Biopesticides are pest and pathogen management agents based on living microorganisms or natural products (botanical origin). Due to their natural origins, they stand out as an environmentally friendly tool, since they quickly decompose and minimize pollution problems produced by synthetic pesticides. However, these products present significant challenges that affect the bioactivities of the active components, due to the degradation of the biomass or bioactive metabolite by factors such as air, light, and temperature. Therefore, in this study, a systematic search of the Scopus database was conducted and scientometric tools were used to evaluate formulation techniques and approaches that seek to improve the bioactivities of natural preparations. The results showed that published research on biopesticides has significantly increased by 71.24% in the last decade (2011–2021). Likewise, the bibliometrics showed, through temporal flow analysis, and in the period from 2010 to 2021, investigations evolved have toward the use of nanotechnology, with the purpose of improving and potentiating the formulations of biopesticides. Consequently, nanotechnology tools can be classified as current strategies of interest that allow the increase and protection of bioefficacy to a greater extent than traditional biopesticide preparations. This review constitutes an important contribution to future research and expands the panorama in relation to biopesticide formulations for the control of agricultural pests.

Sacha inchi (Plukenetia volubilis L.) seeds were employed for oil extraction with supercritical CO2 at laboratory scale. The supercritical extraction was carried out at a temperature of 60 °C, pressure range of 400–500 bars and CO2 flow of 40–80 g/min. The maximum recovery was 58% in 180 min, favored by increasing the residence time of CO2 in the extraction tank. Subsequently, the process was evaluated at pilot scale reaching a maximum recovery of 60% in 105 min, with a temperature of 60 °C, pressure of 450 bars and CO2 flow of 1270 g/min. The fatty acid composition of the oil was not affected for an extraction period of 30–120 min. The Sacha inchi oil was fractionated with supercritical CO2 to obtain an omega-3 concentrate oil without finding a considerable increase in the proportion of this compound, due to the narrow range in the carbon number of fatty acids present in the oil (16–18 carbons), making it difficult for selective separation.