Francesco Peri

Prof. Francesco Peri

Universita degli Studi di Milano - Bicocca, Department of Biotechnology and Biosciences, Milan, Italy
orcid

Research Focus & Metrics

Academic Career Length

32Years (1995-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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4 October 2017 in Vaccines
Verified
Journal Article
Open access
PDF file
NKNikolay Kuzmich
Nikolay Kuzmich
KSKonstantin Sivak
Konstantin Sivak
VCVladimir N. Chubarev
Vladimir N. Chubarev
YPYuri Porozov
Yuri Porozov
TSTatiana N. Savateeva-Lyubimova
Tatiana N. Savateeva-Lyubimova
FPFrancesco Peri
Francesco Peri
Toll-Like Receptor 4 (TLR4) signal pathway plays an important role in initiating the innate immune response and its activation by bacterial endotoxin is responsible for chronic and acute inflammatory disorders that are becoming more and more frequent in developed countries. Modulation of the TLR4 pathway is a potential strategy to specifically target these pathologies. Among the diseases caused by TLR4 abnormal activation by bacterial endotoxin, sepsis is the most dangerous one because it is a life-threatening acute system inflammatory condition that still lacks specific pharmacological treatment. Here, we review molecules at a preclinical or clinical phase of development, that are active in inhibiting the TLR4-MyD88 and TLR4-TRIF pathways in animal models. These are low-molecular weight compounds of natural and synthetic origin that can be considered leads for drug development. The results of in vivo studies in the sepsis model and the mechanisms of action of drug leads are presented and critically discussed, evidencing the differences in treatment results from rodents to humans.

19 December 2012 in Chemical Society Reviews
Verified
Journal Article
Closed access
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ABAnna Bernardi
Anna Bernardi
Jesus Jimenez-BarberoJesus Jimenez-Barbero
Jesus Jimenez-Barbero
ACAlessandro Casnati
Alessandro Casnati
Cristina De CastroCristina De Castro
Cristina De Castro
TDTamis Darbre
Tamis Darbre
AIAnne Imberty
Anne Imberty
Multivalency plays a major role in biological processes and particularly in the relationship between pathogenic microorganisms and their host that involves protein–glycan recognition. These interactions occur during the first steps of infection, for specific recognition between host and bacteria, but also at different stages of the immune response. The search for high-affinity ligands for studying such interactions involves the combination of carbohydrate head groups with different scaffolds and linkers generating multivalent glycocompounds with controlled spatial and topology parameters. By interfering with pathogen adhesion, such glycocompounds including glycopolymers, glycoclusters, glycodendrimers and glyconanoparticles have the potential to improve or replace antibiotic treatments that are now subverted by resistance. Multivalent glycoconjugates have also been used for stimulating the innate and adaptive immune systems, for example with carbohydrate-based vaccines. Bacteria present on their surfaces natural multivalent glycoconjugates such as lipopolysaccharides and S-layers that can also be exploited or targeted in anti-infectious strategies.

29 October 2014 in Chemistry – A European Journal
Verified
Journal Article
Closed access
PDF file
Antonio MolinaroAntonio Molinaro
Antonio Molinaro
OHOtto Holst
Otto Holst
FLFlaviana Di Lorenzo
Flaviana Di Lorenzo
MCMaire Callaghan
Maire Callaghan
ANAlessandra Nurisso
Alessandra Nurisso
SMSonsoles Martin-Santamaria
Sonsoles Martin-Santamaria

9 July 2008 in Glia
Verified
Journal Article
Closed access
PDF file
IBIsabella Bettoni
Isabella Bettoni
FCFrancesca Comelli
Francesca Comelli
CRClara Rossini
Clara Rossini
Francesca GranucciFrancesca Granucci
Francesca Granucci
GGGabriella Giagnoni
Gabriella Giagnoni
BCBarbara Costa
Barbara Costa

4 November 2013 in Journal of Medicinal Chemistry
Verified
Journal Article
Closed access
FPFrancesco Peri
Francesco Peri
VCValentina Calabrese
Valentina Calabrese

1 January 2012 in Biotechnology Advances
Verified
Journal Article
Closed access
FPFrancesco Peri
Francesco Peri
MPMatteo Piazza
Matteo Piazza