Years (2021-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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10 July 2021 in Molecular Neurobiology
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PNPriscila Mantovani Nocetti
Priscila Mantovani Nocetti
AAAdriano Alberti
Adriano Alberti
VFViviane Freiberger
Viviane Freiberger
LVLetícia Ventura
Letícia Ventura
LGLeoberto Ricardo Grigollo
Leoberto Ricardo Grigollo
CCClarissa M. Comim
Clarissa M. Comim

Ferran Cuenca-MartínezFerran Cuenca-Martínez
Ferran Cuenca-Martínez
Luis Suso-MartíLuis Suso-Martí
Luis Suso-Martí
AHAida Herranz-Gómez
Aida Herranz-Gómez
CVClovis Varangot-Reille
Clovis Varangot-Reille
Joaquín CalatayudJoaquín Calatayud
Joaquín Calatayud
Jose Casaña GranellJose Casaña Granell
Jose Casaña Granell
Anxiety, depressive symptoms and stress have a significant influence on chronic musculoskeletal pain. Behavioral modification techniques have proven to be effective to manage these variables; however, the COVID-19 pandemic has highlighted the need for an alternative to face-to-face treatment. We conducted a search of PubMed, the Cumulative Index to Nursing and Allied Health Literature (CINAHL), Web of Science, APA PsychInfo, and Psychological and Behavioural Collections. The aim was to assess the effectiveness of telematic behavioral modification techniques (e-BMT) on psychological variables in patients with chronic musculoskeletal pain through a systematic review with meta-analysis. We used a conventional pairwise meta-analysis and a random-effects model. We calculated the standardized mean difference (SMD) with the corresponding 95% confidence interval (CI). Forty-one randomized controlled trials were included, with a total of 5018 participants. We found a statistically significant small effect size in favor of e-BMT in depressive symptoms (n = 3531; SMD = −0.35; 95% CI −0.46, −0.24) and anxiety (n = 2578; SMD = −0.32; 95% CI −0.42, −0.21) with low to moderate strength of evidence. However, there was no statistically significant effect on stress symptoms with moderate strength of evidence. In conclusion, e-BMT is an effective option for the management of anxiety and depressive symptoms in patients with chronic musculoskeletal pain. However, it does not seem effective to improve stress symptoms.

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JTJose Pablo Trana
Jose Pablo Trana
COCristina Orts
Cristina Orts
FMFrancisco Javier Molina
Francisco Javier Molina
Sergio Montero-NavarroSergio Montero-Navarro
Sergio Montero-Navarro
JBJose Martin Botella-Rico
Jose Martin Botella-Rico
CSCristina Salar-Andreu
Cristina Salar-Andreu
Background/Objectives: The aim of this diagnostic accuracy study was to evaluate the usefulness of transperineal ultrasound parameters of urethral instability for assessing the severity of stress urinary incontinence (SUI) in women and their relationship with health-related quality of life (HRQOL). Methods: This cross-sectional study included 240 women with symptomatic SUI (mean age 41 years). Severity was classified using the Sandvik Severity Index (reference standard). Transperineal ultrasound (index test) was performed to measure the retrovesical angle (RVA) at rest and during Valsalva manoeuvre, bladder neck descent (BND), and urethral rotation angle (URA). Impact on HRQOL was assessed with the ICIQ-SF and King’s Health Questionnaire (KHQ). Operators were blinded to clinical data and vice versa. Results: The RVA at rest showed the best discriminatory capacity for identifying severe/very severe SUI (AUC 0.83, 95% CI 0.77–0.89; sensitivity 71%, specificity 84%), with an optimal cut-off value of 118.1° (adjusted for age, BMI and miscarriage). RVA values increased progressively with SUI severity both at rest and during Valsalva (p < 0.001). Significant positive correlations were found between RVA and ICIQ-SF scores (ρ2 = 0.412 at rest, p < 0.001). In contrast, URA remained within normal limits (<20°) and did not differ across severity groups. Conclusions: Transperineal ultrasound measurement of the RVA at rest is a reliable, non-invasive parameter for grading SUI severity and correlates with its impact on HRQOL. These findings suggest that RVA at rest has good discriminatory capacity for identifying women with severe or very severe SUI and may have potential as an adjunct to clinical assessment. However, given the moderate sensitivity observed and the lack of data on management outcomes, prospective studies are needed to determine its utility in guiding referral or treatment decisions.

16 October 2025 in Encyclopedia
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MFMaria Figueroa-Mayordomo
Maria Figueroa-Mayordomo
CSCristina Salar-Andreu
Cristina Salar-Andreu
Julio Fernández GarridoJulio Fernández Garrido
Julio Fernández Garrido
LLLuis González Lago
Luis González Lago
Josep C. Benítez-MartínezJosep C. Benítez-Martínez
Josep C. Benítez-Martínez
Objectives: This systematic review aimed to examine hip rotator range of motion (ROM) and strength values across athletic, injured, and non-active populations, and to determine how these values differ when measured at different hip flexion angles. Methods: A systematic literature search was conducted in accordance with PRISMA guidelines across six electronic databases (PubMed, Scopus, Web of Science, SPORTDiscus, CINAHL, and Medline) from inception to June 2025. Eligible studies included observational, cross-sectional, case-control, or randomized controlled trial (RCT) studies that quantitatively assessed hip IR/ER ROM and/or strength in defined population groups (athletic, injured, or non-active). Two reviewers independently screened titles, abstracts, and full texts, extracted data on study design, population characteristics, measurement methods, and outcome variables, and assessed risk of bias using an established tool. Discrepancies were resolved by a third reviewer. Results: 11 studies met the inclusion criteria, including 1276 participants across athletic, injured, and non-active populations. Hip rotator ROM was measured in nine studies and strength in three, with varying testing angles (0° and/or 90° hip flexion). Overall, athletes showed greater ROM at 0° compared to injured and non-active groups, but had reduced ROM at 90° relative to non-active participants. Non-active individuals had the lowest ROM at 0°. Strength findings, though limited, indicated higher values at 90° than at 0°. Conclusions: Hip rotator ROM and strength vary across populations and testing angles, with ROM generally lower and strength higher at 90° of hip flexion. Due to methodological inconsistencies, findings should be interpreted as directional evidence, reinforcing the need for standardized assessment protocols in future research.

9 June 2026 in Healthcare
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Journal Article
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JTJose Pablo Trana
Jose Pablo Trana
COCristina Orts
Cristina Orts
Sergio Montero-NavarroSergio Montero-Navarro
Sergio Montero-Navarro
ASAndres Zamora Streber
Andres Zamora Streber
MRMaría José Ramirez Rivera
María José Ramirez Rivera
CSCristina Salar-Andreu
Cristina Salar-Andreu
Background: Stress urinary incontinence (SUI) is defined as involuntary urine loss during activities that increase intra-abdominal pressure. It is highly prevalent among women and significantly affects physical, emotional, and social well-being. Pelvic floor muscle training (PFMT) is the gold-standard conservative therapy. Second-generation radiofrequency (RF) therapy has shown promise as an alternative. It stimulates collagen synthesis and promotes tissue remodeling. This study will compare the effects of PFMT, RF, and their combination on pelvic floor function, urethral stability, and health-related quality of life (HRQoL) in women with SUI due to urethral hypermobility. Methods/Design: This will be a single-blinded, three-arm, randomized controlled trial conducted at Clínica Traña (San José, Costa Rica). Women aged ≥18 years with clinically confirmed SUI and a retrovesical (β) angle ≥ 140° during the Valsalva maneuver on functional transperineal ultrasound will be randomized (1:1:1) to PFMT (16 weeks, twice-weekly supervised sessions), RF (5 weekly sessions using Capenergy® C500 Urogyne), or combined RF + PFMT (39 per arm; total N = 117 accounting for 30% attrition). The primary outcome is the change from baseline in pelvic floor muscle strength at 12 months post-intervention, measured by the modified Oxford scale and vaginal manometry. Secondary outcomes will include urethral stability (retrovesical β angle and bladder neck descent on ultrasound), incontinence severity (Sandvik Severity Index), and HRQoL (ICIQ-UI SF and King’s Health Questionnaire). All outcomes will be assessed at baseline, immediately post-intervention, 15 days, 3 months, 6 months, and 12 months follow-up. Assessments will be performed by blinded evaluators. Analysis will follow intention-to-treat principles using repeated-measures ANOVA or non-parametric equivalents (SPSS v.29; p < 0.05). The trial was prospectively registered on ClinicalTrials.gov (NCT07095283, registered on 24 July 2025), prior to the recruitment of the first participant. Expected outcomes: This study will provide comparative effectiveness data on whether the addition of RF to PFMT offers additional benefits over PFMT alone in the management of SUI.