Several factors may increase the risk of development of ovarian cancer. In this study, we investigated the relationship between social, genetic, and histopathologic factors in women with ovarian serous cystadenocarcinoma and titin (TTN) mutations, whether the TTN gene mutation may be a predictor, and its impact on mortality and survival in these patients. A total of 585 samples from patients with ovarian serous cystadenocarcinoma were collected from The Cancer Genome Atlas and PanCancer Atlas through the cBioPortal for analysis of social, genetic, and histopathological factors. Logistic regression was used to investigate whether TTN mutation could be a predictor, and the Kaplan–Meier method was applied to analyze survival time. TTN mutation frequency did not differ between age at diagnosis, tumor stage, and race, and was related to increased Buffa hypoxia score (p = 0.004), mutation count (p < 0.0001), Winter hypoxia Score (p = 0.030), nonsynonymous tumor mutation burden (TMB) (p < 0.0001), and reduced microsatellite instability sensor score (p = 0.010). The number of mutations (p < 0.0001) and winter hypoxia score (p = 0.008) were positively associated with TTN mutations, and nonsynonymous TMB (p < 0.0001) proved to be a predictor. Mutated TTN affects the score of genetic variables involved in cancer cell metabolism in ovarian cystadenocarcinoma.

The lack of knowledge by health professionals in the management of scoliosis can lead to an erroneous diagnosis. The aim of the current study was to understand the influence of length of professional experience on the knowledge of Brazilian physical therapists regarding international guidelines for the treatment of adolescent idiopathic scoliosis. The study was conducted using an online questionnaire consisting of 23 questions, divided into 8 questions on sociodemographic data and 15 questions based on information provided by the guidelines in the SOSORT 2016. In total, 506 physiotherapists were interviewed, and they comprised the study sample. The results showed that professionals who have been working for more than 6 years in the field have greater knowledge of AIS, seek to become more professional, and with that, have an understanding of AIS that is more aligned with the SOSORT. Length of experience made a difference when considering knowledge of the treatment of idiopathic scoliosis. The present study showed that a time since graduation of 6 years or more was satisfactory.

Objectives: To analyze the level of knowledge of health professionals about the practice of early mobilization (EM) in a reference university hospital in Belém do Pará. Methods: Analytical, cross-sectional, quantitative, single center study with health professionals who are part of the assistance of the João de Barros Barreto University Hospital. The questionnaire was reproduced through the online tool Google Forms. The professionals had access through a link. To compare the results of the questionnaires, as well as the association between the professional category and the items answered, the text Chi Square was used, adopting a significance level (p value) ? 5%. To study the agreement on the indications and contraindications of early mobilization among professionals, the Kappa indicator was used. Results: The sample consisted of 78 professionals, the work sector in which more professionals participated was the Intensive Care Unit with 37 (37.4%) individuals, with the professionals working mostly in the morning shift. About 80% (p= 0.001) of hospital health professionals reported having knowledge about early mobilization. Conclusion: In general, the professionals who most knew the indications and contraindications/interruption criteria for EM were the physiotherapists. The hospital's multidisciplinary team has knowledge about the practice of early mobilization. Resumen Objetivos: Analizar el nivel de conocimiento de los profesionales de la salud sobre la práctica de la movilización temprana (PM) en un hospital universitario de referencia en Belém do Pará. Métodos: Estudio analítico, transversal, cuantitativo, unicéntrico con profesionales de la salud que forman parte de la asistencia del Hospital Universitario João de Barros Barreto. El cuestionario fue reproducido a través de la herramienta en línea Google Forms. Los profesionales tenían acceso a través de un enlace. Para la comparación entre los resultados de los cuestionarios, así como la asociación entre la categoría profesional y los ítems respondidos, se utilizó la prueba de chi-cuadrado, adoptando un nivel de significancia (valor de p) ? 5%. Para estudiar la concordancia sobre las indicaciones y contraindicaciones de la movilización precoz entre los profesionales se utilizó el indicador Kappa. Resultados: La muestra estuvo compuesta por 78 profesionales, el sector de trabajo en el que más profesionales participaron fue la Unidad de Cuidados Intensivos con 37 (37,4%) individuos, y los profesionales actúan mayoritariamente en el turno matutino. Se observó que cerca del 80% (p =0,001) de los profesionales de salud del hospital informaron tener conocimientos sobre movilización temprana. Conclusión: En general, los profesionales que más conocían las indicaciones y contraindicaciones/criterios de interrupción de la MP eran los fisioterapeutas. El equipo multidisciplinario tiene conocimiento sobre la práctica de la movilización temprana. Objetivo: analisar o nível de conhecimento dos profissionais da saúde acerca da prática de Mobilização Precoce (MP) em um hospital universitário de referência de Belém do Pará. Métodos: estudo analítico, transversal, quantitativo, de centro único, com os profissionais da saúde que fazem parte da assistência do Hospital Universitário João de Barros Barreto. O questionário foi reproduzido por intermédio da ferramenta on-line Google Forms. Os profissionais tiveram acesso por meio de um link. Para a comparação entre os resultados dos questionários, assim como a associação entre a categoria profissional e os itens respondidos, foi utilizado o teste qui-quadrado, adotando-se nível de significância (p valor) ? 5%. Para o estudo da concordância sobre as indicações e as contraindicações da MP entre os profissionais, foi utilizado o indicador de Kappa. Resultados: a amostra consistiu em 78 profissionais, o setor de trabalho em que mais profissionais participaram foi a Unidade de Terapia Intensiva com 37 (37,4%) indivíduos, sendo que os profissionais trabalham, em grande parte, no turno da manhã. Observou-se que cerca de 80% (p = 0,001) dos profissionais de saúde do hospital relataram ter conhecimento sobre a MP. Conclusão: de modo geral, os profissionais que mais souberam as indicações e as contraindicações/critérios de interrupção para a MP foram os fisioterapeutas. A equipe multiprofissional possui conhecimento sobre a prática de MP.