For decades, Metal oxide (MOX) gas sensors have been commercially available and used in various applications such as the Smart City, gas monitoring, and safety due to advantages such as high sensitivity, a high detection range, fast reaction time, and cost-effectiveness. However, several factors affect the sensing ability of MOX gas sensors. This article presents the results of a study on the cross-sensitivity of MOX gas sensors toward ambient temperature and humidity. A gas sensor array consisting of temperature and humidity sensors and four different MOX gas sensors (MiCS-5524, GM-402B, GM-502B, and MiCS-6814) was developed. The sensors were subjected to various relative gas concentrations, temperatures (from 16 °C to 30 °C), and humidity levels (from 75% to 45%), representing a typical indoor environment. The results proved that the gas sensor responses were significantly affected by the temperature and humidity. The increased temperature and humidity levels led to a decreased response for all sensors, except for MiCS-6814, which showed the opposite response. Hence, this work proposed regression models for each sensor, which can correct the gas sensor response drift caused by the ambient temperature and humidity variations. The models were validated, and the standard deviations of the corrected sensor response were found to be 1.66 kΩ, 13.17 kΩ, 29.67 kΩ, and 0.12 kΩ, respectively. These values are much smaller compared to the raw sensor response (i.e., 18.22, 24.33 kΩ, 95.18 kΩ, and 2.99 kΩ), indicating that the model provided a more stable output and minimised the drift. Overall, the results also proved that the models can be used for MOX gas sensors employed in the training process, as well as for other sets of gas sensors.