Introduction: Metabolic dysfunction-associated steatotic liver disease (MASLD) prevalence data in Türkiye is limited. We aimed to determine the nationwide prevalence of MASLD and advanced hepatic fibrosis risk in subjects with cardiometabolic risk factors (CMRF). Despite recent international consensus redefining fatty liver disease terminology, no nationwide MASLD study has been reported in Türkiye. Methods: This cross-sectional study included 14,371 adults with ≥1 CMRF from 44 centers across 31 cities. MASLD was diagnosed using liver ultrasonography plus cardiometabolic criteria. Advanced fibrosis risk was assessed by fibrosis-4 (FIB-4) score (≥1.3 for ≤65 years; ≥2.0 for >65 years). Logistic regression was used to identify independent predictors of high FIB-4. Results: A total of 61.4% of participants were women, the mean age was 51.3 ± 14.4 years, and the mean BMI was 31.4 ± 6.0 kg/m². MASLD prevalence was 75.7% (n = 10,873), rising with the number of CMRFs (56.5% with one factor vs. 83.4% with all). The prevalence of high FIB-4 scores was 12.0% overall, being lower in MASLD patients than non-MASLD patients (11.2% vs. 14.4%, p < 0.001). FIB-4 scores decreased with increasing BMI (28.1% underweight vs. 8.7% class III obesity). Male sex, T2DM, and hypertension independently predicted high FIB-4 scores, while smoking, higher BMI, and MASLD were inversely associated. Conclusions: Three-quarters of Turkish adults with CMRF have MASLD. Standard FIB-4 thresholds may underestimate fibrosis risk in obese and smoking populations, underscoring the need for adjusted cut-offs or alternative tools. This study is the first to provide nationwide MASLD prevalence data in Türkiye.

Objectives: Cupping therapy (CT) is an ancient medical treatment since antiquity and is used for the treatment of such various disease states as contagious diseases, chronic or acute inflammatory disease, and autoimmune disorders. Ventricular repolarization is represented by QT and corrected-QT (QTc) intervals from surface ECG. As novel repolarization parameters, Tpeak-toTend (Tp-Te) interval, and Tp-Te/QT and Tp-Te/QTc ratios are suggested to correlate better with ventricular arrhythmia risk in various clinical conditions than sole QT and QTc intervals. In this study, we aimed to determine whether these parameters changed significantly after cupping therapy in healthy individuals. Methods: One hundred and twenty subjects (57 women and 63 men; mean age 49.0 ± 13.0 years) participated in this study. ECGs strips were recorded 1 hour before and 1 hour after cupping therapy from each participant, and relevant ECG parameters were compared. Results: No statistically significant change was observed in mean heart rate, QT and QTc intervals, QT/QRS and cQT/QRS, and frontal QRS/T angle after the procedure compared with the same parameters before the procedure (p >0.05). However, Tp-Te interval [69.51 ± 11.54 msec vs 63.15 ± 10.89 msec, p= 0.001], Tp-Te/QT ratio [0.191 ± 0.030 vs 0.174 ± 0.031, p=0.002] and Tp-Te/QTc ratio [0.175 ± 0.030 vs 0.159 ± 0.026, p=0.001] were found to be significantly decreased 1 hour following the procedure compared with the pre-procedure values. Conclusions: According to the results of our study, it is plausible to conclude that CT may exert cardioprotective effect. However, larger-scale prospective studies are needed to support our findings.

Aim: The phase angle obtained from the maximum reactance (PA max) is a better potential indicator than the phase angles obtained from multiple frequencies. Our aim in this study is to investigate the correlation of PA max with fasting glucose and hemoglobin A1c in Type-2 Diabetes Mellitus (T2 DM). Material and Methods: The study was conducted prospectively, two groups were formed as T2 DM (n=75) and healthy controls (n=32) and their demographic variables were examined. Right hand, left hand, right leg, left leg, hand leg and leg leg segment measurements were taken with electrical impedance method and phase angle was obtained at maximum reactance. Correlations with fasting glucose, hemoglobin A1c and other variables were examined. Results: Fasting glucose, glycated hemoglobin A1c, age, body mass index, body fat percentage were found to be significantly higher in the T2 DM group compared with the healthy group. However, RH PA max, RL PA max, LL PA max, H_L PA max, and L_L PA max values were found to be significantly lower than in the healthy group. In T2 DM group, hemoglobin A1c was found significantly negative correlated with PA max in all segments, while fasting glucose is negatively correlated with all segments except LH Pamax. Conclusion: PA max is significantly reduced by the impaired glycemic index in T2 DM and is a potential marker reflecting metabolic status.

Background:Metabolic age is an important risk marker that can be easily understood by patients in clinical practice. In this study, we aimed to investigate the association of metabolic age with chronological age and physical examination score in male and female patients with type 2 diabetes mellitus. Material and Method:Male (n:50) and female patients (n:72) with T2DM were included in the study. Anthropometric measurements were obtained with Tanita MC-780MA device, waist/hip and waist/height ratios were calculated, variables were compared between groups and correlation with met age was analyzed. Linear regression analysis was used to determine the factors affecting met age. Results:The difference between met-age and chronological age was significantly higher in female patients with T2DM (age difference: 6.0∓3.79 in female group, 3.38∓2.80 in male group) (p<0.001). BMI values, degree of obesity and fat mass were significantly higher in women (p<0.001), waist/hip ratios were lower (p<0.001) and waist/height ratios were higher (p=0.001). Physical examination score, muscle mass, lean mass and BMR were higher in men than in women (p<0.001).There was a significant positive association of met age with chronological age and a significant negative association with physical examination score in both sexes (p<0.05). According to the linear regression model, it was found that met age was positively affected by chronological age and waist/height ratio and negatively affected by physical examination score in the female group (R2 =0.983).In the male group, it was observed that it was positively affected by chronological age, obesity degree, body mass index (BMI) and negatively affected by physical examination score (R2 =0.974). Conclusions:Met age increases with increasing chronological age and decreasing physical examination score in male and female patients with T2DM.

Background: Metabolic age (met-age), a risk marker, may vary within the same chronological age group. Its association with chronological age, waist/height ratio, obesity degree, body mass index (BMI), and physical rating score (PRS)—risk factors for type 2 diabetes—remains unexplored. Methods: A total of 122 type 2 diabetes patients (50 males, 72 females) were analyzed. Bioimpedance measurements were taken using the Tanita MC-780MA, alongside anthropometric data. Variables were compared, and correlations with met-age were assessed. Results: The met-age–chronological age difference was higher in females with type 2 diabetes (p < 0.001). Females also had higher BMI, obesity degree, fat mass, and waist/height ratio (p < 0.05), but lower waist/hip ratio (p < 0.001). Males showed higher PRS, muscle mass, and fat-free mass (p < 0.001). Met-age positively correlated with chronological age and negatively with PRS in both sexes (p < 0.05). According to the linear regression model, in females, the met-age was influenced positively by chronological age and waist/height ratio and negatively by PRS (R² = 0.983). In males, it was positively influenced by chronological age, obesity grade, and BMI, but negatively by PRS (R² = 0.974). Conclusions: Met-age correlates with chronological age and PRS in type 2 diabetes patients. It increases with advancing age and lower PRS, with waist/height ratio impacting females and BMI/obesity degree affecting males.