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Jorlan Fernandes
Laboratory of Hantaviroses and Rickettsioses, Oswaldo Cruz Institute, FIOCRUZ, Rio de Janeiro 21040-900, Brazil

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Journal article
Published: 22 June 2021 in Viruses
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Bats are hosts of a range of viruses, and their great diversity and unique characteristics that distinguish them from all other mammals have been related to the maintenance, evolution, and dissemination of these pathogens. Recently, very divergent hantaviruses have been discovered in distinct species of bats worldwide, but their association with human disease remains unclear. Considering the low success rates of detecting hantavirus RNA in bat tissues and that to date no hantaviruses have been isolated from bat samples, immunodiagnostic tools could be very helpful to understand pathogenesis, epidemiology, and geographic range of bat-borne hantaviruses. In this sense, we aimed to identify in silico immunogenic B-cell epitopes present on bat-borne hantaviruses nucleoprotein (NP) and verify if they are conserved among them and other selected members of Mammantavirinae, using a combination of (the three most used) different prediction algorithms, ELLIPRO, Discotope 2.0, and PEPITO server. To support our data, we in silico modeled 3D structures of NPs from representative members of bat-borne hantaviruses, using comparative and ab initio methods due to the absence of crystallographic structures of studied proteins or similar models in the Protein Data Bank. Our analysis demonstrated the antigenic complexity of the bat-borne hantaviruses group, showing a low sequence conservation of epitopes among members of its own group and a minor conservation degree in comparison to Orthohantavirus, with a recognized importance to public health. Our data suggest that the use of recombinant rodent-borne hantavirus NPs to cross-detect antibodies against bat- or shrew-borne viruses could underestimate the real impact of this virus in nature.

ACS Style

Renata de Oliveira; Jorlan Fernandes; Elba de Sampaio Lemos; Fernando De Paiva Conte; Rodrigo Rodrigues-Da-Silva. The Serological Cross-Detection of Bat-Borne Hantaviruses: A Valid Strategy or Taking Chances? Viruses 2021, 13, 1188 .

AMA Style

Renata de Oliveira, Jorlan Fernandes, Elba de Sampaio Lemos, Fernando De Paiva Conte, Rodrigo Rodrigues-Da-Silva. The Serological Cross-Detection of Bat-Borne Hantaviruses: A Valid Strategy or Taking Chances? Viruses. 2021; 13 (7):1188.

Chicago/Turabian Style

Renata de Oliveira; Jorlan Fernandes; Elba de Sampaio Lemos; Fernando De Paiva Conte; Rodrigo Rodrigues-Da-Silva. 2021. "The Serological Cross-Detection of Bat-Borne Hantaviruses: A Valid Strategy or Taking Chances?" Viruses 13, no. 7: 1188.

Journal article
Published: 11 June 2021 in Viruses
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In Brazil, the first confirmed cases of hantavirus cardiopulmonary syndrome in Indigenous populations occurred in 2001. The purpose of this study was to determine the seroprevalence of orthohantavirus infections in the Utiariti Indigenous land located in the southeastern region of the Brazilian Amazon. In December 2014 and 2015, a survey was conducted using an enzyme-linked immunosorbent assay in nine villages belonging to the Haliti–Paresí Indigenous communities. A total of 301 participants were enrolled in the study. Of the two study cohorts, the one from 2014 showed a prevalence of 12.4%, whereas the one from 2015 had a serum prevalence of 13.4%. Analysis of the paired samples of 110 Indigenous people who participated in both stages of the study enabled identification of four individuals who had seroconverted during the study period. Identifying the circulation of orthohantaviruses in the Utiariti Indigenous land highlights a serious public health problem in viral expansion and highlights the need to implement preventive measures appropriate to the sociocultural reality of these communities.

ACS Style

Ana Terças-Trettel; Alba de Melo; Renata de Oliveira; Alexandro Guterres; Jorlan Fernandes; Liana Pereira; Marina Atanaka; Mariano Espinosa; Bernardo Teixeira; Cibele Bonvicino; Paulo D’Andrea; Elba de Lemos. Orthohantavirus Survey in Indigenous Lands in a Savannah-Like Biome, Brazil. Viruses 2021, 13, 1122 .

AMA Style

Ana Terças-Trettel, Alba de Melo, Renata de Oliveira, Alexandro Guterres, Jorlan Fernandes, Liana Pereira, Marina Atanaka, Mariano Espinosa, Bernardo Teixeira, Cibele Bonvicino, Paulo D’Andrea, Elba de Lemos. Orthohantavirus Survey in Indigenous Lands in a Savannah-Like Biome, Brazil. Viruses. 2021; 13 (6):1122.

Chicago/Turabian Style

Ana Terças-Trettel; Alba de Melo; Renata de Oliveira; Alexandro Guterres; Jorlan Fernandes; Liana Pereira; Marina Atanaka; Mariano Espinosa; Bernardo Teixeira; Cibele Bonvicino; Paulo D’Andrea; Elba de Lemos. 2021. "Orthohantavirus Survey in Indigenous Lands in a Savannah-Like Biome, Brazil." Viruses 13, no. 6: 1122.

Journal article
Published: 23 November 2020 in Cells
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Mammarenaviruses are a diverse genus of emerging viruses that include several causative agents of severe viral hemorrhagic fevers with high mortality in humans. Although these viruses share many similarities, important differences with regard to pathogenicity, type of immune response, and molecular mechanisms during virus infection are different between and within New World and Old World viral infections. Viruses rely exclusively on the host cellular machinery to translate their genome, and therefore to replicate and propagate. miRNAs are the crucial factor in diverse biological processes such as antiviral defense, oncogenesis, and cell development. The viral infection can exert a profound impact on the cellular miRNA expression profile, and numerous RNA viruses have been reported to interact directly with cellular miRNAs and/or to use these miRNAs to augment their replication potential. Our present study indicates that mammarenavirus infection induces metabolic reprogramming of host cells, probably manipulating cellular microRNAs. A number of metabolic pathways, including valine, leucine, and isoleucine biosynthesis, d-Glutamine and d-glutamate metabolism, thiamine metabolism, and pools of several amino acids were impacted by the predicted miRNAs that would no longer regulate these pathways. A deeper understanding of mechanisms by which mammarenaviruses handle these signaling pathways is critical for understanding the virus/host interactions and potential diagnostic and therapeutic targets, through the inhibition of specific pathologic metabolic pathways.

ACS Style

Jorlan Fernandes; Renan Lyra Miranda; Elba Regina Sampaio De Lemos; Alexandro Guterres. MicroRNAs and Mammarenaviruses: Modulating Cellular Metabolism. Cells 2020, 9, 2525 .

AMA Style

Jorlan Fernandes, Renan Lyra Miranda, Elba Regina Sampaio De Lemos, Alexandro Guterres. MicroRNAs and Mammarenaviruses: Modulating Cellular Metabolism. Cells. 2020; 9 (11):2525.

Chicago/Turabian Style

Jorlan Fernandes; Renan Lyra Miranda; Elba Regina Sampaio De Lemos; Alexandro Guterres. 2020. "MicroRNAs and Mammarenaviruses: Modulating Cellular Metabolism." Cells 9, no. 11: 2525.

Virology division news
Published: 04 September 2020 in Archives of Virology
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In March 2020, following the annual International Committee on Taxonomy of Viruses (ICTV) ratification vote on newly proposed taxa, the phylum Negarnaviricota was amended and emended. At the genus rank, 20 new genera were added, two were deleted, one was moved, and three were renamed. At the species rank, 160 species were added, four were deleted, ten were moved and renamed, and 30 species were renamed. This article presents the updated taxonomy of Negarnaviricota as now accepted by the ICTV.

ACS Style

Jens H. Kuhn; Scott Adkins; Daniela Alioto; Sergey V. Alkhovsky; Gaya K. Amarasinghe; Simon J. Anthony; Tatjana Avšič-Županc; María A. Ayllón; Justin Bahl; Anne Balkema-Buschmann; Matthew J. Ballinger; Tomáš Bartonička; Christopher Basler; Sina Bavari; Martin Beer; Dennis A. Bente; Éric Bergeron; Brian H. Bird; Carol Blair; Kim R. Blasdell; Steven B. Bradfute; Rachel Breyta; Thomas Briese; Paul A. Brown; Ursula J. Buchholz; Michael J. Buchmeier; Alexander Bukreyev; Felicity Burt; Nihal Buzkan; Charles H. Calisher; Mengji Cao; Inmaculada Casas; John Chamberlain; Kartik Chandran; Rémi N. Charrel; Biao Chen; Michela Chiumenti; Il-Ryong Choi; J. Christopher S. Clegg; Ian Crozier; John V. Da Graça; Elena Dal Bó; Alberto M. R. Dávila; Juan Carlos De La Torre; Xavier De Lamballerie; Rik L. De Swart; Patrick L. Di Bello; Nicholas Di Paola; Francesco Di Serio; Ralf G. Dietzgen; Michele Digiaro; Valerian V. Dolja; Olga Dolnik; Michael A. Drebot; Jan Felix Drexler; Ralf Dürrwald; Lucie Dufkova; William G. Dundon; W. Paul Duprex; John M. Dye; Andrew J. Easton; Hideki Ebihara; Toufic Elbeaino; Koray Ergünay; Jorlan Fernandes; Anthony R. Fooks; Pierre B. H. Formenty; Leonie F. Forth; Ron A. M. Fouchier; Juliana Freitas-Astúa; Selma Gago-Zachert; George Fú Gāo; María Laura García; Adolfo García-Sastre; Aura R. Garrison; Aiah Gbakima; Tracey Goldstein; Jean-Paul J. Gonzalez; Anthony Griffiths; Martin H. Groschup; Stephan Günther; Alexandro Guterres; Roy A. Hall; John Hammond; Mohamed Hassan; Jussi Hepojoki; Satu Hepojoki; Udo Hetzel; Roger Hewson; Bernd Hoffmann; Seiji Hongo; Dirk Höper; Masayuki Horie; Holly R. Hughes; Timothy H. Hyndman; Amara Jambai; Rodrigo Jardim; Dàohóng Jiāng; Qi Jin; Gilda B. Jonson; Sandra Junglen; Serpil Karadağ; Karen E. Keller; Boris Klempa; Jonas Klingström; Gary Kobinger; Hideki Kondō; Eugene V. Koonin; Mart Krupovic; Gael Kurath; Ivan V. Kuzmin; Lies Laenen; Robert A. Lamb; Amy J. Lambert; Stanley L. Langevin; Benhur Lee; Elba R. S. Lemos; Eric M. Leroy; Dexin Li; Jiànróng Lǐ; Mifang Liang; Wénwén Liú; Yàn Liú; Igor S. Lukashevich; Piet Maes; William Marciel De Souza; Marco Marklewitz; Sergio H. Marshall; Giovanni P. Martelli; Robert R. Martin; Shin-Yi L. Marzano; Sébastien Massart; John W. McCauley; Nicole Mielke-Ehret; Angelantonio Minafra; Maria Minutolo; Ali Mirazimi; Hans-Peter Mühlbach; Elke Mühlberger; Rayapati Naidu; Tomohide Natsuaki; Beatriz Navarro; José A. Navarro; Sergey V. Netesov; Gabriele Neumann; Norbert Nowotny; Márcio R. T. Nunes; Are Nylund; Arnfinn L. Økland; Renata C. Oliveira; Gustavo Palacios; Vicente Pallas; Bernadett Pályi; Anna Papa; Colin R. Parrish; Alex Pauvolid-Corrêa; Janusz T. Pawęska; Susan Payne; Daniel R. Pérez; Florian Pfaff; Sheli R. Radoshitzky; Aziz-Ul Rahman; Pedro L. Ramos-González; Renato O. Resende; Carina A. Reyes; Bertus K. Rima; Víctor Romanowski; Gabriel Robles Luna; Paul Rota; Dennis Rubbenstroth; Jonathan A. Runstadler; Daniel Ruzek; Sead Sabanadzovic; Jiří Salát; Amadou Alpha Sall; Maria S. Salvato; Kamil Sarpkaya; Takahide Sasaya; Martin Schwemmle; Muhammad Z. Shabbir; Xiǎohóng Shí; Zhènglì Shí; Yukio Shirako; Peter Simmonds; Jana Širmarová; Manuela Sironi; Sophie Smither; Teemu Smura; Jin-Won Song; Kirsten M. Spann; Jessica R. Spengler; Mark D. Stenglein; David M. Stone; Petra Straková; Ayato Takada; Robert B. Tesh; Natalie J. Thornburg; Keizō Tomonaga; Noël Tordo; Jonathan S. Towner; Massimo Turina; Ioannis Tzanetakis; Rainer G. Ulrich; Anna Maria Vaira; Bernadette Van Den Hoogen; Arvind Varsani; Nikos Vasilakis; Martin Verbeek; Victoria Wahl; Peter J. Walker; Hui Wang; Jianwei Wang; Xifeng Wang; Lin-Fa Wang; Tàiyún Wèi; Heather Wells; Anna E. Whitfield; John V. Williams; Yuri I. Wolf; Zhìqiáng Wú; Xin Yang; Xīnglóu Yáng; Xuejie Yu; Natalya Yutin; F. Murilo Zerbini; Tong Zhang; Yong-Zhen Zhang; Guohui Zhou; Xueping Zhou. 2020 taxonomic update for phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales. Archives of Virology 2020, 165, 3023 -3072.

AMA Style

Jens H. Kuhn, Scott Adkins, Daniela Alioto, Sergey V. Alkhovsky, Gaya K. Amarasinghe, Simon J. Anthony, Tatjana Avšič-Županc, María A. Ayllón, Justin Bahl, Anne Balkema-Buschmann, Matthew J. Ballinger, Tomáš Bartonička, Christopher Basler, Sina Bavari, Martin Beer, Dennis A. Bente, Éric Bergeron, Brian H. Bird, Carol Blair, Kim R. Blasdell, Steven B. Bradfute, Rachel Breyta, Thomas Briese, Paul A. Brown, Ursula J. Buchholz, Michael J. Buchmeier, Alexander Bukreyev, Felicity Burt, Nihal Buzkan, Charles H. Calisher, Mengji Cao, Inmaculada Casas, John Chamberlain, Kartik Chandran, Rémi N. Charrel, Biao Chen, Michela Chiumenti, Il-Ryong Choi, J. Christopher S. Clegg, Ian Crozier, John V. Da Graça, Elena Dal Bó, Alberto M. R. Dávila, Juan Carlos De La Torre, Xavier De Lamballerie, Rik L. De Swart, Patrick L. Di Bello, Nicholas Di Paola, Francesco Di Serio, Ralf G. Dietzgen, Michele Digiaro, Valerian V. Dolja, Olga Dolnik, Michael A. Drebot, Jan Felix Drexler, Ralf Dürrwald, Lucie Dufkova, William G. Dundon, W. Paul Duprex, John M. Dye, Andrew J. Easton, Hideki Ebihara, Toufic Elbeaino, Koray Ergünay, Jorlan Fernandes, Anthony R. Fooks, Pierre B. H. Formenty, Leonie F. Forth, Ron A. M. Fouchier, Juliana Freitas-Astúa, Selma Gago-Zachert, George Fú Gāo, María Laura García, Adolfo García-Sastre, Aura R. Garrison, Aiah Gbakima, Tracey Goldstein, Jean-Paul J. Gonzalez, Anthony Griffiths, Martin H. Groschup, Stephan Günther, Alexandro Guterres, Roy A. Hall, John Hammond, Mohamed Hassan, Jussi Hepojoki, Satu Hepojoki, Udo Hetzel, Roger Hewson, Bernd Hoffmann, Seiji Hongo, Dirk Höper, Masayuki Horie, Holly R. Hughes, Timothy H. Hyndman, Amara Jambai, Rodrigo Jardim, Dàohóng Jiāng, Qi Jin, Gilda B. Jonson, Sandra Junglen, Serpil Karadağ, Karen E. Keller, Boris Klempa, Jonas Klingström, Gary Kobinger, Hideki Kondō, Eugene V. Koonin, Mart Krupovic, Gael Kurath, Ivan V. Kuzmin, Lies Laenen, Robert A. Lamb, Amy J. Lambert, Stanley L. Langevin, Benhur Lee, Elba R. S. Lemos, Eric M. Leroy, Dexin Li, Jiànróng Lǐ, Mifang Liang, Wénwén Liú, Yàn Liú, Igor S. Lukashevich, Piet Maes, William Marciel De Souza, Marco Marklewitz, Sergio H. Marshall, Giovanni P. Martelli, Robert R. Martin, Shin-Yi L. Marzano, Sébastien Massart, John W. McCauley, Nicole Mielke-Ehret, Angelantonio Minafra, Maria Minutolo, Ali Mirazimi, Hans-Peter Mühlbach, Elke Mühlberger, Rayapati Naidu, Tomohide Natsuaki, Beatriz Navarro, José A. Navarro, Sergey V. Netesov, Gabriele Neumann, Norbert Nowotny, Márcio R. T. Nunes, Are Nylund, Arnfinn L. Økland, Renata C. Oliveira, Gustavo Palacios, Vicente Pallas, Bernadett Pályi, Anna Papa, Colin R. Parrish, Alex Pauvolid-Corrêa, Janusz T. Pawęska, Susan Payne, Daniel R. Pérez, Florian Pfaff, Sheli R. Radoshitzky, Aziz-Ul Rahman, Pedro L. Ramos-González, Renato O. Resende, Carina A. Reyes, Bertus K. Rima, Víctor Romanowski, Gabriel Robles Luna, Paul Rota, Dennis Rubbenstroth, Jonathan A. Runstadler, Daniel Ruzek, Sead Sabanadzovic, Jiří Salát, Amadou Alpha Sall, Maria S. Salvato, Kamil Sarpkaya, Takahide Sasaya, Martin Schwemmle, Muhammad Z. Shabbir, Xiǎohóng Shí, Zhènglì Shí, Yukio Shirako, Peter Simmonds, Jana Širmarová, Manuela Sironi, Sophie Smither, Teemu Smura, Jin-Won Song, Kirsten M. Spann, Jessica R. Spengler, Mark D. Stenglein, David M. Stone, Petra Straková, Ayato Takada, Robert B. Tesh, Natalie J. Thornburg, Keizō Tomonaga, Noël Tordo, Jonathan S. Towner, Massimo Turina, Ioannis Tzanetakis, Rainer G. Ulrich, Anna Maria Vaira, Bernadette Van Den Hoogen, Arvind Varsani, Nikos Vasilakis, Martin Verbeek, Victoria Wahl, Peter J. Walker, Hui Wang, Jianwei Wang, Xifeng Wang, Lin-Fa Wang, Tàiyún Wèi, Heather Wells, Anna E. Whitfield, John V. Williams, Yuri I. Wolf, Zhìqiáng Wú, Xin Yang, Xīnglóu Yáng, Xuejie Yu, Natalya Yutin, F. Murilo Zerbini, Tong Zhang, Yong-Zhen Zhang, Guohui Zhou, Xueping Zhou. 2020 taxonomic update for phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales. Archives of Virology. 2020; 165 (12):3023-3072.

Chicago/Turabian Style

Jens H. Kuhn; Scott Adkins; Daniela Alioto; Sergey V. Alkhovsky; Gaya K. Amarasinghe; Simon J. Anthony; Tatjana Avšič-Županc; María A. Ayllón; Justin Bahl; Anne Balkema-Buschmann; Matthew J. Ballinger; Tomáš Bartonička; Christopher Basler; Sina Bavari; Martin Beer; Dennis A. Bente; Éric Bergeron; Brian H. Bird; Carol Blair; Kim R. Blasdell; Steven B. Bradfute; Rachel Breyta; Thomas Briese; Paul A. Brown; Ursula J. Buchholz; Michael J. Buchmeier; Alexander Bukreyev; Felicity Burt; Nihal Buzkan; Charles H. Calisher; Mengji Cao; Inmaculada Casas; John Chamberlain; Kartik Chandran; Rémi N. Charrel; Biao Chen; Michela Chiumenti; Il-Ryong Choi; J. Christopher S. Clegg; Ian Crozier; John V. Da Graça; Elena Dal Bó; Alberto M. R. Dávila; Juan Carlos De La Torre; Xavier De Lamballerie; Rik L. De Swart; Patrick L. Di Bello; Nicholas Di Paola; Francesco Di Serio; Ralf G. Dietzgen; Michele Digiaro; Valerian V. Dolja; Olga Dolnik; Michael A. Drebot; Jan Felix Drexler; Ralf Dürrwald; Lucie Dufkova; William G. Dundon; W. Paul Duprex; John M. Dye; Andrew J. Easton; Hideki Ebihara; Toufic Elbeaino; Koray Ergünay; Jorlan Fernandes; Anthony R. Fooks; Pierre B. H. Formenty; Leonie F. Forth; Ron A. M. Fouchier; Juliana Freitas-Astúa; Selma Gago-Zachert; George Fú Gāo; María Laura García; Adolfo García-Sastre; Aura R. Garrison; Aiah Gbakima; Tracey Goldstein; Jean-Paul J. Gonzalez; Anthony Griffiths; Martin H. Groschup; Stephan Günther; Alexandro Guterres; Roy A. Hall; John Hammond; Mohamed Hassan; Jussi Hepojoki; Satu Hepojoki; Udo Hetzel; Roger Hewson; Bernd Hoffmann; Seiji Hongo; Dirk Höper; Masayuki Horie; Holly R. Hughes; Timothy H. Hyndman; Amara Jambai; Rodrigo Jardim; Dàohóng Jiāng; Qi Jin; Gilda B. Jonson; Sandra Junglen; Serpil Karadağ; Karen E. Keller; Boris Klempa; Jonas Klingström; Gary Kobinger; Hideki Kondō; Eugene V. Koonin; Mart Krupovic; Gael Kurath; Ivan V. Kuzmin; Lies Laenen; Robert A. Lamb; Amy J. Lambert; Stanley L. Langevin; Benhur Lee; Elba R. S. Lemos; Eric M. Leroy; Dexin Li; Jiànróng Lǐ; Mifang Liang; Wénwén Liú; Yàn Liú; Igor S. Lukashevich; Piet Maes; William Marciel De Souza; Marco Marklewitz; Sergio H. Marshall; Giovanni P. Martelli; Robert R. Martin; Shin-Yi L. Marzano; Sébastien Massart; John W. McCauley; Nicole Mielke-Ehret; Angelantonio Minafra; Maria Minutolo; Ali Mirazimi; Hans-Peter Mühlbach; Elke Mühlberger; Rayapati Naidu; Tomohide Natsuaki; Beatriz Navarro; José A. Navarro; Sergey V. Netesov; Gabriele Neumann; Norbert Nowotny; Márcio R. T. Nunes; Are Nylund; Arnfinn L. Økland; Renata C. Oliveira; Gustavo Palacios; Vicente Pallas; Bernadett Pályi; Anna Papa; Colin R. Parrish; Alex Pauvolid-Corrêa; Janusz T. Pawęska; Susan Payne; Daniel R. Pérez; Florian Pfaff; Sheli R. Radoshitzky; Aziz-Ul Rahman; Pedro L. Ramos-González; Renato O. Resende; Carina A. Reyes; Bertus K. Rima; Víctor Romanowski; Gabriel Robles Luna; Paul Rota; Dennis Rubbenstroth; Jonathan A. Runstadler; Daniel Ruzek; Sead Sabanadzovic; Jiří Salát; Amadou Alpha Sall; Maria S. Salvato; Kamil Sarpkaya; Takahide Sasaya; Martin Schwemmle; Muhammad Z. Shabbir; Xiǎohóng Shí; Zhènglì Shí; Yukio Shirako; Peter Simmonds; Jana Širmarová; Manuela Sironi; Sophie Smither; Teemu Smura; Jin-Won Song; Kirsten M. Spann; Jessica R. Spengler; Mark D. Stenglein; David M. Stone; Petra Straková; Ayato Takada; Robert B. Tesh; Natalie J. Thornburg; Keizō Tomonaga; Noël Tordo; Jonathan S. Towner; Massimo Turina; Ioannis Tzanetakis; Rainer G. Ulrich; Anna Maria Vaira; Bernadette Van Den Hoogen; Arvind Varsani; Nikos Vasilakis; Martin Verbeek; Victoria Wahl; Peter J. Walker; Hui Wang; Jianwei Wang; Xifeng Wang; Lin-Fa Wang; Tàiyún Wèi; Heather Wells; Anna E. Whitfield; John V. Williams; Yuri I. Wolf; Zhìqiáng Wú; Xin Yang; Xīnglóu Yáng; Xuejie Yu; Natalya Yutin; F. Murilo Zerbini; Tong Zhang; Yong-Zhen Zhang; Guohui Zhou; Xueping Zhou. 2020. "2020 taxonomic update for phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales." Archives of Virology 165, no. 12: 3023-3072.

Short communication
Published: 01 January 2020 in Revista da Sociedade Brasileira de Medicina Tropical
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Demographic density in the Brazilian Amazonian region is low (4.7 persons/km2), and many areas are nearly bereft of healthcare facilities. Paradoxically, an intense urbanization process has been taking place in this region in the last few years1,2. Since the 1970s, the Brazilian government has been creating rural settlements in the Amazon, and in this region, agriculture and farming are the two main economic activities conducted for livelihood2.

ACS Style

Jorlan Fernandes; Thayssa Alves Coelho; Renata Carvalho De Oliveira; Alexandro Guterres; Claudia Lamarca Vitral; Bernardo Teixeira; Fernando De Oliveira Santos; Jaqueline Mendes De Oliveira; Mônica Da Silva-Nunes; Marco Aurélio Pereira Horta; Silvana C. Levis; Marcelo Urbano Ferreira; Elba Regina Sampaio De Lemos. A Retrospective Survey of Rodent-borne Viruses in Rural Populations of Brazilian Amazon. Revista da Sociedade Brasileira de Medicina Tropical 2020, 53, e20190511 .

AMA Style

Jorlan Fernandes, Thayssa Alves Coelho, Renata Carvalho De Oliveira, Alexandro Guterres, Claudia Lamarca Vitral, Bernardo Teixeira, Fernando De Oliveira Santos, Jaqueline Mendes De Oliveira, Mônica Da Silva-Nunes, Marco Aurélio Pereira Horta, Silvana C. Levis, Marcelo Urbano Ferreira, Elba Regina Sampaio De Lemos. A Retrospective Survey of Rodent-borne Viruses in Rural Populations of Brazilian Amazon. Revista da Sociedade Brasileira de Medicina Tropical. 2020; 53 ():e20190511.

Chicago/Turabian Style

Jorlan Fernandes; Thayssa Alves Coelho; Renata Carvalho De Oliveira; Alexandro Guterres; Claudia Lamarca Vitral; Bernardo Teixeira; Fernando De Oliveira Santos; Jaqueline Mendes De Oliveira; Mônica Da Silva-Nunes; Marco Aurélio Pereira Horta; Silvana C. Levis; Marcelo Urbano Ferreira; Elba Regina Sampaio De Lemos. 2020. "A Retrospective Survey of Rodent-borne Viruses in Rural Populations of Brazilian Amazon." Revista da Sociedade Brasileira de Medicina Tropical 53, no. : e20190511.

Journal article
Published: 25 May 2019 in International Journal of Environmental Research and Public Health
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People living in mining regions are exposed to numerous biological agents by several specific types of transmission mechanisms. This study is designed to describe fatal hantavirus pulmonary syndrome (HPS) cases confirmed by serology and molecular analysis, where a seroprevalence survey was conducted in the gold mining regions of the state of Mato Grosso, in the official Amazon region, Brazil. Two fatal cases of HPS were confirmed in a mining area in the Legal Amazon, where malaria is one of the most important public health problems. A molecular analysis detected the presence of the genome of the Castelo dos Sonhos virus. Out of the 112 blood samples analyzed, five were positive for Plasmodium infection (four P. falciparum and one P. vivax), and four were seropositive for hantavirus, showing a seroprevalence of 3.57%. One of the four miners who was seroreactive for hantavirus concomitantly had P. falciparum infection, which was confirmed by thick blood smear. This manuscript highlights the importance of considering hantavirus pulmonary syndrome as a diagnostic possibility in febrile infection associated with pulmonary manifestations in mining areas where malaria cases are often identified.

ACS Style

Ana Cláudia Pereira Terças-Trettel; Elaine Cristina de Oliveira; Cor Jesus Fernandes Fontes; Alba Valéria Gomes de Melo; Renata Carvalho de Oliveira; Alexandro Guterres; Jorlan Fernandes; Raphael Gomes da Silva; Marina Atanaka; Mariano Martinez Espinosa; Elba Regina Sampaio de Lemos. Malaria and Hantavirus Pulmonary Syndrome in Gold Mining in the Amazon Region, Brazil. International Journal of Environmental Research and Public Health 2019, 16, 1852 .

AMA Style

Ana Cláudia Pereira Terças-Trettel, Elaine Cristina de Oliveira, Cor Jesus Fernandes Fontes, Alba Valéria Gomes de Melo, Renata Carvalho de Oliveira, Alexandro Guterres, Jorlan Fernandes, Raphael Gomes da Silva, Marina Atanaka, Mariano Martinez Espinosa, Elba Regina Sampaio de Lemos. Malaria and Hantavirus Pulmonary Syndrome in Gold Mining in the Amazon Region, Brazil. International Journal of Environmental Research and Public Health. 2019; 16 (10):1852.

Chicago/Turabian Style

Ana Cláudia Pereira Terças-Trettel; Elaine Cristina de Oliveira; Cor Jesus Fernandes Fontes; Alba Valéria Gomes de Melo; Renata Carvalho de Oliveira; Alexandro Guterres; Jorlan Fernandes; Raphael Gomes da Silva; Marina Atanaka; Mariano Martinez Espinosa; Elba Regina Sampaio de Lemos. 2019. "Malaria and Hantavirus Pulmonary Syndrome in Gold Mining in the Amazon Region, Brazil." International Journal of Environmental Research and Public Health 16, no. 10: 1852.

Journal article
Published: 23 March 2019 in Molecular Phylogenetics and Evolution
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Hantaviruses (order Bunyavirales, family Hantaviridae) are important zoonotic pathogens. Because of the great diversity of their reservoir hosts, hantaviruses are excellent models to evaluate the dynamics of virus-host co-evolution. To understand the mechanisms behind the evolutionary history of hantaviruses through virus-reservoir interactions, it is important to know how the radiation and diversity of hantaviruses occurred. In this paper, we evaluate the pattern of hantavirus diversification based on a complete S segment representing major groups of hantaviruses found in the Americas. Phylogenetic analyses revealed a high degree of phylogeographic structure and a surprising pattern of geographical distribution of New World hantaviruses. The available data suggest that hantaviruses related to the Arvicolinae rodent subfamily in North America probably emerged and initially adapted from a shared common ancestor of the Tula virus. The first clade of hantaviruses associated with Neotominae occupied a stem lineage, especially those that emerged in Central America or Mexico. Hantaviruses from Central America and Mexico found in Neotominae rodents spread northward and probably gave rise to the first phylogroup of hantaviruses associated with Sigmodontinae in North America. Two preferential host-switching transmissions in hantaviruses apparently gave rise to two different paraphyletic group in Neotominae and Sigmodontinae. Our study supports a probable epicenter of diversification in Central America and/or Mexico for hantaviruses related to both the Neotominae and Sigmodontinae subfamilies.

ACS Style

Alexandro Guterres; Renata Carvalho de Oliveira; Jorlan Fernandes; Elba Regina Sampaio de Lemos. The mystery of the phylogeographic structural pattern in rodent-borne hantaviruses. Molecular Phylogenetics and Evolution 2019, 136, 35 -43.

AMA Style

Alexandro Guterres, Renata Carvalho de Oliveira, Jorlan Fernandes, Elba Regina Sampaio de Lemos. The mystery of the phylogeographic structural pattern in rodent-borne hantaviruses. Molecular Phylogenetics and Evolution. 2019; 136 ():35-43.

Chicago/Turabian Style

Alexandro Guterres; Renata Carvalho de Oliveira; Jorlan Fernandes; Elba Regina Sampaio de Lemos. 2019. "The mystery of the phylogeographic structural pattern in rodent-borne hantaviruses." Molecular Phylogenetics and Evolution 136, no. : 35-43.

Genome announcement and highlight
Published: 01 January 2019 in Memórias do Instituto Oswaldo Cruz
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Here, we report the complete genome sequence of the Aporé virus (Bunyavirales: Arenaviridae), obtained from a wild rodent Oligoryzomys mattogrossae captured in Mato Grosso do Sul state, Brazil. The genome of this virus showed strong similarity to highly pathogenic mammarenavirus from South America.

ACS Style

Jorlan Fernandes; Alexandro Guterres; Renata Carvalho De Oliveira; Rodrigo Jardim; Alberto Dávila; Roger Hewson; Elba Regina Sampaio de Lemos. Aporé virus, a novel mammarenavirus (Bunyavirales: Arenaviridae) related to highly pathogenic virus from South America. Memórias do Instituto Oswaldo Cruz 2019, 114, e180586 .

AMA Style

Jorlan Fernandes, Alexandro Guterres, Renata Carvalho De Oliveira, Rodrigo Jardim, Alberto Dávila, Roger Hewson, Elba Regina Sampaio de Lemos. Aporé virus, a novel mammarenavirus (Bunyavirales: Arenaviridae) related to highly pathogenic virus from South America. Memórias do Instituto Oswaldo Cruz. 2019; 114 ():e180586.

Chicago/Turabian Style

Jorlan Fernandes; Alexandro Guterres; Renata Carvalho De Oliveira; Rodrigo Jardim; Alberto Dávila; Roger Hewson; Elba Regina Sampaio de Lemos. 2019. "Aporé virus, a novel mammarenavirus (Bunyavirales: Arenaviridae) related to highly pathogenic virus from South America." Memórias do Instituto Oswaldo Cruz 114, no. : e180586.

Brief communication
Published: 01 January 2019 in Revista do Instituto de Medicina Tropical de São Paulo
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Hantaviruses and arenaviruses are naturally occurring viruses of rodents, and human infections are classic examples of emerging diseases caused by the invasion of urban, agricultural, and livestock areas that are rodent habitats 1 .

ACS Style

Jorlan Fernandes; Thayssa Alves Coelho; Renata Carvalho De Oliveira; Livia Stefânia Alves Lima Guedes; Bernardo Rodrigues Teixeira; Alexandro Guterres; Christian Niel; Silvana C. Levis; Barbara Vieira Lago; Ana Rita Motta-Castro; Elba Regina Sampaio De Lemos. Seroprevalence of rodent-borne viruses in Afro-descendent communities in Brazil. Revista do Instituto de Medicina Tropical de São Paulo 2019, 61, e66 .

AMA Style

Jorlan Fernandes, Thayssa Alves Coelho, Renata Carvalho De Oliveira, Livia Stefânia Alves Lima Guedes, Bernardo Rodrigues Teixeira, Alexandro Guterres, Christian Niel, Silvana C. Levis, Barbara Vieira Lago, Ana Rita Motta-Castro, Elba Regina Sampaio De Lemos. Seroprevalence of rodent-borne viruses in Afro-descendent communities in Brazil. Revista do Instituto de Medicina Tropical de São Paulo. 2019; 61 ():e66.

Chicago/Turabian Style

Jorlan Fernandes; Thayssa Alves Coelho; Renata Carvalho De Oliveira; Livia Stefânia Alves Lima Guedes; Bernardo Rodrigues Teixeira; Alexandro Guterres; Christian Niel; Silvana C. Levis; Barbara Vieira Lago; Ana Rita Motta-Castro; Elba Regina Sampaio De Lemos. 2019. "Seroprevalence of rodent-borne viruses in Afro-descendent communities in Brazil." Revista do Instituto de Medicina Tropical de São Paulo 61, no. : e66.

Original article
Published: 01 January 2019 in Revista do Instituto de Medicina Tropical de São Paulo
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Hantavirus Cardiopulmonary Syndrome (HCPS) is an important emergent zoonosis associated with wild rodents in Brazil, where this viral infection in children is generally rare. We present HCPS in a child from the Pantanal Biome and a review of all reported pediatric cases in Mato Grosso State, an endemic area for HCPS in Brazil. The investigation used the Information System for Notifiable Diseases database (SINAN). A 12-year-old boy was hospitalized with fever and respiratory failure and hantavirus IgM and IgG antibodies were detected by ELISA in serum samples. During the period of 1999 to 2016, 32 HCPS pediatric cases confirmed by serology were reported to SINAN with a mortality rate of 34.4%. The possibility of hantavirus infection in children with acute febrile illness associated with respiratory failure should be considered mainly in recognized endemic areas as Mato Grosso State, contradicting a hypothesis that children are more protected from lung involvement.

ACS Style

Ana Cláudia Pereira Terças-Trettel; Alba Valéria Gomes De Melo; Sandra Mara Fernandes Bonilha; Josdemar Muniz De Moraes; Renata Carvalho De Oliveira; Alexandro Guterres; Jorlan Fernandes; Marina Atanaka; Mariano Martinez Espinosa; Luciana Sampaio; Sumako Kinoshieta Ueda; Elba Regina Sampaio De Lemos. Hantavirus pulmonary syndrome in children: case report and case series from an endemic area of Brazil. Revista do Instituto de Medicina Tropical de São Paulo 2019, 61, e65 .

AMA Style

Ana Cláudia Pereira Terças-Trettel, Alba Valéria Gomes De Melo, Sandra Mara Fernandes Bonilha, Josdemar Muniz De Moraes, Renata Carvalho De Oliveira, Alexandro Guterres, Jorlan Fernandes, Marina Atanaka, Mariano Martinez Espinosa, Luciana Sampaio, Sumako Kinoshieta Ueda, Elba Regina Sampaio De Lemos. Hantavirus pulmonary syndrome in children: case report and case series from an endemic area of Brazil. Revista do Instituto de Medicina Tropical de São Paulo. 2019; 61 ():e65.

Chicago/Turabian Style

Ana Cláudia Pereira Terças-Trettel; Alba Valéria Gomes De Melo; Sandra Mara Fernandes Bonilha; Josdemar Muniz De Moraes; Renata Carvalho De Oliveira; Alexandro Guterres; Jorlan Fernandes; Marina Atanaka; Mariano Martinez Espinosa; Luciana Sampaio; Sumako Kinoshieta Ueda; Elba Regina Sampaio De Lemos. 2019. "Hantavirus pulmonary syndrome in children: case report and case series from an endemic area of Brazil." Revista do Instituto de Medicina Tropical de São Paulo 61, no. : e65.

Journal article
Published: 01 December 2018 in Revista da Sociedade Brasileira de Medicina Tropical
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ACS Style

Jorlan Fernandes; Thayssa Alves Coelho da Silva; Renata Carvalho de Oliveira; Alexandro Guterres; Elaine Cristina de Oliveira; Ana Claudia Pereira Terças; Silvana C. Levis; Cor Jesus Fernandes Fontes; Marina Atakana; Elba Regina Sampaio de Lemos. Letter. Revista da Sociedade Brasileira de Medicina Tropical 2018, 51, 881 -882.

AMA Style

Jorlan Fernandes, Thayssa Alves Coelho da Silva, Renata Carvalho de Oliveira, Alexandro Guterres, Elaine Cristina de Oliveira, Ana Claudia Pereira Terças, Silvana C. Levis, Cor Jesus Fernandes Fontes, Marina Atakana, Elba Regina Sampaio de Lemos. Letter. Revista da Sociedade Brasileira de Medicina Tropical. 2018; 51 (6):881-882.

Chicago/Turabian Style

Jorlan Fernandes; Thayssa Alves Coelho da Silva; Renata Carvalho de Oliveira; Alexandro Guterres; Elaine Cristina de Oliveira; Ana Claudia Pereira Terças; Silvana C. Levis; Cor Jesus Fernandes Fontes; Marina Atakana; Elba Regina Sampaio de Lemos. 2018. "Letter." Revista da Sociedade Brasileira de Medicina Tropical 51, no. 6: 881-882.

Journal article
Published: 10 September 2018 in BMC Veterinary Research
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The role of bats as reservoirs of zoonotic agents, especially pathogenic bacteria such as Bartonella and Coxiella, has been discussed around the world. Recent studies have identified bats as potential hosts of species from the proteobacteria phylum. In Brazil, however, the role of bats in the natural cycle of these agents is poorly investigated and generally neglected. In order to analyze the participation of bats in the epidemiology of diseases caused by Bartonella, Coxiella, Rickettsia, Anaplasma and Ehrlichia, we conducted a descriptive epidemiological study in three biogeographic regions of the Brazilian Atlantic Forest. Tissues of 119 bats captured in preserved areas in the states of Rio de Janeiro, Bahia and Santa Catarina from 2014 to 2015 were submitted to molecular analysis using specific primers. Bartonella spp. was detected in 22 spleen samples (18.5%, 95% CI: 11.9–26.6), whose phylogenetic analysis revealed the generation of at least two independent clusters, suggesting that these may be new unique genotypes of Bartonella species. In addition, four samples (3.4%, 95% CI: 0.9–8.3) were positive for the htpAB gene of C. burnetii [spleen (2), liver (1) and heart (1)]. Rickettsia spp., Anaplasma and Ehrlichia were not identified. This is the first study reporting C. burnetii and Bartonella spp. infections in bats from the Atlantic Forest biome. These findings shed light on potential host range for these bacteria, which are characterized as important zoonotic pathogens.

ACS Style

Michelle Santos Ferreira; Alexandro Guterres; Tatiana Rozental; Roberto Leonan Morim Novaes; Emmanuel Messias Vilar; Renata Carvalho De Oliveira; Jorlan Fernandes; Danielle Forneas; Adonai Alvino Junior; Martha Lima Brandão; José Luis Passos Cordeiro; Martín Roberto Del Valle Alvarez; Sérgio Luiz Althoff; Ricardo Moratelli; Pedro Cordeiro-Estrela; Rui Cerqueira Da Silva; Elba Regina Sampaio De Lemos. Coxiella and Bartonella spp. in bats (Chiroptera) captured in the Brazilian Atlantic Forest biome. BMC Veterinary Research 2018, 14, 279 .

AMA Style

Michelle Santos Ferreira, Alexandro Guterres, Tatiana Rozental, Roberto Leonan Morim Novaes, Emmanuel Messias Vilar, Renata Carvalho De Oliveira, Jorlan Fernandes, Danielle Forneas, Adonai Alvino Junior, Martha Lima Brandão, José Luis Passos Cordeiro, Martín Roberto Del Valle Alvarez, Sérgio Luiz Althoff, Ricardo Moratelli, Pedro Cordeiro-Estrela, Rui Cerqueira Da Silva, Elba Regina Sampaio De Lemos. Coxiella and Bartonella spp. in bats (Chiroptera) captured in the Brazilian Atlantic Forest biome. BMC Veterinary Research. 2018; 14 (1):279.

Chicago/Turabian Style

Michelle Santos Ferreira; Alexandro Guterres; Tatiana Rozental; Roberto Leonan Morim Novaes; Emmanuel Messias Vilar; Renata Carvalho De Oliveira; Jorlan Fernandes; Danielle Forneas; Adonai Alvino Junior; Martha Lima Brandão; José Luis Passos Cordeiro; Martín Roberto Del Valle Alvarez; Sérgio Luiz Althoff; Ricardo Moratelli; Pedro Cordeiro-Estrela; Rui Cerqueira Da Silva; Elba Regina Sampaio De Lemos. 2018. "Coxiella and Bartonella spp. in bats (Chiroptera) captured in the Brazilian Atlantic Forest biome." BMC Veterinary Research 14, no. 1: 279.

Journal article
Published: 24 August 2018 in Acta Tropica
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Necromys lasiurus is a generalist rodent that is thought to be the main reservoir of the Araraquara hantavirus, which causes Hantavirus Pulmonary Syndrome, in the Brazilian Cerrado savanna. This species occurs naturally in the open habitats of the Cerrado, Pantanal and Caatinga biomes, where it often occurs at high densities, although the distribution of the species has recently been observed expanding into the Brazilian state of Rio de Janeiro. This study aimed to map the occurrence of N. lasiurus within the Atlantic Forest of Rio de Janeiro state and discuss the potential role of the species as a reservoir of the Araraquara hantavirus in these areas. The study was based on a comprehensive literature search and four expeditions for the collection of specimens in the state of Rio de Janeiro. The data were used to predict the distribution of N. lasiurus, confirm the distribution of the species in the state, and detect the rates of hantavirus infection in these rodents. Necromys lasiurus has been recorded at 16 localities in 10 municipalities of Rio de Janeiro state. The relative abundance of N. lasiurus was low at all localities, except for the REBIO Poço das Antas and APA-BRSJ, two protected areas. Necromys lasiurus was associated primarily with landscapes dominated by farmland (plantations or pasture) at relatively low altitudes in the vicinity of bodies of water. A total of 204 serum samples were collected, but none were reactive for hantavirus. The distribution of N. lasiurus is expanding into many areas of the anthropogenic matrix, but it is not usually either abundant or dominant in these areas. The relatively reduced abundance of N. lasiurus in Rio de Janeiro and the lack of infection in all the areas investigated indicate that it is unlikely to be a reservoir of hantavirus in this region in the near future.

ACS Style

Fernando Santos; Bernardo Teixeira; José Luis Passos Cordeiro; Rute Hilário Albuquerque De Sousa; Camila Dos Santos Lucio; Pablo Gonçalves; Hudson Lemos; Renata Carvalho De Oliveira; Jorlan Fernandes; Gabriel Rosa Cavalcanti; Elba Regina Sampaio De Lemos; Paulo Sérgio D'andrea. Expansion of the range of Necromys lasiurus (Lund, 1841) into open areas of the Atlantic Forest biome in Rio de Janeiro state, Brazil, and the role of the species as a host of the hantavirus. Acta Tropica 2018, 188, 195 -205.

AMA Style

Fernando Santos, Bernardo Teixeira, José Luis Passos Cordeiro, Rute Hilário Albuquerque De Sousa, Camila Dos Santos Lucio, Pablo Gonçalves, Hudson Lemos, Renata Carvalho De Oliveira, Jorlan Fernandes, Gabriel Rosa Cavalcanti, Elba Regina Sampaio De Lemos, Paulo Sérgio D'andrea. Expansion of the range of Necromys lasiurus (Lund, 1841) into open areas of the Atlantic Forest biome in Rio de Janeiro state, Brazil, and the role of the species as a host of the hantavirus. Acta Tropica. 2018; 188 ():195-205.

Chicago/Turabian Style

Fernando Santos; Bernardo Teixeira; José Luis Passos Cordeiro; Rute Hilário Albuquerque De Sousa; Camila Dos Santos Lucio; Pablo Gonçalves; Hudson Lemos; Renata Carvalho De Oliveira; Jorlan Fernandes; Gabriel Rosa Cavalcanti; Elba Regina Sampaio De Lemos; Paulo Sérgio D'andrea. 2018. "Expansion of the range of Necromys lasiurus (Lund, 1841) into open areas of the Atlantic Forest biome in Rio de Janeiro state, Brazil, and the role of the species as a host of the hantavirus." Acta Tropica 188, no. : 195-205.

Journal article
Published: 29 June 2018 in Emerging Microbes & Infections
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Mammarenavirus RNA was detected in Musser’s bristly mouse (Neacomys musseri) from the Amazon region, and this detection indicated that rodents were infected with a novel mammarenavirus, with the proposed name Xapuri virus (XAPV), which is phylogenetically related to New World Clade B and Clade C viruses. XAPV may represent the first natural reassortment of the Arenaviridae family and a new unrecognized clade within the Tacaribe serocomplex group.

ACS Style

Jorlan Fernandes; Alexandro Guterres; Renata Carvalho Renata Carvalho de Oliveira Laboratory of Hantaviruses and Rickettsiosis, Oswaldo Cruz FoundationOswaldo Cruz Institute 21040-360 Rio de Janeiro – RJ Brazil; John John Chamberlain National Infection ServicePublic Health England, Porton Down SP4 0JG Salisbury Wiltshire UK; Kuiama Kuiama Lewandowski National Infection ServicePublic Health England, Porton Down SP4 0JG Salisbury Wiltshire UK; Bernardo Teixeira; Charle Ferreira Charle Ferreira Crisóstomo Laboratory of Biology and Parasitology of Wild Mammals Reservoirs, Oswaldo Cruz FoundationOswaldo Cruz Institute 21040-360 Rio de Janeiro – RJ Brazil; Federal Institute of Acre 69900-640 Rio Branco – AC Brazil; Postgraduate Prog; Cibele Rodrigues Cibele Rodrigues Bonvicino Laboratory of Biology and Parasitology of Wild Mammals Reservoirs, Oswaldo Cruz FoundationOswaldo Cruz Institute 21040-360 Rio de Janeiro – RJ Brazil; Nacional Cancer Institute 20230-130 Rio de Janeio – RJ Brazil; Paulo Sérgio Paulo Sérgio D’Andrea Laboratory of Biology and Parasitology of Wild Mammals Reservoirs, Oswaldo Cruz FoundationOswaldo Cruz Institute 21040-360 Rio de Janeiro – RJ Brazil; Postgraduate Program in Biodiversity and Health, Oswaldo Cruz FoundationOswaldo Cr; Elba Regina Sampaio de Lemos. Xapuri virus, a novel mammarenavirus: natural reassortment and increased diversity between New World viruses. Emerging Microbes & Infections 2018, 7, 1 -10.

AMA Style

Jorlan Fernandes, Alexandro Guterres, Renata Carvalho Renata Carvalho de Oliveira Laboratory of Hantaviruses and Rickettsiosis, Oswaldo Cruz FoundationOswaldo Cruz Institute 21040-360 Rio de Janeiro – RJ Brazil, John John Chamberlain National Infection ServicePublic Health England, Porton Down SP4 0JG Salisbury Wiltshire UK, Kuiama Kuiama Lewandowski National Infection ServicePublic Health England, Porton Down SP4 0JG Salisbury Wiltshire UK, Bernardo Teixeira, Charle Ferreira Charle Ferreira Crisóstomo Laboratory of Biology and Parasitology of Wild Mammals Reservoirs, Oswaldo Cruz FoundationOswaldo Cruz Institute 21040-360 Rio de Janeiro – RJ Brazil; Federal Institute of Acre 69900-640 Rio Branco – AC Brazil; Postgraduate Prog, Cibele Rodrigues Cibele Rodrigues Bonvicino Laboratory of Biology and Parasitology of Wild Mammals Reservoirs, Oswaldo Cruz FoundationOswaldo Cruz Institute 21040-360 Rio de Janeiro – RJ Brazil; Nacional Cancer Institute 20230-130 Rio de Janeio – RJ Brazil, Paulo Sérgio Paulo Sérgio D’Andrea Laboratory of Biology and Parasitology of Wild Mammals Reservoirs, Oswaldo Cruz FoundationOswaldo Cruz Institute 21040-360 Rio de Janeiro – RJ Brazil; Postgraduate Program in Biodiversity and Health, Oswaldo Cruz FoundationOswaldo Cr, Elba Regina Sampaio de Lemos. Xapuri virus, a novel mammarenavirus: natural reassortment and increased diversity between New World viruses. Emerging Microbes & Infections. 2018; 7 (1):1-10.

Chicago/Turabian Style

Jorlan Fernandes; Alexandro Guterres; Renata Carvalho Renata Carvalho de Oliveira Laboratory of Hantaviruses and Rickettsiosis, Oswaldo Cruz FoundationOswaldo Cruz Institute 21040-360 Rio de Janeiro – RJ Brazil; John John Chamberlain National Infection ServicePublic Health England, Porton Down SP4 0JG Salisbury Wiltshire UK; Kuiama Kuiama Lewandowski National Infection ServicePublic Health England, Porton Down SP4 0JG Salisbury Wiltshire UK; Bernardo Teixeira; Charle Ferreira Charle Ferreira Crisóstomo Laboratory of Biology and Parasitology of Wild Mammals Reservoirs, Oswaldo Cruz FoundationOswaldo Cruz Institute 21040-360 Rio de Janeiro – RJ Brazil; Federal Institute of Acre 69900-640 Rio Branco – AC Brazil; Postgraduate Prog; Cibele Rodrigues Cibele Rodrigues Bonvicino Laboratory of Biology and Parasitology of Wild Mammals Reservoirs, Oswaldo Cruz FoundationOswaldo Cruz Institute 21040-360 Rio de Janeiro – RJ Brazil; Nacional Cancer Institute 20230-130 Rio de Janeio – RJ Brazil; Paulo Sérgio Paulo Sérgio D’Andrea Laboratory of Biology and Parasitology of Wild Mammals Reservoirs, Oswaldo Cruz FoundationOswaldo Cruz Institute 21040-360 Rio de Janeiro – RJ Brazil; Postgraduate Program in Biodiversity and Health, Oswaldo Cruz FoundationOswaldo Cr; Elba Regina Sampaio de Lemos. 2018. "Xapuri virus, a novel mammarenavirus: natural reassortment and increased diversity between New World viruses." Emerging Microbes & Infections 7, no. 1: 1-10.

Journal article
Published: 01 March 2018 in Acta Tropica
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Mammarenavirus species are associated with a specific rodent host species, although an increasing number of virus has been associated to more than one host, suggesting that co-evolution is less robust than initially thought. There are few eco-epidemiological studies of South America mammarenaviruses in non-endemic areas of Arenavirus Hemorrhagic Fever, affecting specially our current knowledge about animal reservoirs and virus range and host-virus relations. In Brazil, seven arenavirus species were described in seven different rodent species. Here in we describe a new rodent reservoir species in Brazil related to the previously described Latino mammarenavirus (LATV) MARU strain. Samples of 148 rodents from Mato Grosso state, Brazil were analyzed. Amplification of the glycoprotein precursor gene (GPC) was observed in six Calomys callidus rodents. According to phylogenetic inferences, is observed a well-supported monophyletic clade of LATV from C. callidus and other Clade C mammarenavirus. In addition, the phylogenetic relations of both genes showed a close relation between LATV MARU and Capão Seco strains, two distinct lineages. Additionally, the results obtained in this study point out to a change of scenario and in previously stabilized patterns in the dynamics of South American mammarenaviruses, showing that with more studies in AHF non-endemic or silent areas, more potential hosts for this virus will be discovered.

ACS Style

Jorlan Fernandes; Renata Carvalho De Oliveira; Alexandro Guterres; Débora Ferreira Barreto-Vieira; Ana Claudia Pereira Terças; Bernardo Teixeira; Marcos Alexandre Nunes Da Silva; Gabriela Cardoso Caldas; Janice Mery Chicarino De Oliveira Coelho; Ortrud Monika Barth; Paulo Sergio D'Andrea; Cibele Rodrigues Bonvicino; Elba Regina Sampaio De Lemos. Detection of Latino virus (Arenaviridae: Mammarenavirus) naturally infecting Calomys callidus. Acta Tropica 2018, 179, 17 -24.

AMA Style

Jorlan Fernandes, Renata Carvalho De Oliveira, Alexandro Guterres, Débora Ferreira Barreto-Vieira, Ana Claudia Pereira Terças, Bernardo Teixeira, Marcos Alexandre Nunes Da Silva, Gabriela Cardoso Caldas, Janice Mery Chicarino De Oliveira Coelho, Ortrud Monika Barth, Paulo Sergio D'Andrea, Cibele Rodrigues Bonvicino, Elba Regina Sampaio De Lemos. Detection of Latino virus (Arenaviridae: Mammarenavirus) naturally infecting Calomys callidus. Acta Tropica. 2018; 179 ():17-24.

Chicago/Turabian Style

Jorlan Fernandes; Renata Carvalho De Oliveira; Alexandro Guterres; Débora Ferreira Barreto-Vieira; Ana Claudia Pereira Terças; Bernardo Teixeira; Marcos Alexandre Nunes Da Silva; Gabriela Cardoso Caldas; Janice Mery Chicarino De Oliveira Coelho; Ortrud Monika Barth; Paulo Sergio D'Andrea; Cibele Rodrigues Bonvicino; Elba Regina Sampaio De Lemos. 2018. "Detection of Latino virus (Arenaviridae: Mammarenavirus) naturally infecting Calomys callidus." Acta Tropica 179, no. : 17-24.

Journal article
Published: 07 February 2018 in VIRUS Reviews & Research
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Rabies is a disease caused by a virus belonging to the family Rhabdoviridae, genus Lyssavirus (RABV), and is characterized as a progressive and acute encephalitis that presents high lethality. Between 2002 and 2012, 2149 wild animals were found positive for RABV in Brazil where 79% were associated with the aerial cycle of the disease. As part of the active surveillance of rabies in Brazil, the objective of this study was to investigate the presence of RABV infection in bats captured in two different regions of Brazil. Bat specimens were collected in (i) the metropolitan region of Rio de Janeiro city, (ii) Igrapiúna Municipality, Bahia State, and (iii) Serra do Tabuleiro State Park (PEST) in Santa Catarina State. Forty-four bats from the two first areas were tested for RABV at Institute Jorge Vaitsman (IJV), reference laboratory for rabies in Rio de Janeiro State. Of the individuals captured and sent for the diagnosis of rabies, a total of 15 were identified as being hematophagous, all of them belonging to the species Desmodus rotundus. Twenty-four individuals were considered as frugivorous, four as insectivores and one individual (Lonchophylla peracchii) identified as having a pollen/nectar feeding habit. All specimen sent to RABV diagnosis presented negative results. Considering the active surveillance for RABV in Brazil, studies of fauna survey with serological characterization are important in the strengthening of epidemiological surveillance and protection of human life.

ACS Style

Marco Aurélio Horta; Dayse G. Oliveira; Eliane M. C. Miranda; Jorlan Fernandes; Michelle Ferreira; Alexandro Guterres; Jose L.P. Cordeiro; Martha Brandão; Roberto Novaes; Jairo D. Barreira; Renata Oliveira; Arnaldo L. Lassance; Ricardo Moratelli; Elba R.S. Lemos; Phyllis Romijn. Serological Survey of Rabies Virus Infection among Bats in Brazil. VIRUS Reviews & Research 2018, 23, 1 -10.

AMA Style

Marco Aurélio Horta, Dayse G. Oliveira, Eliane M. C. Miranda, Jorlan Fernandes, Michelle Ferreira, Alexandro Guterres, Jose L.P. Cordeiro, Martha Brandão, Roberto Novaes, Jairo D. Barreira, Renata Oliveira, Arnaldo L. Lassance, Ricardo Moratelli, Elba R.S. Lemos, Phyllis Romijn. Serological Survey of Rabies Virus Infection among Bats in Brazil. VIRUS Reviews & Research. 2018; 23 ():1-10.

Chicago/Turabian Style

Marco Aurélio Horta; Dayse G. Oliveira; Eliane M. C. Miranda; Jorlan Fernandes; Michelle Ferreira; Alexandro Guterres; Jose L.P. Cordeiro; Martha Brandão; Roberto Novaes; Jairo D. Barreira; Renata Oliveira; Arnaldo L. Lassance; Ricardo Moratelli; Elba R.S. Lemos; Phyllis Romijn. 2018. "Serological Survey of Rabies Virus Infection among Bats in Brazil." VIRUS Reviews & Research 23, no. : 1-10.

Case reports
Published: 12 July 2017 in The American Journal of Tropical Medicine and Hygiene
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We report the results of an investigation into a fatal case of hantavirus pulmonary syndrome (HPS) in Rio de Janeiro State, Brazil, where the disease had not been reported previous to 2015. Following the notification of an HPS case, serum samples were collected from the household members and work contacts of the HPS patient and tested for antibody to hantaviruses. Seroprevalence of 22% (10/45) was indicated for hantavirus out of 45 human samples tested. Blood and tissue samples were collected from 72 rodents during fieldwork to evaluate the prevalence of hantavirus infection, by using enzyme-linked immunosorbent assay IgG, and to characterize the rodent hantavirus reservoir(s), by reverse transcription polymerase chain reaction and sequencing. Antibody prevalence was 6.9%. The circulation of a single genotype, the Juquitiba hantavirus, carried by two rodent species, black-footed pigmy rice rat (Oligoryzomys nigripes) and cursor grass mouse (Akodon cursor), was shown by analysis of the nucleotide sequences of the S segment. Juquitiba hantavirus circulates in rodents of various species, but mainly in the black-footed pigmy rice rat. HPS is a newly recognized clinical entity in Rio de Janeiro State and should be considered in patients with febrile illness and acute respiratory distress.

ACS Style

Renata Carvalho De Oliveira; Alexandro Guterres; Bernardo Teixeira; Jorlan Fernandes; João Marcos Penna Júnior; Reynaldo De Jesus Oliveira Júnior; Liana Strecht Pereira; João Bosco Júnior; Patrícia Soares Meneguete; Cristina Maria Giordano Dias; Cibele Rodrigues Bonvicino; Paulo Sérgio D'andrea; Elba Regina Sampaio De Lemos. A Fatal Hantavirus Pulmonary Syndrome Misdiagnosed as Dengue: An Investigation into the First Reported Case in Rio de Janeiro State, Brazil. The American Journal of Tropical Medicine and Hygiene 2017, 97, 125 -129.

AMA Style

Renata Carvalho De Oliveira, Alexandro Guterres, Bernardo Teixeira, Jorlan Fernandes, João Marcos Penna Júnior, Reynaldo De Jesus Oliveira Júnior, Liana Strecht Pereira, João Bosco Júnior, Patrícia Soares Meneguete, Cristina Maria Giordano Dias, Cibele Rodrigues Bonvicino, Paulo Sérgio D'andrea, Elba Regina Sampaio De Lemos. A Fatal Hantavirus Pulmonary Syndrome Misdiagnosed as Dengue: An Investigation into the First Reported Case in Rio de Janeiro State, Brazil. The American Journal of Tropical Medicine and Hygiene. 2017; 97 (1):125-129.

Chicago/Turabian Style

Renata Carvalho De Oliveira; Alexandro Guterres; Bernardo Teixeira; Jorlan Fernandes; João Marcos Penna Júnior; Reynaldo De Jesus Oliveira Júnior; Liana Strecht Pereira; João Bosco Júnior; Patrícia Soares Meneguete; Cristina Maria Giordano Dias; Cibele Rodrigues Bonvicino; Paulo Sérgio D'andrea; Elba Regina Sampaio De Lemos. 2017. "A Fatal Hantavirus Pulmonary Syndrome Misdiagnosed as Dengue: An Investigation into the First Reported Case in Rio de Janeiro State, Brazil." The American Journal of Tropical Medicine and Hygiene 97, no. 1: 125-129.

Journal article
Published: 01 April 2017 in Infection, Genetics and Evolution
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The standard virus classification scheme for arenaviruses and bunyaviruses shifted dramatically when several groups reported the detection and isolation of divergent groups of viruses in a variety of insect collections. Although these viral families can differ in terms of morphology, structure and genetics, recent findings indicate these viruses may have a shared evolutionary origin. To determine the phylogenetic relations among these families, we inferred phylogenetic trees using three methods. The Maximum Likelihood and Bayesian trees were rooted as suggested by the (molecular clock-rooted) BEAST tree. Our results highlight a noteworthy relation among these viral supergroups of different genome organizations. Our study suggests that the best scenario is the existence of at least three monophyletic supergroups, all of them well supported. The recent data indicate that these viruses are evolutionarily and genetically interconnected. While these supergroups appear to be closely related in our phylogenetic analysis, other viruses should be investigated in future research. In sum, our results also provide insights into the classification scheme, thereby providing a new perspective about the fundamental questions of family origins, diversity and genome evolution.

ACS Style

Alexandro Guterres; Renata Carvalho de Oliveira; Jorlan Fernandes; Elba Regina Sampaio de Lemos; Carlos Schrago. New bunya-like viruses: Highlighting their relations. Infection, Genetics and Evolution 2017, 49, 164 -173.

AMA Style

Alexandro Guterres, Renata Carvalho de Oliveira, Jorlan Fernandes, Elba Regina Sampaio de Lemos, Carlos Schrago. New bunya-like viruses: Highlighting their relations. Infection, Genetics and Evolution. 2017; 49 ():164-173.

Chicago/Turabian Style

Alexandro Guterres; Renata Carvalho de Oliveira; Jorlan Fernandes; Elba Regina Sampaio de Lemos; Carlos Schrago. 2017. "New bunya-like viruses: Highlighting their relations." Infection, Genetics and Evolution 49, no. : 164-173.

Evaluation study
Published: 01 December 2015 in Virus Research
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ACS Style

Alexandro Guterres; Renata Carvalho De Oliveira; Jorlan Fernandes; Carlos Guerra Schrago; Elba Regina Sampaio De Lemos. Detection of different South American hantaviruses. Virus Research 2015, 210, 106 -113.

AMA Style

Alexandro Guterres, Renata Carvalho De Oliveira, Jorlan Fernandes, Carlos Guerra Schrago, Elba Regina Sampaio De Lemos. Detection of different South American hantaviruses. Virus Research. 2015; 210 ():106-113.

Chicago/Turabian Style

Alexandro Guterres; Renata Carvalho De Oliveira; Jorlan Fernandes; Carlos Guerra Schrago; Elba Regina Sampaio De Lemos. 2015. "Detection of different South American hantaviruses." Virus Research 210, no. : 106-113.

Journal article
Published: 01 October 2015 in Infection, Genetics and Evolution
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ACS Style

Alexandro Guterres; Renata Carvalho De Oliveira; Jorlan Fernandes; Elba Lemos. Is the evolution of Hantavirus driven by its host? Infection, Genetics and Evolution 2015, 35, 142 -143.

AMA Style

Alexandro Guterres, Renata Carvalho De Oliveira, Jorlan Fernandes, Elba Lemos. Is the evolution of Hantavirus driven by its host? Infection, Genetics and Evolution. 2015; 35 ():142-143.

Chicago/Turabian Style

Alexandro Guterres; Renata Carvalho De Oliveira; Jorlan Fernandes; Elba Lemos. 2015. "Is the evolution of Hantavirus driven by its host?" Infection, Genetics and Evolution 35, no. : 142-143.