Climate change has significantly influenced the spread of waterborne diseases (WBDs), which affect environmental quality and human life. The impact of climate change is greatest in developing countries, especially in the Association of Southeast Asian Nations (ASEAN) countries. Vibrio cholerae, a waterborne pathogen, is most susceptible to and most prevalent during severe climatic changes. The Philippines is regularly exposed to tropical cyclones, such as Bopha in 2012 and Haiyan in 2013, because of its geographical location, while Cyclone Nargis in 2008 caused over 95% of the damage and casualties seen in the preceding two decades in Myanmar. Therefore, implementing policies to adjust to these climate changes and to safeguard their citizens from the effects of WBDs is imperative for ASEAN countries. This study aimed to (1) investigate the effects of climate change on health and to understand the policy requirements to prevent or minimize its negative impact and (2) explore the link between the Sustainable Development Goals (SDGs) and the effects of climate change on WBDs to determine perspectives for global sustainability. The framework of the SDGs should be adapted to ASEAN countries to improve legislation, laws, and regulations on climate-related health issues. Efficient collaboration among scientists, researchers, health professionals, and policymakers will assist in addressing the problems associated with the impact of climate change on WBDs in ASEAN countries.

Jeong In Lee & Sim Namkoong. BMB Reports 2022;55:577-86. https://doi.org/10.5483/BMBRep.2022.55.12.141

Mounting evidence supports the relationship between obesity and cancer. However, the molecular mechanisms linking obesity with cancer remain largely uninvestigated. In this study, we demonstrate that the expression of C1q/TNF-related protein 1 (CTRP1), an adiponectin paralogue, contributes to tumor growth by regulating the tumor suppressor p53. In our study, obese mice on a high-fat diet showed higher serum CTRP1 levels. Through in vitro experiments, we showed that the secreted form of CTRP1 in the culture medium decreased p53 expression and p53-dependent transcription in the cells. Moreover, CTRP1 treatment enhanced colony formation and cell migration. These results collectively suggest that elevated levels of CTRP1 in obesity significantly contribute to tumor progression.

Transposable elements (TEs) are DNA sequences that can transpose and replicate within the genome, leading to genetic changes that affect various aspects of host biology. Evolutionarily, hosts have also developed molecular mechanisms to suppress TEs at the transcriptional and post-transcriptional levels. Recent studies suggest that stress-induced formation of ribonucleoprotein (RNP) granules, including stress granule (SG) and processing body (P-body), can play a role in the sequestration of TEs to prevent transposition, suggesting an additional layer of the regulatory mechanism for TEs. RNP granules have been shown to contain factors involved in RNA regulation, including mRNA decay enzymes, RNA-binding proteins, and noncoding RNAs, which could potentially contribute to the regulation of TEs. Therefore, understanding the interplay between TEs and RNP granules is crucial for elucidating the mechanisms for maintaining genomic stability and controlling gene expression. In this review, we provide a brief overview of the current knowledge regarding the interplay between TEs and RNP granules, proposing RNP granules as a novel layer of the regulatory mechanism for TEs during stress.

Waterborne pathogens and associated diseases continue to pose a significant global health challenge, requiring effective monitoring, detection, and treatment strategies. This review examines the current state of waterborne pathogen management, highlighting persistent issues and recent advancements. Here, we review cutting-edge detection methods and treatment technology, emphasizing their roles in water safety and outbreak prevention. The impact of climate change on waterborne pathogen dynamics is explored, alongside a discussion of interdisciplinary research approaches. We also aimed to investigate the crucial relationship between waterborne disease control and Sustainable Development Goals (SDGs), focusing on community engagement, well-being, water sanitation, public health policies, and international cooperation. The PRISMA protocol systematic process was used to filter papers for this study and carry out the review process. Machine learning and remote sensing techniques are promising features in the pathogen detection field. SDGs 3, 6, 11, 13, and 17 are the most closely interrelated with waterborne diseases. This review provides an in-depth overview of waterborne pathogen management, contributing to improved global water quality and public health strategies. This integrated approach aims to enhance health outcomes and promote resilience against waterborne diseases, particularly for vulnerable communities.