Although, quantum dots (QDs) of two-dimensional (2D) molybdenum disulfide (MoS₂) have shown great potential for various applications, such as sensing, catalysis, energy storage, and electronics. However, the lack of a simple, scalable, and inexpensive fabrication method for QDs is still a challenge. To overcome this challenge, a lot of attention has been given to the fabrication of QDs, and several fabrication strategies have been established. These exfoliation processes are mainly divided into two categories, the ‘top-down’ and ‘bottom-up’ methods. In this review, we have discussed different top-down exfoliation methods used for the fabrication of MoS₂ QDs and the advantages and limitations of these methods. A detailed description of the various properties of QDs is also presented.