May Griffith

Prof. May Griffith

orcid

Research Focus & Metrics

Academic Career Length

37Years (1990-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

View All Publications
8 January 2016 in International Journal of Polymeric Materials and Polymeric Biomaterials
Verified
Journal Article
Closed access
DMDebasish Mondal
Debasish Mondal
MGMay Griffith
May Griffith
SVSubbu Venkatraman
Subbu Venkatraman
Recently, poly (є-caprolactone) (PCL) has gained a lot of attention, and shown great potential in biomedical applications. Among synthetic polymers, PCL is one of the easiest to process and manipulate into a large range of shapes and sizes due to its low melting temperature and its superior viscoelastic properties. In this review article the authors focus mainly on the properties of PCL-based biomaterials relevant to drug delivery and tissue engineering applications. The authors provide an insight into the recent developments and challenges of PCL-based biomaterials as a critical component of new therapeutic strategies for many diseases.

10 December 1999 in Science
Verified
Journal Article
Closed access
PDF file
MGMay Griffith
May Griffith
RORosemarie Osborne
Rosemarie Osborne
RMRejean Munger
Rejean Munger
XXXiaojuan Xiong
Xiaojuan Xiong
CDCharles J. Doillon
Charles J. Doillon
Mitchell WatskyMitchell Watsky
Mitchell Watsky
Human corneal equivalents comprising the three main layers of the cornea (epithelium, stroma, and endothelium) were constructed. Each cellular layer was fabricated from immortalized human corneal cells that were screened for use on the basis of morphological, biochemical, and electrophysiological similarity to their natural counterparts. The resulting corneal equivalents mimicked human corneas in key physical and physiological functions, including morphology, biochemical marker expression, transparency, ion and fluid transport, and gene expression. Morphological and functional equivalents to human corneas that can be produced in vitro have immediate applications in toxicity and drug efficacy testing, and form the basis for future development of implantable tissues.

1 October 2008 in Biomaterials
Verified
Journal Article
Closed access
MRMehrdad Rafat
Mehrdad Rafat
FLFengfu Li
Fengfu Li
PFPer Fagerholm
Per Fagerholm
NLNeil Satish Lagali
Neil Satish Lagali
Mitchell WatskyMitchell Watsky
Mitchell Watsky
MGMay Griffith
May Griffith

25 August 2010 in Science Translational Medicine
Verified
Journal Article
Closed access
PDF file
PFPer Fagerholm
Per Fagerholm
NLNeil Satish Lagali
Neil Satish Lagali
KMKimberley Merrett
Kimberley Merrett
WJW. Bruce Jackson
W. Bruce Jackson
RMRejean Munger
Rejean Munger
MGMay Griffith
May Griffith
A biosynthetic cornea is stably integrated with host tissues for 2 years after implantation and produces nerve regeneration and vision improvement.

1 May 2021 in iScience
Verified
Journal Article
Open access
IGIrene Guzmán-Soto
Irene Guzmán-Soto
CMChristopher McTiernan
Christopher McTiernan
MGMayte Gonzalez-Gomez
Mayte Gonzalez-Gomez
ARAlex Ross
Alex Ross
KGKeshav Gupta
Keshav Gupta
EAEmilio Alarcon
Emilio Alarcon
Biofilm formation in living organisms is associated to tissue and implant infections, and it has also been linked to the contribution of antibiotic resistance. Thus, understanding biofilm development and being able to mimic such processes is vital for the successful development of antibiofilm treatments and therapies. Several decades of research have contributed to building the foundation for developing in vitro and in vivo biofilm models. However, no such thing as an “all fit” in vitro or in vivo biofilm models is currently available. In this review, in addition to presenting an updated overview of biofilm formation, we critically revise recent approaches for the improvement of in vitro and in vivo biofilm models.

1 March 2014 in Biomaterials
Verified
Journal Article
Open access
PFPer Fagerholm
Per Fagerholm
NLNeil Satish Lagali
Neil Satish Lagali
JOJeb A. Ong
Jeb A. Ong
KMKimberley Merrett
Kimberley Merrett
WJW. Bruce Jackson
W. Bruce Jackson
MGMay Griffith
May Griffith
We developed cell-free implants, comprising carbodiimide crosslinked recombinant human collagen (RHC), to enable corneal regeneration by endogenous cell recruitment, to address the worldwide shortage of donor corneas. Patients were grafted with RHC implants. Over four years, the regenerated neo-corneas were stably integrated without rejection, without the long immunosuppression regime needed by donor cornea patients. There was no recruitment of inflammatory dendritic cells into the implant area, whereas, even with immunosuppression, donor cornea recipients showed dendritic cell migration into the central cornea and a rejection episode was observed. Regeneration as evidenced by continued nerve and stromal cell repopulation occurred over the four years to approximate the micro-architecture of healthy corneas. Histopathology of a regenerated, clear cornea from a regrafted patient showed normal corneal architecture. Donor human cornea grafted eyes had abnormally tortuous nerves and stromal cell death was found. Implanted patients had a 4-year average corrected visual acuity of 20/54 and gained more than 5 Snellen lines of vision on an eye chart. The visual acuity can be improved with more robust materials for better shape retention. Nevertheless, these RHC implants can achieve stable regeneration and therefore, represent a potentially safe alternative to donor organ transplantation.