Purpose: The purpose of this in vitro study was to compare four methods of root canal obturation in primary teeth using conventional radiography. Materials and Methods: A total of 96 root canals of primary molars were prepared and obturated with zinc oxide eugenol. Obturation methods compared were endodontic pressure syringe, insulin syringe, jiffy tube, and local anesthetic syringe. The root canal obturations were evaluated by conventional radiography for the length of obturation and presence of voids. The obtained data were analyzed using Chi-square test. Results: The results showed significant differences between the four groups for the length of obturation (P < 0.05). The endodontic pressure syringe showed the best results (98.5% optimal fillings) and jiffy tube showed the poor results (37.5% optimal fillings) for the length of obturation. The insulin syringe (79.2% optimal fillings) and local anesthetic syringe (66.7% optimal fillings) showed acceptable results for the length of root canal obturation. However, minor voids were present in all the four techniques used. Conclusions: Endodontic pressure syringe produced the best results in terms of length of obturation and controlling paste extrusion from the apical foramen. However, insulin syringe and local anesthetic syringe can be used as effective alternative methods.

The amide macrocyclic complexes of zinc [ZnMc1, ZnMc2, and ZnMc3 (1–3)] were synthesized through template condensation of oxalic acid with different diamines, p-phenylenediamine, ethylenediamine, and propylenediamine, respectively. These zinc complexes (1–3) were characterized using FT-IR, UV-Vis, ^IHNMR spectral studies, conductance measurements, and DFT analysis. Compounds 1–3 were also tested for in vitro antibacterial and anticancer activities against Bacillus subtilis and HCT-15 cell lines. The results suggest that these complexes have promising antimicrobial and anticancer properties. The molecular structures of these zinc (II) complexes (1–3) were also optimized theoretically, and their electronic and thermodynamic properties were determined with density functional theory (DFT). Finally, molecular docking studies using Auto Dock, evaluated the biological relevance of the synthesized complexes, identifying the most effective binding modes between the complexes and the receptor protein’s active site. Two protein receptors, 6COX and 7AHL, were used to dock the macrocyclic complexes. The binding energies provide insights into their pharmaceutical potential. SwissADME and pkCSM were used to predict pharmacokinetic properties and toxicity. The ADMET profile of these macrocyclic architectures (1–3) revealed their oral bio-availability and drug-like properties. Zinc complexes are well-known for their medicinal applications, so the present work was aimed to synthesize and study their promising behavior as drug candidates for the future. However, further research and optimization strategies are required to enhance their biological activity and develop them into potent inhibitors.

The amide macrocyclic complexes of zinc (ZnMc1, ZnMc2, and ZnMc3) were synthesized through template condensation of oxalic acid with different diamines (p-phenylenediamine, ethylenediamine, and propylenediamine). These zinc complexes were characterized using FT-IR, UV-Vis, conductance measurements, and DFT analysis, then tested for in vitro antibacterial and anticancer activities against Bacillus subtilis and HCT-15 cell lines, respectively. The results suggest that the complexes have promising antimicrobial and anticancer properties. The molecular structures of these zinc (II) complexes were also optimized theoretically, and their electronic and thermodynamic properties were determined with density functional theory (DFT). Finally, molecular docking studies using AutoDock evaluated the biological relevance of the synthesized complexes, identifying the most effective binding modes between the complexes and the receptor protein's active site. Two protein receptors, 6COX and 7AHL, were used to dock the macrocyclic complexes. The binding energies provide insights into their pharmaceutical potential. SwissADME and pkCSM were used to predict pharmacokinetic properties and toxicity. The ADMET profile of these macrocyclic architectures revealed their oral bioavailability and drug-like properties. Zinc complexes are known for their medicinal applications. So, these complexes were synthesized and studied as promising drug candidates for the future, though further research is needed to develop potent inhibitors.