Objectives: The aim of the article was to evaluate the lesion detectability, image quality, and radiation dose of a dedicated clinical spiral breast computed tomography (CT) system equipped with a photon-counting detector, and to propose optimal scan parameter settings to achieve low patient dose levels and optimal image quality. Methods: A breast phantom containing inserts mimicking microcalcifications (diameters 196, 290, and 400 μm) and masses (diameters 1.8, 3.18, 4.76, and 6.32 mm) was examined in a spiral breast CT system with systematic variations of x-ray tube currents between 5 and 125 mA, using 2 slabs of 100 and 160 mm. Signal-to-noise ratio and contrast-to-noise ratio measurements were performed by region of interest analysis. Two experienced radiologists assessed the detectability of the inserts. The average absorbed dose was calculated in Monte Carlo simulations. Results: Microcalcifications in diameters of 290 and 400 μm and masses in diameters of 3.18, 4.76, and 6.32 mm were visible for all tube currents between 5 and 125 mA. Soft tissue masses in a diameter of 1.8 mm were visible at tube currents of 25 mA and higher. Microcalcifications with a diameter of 196 μm were detectable at a tube current of 25 mA and higher in the small, and at a tube current of 40 mA and higher in the large slab. For the small and large breast, at a tube current of 25 and 40 mA, an average dose value of 4.30 ± 0.01 and 5.70 ± 0.02 mGy was calculated, respectively. Conclusions: Optimizing tube current of spiral breast CT according to the breast size enables the visualization of microcalcifications as small as 196 μm while keeping dose values in the range of conventional mammography.

Objectives: Breast density is considered an independent risk factor for the development of breast cancer. This study aimed to quantitatively assess the percent breast density (PBD) and the mammary glands volume (MGV) according to the patient’s age and breast quadrant. We propose a regression model to estimate PBD and MGV as a function of the patient’s age. Methods: The breast composition in 1027 spiral breast CT (BCT) datasets without soft tissue masses, calcifications, or implants from 517 women (57 ± 8 years) were segmented. The breast tissue volume (BTV), MGV, and PBD of the breasts were measured in the entire breast and each of the four quadrants. The three breast composition features were analyzed in the seven age groups, from 40 to 74 years in 5-year intervals. A logarithmic model was fitted to the BTV, and a multiplicative inverse model to the MGV and PBD as a function of age was established using a least-squares method. Results: The BTV increased from 545 ± 345 to 676 ± 412 cm³, and the MGV and PBD decreased from 111 ± 164 to 57 ± 43 cm³ and from 21 ± 21 to 11 ± 9%, respectively, from the youngest to the oldest group (p < 0.05). The average PBD over all ages were 14 ± 13%. The regression models could predict the BTV, MGV, and PBD based on the patient’s age with residual standard errors of 386 cm³, 67 cm³, and 13%, respectively. The reduction in MGV and PBD in each quadrant followed the ones in the entire breast. Conclusions: The PBD and MGV computed from BCT examinations provide important information for breast cancer risk assessment in women. The study quantified the breast mammary gland reduction and density decrease over the entire breast. It established mathematical models to estimate the breast composition features—BTV, MGV, and PBD, as a function of the patient’s age.