Worldwide, at least 200 million people are affected by peripheral vascular diseases (PVDs), including peripheral arterial disease (PAD), chronic venous insufficiency (CVI) and deep vein thrombosis (DVT). The high prevalence and serious consequences of PVDs have led to the development of several diagnostic tools and clinical guidelines to assist timely diagnosis and patient management. Given the increasing number of diagnostic methods available, a comprehensive review of available technologies is timely in order to understand their limitations and direct future development effort. This paper reviews the available diagnostic methods for PAD, CVI, and DVT with a focus on non-invasive modalities. Each method is critically evaluated in terms of sensitivity, specificity, accuracy, ease of use, procedure time duration, and training requirements where applicable. This review emphasizes the limitations of existing methods, highlighting a latent need for the development of new non-invasive, efficient diagnostic methods. Some newly emerging technologies are identified, in particular wearable sensors, which demonstrate considerable potential to address the need for simple, cost-effective, accurate and timely diagnosis of PVDs.

The use of wearable sensors in health monitoring is increasing dramatically, largely due to their convenience and low-cost. Understanding the accuracy of any given sensor is paramount to avoid potential misdiagnosis. Commercially available electro-resistive band (ERB) sensors have been integrated into several newly developed wearable devices with a view to using these sensors to monitor a range of respiratory and cardiovascular metrics. Quantification of the ERBs is a necessary to step towards validation of these prototypes, as it provides valuable information, which could be exploited for compensation and ultimately, for improvement of their performance. Here, we present an analysis of the ERB sensors using an expansion/contraction simulator machine. Using the developed rig, the characteristics of four ERBs were compared with a linear displacement sensor (string potentiometer) during continuous use over the course of four-and-a-half days to investigate the error and nonlinearity of the ERBs. The analysis of the recorded data includes calculation and comparison of the total harmonic distortions of the two sensors to quantify ERB nonlinearity. Moreover, comparisons between the peak-to-peak voltages and signal-to-noise ratios of the ERB and string potentiometer demonstrate the effect nonlinearity on these factors. This paper demonstrates the nonlinearity of ERBs and highlights the implications for their use in practice.