Oropouche fever, caused by the Oropouche virus (OROV), has become a significant public health concern. Recent outbreaks highlight its increasing global spread, driven by environmental, social, and ecological factors. The disease presents clinical similarities to other arboviral infections, making accurate diagnosis essential for effective management and prevention. This article examines the epidemiological patterns of Oropouche fever, including its geographic distribution and outbreak drivers. It explores the clinical manifestations of the disease, focusing on common symptoms, complications such as fatal cases and fetal abnormalities, and the necessity of differential diagnosis. The pathophysiology of OROV infection is analyzed, detailing viral entry mechanisms, immune responses, and the role of vectors in transmission. Additionally, we assess diagnostic challenges, comparing serological and molecular methods while identifying their limitations. Therapeutic strategies are also reviewed, including symptomatic treatments and potential antiviral candidates. Findings indicate that OROV infections mimic other arboviral diseases, complicating clinical diagnosis. Current diagnostic tools have limitations in accuracy and accessibility, particularly in resource-limited settings. Symptomatic treatment remains the primary approach, as no specific antiviral therapies or vaccines exist. The study identifies gaps in diagnostic development, vaccine research, and public health surveillance. Oropouche fever threatens global health, necessitating improved surveillance, diagnostic tools, and targeted research efforts. Enhancing epidemiological studies and developing effective vaccines will mitigate its impact. Strengthening public health strategies can help control the spread of OROV and reduce its burden on affected populations.

Skin is designed to protect various tissues, and because it is the largest and first human bodily organ to sustain damage, it has an incredible ability to regenerate. On account of extreme injuries or extensive surface loss, the normal injury recuperating interaction might be inadequate or deficient, bringing about risky and disagreeable circumstances that request the utilization of fixed adjuvants and tissue substitutes. Due to their remarkable biocompatibility, biodegradability, and bioactive abilities, such as antibacterial, immunomodulatory, cell proliferative, and wound mending properties, biodegradable polymers, both synthetic and natural, are experiencing remarkable progress. Furthermore, the ability to convert these polymers into submicrometric filaments has further enhanced their potential (e.g., by means of electrospinning) to impersonate the stringy extracellular grid and permit neo-tissue creation, which is a basic component for delivering a mending milieu. Together with natural biomaterial, synthetic polymers are used to solve stability problems and make scaffolds that can dramatically improve wound healing. Biodegradable polymers, commonly referred to as biopolymers, are increasingly used in other industrial sectors to reduce the environmental impact of material and energy usage as they are fabricated using renewable biological sources. Electrospinning is one of the best ways to fabricate nanofibers and membranes that are very thin and one of the best ways to fabricate continuous nanomaterials with a wide range of biological, chemical, and physical properties. This review paper concludes with a summary of the electrospinning (applied electric field, needle-to-collector distance, and flow rate), solution (solvent, polymer concentration, viscosity, and solution conductivity), and environmental (humidity and temperature) factors that affect the production of nanofibers and the use of bio-based natural and synthetic electrospun scaffolds in wound healing.