Background: This study challenges state-of-the-art cardiac amyloidosis (CA) diagnostics by feeding multi-chamber strain and cardiac function into supervised machine (SVM) learning algorithms. Methods: Forty-three CA (32 males; 79 years (IQR 71; 85)), 20 patients with hypertrophic cardiomyopathy (HCM, 10 males; 63.9 years (±7.4)) and 44 healthy controls (CTRL, 23 males; 56.3 years (IQR 52.5; 62.9)) received cardiovascular magnetic resonance imaging. Left atrial, right atrial and right ventricular strain parameters and cardiac function generated a 41-feature matrix for decision tree (DT), k-nearest neighbor (KNN), SVM linear and SVM radial basis function (RBF) kernel algorithm processing. A 10-feature principal component analysis (PCA) was conducted using SVM linear and RBF. Results: Forty-one features resulted in diagnostic accuracies of 87.9% (AUC = 0.960) for SVM linear, 90.9% (0.996; Precision = 94%; Sensitivity = 100%; F1-Score = 97%) using RBF kernel, 84.9% (0.970) for KNN, and 78.8% (0.787) for DT. The 10-feature PCA achieved 78.9% (0.962) via linear SVM and 81.8% (0.996) via RBF SVM. Explained variance presented bi-atrial longitudinal strain and left and right atrial ejection fraction as valuable CA predictors. Conclusion: SVM RBF kernel achieved competitive diagnostic accuracies under supervised conditions. Machine learning of multi-chamber cardiac strain and function may offer novel perspectives for non-contrast clinical decision-support systems in CA diagnostics.

Background: Hindered by its unspecific clinical and phenotypical presentation, cardiac sarcoidosis (CS) remains a challenging diagnosis. Objective: Utilizing cardiac magnetic resonance imaging (CMR), we acquired multi-chamber volumetrics and strain feature tracking for a support vector machine learning (SVM)-based diagnostic approach to CS. Method: Forty-five CMR-negative (CMR(−), 56.5(53.0;63.0)years), eighteen CMR-positive (CMR(+), 64.0(57.8;67.0)years) sarcoidosis patients and forty-four controls (CTRL, 56.5(53.0;63.0)years)) underwent CMR examination. Cardiac parameters were processed using the classifiers of logistic regression, KNN(K-nearest-neighbor), DT (decision tree), RF (random forest), SVM, GBoost, XGBoost, Voting and feature selection. Results: In a three-cluster analysis of CTRL versus vs. CMR(+) vs. CMR(−), RF and Voting classifier yielded the highest prediction rates (81.82%). The two-cluster analysis of CTRL vs. all sarcoidosis (All Sarc.) yielded high prediction rates with the classifiers logistic regression, RF and SVM (96.97%), and low prediction rates for the analysis of CMR(+) vs. CMR(−), which were augmented using feature selection with logistic regression (89.47%). Conclusion: Multi-chamber cardiac function and strain-based supervised machine learning provides a non-contrast approach to accurately differentiate between healthy individuals and sarcoidosis patients. Feature selection overcomes the algorithmically challenging discrimination between CMR(+) and CMR(−) patients, yielding high accuracy predictions. The study findings imply higher prevalence of cardiac involvement than previously anticipated, which may impact clinical disease management.

Supply chains for embedded hardware devices are subject to a variety of security threats that are concerning to governments and industry. Such threats include counterfeit parts, cyber-attacks, Trojan attacks, reliance on offshore-manufactured and controlled hardware, software, and rapid increase of network technologies. Addressing these threats is vital to maintain and enhance system trust and security. This article develops a framework to address initiatives and success criteria which accounts for different perspectives of system stakeholders and identify different potential emergent conditions and scenarios which are most and least impactful to the trust and security of the supply chain. The article demonstrates a research and development priorities preferences method that accounts for evolving perspectives of supply chain stakeholders and describing the example application of embedded hardware devices as a system.

Artificial intelligence (AI) is advancing across technology domains including healthcare, commerce, the economy, the environment, cybersecurity, transportation, etc. AI will transform healthcare systems, bringing profound changes to diagnosis, treatment, patient care, data, medicines, devices, etc. However, AI in healthcare introduces entirely new categories of risk for assessment, management, and communication. For this topic, the framing of conventional risk and decision analyses is ongoing. This paper introduces a method to quantify risk as the disruption of the order of AI initiatives in healthcare systems, aiming to find the scenarios that are most and least disruptive to system order. This novel approach addresses scenarios that bring about a re-ordering of initiatives in each of the following three characteristic layers: purpose, structure, and function. In each layer, the following model elements are identified: 1. Typical research and development initiatives in healthcare. 2. The ordering criteria of the initiatives. 3. Emergent conditions and scenarios that could influence the ordering of the AI initiatives. This approach is a manifold accounting of the scenarios that could contribute to the risk associated with AI in healthcare. Recognizing the context-specific nature of risks and highlighting the role of human in the loop, this study identifies scenario s.06—non-interpretable AI and lack of human–AI communications—as the most disruptive across all three layers of healthcare systems. This finding suggests that AI transparency solutions primarily target domain experts, a reasonable inclination given the significance of “high-stakes” AI systems, particularly in healthcare. Future work should connect this approach with decision analysis and quantifying the value of information. Future work will explore the disruptions of system order in additional layers of the healthcare system, including the environment, boundary, interconnections, workforce, facilities, supply chains, and others.