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Recently, inflammasomes such as NLRP3 as cytosolic pattern-recognition receptors have been implicated in the development of inflammation; however, limited investigations report the circulating levels of this protein. The objective, thus, was to investigative circulating NLRP3 levels in Saudi patients with a low-grade inflammatory disorder called metabolic syndrome (MetS). Two hundred Saudi adults aged 30–65, with or without MetS diagnosed on the basis of National Cholesterol Education Programme Adult Treatment Panel III (NCEP ATP III) criteria, were randomly recruited. Five MetS components were established according to the diagnostic criteria in the study subjects. Circulating levels of NLRP3 and known inflammation markers, such as tumor necrosis factor α (TNF-α), C-reactive protein (CRP) and interleukins (IL-1β and IL-18), were measured in the blood samples taken from the study subjects. Gender-based analysis showed a significant elevated circulating levels of NLRP3 in non-MetS men compared to non-MetS females (p< 0.001). Moreover, an increase in circulating levels of NLRP3 with a number of MetS components (p = 0.038) was observed only in females. A significant positive correlation of NLRP3 levels with age (r = 0.20, p = 0.04), BMI (r = 0.32, p< 0.01) and waist (r = 0.24, p = 0.02) and a significant negative correlation between NLRP3 and HDL-cholesterol (r= −0.21, p = 0.03) were also observed in females. Logistic regression analysis also yielded a sex-specific positive association of NLRP3 with MetS in females, with this association influenced mostly by central obesity and dyslipidemia components of MetS. In conclusion, this study suggests a sexual disparity in the circulating levels of NLRP3, with a trend of increasing circulating NLRP3 levels with increasing MetS components observed only in females, influenced mostly by adiposity and dyslipidemia components of MetS. Longitudinal studies with a larger sample size and investigating sex-specific hormones with NLRP3 would be needed to establish a causal relationship of NLRP3 with MetS.
Nasser Al-Daghri; Kaiser Wani; Hind AlHarthi; Amani Alghamdi; Abdullah Alnaami; Sobhy Yakout. Sex-Specific Signature in the Circulating NLRP3 Levels of Saudi Adults with Metabolic Syndrome. Journal of Clinical Medicine 2021, 10, 3288 .
AMA StyleNasser Al-Daghri, Kaiser Wani, Hind AlHarthi, Amani Alghamdi, Abdullah Alnaami, Sobhy Yakout. Sex-Specific Signature in the Circulating NLRP3 Levels of Saudi Adults with Metabolic Syndrome. Journal of Clinical Medicine. 2021; 10 (15):3288.
Chicago/Turabian StyleNasser Al-Daghri; Kaiser Wani; Hind AlHarthi; Amani Alghamdi; Abdullah Alnaami; Sobhy Yakout. 2021. "Sex-Specific Signature in the Circulating NLRP3 Levels of Saudi Adults with Metabolic Syndrome." Journal of Clinical Medicine 10, no. 15: 3288.
Objective: Vitamin D deficiency has been associated with an increased risk of COVID-19 severity. This multi-center randomized clinical trial aims to determine the effects of 5000 IU versus 1000 IU daily oral vitamin D3 supplementation in the recovery of symptoms and other clinical parameters among mild to moderate COVID-19 patients with sub-optimal vitamin D status. Study Design and Setting: A total of 69 reverse transcriptase polymerase chain reaction (RT-PCR) SARS-CoV-2 positive adults who were hospitalized for mild to moderate COVID-19 disease were allocated to receive once daily for 2 weeks either 5000 IU oral vitamin D3 (n = 36, 21 males; 15 females) or 1000 IU oral vitamin D3 (standard control) (n = 33, 13 males; 20 females). Anthropometrics were measured and blood samples were taken pre- and post-supplementation. Fasting blood glucose, lipids, serum 25(OH)D, and inflammatory markers were measured. COVID-19 symptoms were noted on admission and monitored until full recovery. Results: Vitamin D supplementation for 2 weeks caused a significant increase in serum 25(OH)D levels in the 5000 IU group only (adjusted p = 0.003). Within-group comparisons also showed a significant decrease in BMI and IL-6 levels overtime in both groups (p-values < 0.05) but was not clinically significant in between-group comparisons. Kaplan–Meier survival analysis revealed that the 5000 IU group had a significantly shorter time to recovery (days) than the 1000 IU group in resolving cough, even after adjusting for age, sex, baseline BMI, and D-dimer (6.2 ± 0.8 versus 9.1 ± 0.8; p = 0.039), and ageusia (loss of taste) (11.4 ± 1.0 versus 16.9 ± 1.7; p = 0.035). Conclusion: A 5000 IU daily oral vitamin D3 supplementation for 2 weeks reduces the time to recovery for cough and gustatory sensory loss among patients with sub-optimal vitamin D status and mild to moderate COVID-19 symptoms. The use of 5000 IU vitamin D3 as an adjuvant therapy for COVID-19 patients with suboptimal vitamin D status, even for a short duration, is recommended.
Shaun Sabico; Mushira Enani; Eman Sheshah; Naji Aljohani; Dara Aldisi; Naif Alotaibi; Naemah Alshingetti; Suliman Alomar; Abdullah Alnaami; Osama Amer; Syed Hussain; Nasser Al-Daghri. Effects of a 2-Week 5000 IU versus 1000 IU Vitamin D3 Supplementation on Recovery of Symptoms in Patients with Mild to Moderate Covid-19: A Randomized Clinical Trial. Nutrients 2021, 13, 2170 .
AMA StyleShaun Sabico, Mushira Enani, Eman Sheshah, Naji Aljohani, Dara Aldisi, Naif Alotaibi, Naemah Alshingetti, Suliman Alomar, Abdullah Alnaami, Osama Amer, Syed Hussain, Nasser Al-Daghri. Effects of a 2-Week 5000 IU versus 1000 IU Vitamin D3 Supplementation on Recovery of Symptoms in Patients with Mild to Moderate Covid-19: A Randomized Clinical Trial. Nutrients. 2021; 13 (7):2170.
Chicago/Turabian StyleShaun Sabico; Mushira Enani; Eman Sheshah; Naji Aljohani; Dara Aldisi; Naif Alotaibi; Naemah Alshingetti; Suliman Alomar; Abdullah Alnaami; Osama Amer; Syed Hussain; Nasser Al-Daghri. 2021. "Effects of a 2-Week 5000 IU versus 1000 IU Vitamin D3 Supplementation on Recovery of Symptoms in Patients with Mild to Moderate Covid-19: A Randomized Clinical Trial." Nutrients 13, no. 7: 2170.
Tristetraprolin (TTP) is an mRNA binding protein suggested to have a substantial role in regulating the mRNA expression of numerous inflammatory factors, but data on TTP and its association with metabolic syndrome (MetS), a chronic low-grade inflammatory disorder, are scarce. We hypothesize that TTP may modulate MetS and its components. A total of 200 Saudi adults (aged 38.6 ± 8.3 years) were included in this cross-sectional study. Anthropometrics data were collected and fasting blood glucose taken for the assessment of glycemic, lipids and inflammatory markers using commercially available assays. The National Cholesterol Education Program Adult Treatment Panel (NCEP ATP III) criteria were used to define MetS. Results showed significantly higher levels of TTP in the MetS group than in controls [288.1 pg/mL vs. 150.9 pg/mL, p< 0.001]. Circulating TTP was significantly associated with tumor necrosis factor alpha [TNF-α, R = 0.30, p< 0.05], interleukin 1β [IL-1β, R = 0.41, p< 0.01] and C-reactive protein [CRP, R = 0.36, p< 0.01], adiponectin [R = 0.36, p< 0.05], insulin [R = 0.37, p< 0.05], and insulin resistance [HOMA-IR, R = 0.40, p< 0.05]. Receiver operating characteristics (ROC) suggest a potential use of TTP as diagnostic biomarker for MetS [AUC = 0.819, p< 0.001]. The findings suggest that TTP is associated with inflammation and glycemia, which may influence MetS. TTP is a promising diagnostic biomarker for MetS which can be confirmed in larger cohorts.
Nasser Al-Daghri; Albatul Al-Shuwaie; Amani Alghamdi; Osama Amer; Malak Khattak; Mohammed Ansari; Abdullah Alnaami; Shaun Sabico. Tristetraprolin, Inflammation, and Metabolic Syndrome in Arab Adults: A Case Control Study. Biology 2021, 10, 550 .
AMA StyleNasser Al-Daghri, Albatul Al-Shuwaie, Amani Alghamdi, Osama Amer, Malak Khattak, Mohammed Ansari, Abdullah Alnaami, Shaun Sabico. Tristetraprolin, Inflammation, and Metabolic Syndrome in Arab Adults: A Case Control Study. Biology. 2021; 10 (6):550.
Chicago/Turabian StyleNasser Al-Daghri; Albatul Al-Shuwaie; Amani Alghamdi; Osama Amer; Malak Khattak; Mohammed Ansari; Abdullah Alnaami; Shaun Sabico. 2021. "Tristetraprolin, Inflammation, and Metabolic Syndrome in Arab Adults: A Case Control Study." Biology 10, no. 6: 550.
Healthy diet and supplement use may prove as sustainable strategies to lower COVID-19 infection. Our study investigated the dietary changes before and during lockdown and observed dietary supplements (DS) use among residents in Saudi Arabia. This cross-sectional study collected data via an online electronic survey questionnaire among males (N = 921) and females (N = 1044) residing in Saudi Arabia, 15 years of age and above. There was a significant decrease in the prevalence of males (before vs. during lockdown) having improved changes in dietary habit (68.6% vs. 65.8%; p = 0.004), which was similar in female participants (69 vs. 73.4% vs. 69%; p< 0.001). The frequency of multivitamin users among COVID-19 participants was significantly lower than non-users (44.4 vs. 55.6; p< 0.003). Male respondents within 26–35 years of age were more likely to use multivitamin supplements than females (30.1 vs. 22.6%; p< 0.05) of same age group. Predictors for DS use were increased age group, income, education level and COVID-19 status. In conclusion, an increase in unhealthy diet behavior was observed among Saudi males and females during the pandemic lockdown and the predictors of DS use included increased age, income, education level and COVID-19 status.
Hanan Alfawaz; Nasiruddin Khan; Ghadah Aljumah; Syed Hussain; Nasser Al-Daghri. Dietary Intake and Supplement Use Among Saudi Residents during COVID-19 Lockdown. International Journal of Environmental Research and Public Health 2021, 18, 6435 .
AMA StyleHanan Alfawaz, Nasiruddin Khan, Ghadah Aljumah, Syed Hussain, Nasser Al-Daghri. Dietary Intake and Supplement Use Among Saudi Residents during COVID-19 Lockdown. International Journal of Environmental Research and Public Health. 2021; 18 (12):6435.
Chicago/Turabian StyleHanan Alfawaz; Nasiruddin Khan; Ghadah Aljumah; Syed Hussain; Nasser Al-Daghri. 2021. "Dietary Intake and Supplement Use Among Saudi Residents during COVID-19 Lockdown." International Journal of Environmental Research and Public Health 18, no. 12: 6435.
Widespread vitamin D deficiency (serum 25-hydroxyvitamin D < 50 nmol/L) in Saudi Arabia (SA) has been documented, yet a time trend is needed to establish where the prevalence is headed. This study aims to fill this gap. This cross-sectional series (N = 7360) were conducted in the central region of SA from 2008 to 2017. Participants of all ages were taken from multiple cohorts that included the Biomarker Screening in Riyadh (2008–2010; N = 1460), the Osteoporosis Registry (2014–2017; N = 1225), Gestational Diabetes Mellitus cohort (2014–2017, N = 281), Vitamin D School Project (2011–2017; N = 3039) and Prediabetes cohort (2012–2017; N = 1355) master databases. Vitamin D deficiency in SA has a 10-year prevalence of 73.2 %. Between 2008–2017, the prevalence of vitamin D deficiency decreased from 87.1% to 64.7% for participants aged 18−40 years (p-trend 40 years (p-trend<0.001). During this period, vitamin D deficiency in females decreased from 80.1% to 69.6% (p-trend<0.001), whereas in males, it decreased from 93.2% to 49.3% (p-trend<0.001). Serum 25(OH)D was observed to have an overall increase of 2.2 ± 0.1 nmol/l (p < 0.001) along with the seasonally adjusted annual increase of 1.3 ± 0.2 nmol/l from 2008 to 2017 (p < 0.001). The decreasing trend in vitamin D deficiency in SA across all demographics suggests successful public health campaigns over time. It will be interesting to investigate further whether the general improvement in the vitamin D status at the community level also translated in lesser incidences of vitamin d-related diseases over time.
Nasser M. Al-Daghri; Syed Danish Hussain; Mohammed G.A. Ansari; Malak N.K. Khattak; Naji Aljohani; Yousef Al-Saleh; Mohammed Y. Al-Harbi; Shaun Sabico; Majed S. Alokail. Decreasing prevalence of vitamin D deficiency in the central region of Saudi Arabia (2008-2017). The Journal of Steroid Biochemistry and Molecular Biology 2021, 212, 105920 .
AMA StyleNasser M. Al-Daghri, Syed Danish Hussain, Mohammed G.A. Ansari, Malak N.K. Khattak, Naji Aljohani, Yousef Al-Saleh, Mohammed Y. Al-Harbi, Shaun Sabico, Majed S. Alokail. Decreasing prevalence of vitamin D deficiency in the central region of Saudi Arabia (2008-2017). The Journal of Steroid Biochemistry and Molecular Biology. 2021; 212 ():105920.
Chicago/Turabian StyleNasser M. Al-Daghri; Syed Danish Hussain; Mohammed G.A. Ansari; Malak N.K. Khattak; Naji Aljohani; Yousef Al-Saleh; Mohammed Y. Al-Harbi; Shaun Sabico; Majed S. Alokail. 2021. "Decreasing prevalence of vitamin D deficiency in the central region of Saudi Arabia (2008-2017)." The Journal of Steroid Biochemistry and Molecular Biology 212, no. : 105920.
The homeostasis of trace elements were observed to contribute to certain diabetic outcomes. This cross-sectional study determined the differences and associations between serum levels of copper (Cu), iron (Fe) and zinc (Zn) in Saudi patients with and without type 2 diabetes mellitus (T2DM) as well as those with prediabetes. Anthropometrics were measured, and fasting blood samples were collected from 119 patients with T2DM (aged 41–64 years), 95 non-T2DM (aged 27–55 years) and 80 with prediabetes (aged 35–57 years). Circulating trace minerals were determined using an inductively coupled plasma–mass spectrometer. Serum levels of Cu and Fe were significantly lower in T2DM than non-T2DM (adjusted p-values < 0.001). There was no difference in the Zn levels of the T2DM and non-T2DM groups. The serum Cu levels were significantly lower in the prediabetes group than the non-T2DM group (p < 0.05). The serum levels of Cu, Fe and Zn were inversely associated with circulating glucose in the T2DM and prediabetes subjects (p-values < 0.001). In conclusion, the differences in circulating trace elements were observed in Saudi subjects with varying glycemic statuses, suggesting an inverse association between T2DM progression and the decreasing serum Cu, Fe and Zn levels. Intervention trials are warranted to determine whether early correction of trace mineral deficiencies is beneficial in populations at higher risk for T2DM.
Sobhy Yakout; Fatimah Faqeeh; Omar Al-Attas; Syed Hussain; Nasser Al-Daghri. Patterns and Associations of Essential Trace Elements (Cu, Fe and Zn) in Saudi Adults with Varying Levels of Glycemia. Metabolites 2021, 11, 297 .
AMA StyleSobhy Yakout, Fatimah Faqeeh, Omar Al-Attas, Syed Hussain, Nasser Al-Daghri. Patterns and Associations of Essential Trace Elements (Cu, Fe and Zn) in Saudi Adults with Varying Levels of Glycemia. Metabolites. 2021; 11 (5):297.
Chicago/Turabian StyleSobhy Yakout; Fatimah Faqeeh; Omar Al-Attas; Syed Hussain; Nasser Al-Daghri. 2021. "Patterns and Associations of Essential Trace Elements (Cu, Fe and Zn) in Saudi Adults with Varying Levels of Glycemia." Metabolites 11, no. 5: 297.
Objectives Vitamin D status in patients with COVID-19 is an on-going controversial issue. This study aims to determine differences in the serum 25(OH)D concentrations of Arab Gulf adult residents screened for SARS-CoV-2 and its association with risk of COVID-19 infection together with other comorbidities. Methods In this multi-center, case–control study, a total of 220 male and female adults presenting with none to mild symptoms were screened for COVID-19 (n = 138 RT-PCR-confirmed SARS-CoV-2 positive and 82 negative controls). Medical history was noted. Anthropometrics were measured and non-fasting blood samples were collected for the assessment of glucose, lipids, inflammatory markers and serum 25(OH)D concentrations. Results Serum 25(OH)D levels were significantly lower in the SARS-CoV-2 positive group compared to the negative group after adjustment for age and BMI (52.8 nmol/l ± 11.0 versus 64.5 nmol/l ± 11.1; p = 0.009). Being elderly (> 60 years) [Odds ratio 6 (95% Confidence Interval, CI 2–18; p = 0.001) as well as having type 2 diabetes (T2D) [OR 6 (95% CI 3–14); p < 0.001)] and low HDL cholesterol (HDL-c) [OR 6 (95% CI 3–14); p < 0.001)] were significant risk factors for COVID-19 infection independent of age, sex and obesity. Conclusions Among Arab Gulf residents screened for SARS-CoV-2, serum 25(OH) D levels were observed to be lower in those who tested positive than negative individuals, but it was the presence of old age, diabetes mellitus and low-HDL-c that were significantly associated with risk of COVID-19 infection. Large population-based randomized controlled trials should be conducted to assess the protective effects of vitamin D supplementation against COVID-19.
Nasser M. Al-Daghri; Osama E. Amer; Naif H. Alotaibi; Dara A. Aldisi; Mushira A. Enani; Eman Sheshah; Naji J. Aljohani; Naemah Alshingetti; Suliman Y. Alomar; Hanan Alfawaz; Syed D. Hussain; Abdullah M. Alnaami; Shaun Sabico. Vitamin D status of Arab Gulf residents screened for SARS-CoV-2 and its association with COVID-19 infection: a multi-centre case–control study. Journal of Translational Medicine 2021, 19, 1 -8.
AMA StyleNasser M. Al-Daghri, Osama E. Amer, Naif H. Alotaibi, Dara A. Aldisi, Mushira A. Enani, Eman Sheshah, Naji J. Aljohani, Naemah Alshingetti, Suliman Y. Alomar, Hanan Alfawaz, Syed D. Hussain, Abdullah M. Alnaami, Shaun Sabico. Vitamin D status of Arab Gulf residents screened for SARS-CoV-2 and its association with COVID-19 infection: a multi-centre case–control study. Journal of Translational Medicine. 2021; 19 (1):1-8.
Chicago/Turabian StyleNasser M. Al-Daghri; Osama E. Amer; Naif H. Alotaibi; Dara A. Aldisi; Mushira A. Enani; Eman Sheshah; Naji J. Aljohani; Naemah Alshingetti; Suliman Y. Alomar; Hanan Alfawaz; Syed D. Hussain; Abdullah M. Alnaami; Shaun Sabico. 2021. "Vitamin D status of Arab Gulf residents screened for SARS-CoV-2 and its association with COVID-19 infection: a multi-centre case–control study." Journal of Translational Medicine 19, no. 1: 1-8.
Studies have explored how vitamin B12 status affects sleep among elders and children, but this remains to be investigated among young adults. We used the Pittsburgh Sleep Quality Index (PSQI) to assess the association between serum vitamin B12 and sleep among female college students in Saudi Arabia. In this cross-sectional study, we enrolled 355 participants (age (years), 20.7 ± 1.5; body mass index, 23.6 kg/m2 ± 5.2) at King Saud University, Riyadh, Saudi Arabia. Fasting blood samples were analyzed regarding the serum vitamin B12 and blood lipids. Anthropometric, socio-demographic, clinical history, stress, physical activity, and dietary data were collected. We assessed the sleep statuses of the participants using the PSQI. Around 72% of the participants were “poor” sleepers (PSQI > 5). Subgroup analysis within the tertiles showed that participants with higher vitamin B12 in the second and third tertiles reported better scores for sleep quality (B ± SE = −12.7 ± 5.6, p = 0.03; B ± SE = −32.7 ± 16.4, p = 0.05, respectively) and also reported a lower use of sleep medication (B ± SE = −21.2 ± 9.9, p = 0.03, in the second tertile only), after adjusting for the waist–hip ratio and stress. However, sleep was not found to be directly associated with either serum vitamin B12 or dietary vitamin B12. In conclusion, the serum vitamin B12 results show that the participants with higher vitamin B12 in the second and third tertiles reported better scores on the sleep quality scale and a lower use of sleep medication. However, no such associations were observed with the overall PSQI. More studies with larger sample sizes are needed to establish a direct relationship between sleep and vitamin B12.
Sara Al-Musharaf; Alanoud Alabdulaaly; Hanadi Bin Mujalli; Hatoun Alshehri; Hind Alajaji; Rania Bogis; Ruyuf Alnafisah; Shaden Alfehaid; Hala Alhodaib; Alice Murphy; Syed Hussain; Shaun Sabico; Philip McTernan; Nasser Al-Daghri. Sleep Quality Is Associated with Vitamin B12 Status in Female Arab Students. International Journal of Environmental Research and Public Health 2021, 18, 4548 .
AMA StyleSara Al-Musharaf, Alanoud Alabdulaaly, Hanadi Bin Mujalli, Hatoun Alshehri, Hind Alajaji, Rania Bogis, Ruyuf Alnafisah, Shaden Alfehaid, Hala Alhodaib, Alice Murphy, Syed Hussain, Shaun Sabico, Philip McTernan, Nasser Al-Daghri. Sleep Quality Is Associated with Vitamin B12 Status in Female Arab Students. International Journal of Environmental Research and Public Health. 2021; 18 (9):4548.
Chicago/Turabian StyleSara Al-Musharaf; Alanoud Alabdulaaly; Hanadi Bin Mujalli; Hatoun Alshehri; Hind Alajaji; Rania Bogis; Ruyuf Alnafisah; Shaden Alfehaid; Hala Alhodaib; Alice Murphy; Syed Hussain; Shaun Sabico; Philip McTernan; Nasser Al-Daghri. 2021. "Sleep Quality Is Associated with Vitamin B12 Status in Female Arab Students." International Journal of Environmental Research and Public Health 18, no. 9: 4548.
Central adiposity is one of the significant determinants of obesity-related hypertension risk, which may arise due to the abdominal fat depot's pathogenic inflammatory nature. Pro-inflammatory cytokines and adipokines up-regulation through nuclear factor-kappa B (NF-κB) activation in adipose tissue has been considered an essential function in the pathogenesis of obesity-related hypertension. This study aimed to ascertain the NF-κB inhibitor (SN50) effect on TNF-α and angiotensinogen (AGT) secretion and expression in mediating the anti-inflammatory effect through its impact on NF-κB activity in humans adipose tissue. Primary human adipocytes were isolated from 20 subjects among 10 overweight and 10 obese with and without hypertension and treated with 10ng/ml LPS in the presence and absence of NF-κB inhibitor, SN50 (50μg/ml). TNF-α secretion and NF-κB p65 activity were detected in supernatants extracted from cultured cells treated and untreated with LPS (10ng/ml) and SN50 (50μg/ml) using enzyme-linked immunosorbent assay (ELISA). The western blot technique detected the protein of NF-κB p65 and AGT. Gene expression of TNF-α and AGT was detected in cells and performed using quantitative real-time polymerase chain reaction (RT-PCR). Treatment of AbdSc adipocytes with LPS (10ng/ml) caused a significant increase in NF-κB p65 among overweight and obese subjects with and without hypertension (P= 0.001) at 24 hours incubation. In contrast, SN50-NF-κB inhibitor causes a reduction of NF-κB p65 in overweight (P= <0.001) and obese subjects with and without hypertension (P= 0.001) at 24 hours incubation. Treatment of AbdSc adipocytes with 10ng/ml LPS caused a significant increase in TNF-α secretion in overweight and obese subjects at all-time points (P= <0.001), whereas SN50 leads to a decrease in TNF-α secretion at 3 and 12 hours incubation. Treatment of AbdSc adipocytes with LPS (10ng/ml) caused increased TNF-α and AGT gene expression twofold compared with untreated cells, whereas, in the presence of SN50, it reduces mRNA AGT levels in both groups. Taken together, these adipokines with NF-κB activation may represent essential biomarkers to evaluate hypertension risk and to provide insight into the pathogenesis of obesity-related hypertension.
Nasser M. Al-Dagheri; Assim A. Alfadda; Reem M. Sallam; Philip G. McTernan; Lotfi S. Bin Dahman. Assessment of NF-κB Inhibitor (SN50) Effect on Adipose Tumor Necrosis Factor-Alpha and Angiotensinogen Secretion and Expression. 2021, 1 .
AMA StyleNasser M. Al-Dagheri, Assim A. Alfadda, Reem M. Sallam, Philip G. McTernan, Lotfi S. Bin Dahman. Assessment of NF-κB Inhibitor (SN50) Effect on Adipose Tumor Necrosis Factor-Alpha and Angiotensinogen Secretion and Expression. . 2021; ():1.
Chicago/Turabian StyleNasser M. Al-Dagheri; Assim A. Alfadda; Reem M. Sallam; Philip G. McTernan; Lotfi S. Bin Dahman. 2021. "Assessment of NF-κB Inhibitor (SN50) Effect on Adipose Tumor Necrosis Factor-Alpha and Angiotensinogen Secretion and Expression." , no. : 1.
Background This study aimed to assess the telomere length and plasma telomere repeat-binding factor 2 (TRF2) levels in addition to other inflammatory markers in children with sickle cell disease (SCD). Methods We enrolled 106 children (90 SCD and 26 controls) aged 1–15 years from the Hematology unit of King Fahad Medical City (KFMC), Saudi Arabia. Genomic DNA extracted from blood and leukocyte TL was determined using quantitative reverse transcription PCR, whereas TRF2, C-reactive protein, interleukin-6, and DNA oxidative damage were determined by using respective commercially available assays. Results Leukocyte TL was inversely correlated with age in the SCD patients (r = −0.24, P = 0.02) and the controls (r = −0.68, P < 0.0001). In addition, SCD patients had significantly shorter TL (7.74 ± 0.81 kb) (P = 0.003) than controls (8.28 ± 0.73 kb). In contrast, no significant difference in TL among the SCD genotypes (HbSS and HbSβ0) has been observed. A modest, positive correlation was seen between TL and reticulocyte % (r = 0.21; P = 0.06). There were no significant differences in the TL and TRF2 concentrations between subjects with HbSS and HbSβ0 genotypes. Conclusions Short leukocyte TL was significantly associated with SCD. An inverse association was observed between TL and hemoglobin. Hydroxyurea treatment revealed no impact on TL. Impact This study explored the TL and plasma TRF2 in Saudi children with SCD. This is the first documentation that SCD children have shorter TL than their healthy counterparts, and no association between TL and TRF2 has been observed. Hydroxyurea treatment showed no impact on TL in children with SCD. This study is the first of its kind in children with SCD. It will pave the way for another study with a larger sample size in a diverse population to scrutinize these findings better.
Mohamed E. Suliman; Mohammed G. A. Ansari; Mohamed A. Rayis; Muaawia A. Hamza; Abdullah A. Saeed; Abdul Khader Mohammed; Nasser M. Al-Daghri. Telomere length and telomere repeat-binding protein in children with sickle cell disease. Pediatric Research 2021, 1 -6.
AMA StyleMohamed E. Suliman, Mohammed G. A. Ansari, Mohamed A. Rayis, Muaawia A. Hamza, Abdullah A. Saeed, Abdul Khader Mohammed, Nasser M. Al-Daghri. Telomere length and telomere repeat-binding protein in children with sickle cell disease. Pediatric Research. 2021; ():1-6.
Chicago/Turabian StyleMohamed E. Suliman; Mohammed G. A. Ansari; Mohamed A. Rayis; Muaawia A. Hamza; Abdullah A. Saeed; Abdul Khader Mohammed; Nasser M. Al-Daghri. 2021. "Telomere length and telomere repeat-binding protein in children with sickle cell disease." Pediatric Research , no. : 1-6.
Public health endorsements during the present COVID-19 pandemic has led the governments of largely affected countries to imply policies that restrict social mobility to slow COVID-19 spread. The study aimed to explore the effects of COVID-19 home quarantine on lifestyle and health behavior of Saudi residents. An online survey in Saudi Arabia was launched from May 11 to June 6, 2020. The survey was designed by multidisciplinary scientists and academics uploaded and shared through the Google platform in Arabic and English languages. Questions presented related to responses “before” and “during” COVID-19 home quarantine. A total of 1965 respondents participated and were included in the analysis [921 (47.0%) males and 1044 (53.0%) females]. Non-Saudis were more likely to increase their physical activity during quarantine [odds ratio (95% confidence interval 1.41 (1.11–1.79);p < 0.005]. Prevalence of participants walking daily for more than 4 times per week significantly decreased during pandemic (before vs during, 30.5% vs 29.1%) which was in parallel to the significant increase in the prevalence of participants who did not perform daily walking during the quarantine (21% vs 22.9%;p < 0.001). The prevalence of participants who often consume snacks between meals increased during quarantine (27.4% vs 29.4%,p < 0.001), while the prevalence of participants who never consumed fresh fruits and vegetables significantly increased during home quarantine (2.4% vs 3.7%;p = 0.019). The lockdown imposed in Saudi Arabia modestly but significantly impacted physical activity and dietary behaviors of several citizens and residents in an unhealthy way. Interventions to alleviate these acute adverse lifestyle behaviors during pandemic should be formulated.
Hanan Alfawaz; Osama E. Amer; Abdulaziz A. Aljumah; Dara A. Aldisi; Mushira A. Enani; Naji J. Aljohani; Naif H. Alotaibi; Naemah Alshingetti; Suliman Y. Alomar; Malak Nawaz Khan Khattak; Shaun Sabico; Nasser M. Al-Daghri. Effects of home quarantine during COVID-19 lockdown on physical activity and dietary habits of adults in Saudi Arabia. Scientific Reports 2021, 11, 1 -7.
AMA StyleHanan Alfawaz, Osama E. Amer, Abdulaziz A. Aljumah, Dara A. Aldisi, Mushira A. Enani, Naji J. Aljohani, Naif H. Alotaibi, Naemah Alshingetti, Suliman Y. Alomar, Malak Nawaz Khan Khattak, Shaun Sabico, Nasser M. Al-Daghri. Effects of home quarantine during COVID-19 lockdown on physical activity and dietary habits of adults in Saudi Arabia. Scientific Reports. 2021; 11 (1):1-7.
Chicago/Turabian StyleHanan Alfawaz; Osama E. Amer; Abdulaziz A. Aljumah; Dara A. Aldisi; Mushira A. Enani; Naji J. Aljohani; Naif H. Alotaibi; Naemah Alshingetti; Suliman Y. Alomar; Malak Nawaz Khan Khattak; Shaun Sabico; Nasser M. Al-Daghri. 2021. "Effects of home quarantine during COVID-19 lockdown on physical activity and dietary habits of adults in Saudi Arabia." Scientific Reports 11, no. 1: 1-7.
The study aimed to explore the influence of the COVID-19 lockdown on the mental status and dietary intake of residents in Saudi Arabia. In this cross-sectional study, an online survey was conducted from 11 May to 6 June 2020 corresponding to almost two weeks during and after Ramadan (23 April–23 May 2020). The Patient Health Questionnaire was used to assess anxiety, depression, and insomnia. Logistic regression analysis was used to identify predictors of anxiety, depression, and insomnia. The prevalence of anxiety, depression, and insomnia among the participants was 25.4%, 27.7%, and 19.6%, respectively. Participants aged ≥50 years with high income (≥8000 SAR) were at a lower risk of developing depression, whereas participants of the same age group with income 5000–7000 SAR were at high risk of developing anxiety. Students and master-educated participants suffer from median elevated depression and are required to take more multivitamins and vitamin D than others. Anxiety and depression were more common among married participants with low income. There is a wide range of Saudi residents who are at a higher risk of mental illness during the COVID-19 pandemic. Policymakers and mental healthcare providers are advised to provide continuous monitoring of the psychological consequences during this pandemic and provide mental support.
Hanan Alfawaz; Sobhy Yakout; Kaiser Wani; Ghadah Aljumah; Mohammed Ansari; Malak Khattak; Syed Hussain; Nasser Al-Daghri. Dietary Intake and Mental Health among Saudi Adults during COVID-19 Lockdown. International Journal of Environmental Research and Public Health 2021, 18, 1653 .
AMA StyleHanan Alfawaz, Sobhy Yakout, Kaiser Wani, Ghadah Aljumah, Mohammed Ansari, Malak Khattak, Syed Hussain, Nasser Al-Daghri. Dietary Intake and Mental Health among Saudi Adults during COVID-19 Lockdown. International Journal of Environmental Research and Public Health. 2021; 18 (4):1653.
Chicago/Turabian StyleHanan Alfawaz; Sobhy Yakout; Kaiser Wani; Ghadah Aljumah; Mohammed Ansari; Malak Khattak; Syed Hussain; Nasser Al-Daghri. 2021. "Dietary Intake and Mental Health among Saudi Adults during COVID-19 Lockdown." International Journal of Environmental Research and Public Health 18, no. 4: 1653.
While the independent roles of vitamin D and sex hormones in skeletal health are well established, the associations of vitamin D and its metabolites to sex hormones and their indices are less investigated. In this observational study, clinical information of 189 Saudi postmenopausal women aged ≥50 years old [N = 80 with normal bone mineral density (BMD), aged 53.3 ± 7.7 years with body mass index (BMI)= 34.1kg/m2 ± 5.8, and N = 109 with low BMD (T-score −1.0 to −2.5), aged 57.0 ± 8.2 years, BMI = 32.4kg/m2 ± 6.2] was extracted from an existing capital-wide osteoporosis registry in Riyadh, Saudi Arabia. Data included were BMD scores, serum total 25(OH)D, sex hormones, and bone turnover markers which were measured using commercially available assays. Age- and BMI-adjusted comparisons revealed significantly higher parathyroid hormone (PTH) levels as well as significantly lower testosterone and bioavailable testosterone in the low BMD group than the normal BMD group (p-values 0.04, 0.02, and 0.03, respectively). Stepwise linear regression showed that circulating testosterone levels accounted for 9.7% and 8.9% of the variances perceived in bioavailable 25(OH)D and free 25(OH)D, respectively (p < 0.01), independent of other sex hormones, sex hormone indices, and bone turnover markers. Our study suggests that androgens are significantly associated with non-conventional vitamin D metabolites and these associations may have clinical relevance in assessing risk for low BMD and osteoporosis in Arab postmenopausal women.
Nasser Al-Daghri; Sobhy Yakout; Mohammed Ansari; Syed Hussain; Kaiser Wani; Shaun Sabico. Vitamin D Metabolites and Sex Steroid Indices in Postmenopausal Women with and without Low Bone Mass. Metabolites 2021, 11, 86 .
AMA StyleNasser Al-Daghri, Sobhy Yakout, Mohammed Ansari, Syed Hussain, Kaiser Wani, Shaun Sabico. Vitamin D Metabolites and Sex Steroid Indices in Postmenopausal Women with and without Low Bone Mass. Metabolites. 2021; 11 (2):86.
Chicago/Turabian StyleNasser Al-Daghri; Sobhy Yakout; Mohammed Ansari; Syed Hussain; Kaiser Wani; Shaun Sabico. 2021. "Vitamin D Metabolites and Sex Steroid Indices in Postmenopausal Women with and without Low Bone Mass." Metabolites 11, no. 2: 86.
Receptor activator of the nuclear factor-κB ligand (RANKL) and osteoprotegerin genes (OPG) were identified as susceptible loci for postmenopausal osteoporosis (PMO) in various ethnicities, but neither have been studied in an Arabian population. Hence, the current study aimed to fill this gap. A total of 372 postmenopausal women (174 osteoporosis (OP) and 198 control group (CTRs)) were genotyped for four SNPs: rs2277438A/G and rs9533156T/C (RANKL), and rs2073618C/G and rs3102735T/C (OPG). Anthropometrics, bone mineral density, 25(OH)D and several other bone markers were measured. The frequency distribution of the heterozygous CG genotype of rs2073618 (OPG) was lower in the OP (36.8%) than in CTRs (47%) (OR: 0.6, 95% CI: 0.3–0.97; p = 0.041). No differences in the allelic/genotypic frequencies were detected between the two groups for all other studied SNPs. However, the heterozygous TC genotype of rs3102735 (OPG) was associated significantly with lower BMD at the femoral neck in OP subjects (p = 0.04). The homozygous rare CC genotype of rs9533156 (RANKL) was associated with lower 25(OH)D levels in CTRs (p = 0.032). In contrast, heterozygous AG genotype of rs2277438 (RANKL) is associated with lower 25(OH)D in the OP group (p = 0.02). Our results suggest that RANKL SNPs may impact 25(OH)D levels and that OPG SNP rs2073618A/G is a significant genetic risk factor for PMO Saudi Arabian women.
Saba Abdi; Rawan Binbaz; Abdul Mohammed; Mohammed Ansari; Kaiser Wani; Osama Amer; Abdullah Alnaami; Naji Aljohani; Nasser Al-Daghri. Association of RANKL and OPG Gene Polymorphism in Arab Women with and without Osteoporosis. Genes 2021, 12, 200 .
AMA StyleSaba Abdi, Rawan Binbaz, Abdul Mohammed, Mohammed Ansari, Kaiser Wani, Osama Amer, Abdullah Alnaami, Naji Aljohani, Nasser Al-Daghri. Association of RANKL and OPG Gene Polymorphism in Arab Women with and without Osteoporosis. Genes. 2021; 12 (2):200.
Chicago/Turabian StyleSaba Abdi; Rawan Binbaz; Abdul Mohammed; Mohammed Ansari; Kaiser Wani; Osama Amer; Abdullah Alnaami; Naji Aljohani; Nasser Al-Daghri. 2021. "Association of RANKL and OPG Gene Polymorphism in Arab Women with and without Osteoporosis." Genes 12, no. 2: 200.
Objective. To examine differences in maternal serum levels of adipokines (adiponectin, leptin, and resistin) and inflammatory markers (tumor necrosis factor-alpha (TNF-α) and interlukin-6 (IL-6)) from early to midpregnancy among Arab women with or without gestational diabetes mellitus (GDM), along with their links to GDM risk. Methods. This is a multicenter prospective study involving 232 Saudi women attending obstetric care. Both circulating adipokine and markers of inflammation were observed at the first (eight to 12 weeks) and second trimesters (24 to 28 weeks). GDM was screened at 24 to 28 weeks using the International Association of the Diabetes and Pregnancy Study Groups (IADPSG) criteria. Results. Age and body mass index- (BMI-) matched circulating TNF-α was significantly higher in women with GDM in comparison to non-GDM women ( p = 0.01 ). Adiponectin and resistin significantly decreased from the first to second trimester in women without GDM ( p = 0.002 and 0.026, respectively). Leptin presented a significant rise from the first to second trimester in both groups, with a higher increase in women with GDM ( p = 0.013 ). Multivariate logistic regression analysis revealed that TNF-α was significantly correlated with GDM ( p = 0.03 ). However, significance was lost after adjustments for maternal and lifestyle risk factors (OR 23.58 (0.50 to 1119.98), p = 0.11 ). Conclusion. Inflammatory and adipocytokine profiles are altered in Arab women with GDM, TNF-α in particular. Further studies are needed to establish whether maternal inflammatory and adipocytokine profile influence fetal levels in the same manner.
Sara Al-Musharaf; Shaun Sabico; Syed Danish Hussain; Fatima Al-Tawashi; Haifa Bandar AlWaily; Nasser M. Al-Daghri; Philip McTernan. Inflammatory and Adipokine Status from Early to Midpregnancy in Arab Women and Its Associations with Gestational Diabetes Mellitus. Disease Markers 2021, 2021, 1 -8.
AMA StyleSara Al-Musharaf, Shaun Sabico, Syed Danish Hussain, Fatima Al-Tawashi, Haifa Bandar AlWaily, Nasser M. Al-Daghri, Philip McTernan. Inflammatory and Adipokine Status from Early to Midpregnancy in Arab Women and Its Associations with Gestational Diabetes Mellitus. Disease Markers. 2021; 2021 ():1-8.
Chicago/Turabian StyleSara Al-Musharaf; Shaun Sabico; Syed Danish Hussain; Fatima Al-Tawashi; Haifa Bandar AlWaily; Nasser M. Al-Daghri; Philip McTernan. 2021. "Inflammatory and Adipokine Status from Early to Midpregnancy in Arab Women and Its Associations with Gestational Diabetes Mellitus." Disease Markers 2021, no. : 1-8.
NLRP3 inflammasome is one of the multimeric protein complexes of the nucleotide-binding domain, leucine-rich repeat (NLR)-containing pyrin and HIN domain family (PYHIN). When activated, NLRP3 inflammasome triggers the release of pro-inflammatory interleukins (IL)-1β and IL-18, an essential step in innate immune response; however, defective checkpoints in inflammasome activation may lead to autoimmune, autoinflammatory, and metabolic disorders. Among the consequences of NLRP3 inflammasome activation is systemic chronic low-grade inflammation, a cardinal feature of obesity and insulin resistance. Understanding the mechanisms involved in the regulation of NLRP3 inflammasome in adipose tissue may help in the development of specific inhibitors for the treatment and prevention of obesity-mediated metabolic diseases. In this narrative review, the current understanding of NLRP3 inflammasome activation and regulation is highlighted, including its putative roles in adipose tissue dysfunction and insulin resistance. Specific inhibitors of NLRP3 inflammasome activation which can potentially be used to treat metabolic disorders are also discussed.
Kaiser Wani; Hind Alharthi; Amani Alghamdi; Shaun Sabico; Nasser M. Al-Daghri. Role of NLRP3 Inflammasome Activation in Obesity-Mediated Metabolic Disorders. International Journal of Environmental Research and Public Health 2021, 18, 511 .
AMA StyleKaiser Wani, Hind Alharthi, Amani Alghamdi, Shaun Sabico, Nasser M. Al-Daghri. Role of NLRP3 Inflammasome Activation in Obesity-Mediated Metabolic Disorders. International Journal of Environmental Research and Public Health. 2021; 18 (2):511.
Chicago/Turabian StyleKaiser Wani; Hind Alharthi; Amani Alghamdi; Shaun Sabico; Nasser M. Al-Daghri. 2021. "Role of NLRP3 Inflammasome Activation in Obesity-Mediated Metabolic Disorders." International Journal of Environmental Research and Public Health 18, no. 2: 511.
Vitamin B12 insufficiency is a global health issue among women of childbearing age, yet few studies have investigated its prevalence and risk factors among healthy Middle Eastern populations. This cross-sectional study included 346 Saudi women aged 19–30 years and enrolled at King Saud University, Riyadh, Saudi Arabia. A series of questionnaires were administered to record the study participants’ sociodemographic status, medical history, dietary intake, and physical activity. Participants’ anthropometric data were also recorded and their fasting blood samples were analyzed. The rate of vitamin B12 insufficiency (≤220 pmol/L) was approximately 6% among the study participants. After adjusting for confounding factors, it was observed that the risk factors for vitamin B12 insufficiency included daily sitting time ≥ 7 h, low income (2.4 mcg/day) has been shown to confer reasonable protection against vitamin B12 insufficiency. These study findings highlight that a combination of increased physical activity and dietary vitamin B12 intake above the current recommended dietary allowance may help improve the serum vitamin B12 levels of young women of childbearing age, especially those with a low socioeconomic status. Timely detection and protection against vitamin B12 insufficiency in this subpopulation are important to prevent maternal and fetal health risks.
Sara Al-Musharaf; Philip G. McTernan; Syed Danish Hussain; Khalid Abdullah Aleisa; Abdullah M. Alnaami; Kaiser Wani; Ponnusamy Saravanan; Nasser Al-Daghri. Prevalence and Indicators of Vitamin B12 Insufficiency among Young Women of Childbearing Age. International Journal of Environmental Research and Public Health 2020, 18, 1 .
AMA StyleSara Al-Musharaf, Philip G. McTernan, Syed Danish Hussain, Khalid Abdullah Aleisa, Abdullah M. Alnaami, Kaiser Wani, Ponnusamy Saravanan, Nasser Al-Daghri. Prevalence and Indicators of Vitamin B12 Insufficiency among Young Women of Childbearing Age. International Journal of Environmental Research and Public Health. 2020; 18 (1):1.
Chicago/Turabian StyleSara Al-Musharaf; Philip G. McTernan; Syed Danish Hussain; Khalid Abdullah Aleisa; Abdullah M. Alnaami; Kaiser Wani; Ponnusamy Saravanan; Nasser Al-Daghri. 2020. "Prevalence and Indicators of Vitamin B12 Insufficiency among Young Women of Childbearing Age." International Journal of Environmental Research and Public Health 18, no. 1: 1.
Compelling evidence from epidemiological and experimental studies indicate that the disruption of circadian rhythm and decreased melatonin synthesis are risk factors for breast cancer. With the ever-increasing rate of breast cancer cases globally, there is a strong need for safer, effective, and alternate treatment strategies with lesser side effects. This study aimed to investigate the effects of melatonin and vitamin D3 on the gene expression of two apoptotic factors, BCL-2 and Bax, in the MCF-7 cancer cell line. Cell viability (MCF-7) was studied through MTT reduction assay in response to melatonin (1 nM, 5 nM and 10 nM) and vitamin D3 (0.5 nM, 1 nM and 10 NM). The optimum dose of melatonin (5 nM) and vitamin D3 (0.5 nM) were selected for their combination and Bax/BCL-2 ratio determination. Changes on the expression of genes BCL-2 and Bax, were determined through mRNA expression while Western blot analysis was used to detect changes in the expression of BCL-2 and Bax at the protein level. There was an upregulation of Bax gene expression and protein expression with the treatments of melatonin, vitamin D3, and their combination, with concomitant downregulation of Bcl-2 gene and protein expression. The Bax/BCL-2 ratio was increased significantly (p < 0.001) suggesting potential therapeutic treatments. The results suggest that treatment with melatonin and vitamin D3 inhibits the proliferation and induced apoptosis in breast cancer cells. We report here for the first time that this combination has effectively activated Bax and downregulated BCL-2 at the DNA and protein level.
Abir A. Alamro; Manal M. Al-Malky; Mohammed G.A. Ansari; Osama E. Amer; Abdullah M. Alnaami; Syed D. Hussain; Tlili A. Barhoumi; Amani A. Alghamdi; Samina H. Haq; Shaun Sabico; Nasser M. Al-Daghri. The effects of melatonin and vitamin D3 on the gene expression of BCl-2 and BAX in MCF-7 breast cancer cell line. Journal of King Saud University - Science 2020, 33, 101287 .
AMA StyleAbir A. Alamro, Manal M. Al-Malky, Mohammed G.A. Ansari, Osama E. Amer, Abdullah M. Alnaami, Syed D. Hussain, Tlili A. Barhoumi, Amani A. Alghamdi, Samina H. Haq, Shaun Sabico, Nasser M. Al-Daghri. The effects of melatonin and vitamin D3 on the gene expression of BCl-2 and BAX in MCF-7 breast cancer cell line. Journal of King Saud University - Science. 2020; 33 (2):101287.
Chicago/Turabian StyleAbir A. Alamro; Manal M. Al-Malky; Mohammed G.A. Ansari; Osama E. Amer; Abdullah M. Alnaami; Syed D. Hussain; Tlili A. Barhoumi; Amani A. Alghamdi; Samina H. Haq; Shaun Sabico; Nasser M. Al-Daghri. 2020. "The effects of melatonin and vitamin D3 on the gene expression of BCl-2 and BAX in MCF-7 breast cancer cell line." Journal of King Saud University - Science 33, no. 2: 101287.
The RANKL/RANK/OPG pathway regulates bone remodelling and turnover. However, the genetic background of bone mineral density (BMD) and osteopenia in Saudi postmenopausal women is yet to be studied. We studied the genetic polymorphism of RANKL/RANK/OPG with BMD and other associated factors in Saudi postmenopausal osteopenic women. A total of 439 (223 osteopenia and 216 control) postmenopausal women were recruited from the orthopaedic department of the King Khalid University Hospital, Riyadh, KSA. Genetic variants of RANK (rs1805034 and rs35211496), RANKL (rs2277438 and rs9533156), and OPG (rs2073618 and rs3102735) were genotyped using RT-PCR. Anthropometrics, bone mineral density, and other bone markers were measured. The levels of bone turnover markers, PTH, and RANKL were found to be significantly different between control and the osteopenia group. The odds ratio of 2.37 (1.00–5.69) for RANK SNP (rs1805034) indicates that subjects with CC genotype are more vulnerable to developing osteopenia as compared to subjects with TT genotype. Similarly, for RANKL SNP (rs2277438), the significant odds ratio of 20.56 (9.82–43.06) indicates that the subjects with GG genotype are at significantly higher risk of having osteopenia compared with the AA genotype subjects. In addition, G allele in rs2277438 also found to be a risk factor for osteopenia 4.54 (3.18–6.49) compared with A allele. However, none of the OPG genotypes shows association with osteopenia. The association of RANK polymorphisms with osteopenia shows its clinical importance in the diagnosis and prognosis of the bone diseases; here, we suggest that the subjects with RANK and RANKL polymorphisms may develop osteoporosis.
Saba Abdi; Ihtisham Bukhari; Mohammed G. A. Ansari; Rawan A. Binbaz; Abdul Khader Mohammed; Syed Danish Hussain; Naji Aljohani; Nasser M. Al-Daghri. Association of Polymorphisms in RANK and RANKL Genes with Osteopenia in Arab Postmenopausal Women. Disease Markers 2020, 2020, 1 -7.
AMA StyleSaba Abdi, Ihtisham Bukhari, Mohammed G. A. Ansari, Rawan A. Binbaz, Abdul Khader Mohammed, Syed Danish Hussain, Naji Aljohani, Nasser M. Al-Daghri. Association of Polymorphisms in RANK and RANKL Genes with Osteopenia in Arab Postmenopausal Women. Disease Markers. 2020; 2020 ():1-7.
Chicago/Turabian StyleSaba Abdi; Ihtisham Bukhari; Mohammed G. A. Ansari; Rawan A. Binbaz; Abdul Khader Mohammed; Syed Danish Hussain; Naji Aljohani; Nasser M. Al-Daghri. 2020. "Association of Polymorphisms in RANK and RANKL Genes with Osteopenia in Arab Postmenopausal Women." Disease Markers 2020, no. : 1-7.
Measures to control the on-going COVID-19 pandemic such as quarantine and social distancing, together with information overload about the sporadic spread of the disease have negatively impacted many individuals’ mental and psychosocial health. This study aimed to investigate the prevalence of self-reported mental health parameters and the coping mechanisms of employees and students in a Saudi State University. An online survey in both Arabic and English was launched targeting students, staff and faculty of King Saud University from May 11 to June 6, 2020, the peak of Saudi Arabia’s nationwide lockdown. A total of 1542 respondents (726 males and 816 females) aged 20–65 years old participated. Majority of the respondents claimed to have suffered from anxiety (58.1%), depression (50.2%) and insomnia (32.2%) during the lockdown. On average, 65.3% respondents agreed that family bond strengthened during lockdown. Those in the highest quartile of family bonding score (Q4) were 41% [odds ratio (OR) and 95% confidence interval (CI) of 0.59 (0.39–0.87), p < 0.001] and 59% [OR 0.41 (CI 0.27–0.64), p < 0.001] were less likely to be anxious and depressed, respectively, even after adjusting for covariates. This independent and significant inverse association was more apparent in females than males. Self-reported acute mental health disorders were common within the academic community during the COVID-19 lockdown. Strength of family bonding as a coping mechanism was instrumental in preserving mental well-being, especially in females.
Hanan A. Alfawaz; Kaiser Wani; Abdulaziz A. Aljumah; Dara Aldisi; Mohammed G.A. Ansari; Sobhy M. Yakout; Shaun Sabico; Nasser M. Al-Daghri. Psychological well-being during COVID-19 lockdown: Insights from a Saudi State University’s Academic Community. Journal of King Saud University - Science 2020, 33, 101262 -101262.
AMA StyleHanan A. Alfawaz, Kaiser Wani, Abdulaziz A. Aljumah, Dara Aldisi, Mohammed G.A. Ansari, Sobhy M. Yakout, Shaun Sabico, Nasser M. Al-Daghri. Psychological well-being during COVID-19 lockdown: Insights from a Saudi State University’s Academic Community. Journal of King Saud University - Science. 2020; 33 (1):101262-101262.
Chicago/Turabian StyleHanan A. Alfawaz; Kaiser Wani; Abdulaziz A. Aljumah; Dara Aldisi; Mohammed G.A. Ansari; Sobhy M. Yakout; Shaun Sabico; Nasser M. Al-Daghri. 2020. "Psychological well-being during COVID-19 lockdown: Insights from a Saudi State University’s Academic Community." Journal of King Saud University - Science 33, no. 1: 101262-101262.