As the population ages, promoting healthy aging through targeted interventions becomes increasingly crucial. Growing evidence suggests that dietary interventions can significantly impact this process by modulating fundamental molecular pathways. This review focuses on the potential of targeted dietary strategies in promoting healthy aging and the mechanisms by which specific nutrients and dietary patterns influence key pathways involved in cellular repair, inflammation, and metabolic regulation. Caloric restriction, intermittent fasting, the Mediterranean diet, as well as the ketogenic diet showed promising effects on promoting healthy aging, possibly by modulating mTORC1 AMPK, an insulin signaling pathway. By understanding the intricate interplay between diet and molecular pathways, we can develop personalized dietary strategies that not only prevent age-related diseases, but also promote overall health and well-being throughout the aging process.

Background/Objectives: Vaccination programs are essential for preventing infectious diseases, yet the effectiveness of these programs varies significantly across Central and Eastern European countries due to diverse socio-economic, cultural, and political influences. This study examines vaccination trends in Hungary, Slovakia, Romania, the Czech Republic, Poland, Ukraine, and Lithuania, focusing on misinformation, regional healthcare disparities, and socio-cultural factors on vaccination rates. Methods: A comprehensive review of national policies, vaccination rates, and factors influencing vaccine hesitancy was conducted across seven Central and Eastern European countries. Input from local health stakeholders and national data sources was analysed to contextualize vaccination patterns and challenges. Results: Significant cross-country variation was observed. Hungary and the Czech Republic reported consistently high coverage of mandatory childhood vaccinations, while Romania and Ukraine experienced severe declines in uptake, leading to outbreaks of measles and polio. Slovakia demonstrated low COVID-19 vaccination willingness, and Poland recorded a sharp increase in formal vaccine refusals. Conversely, Lithuania implemented successful campaigns that improved uptake, particularly for influenza and pneumococcal vaccines. Differences were influenced by healthcare system structure, public trust, exposure to misinformation, and digital communication strategies. Conclusion: Addressing vaccine hesitancy requires targeted, context-sensitive communication and digital literacy programs. Additionally, policy reforms to enhance accessibility, particularly in rural areas, and real-time monitoring systems can strengthen vaccination rates. Cross-border collaboration and tailored public health campaigns addressing cultural and socio-economic challenges are necessary to improve immunization coverage in these regions.

The COVID-19 pandemic is currently delaying the process of chronic hepatitis C (HCV) eradication, since most of the chronic diseases are neglected. Thus, there is a need for alternative programs for HCV therapy implementation and disease monitoring. Our aim was to provide a multidisciplinary approach, so that HCV-infected patients from distant locations may benefit from HCV antivirals during the COVID-19 outbreak and within the lockdown period in Romania. Previously diagnosed HCV patients willing to participate in this telemedicine pilot study were included. Patient characteristics and medical adherence were assessed and compared to the year preceding the pandemic. We proposed a multidisciplinary approach by using a telemedicine program for HCV therapy monitoring. Patients also received a satisfaction questionnaire after delivering the sustained virologic response (SVR) result. A total of 41 patients agreed to participate in this study. The medication adherence was 100% for patients included in the telemedicine group, with a statistically significant difference from the medication adherence of the patients treated in 2019. The satisfaction item score was 4.92 out of 5 and our results (r = −0.94, p < 0.0001) suggested that older patients embraced the telemedicine program less, but with the same success in terms of SVR (100%) and medication adherence (100%). Our pilot study offers the first example of a telemedicine program in Romania for HCV therapeutic management. During the lockdown period, telemedicine has served as a reliable tool and novel alternative for conventional monitoring of patients treated with direct antiviral agents and should be further considered even following the pandemic.

Health and social care systems in Central and Eastern European (CEE) countries have undergone significant changes and are currently dealing with serious problems of system disintegration, coordination and a lack of control over the market environment. The increased health needs related to the ageing society and epidemiological patterns in these countries also require funding needs to increase, rationing to be reformed, sectors to be integrated (the managed care approach), and an analytical information base to be developed if supervision of new technological approaches is to improve. The period of system transitions in CEE countries entailed significant changes in their health systems, including health care financing. Large deficits in the public financing of health systems were just one of the challenges arising from the economic downturn of the 1990s, which was coupled with inflation, increasing unemployment, low salaries, a large informal sector and tax evasion in a number of CEE countries. During the communist period, there was universal access to a wide range of health services, proving it difficult to retain this coverage. As a result, many states sought to ration publicly funded health services – for example, through patient cost-sharing or decreasing the scope of basic benefits. Yet, not all of these reform plans were implemented, and in fact, some were rolled back or not implemented at all due to a lack of social or political consensus. CEE health systems had come to practice implicit rationing in the form of under-the-table payments from patients, quasi-formal payments to providers to compensate for lack of funding, and long waiting lists forcing patients to the private sector. All these difficulties pose a challenge to the implementation of integrated care.

Background: Social prescribing initiatives are tailored coaching programs created to assist participants in improving their personal circumstances and might constitute a creative way to enhance public and preventive health as we work toward providing universal financially sustainable healthcare. Methods: We conducted a scoping review with the aim of summarizing the main global trends on social prescribing and to identify the existing resources and potential targets of social prescribing in Romania. Results: One of the main concerns that arose from this review is the lack of defined pathways to access social programs and the lack of link workers, recognized as a valuable form of support in directing people toward the most appropriate intervention, necessary to increase long-term sustainability. We also acknowledge the importance of primary care in social prescribing, especially in prevention. The level of awareness and the capacity of primary care providers to identify the need for social prescription to increase the awareness of resources and encourage teamwork should be increased. Conclusions: By focusing on these areas, we can enhance the health and well-being of the population and fully realize the benefits of social prescribing in Romania. Further research and collaboration on social prescribing are crucial for optimizing its impact in Romania.

Introduction: Vaccine hesitancy remains a critical barrier to achieving widespread vaccination, particularly in settings with limited public trust and high exposure to misinformation. This study aims to measure the level of vaccine hesitancy, identifying the factors contributing to it, and to evaluate the effectiveness of two targeted interventions—group and individual counseling—designed to address vaccine hesitancy among employees in seven industrial companies in Romania during the Coronavirus disease 2019 (COVID-19) pandemics. Methods: A total of 256 participants were included in the study, and interventions were delivered by family physicians and occupational medicine specialists trained in motivational interviewing (MI) techniques. Data on sociodemographic factors, vaccine hesitancy, and willingness to vaccinate were collected using a questionnaire and a Visual Analogue Scale (VAS) for vaccine willingness. Results: Both interventions led to significant increases in willingness to vaccinate, with group counseling showing a 1.4-point increase on the VAS (p-value < 0.0001) and individual counseling showing a 1.5-point increase (p-value < 0.0001), though the differences between the two approaches were not statistically significant (p-value = 0.209). Key factors correlated with higher levels of vaccine hesitancy included younger age, lower education levels, marital status (single or divorced), having children, the presence of chronic diseases, a lack of general antivaccine beliefs, and a lack of trust in the natural origin of the novel coronavirus (SARS-CoV-2). Conclusion: This study highlights the effectiveness of dual interventions involving family doctors and occupational medicine specialists in reducing COVID-19 vaccine hesitancy among industrial workers in Romania. Key factors influencing hesitancy included demographic characteristics (age, marital status) and social determinants (education level, anti-vaccine beliefs, parenthood, and chronic illness). The findings emphasize the role of trusted healthcare professionals in addressing these concerns through targeted communication strategies, such as motivational interviewing.