Energy conservation in buildings has been the focus of many studies since nearly one-third of global energy consumption is due to buildings. Phase change material (PCM) technology promises to be an attractive solution for energy saving in buildings since it is a passive and effective technology, as demonstrated in the literature. Therefore, this study focuses on the energy-saving performance of PCM-integrated buildings located in a Mediterranean climate to reveal their energy-saving potential. PCM is integrated both in external or internal south walls and roofs of buildings under four different climatic conditions. EnergyPlus, which is a well-known building simulation software, is adopted for building thermal analyses. The effects of melting temperature, location of PCM layer in the wall, thickness of PCM layer, type of envelope (wall or roof), and PCM double-layer system in the wall are investigated. The corresponding energy savings and CO₂ emission reductions are obtained for the considered cases. The results showed that up to 41.6% reduction in energy demand can be obtained depending on the PCM application. Besides, PCM with a low melting temperature (21 °C) favored heating energy savings, while PCM with a high melting temperature (29 °C) favored cooling energy savings. Moreover, the double-layer PCM system provided higher energy savings than the single-layer PCM system, especially in warm and arid regions (Sousse and Tozeur).